Alterations in System xc− Expression in the Retina of Type 1 Diabetic Rats and the Role of Nrf2

Epigenetic regulation of redox signaling in diabetic retinopathy: Role of Nrf2

(2017) Renu A. Kowluru et al.   FREE RADICAL BIOLOGY AND MEDICINE

Inhibiting the system xC−/glutathione axis selectively targets cancers with mutant-p53 accumulation

(2017) David S. Liu et al.   Nature Communications

The Nrf2/Keap1/ARE Pathway and Oxidative Stress as a Therapeutic Target in Type II Diabetes Mellitus

(2017) Joshua A. David et al.   Journal of Diabetes Research

MiR-20b targets AKT3 and modulates vascular endothelial growth factor-mediated changes in diabetic retinopathy

(2016) Bo Qin et al.   ACTA BIOCHIMICA ET BIOPHYSICA SINICA

Early changes in system xc− and glutathione in the retina of diabetic rats

(2016) Raul Carpi-Santos et al.   EXPERIMENTAL EYE RESEARCH

Bach1 differentially regulates distinct Nrf2-dependent genes in human venous and coronary artery endothelial cells adapted to physiological oxygen levels

(2016) Sarah J. Chapple et al.   FREE RADICAL BIOLOGY AND MEDICINE

Effects of blueberry anthocyanins on retinal oxidative stress and inflammation in diabetes through Nrf2/HO-1 signaling

(2016) Yu Song et al.   JOURNAL OF NEUROIMMUNOLOGY

The Keap1–Nrf2 system and diabetes mellitus

(2015) Akira Uruno et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Oxidative stress, mitochondrial damage and diabetic retinopathy

(2015) Renu A. Kowluru et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Sigma 1 receptor regulates the oxidative stress response in primary retinal Müller glial cells via NRF2 signaling and system xc−, the Na+-independent glutamate–cystine exchanger

(2015) Jing Wang et al.   FREE RADICAL BIOLOGY AND MEDICINE

Molecular Mechanism of Transcriptional Regulation of Matrix Metalloproteinase-9 in Diabetic Retinopathy

(2015) Manish Mishra et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Betaine inhibits vascularization via suppression of Akt in the retinas of streptozotocin-induced hyperglycemic rats

(2015) YOUNG-GIUN KIM et al.   Molecular Medicine Reports

The emerging role of redox-sensitive Nrf2–Keap1 pathway in diabetes

(2015) Elango Bhakkiyalakshmi et al.   PHARMACOLOGICAL RESEARCH

Expression of xCT and activity of system x c − are regulated by NRF2 in human breast cancer cells in response to oxidative stress

(2015) Eric Habib et al.   Redox Biology

TIAM1–RAC1 signalling axis-mediated activation of NADPH oxidase-2 initiates mitochondrial damage in the development of diabetic retinopathy

(2014) Renu A. Kowluru et al.   DIABETOLOGIA

Epigenetic modifications of Nrf2-mediated glutamate–cysteine ligase: implications for the development of diabetic retinopathy and the metabolic memory phenomenon associated with its continued progression

(2014) Manish Mishra et al.   FREE RADICAL BIOLOGY AND MEDICINE

Regulation of Nrf2—an update

(2013) Suryakant K. Niture et al.   FREE RADICAL BIOLOGY AND MEDICINE

A compensatory mechanism protects retinal mitochondria from initial insult in diabetic retinopathy

(2012) Julia M. Santos et al.   FREE RADICAL BIOLOGY AND MEDICINE

Sulforaphane prevention of diabetes-induced aortic damage was associated with the up-regulation of Nrf2 and its down-stream antioxidants

(2012) Xiao Miao et al.   Nutrition & Metabolism

A defect in Nrf2 signaling constitutes a mechanism for cellular stress hypersensitivity in a genetic rat model of type 2 diabetes

(2011) Milad S. Bitar et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Diabetic Downregulation of Nrf2 Activity via ERK Contributes to Oxidative Stress-Induced Insulin Resistance in Cardiac Cells In Vitro and In Vivo

(2011) Y. Tan et al.   DIABETES

Acetylation-Deacetylation of the Transcription Factor Nrf2 (Nuclear Factor Erythroid 2-related Factor 2) Regulates Its Transcriptional Activity and Nucleocytoplasmic Localization

(2011) Yumiko Kawai et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

SCF/ -TrCP Promotes Glycogen Synthase Kinase 3-Dependent Degradation of the Nrf2 Transcription Factor in a Keap1-Independent Manner

(2011) P. Rada et al.   MOLECULAR AND CELLULAR BIOLOGY

Role of histone acetylation in the development of diabetic retinopathy and the metabolic memory phenomenon

(2010) Qing Zhong et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Antioxidant-induced Phosphorylation of Tyrosine 486 Leads to Rapid Nuclear Export of Bach1 That Allows Nrf2 to Bind to the Antioxidant Response Element and Activate Defensive Gene Expression

(2009) James W. Kaspar et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Nrf2-Antioxidant Response Element Signaling Pathway and Its Activation by Oxidative Stress

(2009) Truyen Nguyen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Pentosidine – A New Biochemical Marker in Diabetic Retinopathy

(2009) Abdelrahman Gaber Salman et al.   OPHTHALMIC RESEARCH

Projection of Diabetic Retinopathy and Other Major Eye Diseases Among People With Diabetes Mellitus

(2008) Jinan B. Saaddine   ARCHIVES OF OPHTHALMOLOGY

Ocular Associations of Diabetes Other Than Diabetic Retinopathy

(2008) V. S. E. Jeganathan et al.   DIABETES CARE

GSK-3β down-regulates the transcription factor Nrf2 after oxidant damage: relevance to exposure of neuronal cells to oxidative stress

(2008) Ana I. Rojo et al.   JOURNAL OF NEUROCHEMISTRY

Regulation of glutathione synthesis

(2008) Shelly C. Lu   MOLECULAR ASPECTS OF MEDICINE

Altered Nrf2/Keap1-Bach1 equilibrium in pulmonary emphysema

(2008) D Goven et al.   THORAX

The role of vascular endothelial growth factor, tumor necrosis factor alpha and interleukin-6 in pathogenesis of diabetic retinopathy

(2007) Małgorzata Myśliwiec et al.   DIABETES RESEARCH AND CLINICAL PRACTICE