Notoginsenoside R1 Protects Against Diabetic Cardiomyopathy Through Activating Estrogen Receptor α and Its Downstream Signaling

Potential role of cyanidin 3-glucoside (C3G) in diabetic cardiomyopathy in diabetic rats: An in vivo approach

(2018) Weizhen Li et al.   SAUDI JOURNAL OF BIOLOGICAL SCIENCES

Hepatocyte estrogen receptor alpha mediates estrogen action to promote reverse cholesterol transport during Western-type diet feeding

(2018) Lin Zhu et al.   Molecular Metabolism

Estrogen Signals Through Peroxisome Proliferator-Activated Receptor−γ Coactivator 1α to Reduce Oxidative Damage Associated With Diet-Induced Fatty Liver Disease

(2017) Aurèle Besse-Patin et al.   GASTROENTEROLOGY

RNF11 sequestration of the E3 ligase SMURF2 on membranes antagonizes SMAD7 down-regulation of transforming growth factor β signaling

(2017) Ryan J. Malonis et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Nrf2 Activation as a Protective Feedback to Limit Cell Death in High Glucose-Exposed Cardiomyocytes

(2017) Cheng-Yen Tsai et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

miR-29c is implicated in the cardioprotective activity of Panax notoginseng saponins against isoproterenol-induced myocardial fibrogenesis

(2017) Li Liu et al.   JOURNAL OF ETHNOPHARMACOLOGY

Acquired CYP19A1 amplification is an early specific mechanism of aromatase inhibitor resistance in ERα metastatic breast cancer

(2017) Luca Magnani et al.   NATURE GENETICS

Advanced glycation end products and lipopolysaccharides stimulate interleukin‑6 secretion via the RAGE/TLR4‑NF‑κB‑ROS pathways and resveratrol attenuates these inflammatory responses in mouse macrophages

(2017) Ayaka Ohtsu et al.   Experimental and Therapeutic Medicine

Attenuation of TNF-α-Induced Inflammatory Injury in Endothelial Cells by Ginsenoside Rb1 via Inhibiting NF-κB, JNK and p38 Signaling Pathways

(2017) Ping Zhou et al.   Frontiers in Pharmacology

Myricitrin Alleviates Oxidative Stress-induced Inflammation and Apoptosis and Protects Mice against Diabetic Cardiomyopathy

(2017) Bin Zhang et al.   Scientific Reports

Metformin exerts glucose-lowering action in high-fat fed mice via attenuating endotoxemia and enhancing insulin signaling

(2016) Zi-yu Zhou et al.   ACTA PHARMACOLOGICA SINICA

Butein provides neuroprotective and anti-neuroinflammatory effects through Nrf2/ARE-dependent haem oxygenase 1 expression by activating the PI3K/Akt pathway

(2016) Dong-Sung Lee et al.   BRITISH JOURNAL OF PHARMACOLOGY

Mangiferin suppressed advanced glycation end products (AGEs) through NF-κB deactivation and displayed anti-inflammatory effects in streptozotocin and high fat diet-diabetic cardiomyopathy rats

(2016) Jun Hou et al.   CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY

Chrysin, a PPAR-γ agonist improves myocardial injury in diabetic rats through inhibiting AGE-RAGE mediated oxidative stress and inflammation

(2016) Neha Rani et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Methylglyoxal-Induced Endothelial Cell Loss and Inflammation Contribute to the Development of Diabetic Cardiomyopathy

(2016) Branka Vulesevic et al.   DIABETES

Advanced glycation end products inhibit testosterone secretion by rat Leydig cells by inducing oxidative stress and endoplasmic reticulum stress

(2016) Yun-Tao Zhao et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Estrogenic compound attenuates angiotensin II-induced vascular smooth muscle cell proliferation through interaction between LKB1 and estrogen receptor α

(2016) Sun Ae Kim et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

Exogenous hydrogen sulphide ameliorates diabetic cardiomyopathy in rats by reversing disordered calcium-handling system in sarcoplasmic reticulum

(2016) Yu-Si Cheng et al.   JOURNAL OF PHARMACY AND PHARMACOLOGY

Inhibition of human colorectal cancer metastasis by notoginsenoside R1, an important compound from Panax notoginseng

(2016) Chang-Yin Lee et al.   ONCOLOGY REPORTS

Skeletal muscle action of estrogen receptor α is critical for the maintenance of mitochondrial function and metabolic homeostasis in females

(2016) Vicent Ribas et al.   Science Translational Medicine

Broccoli sprout extract prevents diabetic cardiomyopathy via Nrf2 activation in db/db T2DM mice

(2016) Zheng Xu et al.   Scientific Reports

High Glucose-Induced Oxidative Stress Mediates Apoptosis and Extracellular Matrix Metabolic Imbalances Possibly via p38 MAPK Activation in Rat Nucleus Pulposus Cells

(2016) Xiaofei Cheng et al.   Journal of Diabetes Research

Metformin Inhibits Advanced Glycation End Products-Induced Inflammatory Response in Murine Macrophages Partly through AMPK Activation and RAGE/NFκB Pathway Suppression

(2016) Zhong’e Zhou et al.   Journal of Diabetes Research

Cardioprotective effects of Notoginsenoside R1 against ischemia/reperfusion injuries by regulating oxidative stress- and endoplasmic reticulum stress- related signaling pathways

(2016) Yingli Yu et al.   Scientific Reports

Suppression of antioxidant Nrf-2 and downstream pathway in H9c2 cells by advanced glycation end products (AGEs) via ERK phosphorylation

(2015) Shun-Yao Ko et al.   BIOCHIMIE

Correlation between advanced glycation end-products and the expression of fatty inflammatory factors in type II diabetic cardiomyopathy

(2015) Zhengdong Guo et al.   Bosnian Journal of Basic Medical Sciences

Inhibiting microRNA-144 abates oxidative stress and reduces apoptosis in hearts of streptozotocin-induced diabetic mice

(2015) Manli Yu et al.   CARDIOVASCULAR PATHOLOGY

Upregulation of MG53 Induces Diabetic Cardiomyopathy Through Transcriptional Activation of Peroxisome Proliferation-Activated Receptor  

(2015) F. Liu et al.   CIRCULATION

Smad3 Signaling Promotes Fibrosis While Preserving Cardiac and Aortic Geometry in Obese Diabetic MiceCLINICAL PERSPECTIVE

(2015) Anna Biernacka et al.   Circulation-Heart Failure

Estrogen receptor α mediates the effects of notoginsenoside R1 on endotoxin-induced inflammatory and apoptotic responses in H9c2 cardiomyocytes

(2015) LEI ZHONG et al.   Molecular Medicine Reports

Mitochondrial oxidative stress promotes atrial fibrillation

(2015) Wenjun Xie et al.   Scientific Reports

Suppression of NADPH oxidase- and mitochondrion-derived superoxide by Notoginsenoside R1 protects against cerebral ischemia–reperfusion injury through estrogen receptor-dependent activation of Akt/Nrf2 pathways

(2014) X. Meng et al.   FREE RADICAL RESEARCH

Advanced glycation end products-induced chondrocyte apoptosis through mitochondrial dysfunction in cultured rabbit chondrocyte

(2014) Qingshan Yang et al.   FUNDAMENTAL & CLINICAL PHARMACOLOGY

Notoginsenoside R1 attenuates amyloid-β-induced damage in neurons by inhibiting reactive oxygen species and modulating MAPK activation

(2014) Bo Ma et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Inhibition of Smurf2 translation by miR-322/503 modulates TGF-β/Smad2 signaling and intestinal epithelial homeostasis

(2014) Shan Cao et al.   MOLECULAR BIOLOGY OF THE CELL

Metformin and liraglutide ameliorate high glucose-induced oxidative stress via inhibition of PKC-NAD(P)H oxidase pathway in human aortic endothelial cells

(2013) Battsetseg Batchuluun et al.   ATHEROSCLEROSIS

Advanced glycation end-products impair Na+/K+-ATPase activity in diabetic cardiomyopathy: Role of the adenosine monophosphate-activated protein kinase/sirtuin 1 pathway

(2013) Qiong Yuan et al.   CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY

Taxifolin prevents diabetic cardiomyopathy in vivo and in vitro by inhibition of oxidative stress and cell apoptosis

(2013) Xiao Sun et al.   FOOD AND CHEMICAL TOXICOLOGY

The protective effects of 17beta-estradiol against ischemia–reperfusion injury and its effect on pacing postconditioning protection to the heart

(2013) Fawzi A. Babiker et al.   JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY

Notoginsenoside R1 attenuates cardiac dysfunction in endotoxemic mice: an insight into oestrogen receptor activation and PI3K/Akt signalling

(2012) Bing Sun et al.   BRITISH JOURNAL OF PHARMACOLOGY

Allopurinol attenuates left ventricular dysfunction in rats with early stages of streptozotocin-induced diabetes

(2012) Xia Gao et al.   DIABETES-METABOLISM RESEARCH AND REVIEWS

Overexpression of Smad ubiquitin regulatory factor 2 suppresses transforming growth factor-β mediated liver fibrosis

(2012) Yu CAI et al.   Journal of Digestive Diseases

Chemistry and biology of reactive oxygen species in signaling or stress responses

(2011) Bryan C Dickinson et al.   Nature Chemical Biology

The Expression of Wnt4 Is Regulated by Estrogen via an Estrogen Receptor Alpha-dependent Pathway in Rat Pituitary Growth Hormone-producing Cells

(2010) Takashi Miyakoshi et al.   ACTA HISTOCHEMICA ET CYTOCHEMICA

Expansion of human cardiac stem cells in physiological oxygen improves cell production efficiency and potency for myocardial repair

(2010) Tao-Sheng Li et al.   CARDIOVASCULAR RESEARCH

Tachycardia of atrial myocytes induces collagen expression in atrial fibroblasts through transforming growth factor  1

(2010) C.-T. Tsai et al.   CARDIOVASCULAR RESEARCH

Estrogen Inhibits Transforming Growth Factor β Signaling by Promoting Smad2/3 Degradation

(2010) Ichiaki Ito et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Panax notoginseng Attenuates the Infarct Volume in Rat Ischemic Brain and the Inflammatory Response of Microglia

(2009) Hye Young Son et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES