Transcending toward Advanced 3D-Cell Culture Modalities: A Review about an Emerging Paradigm in Translational Oncology

Interplay between tumor microenvironment and partial EMT as the driver of tumor progression

(2021) Vaishali Aggarwal et al.   iScience

Emerging Application of Nanorobotics and Artificial Intelligence To Cross the BBB: Advances in Design, Controlled Maneuvering, and Targeting of the Barriers

(2021) Ajay Vikram Singh et al.   ACS Chemical Neuroscience

Validating Anti-Infective Activity of Pleurotus Opuntiae via Standardization of Its Bioactive Mycoconstituents through Multimodal Biochemical Approach

(2021) Aprajita Tiwari Pandey et al.   Coatings

The use of mixed collagen-Matrigel matrices of increasing complexity recapitulates the biphasic role of cell adhesion in cancer cell migration: ECM sensing, remodeling and forces at the leading edge of cancer invasion

(2020) María Anguiano et al.   PLoS One

Chromatin accessibility dynamics in a model of human forebrain development

(2020) Alexandro E. Trevino et al.   SCIENCE

Colorectal cancer-associated anaerobic bacteria proliferate in tumor spheroids and alter the microenvironment

(2020) Stephen H. Kasper et al.   Scientific Reports

A three-dimensional hyaluronic acid-based niche enhances the therapeutic efficacy of human natural killer cell-based cancer immunotherapy

(2020) Young Ha Ahn et al.   BIOMATERIALS

Commentary on “Peptide-Conjugated Nanoparticles as Targeted Anti-angiogenesis Therapeutic and Diagnostic in Cancer” by Shaker A. Mousa, Pharmaceutical Research Institute, Albany College of Pharmacy and Health Sciences, Rensselaer, NY 12144, United States - Peptide-Conjugated Nanoparticles for Multimodal Nanomedicine

(2020) Ajay Vikram Singh   CURRENT MEDICINAL CHEMISTRY

Inhibition of Ovarian Cancer Cell Spheroid Formation by Synthetic Peptides Derived from Nectin-4

(2020) Kristin L.M. Boylan et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Modeling neoplastic disease with spheroids and organoids

(2020) Michele Zanoni et al.   Journal of Hematology & Oncology

Temporal changes guided by mesenchymal stem cells on a 3D microgel platform enhance angiogenesis in vivo at a low-cell dose

(2020) Dilip Thomas et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Human CNS barrier-forming organoids with cerebrospinal fluid production

(2020) Laura Pellegrini et al.   SCIENCE

Characterization of Uveal Melanoma Cell Lines and Primary Tumor Samples in 3D Culture

(2020) Karen Aughton et al.   Translational Vision Science & Technology

Development of a Smart Scaffold for Sequential Cancer Chemotherapy and Tissue Engineering

(2020) Poulomi Sengupta et al.   ACS Omega

Cells grown in three-dimensional spheroids mirror in vivo metabolic response of epithelial cells

(2020) Simon Lagies et al.   Communications Biology

Urbanization and food consumption in India

(2020) Bhartendu Pandey et al.   Scientific Reports

Three-Dimensional Cell Culture Systems in Radiopharmaceutical Cancer Research

(2020) Alina Doctor et al.   Cancers

Machine-Learning-Based Approach to Decode the Influence of Nanomaterial Properties on Their Interaction with Cells

(2020) Ajay Vikram Singh et al.   ACS Applied Materials & Interfaces

Dynamic single-cell RNA sequencing identifies immunotherapy persister cells following PD-1 blockade

(2020) Kartik Sehgal et al.   JOURNAL OF CLINICAL INVESTIGATION

Emerging paradigm against global antimicrobial resistance via bioprospecting of mushroom into novel nanotherapeutics development

(2020) Aprajita Tiwari Pandey et al.   TRENDS IN FOOD SCIENCE & TECHNOLOGY

Parametric Optimization of an Air–Liquid Interface System for Flow-Through Inhalation Exposure to Nanoparticles: Assessing Dosimetry and Intracellular Uptake of CeO2 Nanoparticles

(2020) Lars Leibrock et al.   Nanomaterials

3D Culture Systems for Exploring Cancer Immunology

(2020) Allison A. Fitzgerald et al.   Cancers

Implantable and Injectable Biomaterial Scaffolds for Cancer Immunotherapy

(2020) Jie Li et al.   Frontiers in Bioengineering and Biotechnology

Harnessing Tissue Engineering Tools to Interrogate Host-Microbiota Crosstalk in Cancer

(2020) Barath Udayasuryan et al.   iScience

The effect of 2D and 3D cell cultures on treatment response, EMT profile and stem cell features in head and neck cancer

(2019) Styliani Melissaridou et al.   Cancer Cell International

Human blood vessel organoids as a model of diabetic vasculopathy

(2019) Reiner A. Wimmer et al.   NATURE

The Role of 3D Printing in Medical Applications: A State of the Art

(2019) Anna Aimar et al.   Journal of Healthcare Engineering

Reversing platinum resistance in ovarian cancer multicellular spheroids by targeting Bcl-2

(2019) Ya'nan Yang et al.   OncoTargets and Therapy

Multiplex chromatin interactions with single-molecule precision

(2019) Meizhen Zheng et al.   NATURE

Current approaches in identification and isolation of cancer stem cells

(2019) Maryam Akbarzadeh et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Cathepsin B defines leader cells during the collective invasion of salivary adenoid cystic carcinoma

(2019) Jia‑Shun Wu et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Anticancer drug discovery using multicellular tumor spheroid models

(2019) Michele Zanoni et al.   Expert Opinion on Drug Discovery

Advances in immunotherapy delivery from implantable and injectable biomaterials

(2019) David G. Leach et al.   Acta Biomaterialia

Self-organization and symmetry breaking in intestinal organoid development

(2019) Denise Serra et al.   NATURE

Multivascular networks and functional intravascular topologies within biocompatible hydrogels

(2019) Bagrat Grigoryan et al.   SCIENCE

The Adoption of Three-Dimensional Additive Manufacturing from Biomedical Material Design to 3D Organ Printing

(2019) Ajay Vikram Singh et al.   Applied Sciences-Basel

Xenograft and organoid model systems in cancer research

(2019) Margit Bleijs et al.   EMBO JOURNAL

3D bioprinting of collagen to rebuild components of the human heart

(2019) A. Lee et al.   SCIENCE

Organoids-on-a-chip

(2019) Sunghee Estelle Park et al.   SCIENCE

Prospective Validation of an Ex Vivo, Patient-Derived 3D Spheroid Model for Response Predictions in Newly Diagnosed Ovarian Cancer

(2019) Stephen Shuford et al.   Scientific Reports

Cancer Stem Cells and Radioresistance: DNA Repair and Beyond

(2019) Alexander Schulz et al.   Cancers

Engineered 3D Model of Cancer Stem Cell Enrichment and Chemoresistance

(2019) Maria R. Ward Rashidi et al.   NEOPLASIA

Cell cycle progression in confining microenvironments is regulated by a growth-responsive TRPV4-PI3K/Akt-p27Kip1 signaling axis

(2019) Sungmin Nam et al.   Science Advances

Cancer Modeling‐on‐a‐Chip with Future Artificial Intelligence Integration

(2019) Kirsten Lee Fetah et al.   Small

Emerging organoid models: leaping forward in cancer research

(2019) Han Fan et al.   Journal of Hematology & Oncology

Comparison of 2D and 3D cell culture models for cell growth, gene expression and drug resistance

(2019) Julia C. Fontoura et al.   Materials Science & Engineering C-Materials for Biological Applications

Implantable Synthetic Immune Niche for Spatiotemporal Modulation of Tumor-Derived Immunosuppression and Systemic Antitumor Immunity: Postoperative Immunotherapy

(2018) Hathaichanok Phuengkham et al.   ADVANCED MATERIALS

Injectable polypeptide hydrogel for dual-delivery of antigen and TLR3 agonist to modulate dendritic cells in vivo and enhance potent cytotoxic T-lymphocyte response against melanoma

(2018) Huijuan Song et al.   BIOMATERIALS

Stress relaxing hyaluronic acid-collagen hydrogels promote cell spreading, fiber remodeling, and focal adhesion formation in 3D cell culture

(2018) Junzhe Lou et al.   BIOMATERIALS

Estimation of clinical trial success rates and related parameters

(2018) Chi Heem Wong et al.   BIOSTATISTICS

Human Pancreatic Tumor Organoids Reveal Loss of Stem Cell Niche Factor Dependence during Disease Progression

(2018) Takashi Seino et al.   Cell Stem Cell

Comparative Assay of 2D and 3D Cell Culture Models: Proliferation, Gene Expression and Anticancer Drug Response

(2018) Aline G. Souza et al.   CURRENT PHARMACEUTICAL DESIGN

Microfluidic co-culture of pancreatic tumor spheroids with stellate cells as a novel 3D model for investigation of stroma-mediated cell motility and drug resistance

(2018) Ji-Hyun Lee et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Engineering Dendritic-Cell-Based Vaccines and PD-1 Blockade in Self-Assembled Peptide Nanofibrous Hydrogel to Amplify Antitumor T-Cell Immunity

(2018) Pengxiang Yang et al.   NANO LETTERS

A surgical orthotopic organoid transplantation approach in mice to visualize and study colorectal cancer progression

(2018) Arianna Fumagalli et al.   Nature Protocols

Concerns, challenges and promises of high-content analysis of 3D cellular models

(2018) Neil Carragher et al.   NATURE REVIEWS DRUG DISCOVERY

In situ formed reactive oxygen species–responsive scaffold with gemcitabine and checkpoint inhibitor for combination therapy

(2018) Chao Wang et al.   Science Translational Medicine

Preclinical Models of Prostate Cancer: Patient-Derived Xenografts, Organoids, and Other Explant Models

(2018) Gail P. Risbridger et al.   Cold Spring Harbor Perspectives in Medicine

Three-Dimensional in Vitro Cell Culture Models in Drug Discovery and Drug Repositioning

(2018) Sigrid A. Langhans   Frontiers in Pharmacology

In-air microfluidics enables rapid fabrication of emulsions, suspensions, and 3D modular (bio)materials

(2018) Claas Willem Visser et al.   Science Advances

Generation of Tumor-Reactive T Cells by Co-culture of Peripheral Blood Lymphocytes and Tumor Organoids

(2018) Krijn K. Dijkstra et al.   CELL

Hepatocyte Culture on 3D Porous Scaffolds of PCL/PMCL

(2018) Yan Xiao et al.   COLLOIDS AND SURFACES B-BIOINTERFACES

Intra-tumour diversification in colorectal cancer at the single-cell level

(2018) Sophie F. Roerink et al.   NATURE

Recent Advances in Body-on-a-Chip Systems

(2018) Jong Hwan Sung et al.   ANALYTICAL CHEMISTRY

Isolation of spheroid-forming single cells from gastric cancer cell lines: enrichment of cancer stem-like cells

(2018) Jong Won Lee et al.   BIOTECHNIQUES

Organoid Modeling of the Tumor Immune Microenvironment

(2018) James T. Neal et al.   CELL

Accelerating anticancer drug development — opportunities and trade-offs

(2018) Sharyl J. Nass et al.   Nature Reviews Clinical Oncology

Biopolymers codelivering engineered T cells and STING agonists can eliminate heterogeneous tumors

(2017) Tyrel T. Smith et al.   JOURNAL OF CLINICAL INVESTIGATION

Distinct populations of inflammatory fibroblasts and myofibroblasts in pancreatic cancer

(2017) Daniel Öhlund et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Organoid cystogenesis reveals a critical role of microenvironment in human polycystic kidney disease

(2017) Nelly M. Cruz et al.   NATURE MATERIALS

Genetic dissection of colorectal cancer progression by orthotopic transplantation of engineered cancer organoids

(2017) Arianna Fumagalli et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ex Vivo Profiling of PD-1 Blockade Using Organotypic Tumor Spheroids

(2017) Russell W. Jenkins et al.   Cancer Discovery

Application of 3D tumoroid systems to define immune and cytotoxic therapeutic responses based on tumoroid and tissue slice culture molecular signatures

(2017) Niklas K. Finnberg et al.   Oncotarget

Multicomponent Injectable Hydrogels for Antigen-Specific Tolerogenic Immune Modulation

(2017) Catia S. Verbeke et al.   Advanced Healthcare Materials

Multiorgan Microphysiological Systems for Drug Development: Strategies, Advances, and Challenges

(2017) Ying I. Wang et al.   Advanced Healthcare Materials

Personalized Proteome Profiles of Healthy and Tumor Human Colon Organoids Reveal Both Individual Diversity and Basic Features of Colorectal Cancer

(2017) Alba Cristobal et al.   Cell Reports

Protocols and characterization data for 2D, 3D, and slice-based tumor models from the PREDECT project

(2017) Ronald de Hoogt et al.   Scientific Data

Multi-tissue interactions in an integrated three-tissue organ-on-a-chip platform

(2017) Aleksander Skardal et al.   Scientific Reports

Design and Construction of a Multi-Organ Microfluidic Chip Mimicking the in vivo Microenvironment of Lung Cancer Metastasis

(2016) Zhiyun Xu et al.   ACS Applied Materials & Interfaces

Growth inhibitory effect of an injectable hyaluronic acid–tyramine hydrogels incorporating human natural interferon-α and sorafenib on renal cell carcinoma cells

(2016) Kosuke Ueda et al.   Acta Biomaterialia

Human engineered heart tissue as a model system for drug testing

(2016) Alexandra Eder et al.   ADVANCED DRUG DELIVERY REVIEWS

A Powerful CD8+T-Cell Stimulating D-Tetra-Peptide Hydrogel as a Very Promising Vaccine Adjuvant

(2016) Zichao Luo et al.   ADVANCED MATERIALS

Organoids as Models for Neoplastic Transformation

(2016) James T. Neal et al.   Annual Review of Pathology-Mechanisms of Disease

2D and 3D cell cultures – a comparison of different types of cancer cell cultures

(2016) Marta Kapałczyńska et al.   Archives of Medical Science

An injectable, low-toxicity phospholipid-based phase separation gel that induces strong and persistent immune responses in mice

(2016) Lu Han et al.   BIOMATERIALS

The effect of surface modification of mesoporous silica micro-rod scaffold on immune cell activation and infiltration

(2016) Weiwei Aileen Li et al.   BIOMATERIALS

3D tumor spheroids: an overview on the tools and techniques used for their analysis

(2016) Elisabete C. Costa et al.   BIOTECHNOLOGY ADVANCES

In vitro models of cancer stem cells and clinical applications

(2016) Sara S. Franco et al.   BMC CANCER

Recapitulating epithelial tumor microenvironment in vitro using three dimensional tri-culture of human epithelial, endothelial, and mesenchymal cells

(2016) Surya P. Lamichhane et al.   BMC CANCER

Analysis of Immune Cells from Human Mammary Ductal Epithelial Organoids Reveals Vδ2 + T Cells That Efficiently Target Breast Carcinoma Cells in the Presence of Bisphosphonate

(2016) Nicholas A. Zumwalde et al.   Cancer Prevention Research

Novel 3-D cell culture system forin vitroevaluation of anticancer drugs under anchorage-independent conditions

(2016) Ayako Aihara et al.   CANCER SCIENCE

A Colorectal Tumor Organoid Library Demonstrates Progressive Loss of Niche Factor Requirements during Tumorigenesis

(2016) Masayuki Fujii et al.   Cell Stem Cell

Comparison of cancer cells in 2D vs 3D culture reveals differences in AKT–mTOR–S6K signaling and drug responses

(2016) Angelika Riedl et al.   JOURNAL OF CELL SCIENCE

The expression of Nectin-4 on the surface of ovarian cancer cells alters their ability to adhere, migrate, aggregate, and proliferate

(2016) Kristin L.M Boylan et al.   Oncotarget

Engineered In Vitro Disease Models

(2015) Kambez H. Benam et al.   Annual Review of Pathology-Mechanisms of Disease

Establishment and Characterization of an In Vitro Model of Ovarian Cancer Stem-like Cells with an Enhanced Proliferative Capacity

(2015) T. Ishiguro et al.   CANCER RESEARCH

Long-Term Culture of Genome-Stable Bipotent Stem Cells from Adult Human Liver

(2015) Meritxell Huch et al.   CELL

Microfluidic 3D cell culture: from tools to tissue models

(2015) Vincent van Duinen et al.   CURRENT OPINION IN BIOTECHNOLOGY

Formation of stable small cell number three-dimensional ovarian cancer spheroids using hanging drop arrays for preclinical drug sensitivity assays

(2015) Shreya Raghavan et al.   GYNECOLOGIC ONCOLOGY

Impact of the spheroid model complexity on drug response

(2015) Oliver Ingo Hoffmann et al.   JOURNAL OF BIOTECHNOLOGY

Kidney organoids from human iPS cells contain multiple lineages and model human nephrogenesis

(2015) Minoru Takasato et al.   NATURE

Modeling colorectal cancer using CRISPR-Cas9–mediated engineering of human intestinal organoids

(2015) Mami Matano et al.   NATURE MEDICINE

Comparison of 2D- and 3D-culture models as drug-testing platforms in breast cancer

(2015) YOSHINORI IMAMURA et al.   ONCOLOGY REPORTS

In vitro human cell line models to predict clinical response to anticancer drugs

(2015) Nifang Niu et al.   PHARMACOGENOMICS

Beyond 3D culture models of cancer

(2015) Kandice Tanner et al.   Science Translational Medicine

Bioprinting for cancer research

(2015) Stephanie Knowlton et al.   TRENDS IN BIOTECHNOLOGY

A spheroid toxicity assay using magnetic 3D bioprinting and real-time mobile device-based imaging

(2015) Hubert Tseng et al.   Scientific Reports

Injectable, Pore-Forming Hydrogels for In Vivo Enrichment of Immature Dendritic Cells

(2015) Catia S. Verbeke et al.   Advanced Healthcare Materials

Spherical Cancer Models in Tumor Biology

(2015) Louis-Bastien Weiswald et al.   NEOPLASIA

Hydrogel dual delivered celecoxib and anti-PD-1 synergistically improve antitumor immunity

(2015) Yongkui Li et al.   OncoImmunology

Fibroblasts Influence Survival and Therapeutic Response in a 3D Co-Culture Model

(2015) Meher Majety et al.   PLoS One

Improved Methods to Generate Spheroid Cultures from Tumor Cells, Tumor Cells & Fibroblasts or Tumor-Fragments: Microenvironment, Microvesicles and MiRNA

(2015) Zheng Lao et al.   PLoS One

Human decellularized adipose tissue scaffold as a model for breast cancer cell growth and drug treatments

(2014) Lina W. Dunne et al.   BIOMATERIALS

Cancer Cell Lines for Drug Discovery and Development

(2014) J. L. Wilding et al.   CANCER RESEARCH

Approaches to in vitro tissue regeneration with application for human disease modeling and drug development

(2014) Mohammad R. Ebrahimkhani et al.   DRUG DISCOVERY TODAY

3D Cell Culture Systems: Advantages and Applications

(2014) Maddaly Ravi et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Biopolymer implants enhance the efficacy of adoptive T-cell therapy

(2014) Sirkka B Stephan et al.   NATURE BIOTECHNOLOGY

Injectable, spontaneously assembling, inorganic scaffolds modulate immune cells in vivo and increase vaccine efficacy

(2014) Jaeyun Kim et al.   NATURE BIOTECHNOLOGY

A breast cancer stem cell niche supported by juxtacrine signalling from monocytes and macrophages

(2014) Haihui Lu et al.   NATURE CELL BIOLOGY

Tackling the cancer stem cells — what challenges do they pose?

(2014) Diwakar R. Pattabiraman et al.   NATURE REVIEWS DRUG DISCOVERY

Construction and characteristics of an E-cadherin-related three-dimensional suspension growth model of ovarian cancer

(2014) Shan Xu et al.   Scientific Reports

Collective Invasion in Breast Cancer Requires a Conserved Basal Epithelial Program

(2013) Kevin J. Cheung et al.   CELL

The tumor microenvironment at a glance

(2013) F. R. Balkwill et al.   JOURNAL OF CELL SCIENCE

Influence of tumour micro-environment heterogeneity on therapeutic response

(2013) Melissa R. Junttila et al.   NATURE

Microenvironmental regulation of tumor progression and metastasis

(2013) Daniela F Quail et al.   NATURE MEDICINE

Lung Collagens Perpetuate Pulmonary Fibrosis via CD204 and M2 Macrophage Activation

(2013) Mirjam Stahl et al.   PLoS One

Fabrication of 3-Dimensional Cellular Constructs via Microstereolithography Using a Simple, Three-Component, Poly(Ethylene Glycol) Acrylate-Based System

(2012) Simon J. Leigh et al.   BIOMACROMOLECULES

Coaxially Electrospun Scaffolds Based on Hydroxyl-Functionalized Poly(ε-caprolactone) and Loaded with VEGF for Tissue Engineering Applications

(2012) Hajar Seyednejad et al.   BIOMACROMOLECULES

Accessories to the Crime: Functions of Cells Recruited to the Tumor Microenvironment

(2012) Douglas Hanahan et al.   CANCER CELL

Three-dimensional cell culture: the missing link in drug discovery

(2012) Susan Breslin et al.   DRUG DISCOVERY TODAY

The tumor microenvironment is a dominant force in multidrug resistance

(2012) Ana Luísa Correia et al.   DRUG RESISTANCE UPDATES

Deconstructing the third dimension – how 3D culture microenvironments alter cellular cues

(2012) Brendon M. Baker et al.   JOURNAL OF CELL SCIENCE

Origins of the Tumor Microenvironment: Quantitative Assessment of Adipose-Derived and Bone Marrow–Derived Stroma

(2012) Shannon Kidd et al.   PLoS One

2D and 3D-Organized Cardiac Cells Shows Differences in Cellular Morphology, Adhesion Junctions, Presence of Myofibrils and Protein Expression

(2012) Carolina Pontes Soares et al.   PLoS One

Microfluidic 3D cell culture: potential application for tissue-based bioassays

(2012) XiuJun (James) Li et al.   Bioanalysis

Eyes Wide Open: A Critical Review of Sphere-Formation as an Assay for Stem Cells

(2011) Erika Pastrana et al.   Cell Stem Cell

PI3K Functions in Cancer Progression, Anticancer Immunity and Immune Evasion by Tumors

(2011) Francesco Dituri et al.   Clinical & Developmental Immunology

Long-term Expansion of Epithelial Organoids From Human Colon, Adenoma, Adenocarcinoma, and Barrett's Epithelium

(2011) Toshiro Sato et al.   GASTROENTEROLOGY

Cancer immunotherapy comes of age

(2011) Ira Mellman et al.   NATURE

The cancer stem cell: premises, promises and challenges

(2011) Hans Clevers   NATURE MEDICINE

High drug attrition rates—where are we going wrong?

(2011) Lisa Hutchinson et al.   Nature Reviews Clinical Oncology

Advances in the preclinical testing of cancer therapeutic hypotheses

(2011) Giordano Caponigro et al.   NATURE REVIEWS DRUG DISCOVERY

ECM components guide IL-10 producing regulatory T-cell (TR1) induction from effector memory T-cell precursors

(2011) P. L. Bollyky et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Immunobiological Characterization of Cancer Stem Cells Isolated from Glioblastoma Patients

(2010) T. Di Tomaso et al.   CLINICAL CANCER RESEARCH

Fabricating Tissue Engineering Scaffolds for Simultaneous Cell Growth and Drug Delivery

(2010) Wenhui Chen et al.   CURRENT PHARMACEUTICAL DESIGN

Three-dimensional culture of hepatocytes for prediction of drug-induced hepatotoxicity

(2010) Qin Meng   Expert Opinion on Drug Metabolism & Toxicology

A Review of Three-Dimensional In Vitro Tissue Models for Drug Discovery and Transport Studies

(2010) Nelita T. Elliott et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Tumor cell-specific bioluminescence platform to identify stroma-induced changes to anticancer drug activity

(2010) Douglas W McMillin et al.   NATURE MEDICINE

Anticancer drug development: the grand challenges

(2010) William N. Hait   NATURE REVIEWS DRUG DISCOVERY

A Comprehensive Panel of Three-Dimensional Models for Studies of Prostate Cancer Growth, Invasion and Drug Responses

(2010) Ville Härmä et al.   PLoS One

Reconstituting Organ-Level Lung Functions on a Chip

(2010) D. Huh et al.   SCIENCE

The Use of Animal Models for Cancer Chemoprevention Drug Development

(2010) Vernon E. Steele et al.   SEMINARS IN ONCOLOGY

Long-term cultivation of HepG2 liver cells encapsulated in alginate hydrogels: A study of cell viability, morphology and drug metabolism

(2010) Shih-Feng Lan et al.   TOXICOLOGY IN VITRO

Can Animal Models of Disease Reliably Inform Human Studies?

(2010) H. Bart van der Worp et al.   PLOS MEDICINE

Nanoparticle interaction with plasma proteins as it relates to particle biodistribution, biocompatibility and therapeutic efficacy

(2009) Parag Aggarwal et al.   ADVANCED DRUG DELIVERY REVIEWS

Models for prevention and treatment of cancer: Problems vs promises

(2009) Bharat B. Aggarwal et al.   BIOCHEMICAL PHARMACOLOGY

Hyaluronic acid-based hydrogels as 3D matrices for in vitro evaluation of chemotherapeutic drugs using poorly adherent prostate cancer cells

(2009) Lisa A. Gurski et al.   BIOMATERIALS

Cell-controlled and spatially arrayed gene delivery from fibrin hydrogels

(2009) Pedro Lei et al.   BIOMATERIALS

Fibrin hydrogels for non-viral vector delivery in vitro

(2009) Anne des Rieux et al.   JOURNAL OF CONTROLLED RELEASE

The cancer genome

(2009) Michael R. Stratton et al.   NATURE

Infection-mimicking materials to program dendritic cells in situ

(2009) Omar A. Ali et al.   NATURE MATERIALS

Spheroid-based drug screen: considerations and practical approach

(2009) Juergen Friedrich et al.   Nature Protocols

Tumour-initiating cells: challenges and opportunities for anticancer drug discovery

(2009) Bin-Bing S. Zhou et al.   NATURE REVIEWS DRUG DISCOVERY

3D cell culture opens new dimensions in cell-based assays

(2008) Bradley A. Justice et al.   DRUG DISCOVERY TODAY

Three-Dimensional Cell Culture Matrices: State of the Art

(2008) Jungwoo Lee et al.   TISSUE ENGINEERING PART B-REVIEWS