Aspalathin Protects the Heart against Hyperglycemia-Induced Oxidative Damage by Up-Regulating Nrf2 Expression

Damaging effects of hyperglycemia on cardiovascular function: spotlight on glucose metabolic pathways

(2016) Rudo F. Mapanga et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Synthesis, evaluation, and metabolism of novel [6]-shogaol derivatives as potent Nrf2 activators

(2016) Yingdong Zhu et al.   FREE RADICAL BIOLOGY AND MEDICINE

Protective effect of thymoquinone improves cardiovascular function, and attenuates oxidative stress, inflammation and apoptosis by mediating the PI3K/Akt pathway in diabetic rats

(2016) HUI LIU et al.   Molecular Medicine Reports

Aspalathin, a dihydrochalconeC-glucoside, protects H9c2 cardiomyocytes against high glucose induced shifts in substrate preference and apoptosis

(2016) Rabia Johnson et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Inhibitory Interactions of Aspalathus linearis (Rooibos) Extracts and Compounds, Aspalathin and Z-2-(β-d-Glucopyranosyloxy)-3-phenylpropenoic Acid, on Cytochromes Metabolizing Hypoglycemic and Hypolipidemic Drugs

(2016) Oelfah Patel et al.   MOLECULES

Phenylpyruvic Acid-2-O-β-D-Glucoside Attenuates High Glucose-Induced Apoptosis in H9c2 Cardiomyocytes

(2016) Phiwayinkosi Dludla et al.   PLANTA MEDICA

Trichostatin A accentuates doxorubicin-induced hypertrophy in cardiac myocytes

(2016) Tom C Karagiannis et al.   Aging-US

Hydroxytyrosol improves mitochondrial function and reduces oxidative stress in the brain of db/db mice: role of AMP-activated protein kinase activation

(2015) Adi Zheng et al.   BRITISH JOURNAL OF NUTRITION

Activated AMPK boosts the Nrf2/HO-1 signaling axis—A role for the unfolded protein response

(2015) Kristin Zimmermann et al.   FREE RADICAL BIOLOGY AND MEDICINE

The emerging role of Nrf2 in mitochondrial function

(2015) Albena T. Dinkova-Kostova et al.   FREE RADICAL BIOLOGY AND MEDICINE

Neohesperidin Dihydrochalcone versus CCl4-Induced Hepatic Injury through Different Mechanisms: The Implication of Free Radical Scavenging and Nrf2 Activation

(2015) Chuanyang Su et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Aspalathin improves glucose and lipid metabolism in 3T3-L1 adipocytes exposed to palmitate

(2015) Sithandiwe E. Mazibuko et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Natural Products for the Treatment of Type 2 Diabetes Mellitus

(2015) José Ríos et al.   PLANTA MEDICA

Resveratrol Protects against Methylglyoxal-Induced Hyperglycemia and Pancreatic Damage In Vivo

(2015) An-Sheng Cheng et al.   Nutrients

Management of Hyperglycemia in Type 2 Diabetes, 2015: A Patient-Centered Approach: Update to a Position Statement of the American Diabetes Association and the European Association for the Study of Diabetes

(2014) Silvio E. Inzucchi et al.   DIABETES CARE

The detrimental effects of acute hyperglycemia on myocardial glucose uptake

(2014) Danzil Joseph et al.   LIFE SCIENCES

New insights into the mechanisms of polyphenols beyond antioxidant properties; lessons from the green tea polyphenol, epigallocatechin 3-gallate

(2014) Hae-Suk Kim et al.   Redox Biology

Diabetic Cardiomyopathy and Its Prevention by Nrf2: Current Status

(2014) Jing Chen et al.   Diabetes & Metabolism Journal

Gene Expression Related to Oxidative Stress in the Heart of Mice after Intestinal Ischemia

(2013) Frederico Somaio Neto et al.   Arquivos Brasileiros de Cardiologia

Sulforaphane protects against ethanol-induced oxidative stress and apoptosis in neural crest cells by the induction of Nrf2-mediated antioxidant response

(2013) X Chen et al.   BRITISH JOURNAL OF PHARMACOLOGY

Nuclear Factor (Erythroid-Derived 2)-Like-2 Factor (Nrf2), a Key Regulator of the Antioxidant Response to Protect Against Atherosclerosis and Nonalcoholic Steatohepatitis

(2013) Anisha A. Gupte et al.   Current Diabetes Reports

The transcription factor Nrf2 promotes survival by enhancing the expression of uncoupling protein 3 under conditions of oxidative stress

(2013) Andrea Anedda et al.   FREE RADICAL BIOLOGY AND MEDICINE

Prevention by sulforaphane of diabetic cardiomyopathy is associated with up-regulation of Nrf2 expression and transcription activation

(2013) Yang Bai et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Concise and Scalable Synthesis of Aspalathin, a Powerful Plasma Sugar-Lowering Natural Product

(2013) Ze Han et al.   JOURNAL OF NATURAL PRODUCTS

Z-2-(β-d-glucopyranosyloxy)-3-phenylpropenoic acid, an α-hydroxy acid from rooibos (Aspalathus linearis) with hypoglycemic activity

(2013) Christo J. F. Muller et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Amelioration of palmitate-induced insulin resistance in C2C12 muscle cells by rooibos (Aspalathus linearis)

(2013) S.E. Mazibuko et al.   PHYTOMEDICINE

Effects of fermented rooibos (Aspalathus linearis) on adipocyte differentiation

(2013) Micheline Sanderson et al.   PHYTOMEDICINE

The cardioprotective effect of an aqueous extract of fermented rooibos (Aspalathus linearis) on cultured cardiomyocytes derived from diabetic rats

(2013) P.V. Dludla et al.   PHYTOMEDICINE

Taking Diabetes to Heart—Deregulation of Myocardial Lipid Metabolism in Diabetic Cardiomyopathy

(2013) Marina Bayeva et al.   Journal of the American Heart Association

Aspalathin improves hyperglycemia and glucose intolerance in obese diabetic ob/ob mice

(2012) Myoung Jin Son et al.   EUROPEAN JOURNAL OF NUTRITION

Acute assessment of an aspalathin-enriched green rooibos (Aspalathus linearis) extract with hypoglycemic potential

(2012) C.J.F. Muller et al.   PHYTOMEDICINE

Emerging roles of Nrf2 and phase II antioxidant enzymes in neuroprotection

(2012) Meijuan Zhang et al.   PROGRESS IN NEUROBIOLOGY

Depletion of 14-3-3 Protein Exacerbates Cardiac Oxidative Stress, Inflammation and Remodeling Process via Modulation of MAPK/NF-ĸB Signaling Pathways after Streptozotocin-induced Diabetes Mellitus

(2011) Rajarajan A. Thandavarayan et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Quercetin modulates Nrf2 and glutathione-related defenses in HepG2 cells: Involvement of p38

(2011) Ana Belén Granado-Serrano et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Diabetic Downregulation of Nrf2 Activity via ERK Contributes to Oxidative Stress-Induced Insulin Resistance in Cardiac Cells In Vitro and In Vivo

(2011) Y. Tan et al.   DIABETES

Oxidative Stress and Diabetic Complications

(2010) Ferdinando Giacco et al.   CIRCULATION RESEARCH

Diabetic cardiomyopathy, causes and effects

(2010) Sihem Boudina et al.   REVIEWS IN ENDOCRINE & METABOLIC DISORDERS

Antioxidant Activity of the Dihydrochalcones Aspalathin and Nothofagin and Their Corresponding Flavones in Relation to Other Rooibos (Aspalathus linearis) Flavonoids, Epigallocatechin Gallate, and Trolox

(2009) Petra W. Snijman et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Structure-antioxidant relationship of flavonoids from fermented rooibos

(2009) Nicole Krafczyk et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Hypoglycemic effect of aspalathin, a rooibos tea component from Aspalathus linearis, in type 2 diabetic model db/db mice

(2009) Atsutoshi Kawano et al.   PHYTOMEDICINE

Type 2 Diabetic Cardiomyopathy in db/db Mice is Associated with Progressive Cardiac Fibrosis, Cardiomyocyte Hypertrophy and Oxidative Stress

(2008) Rebecca Ritchie et al.   Heart Lung and Circulation

Nrf2 is critical in defense against high glucose-induced oxidative damage in cardiomyocytes

(2008) Xiaoqing He et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY