Hepcidin as a key iron regulator mediates glucotoxicity-induced pancreatic β-cell dysfunction

Metabolic activation-driven mitochondrial hyperpolarization predicts insulin secretion in human pancreatic beta-cells

(2018) Akos A. Gerencser   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Link of impaired metal ion homeostasis to mitochondrial dysfunction in neurons

(2018) Eunju Nam et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Estrogen receptor α protects pancreatic β-cells from apoptosis by preserving mitochondrial function and suppressing endoplasmic reticulum stress

(2018) Zhenqi Zhou et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Glucolipotoxic conditions induce β-cell iron import, cytosolic ROS formation and apoptosis

(2018) Jakob Bondo Hansen et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

Mitochondrial–Lysosomal Axis in Acetaminophen Hepatotoxicity

(2018) Anna Moles et al.   Frontiers in Pharmacology

Copper(II) and iron(III) ions inhibit respiration and increase free radical-mediated phospholipid peroxidation in rat liver mitochondria: Effect of antioxidants

(2017) Christian Saporito-Magriñá et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

Iron metabolism and the role of the iron-regulating hormone hepcidin in health and disease

(2017) Raed Daher et al.   PRESSE MEDICALE

Hepcidin links gluco-toxicity to pancreatic beta cell dysfunction by inhibiting Pdx-1 expression

(2017) Xuhua Mao et al.   Endocrine Connections

Iron Regulation of Pancreatic Beta-Cell Functions and Oxidative Stress

(2016) Marie Balslev Backe et al.   Annual Review of Nutrition

Hepcidin in the diagnosis of iron disorders

(2016) D. Girelli et al.   BLOOD

Translocation of iron from lysosomes to mitochondria during acetaminophen-induced hepatocellular injury: Protection by starch-desferal and minocycline

(2016) Jiangting Hu et al.   FREE RADICAL BIOLOGY AND MEDICINE

Mechanisms Linking Glucose Homeostasis and Iron Metabolism Toward the Onset and Progression of Type 2 Diabetes

(2015) José Manuel Fernández-Real et al.   DIABETES CARE

Inadequate hepcidin serum concentrations predict incident type 2 diabetes mellitus

(2015) Raimund Pechlaner et al.   DIABETES-METABOLISM RESEARCH AND REVIEWS

Effect of excess iron on oxidative stress and gluconeogenesis through hepcidin during mitochondrial dysfunction

(2015) Hyo Jung Lee et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Iron regulatory proteins and their role in controlling iron metabolism

(2015) Lukas C. Kühn   Metallomics

Circulating hepcidin in type 2 diabetes: A multivariate analysis and double blind evaluation of metformin effects

(2015) Milton Fabián Suárez-Ortegón et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Ets-1 as an early response gene against hypoxia-induced apoptosis in pancreatic β-cells

(2015) N Qiao et al.   Cell Death & Disease

Modulation of hepcidin to treat iron deregulation: potential clinical applications

(2015) Nicole L. Blanchette et al.   Expert Review of Hematology

Volatile anesthetics suppress glucose-stimulated insulin secretion in MIN6 cells by inhibiting glucose-induced activation of hypoxia-inducible factor 1

(2015) Kengo Suzuki et al.   PeerJ

Fe(III) Is Essential for Porcine Embryonic Development via Mitochondrial Function Maintenance

(2015) Ming-Hui Zhao et al.   PLoS One

Hyperoxia reverses glucotoxicity-induced inhibition of insulin secretion in rat INS-1 β cells

(2014) Tetsuro Matsunaga et al.   BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY

Iron and Diabetes Risk

(2013) Judith A. Simcox et al.   Cell Metabolism

Iron regulation by hepcidin

(2013) Ningning Zhao et al.   JOURNAL OF CLINICAL INVESTIGATION

Effects of excess dietary iron and fat on glucose and lipid metabolism

(2013) Joo Sun Choi et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Glucose acts as a regulator of serum iron by increasing serum hepcidin concentrations

(2012) Elmar Aigner et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Glucose-Induced O2 Consumption Activates Hypoxia Inducible Factors 1 and 2 in Rat Insulin-Secreting Pancreatic Beta-Cells

(2012) Mohammed Bensellam et al.   PLoS One

Dietary iron restriction or iron chelation protects from diabetes and loss of β-cell function in the obese (ob/ob lep−/−) mouse

(2010) Robert C. Cooksey et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Inhibition of the receptor for advanced glycation endproducts (RAGE) protects pancreatic β-cells

(2010) Yunxia Zhu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Intestinal Hypoxia-Inducible Transcription Factors Are Essential for Iron Absorption following Iron Deficiency

(2009) Yatrik M. Shah et al.   Cell Metabolism

HIF-2α, but not HIF-1α, promotes iron absorption in mice

(2009) Maria Mastrogiannaki et al.   JOURNAL OF CLINICAL INVESTIGATION

ER Stress Controls Iron Metabolism Through Induction of Hepcidin

(2009) C. Vecchi et al.   SCIENCE

Thioredoxin-Interacting Protein: A Critical Link Between Glucose Toxicity and  -Cell Apoptosis

(2008) J. Chen et al.   DIABETES

Pancreatic β-cells express hepcidin, an iron-uptake regulatory peptide

(2008) Hasan Kulaksiz et al.   JOURNAL OF ENDOCRINOLOGY