Emerging Application of Nanorobotics and Artificial Intelligence To Cross the BBB: Advances in Design, Controlled Maneuvering, and Targeting of the Barriers

Artificial neural network approach for predicting blood brain barrier permeability based on a group contribution method

(2021) Zeyu Wu et al.   COMPUTER METHODS AND PROGRAMS IN BIOMEDICINE

Validating Anti-Infective Activity of Pleurotus Opuntiae via Standardization of Its Bioactive Mycoconstituents through Multimodal Biochemical Approach

(2021) Aprajita Tiwari Pandey et al.   Coatings

Novel neuroprotection using antioxidant nanoparticles in a mouse model of head trauma

(2020) Toshihide Takahashi et al.   Journal of Trauma and Acute Care Surgery

In Vitro and in Vivo Evaluation of Levodopa Loaded Nanoparticles for Nose to Brain Delivery

(2020) Sema Arisoy et al.   PHARMACEUTICAL DEVELOPMENT AND TECHNOLOGY

Wafer-Scale Fabrication of Micro- to Nanoscale Bubble Swimmers and Their Fast Autonomous Propulsion by Ultrasound

(2020) Jeffrey M. McNeill et al.   ACS Nano

Carbon dots as versatile nanoarchitectures for the treatment of neurological disorders and their theranostic applications: A review

(2020) Milad Ashrafizadeh et al.   ADVANCES IN COLLOID AND INTERFACE SCIENCE

The blood–brain barrier in health and disease: Important unanswered questions

(2020) Caterina P. Profaci et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Recent advances in human iPSC-derived models of the blood–brain barrier

(2020) Michael J. Workman et al.   Fluids and Barriers of the CNS

In vitro modeling of the neurovascular unit: advances in the field

(2020) Aditya Bhalerao et al.   Fluids and Barriers of the CNS

Nanocarriers as Potential Drug Delivery Candidates for Overcoming the Blood–Brain Barrier: Challenges and Possibilities

(2020) Jyoti Ahlawat et al.   ACS Omega

Key for crossing the BBB with nanoparticles: the rational design

(2020) Sonia M Lombardo et al.   Beilstein Journal of Nanotechnology

Artificial Intelligence and Machine Learning in Computational Nanotoxicology: Unlocking and Empowering Nanomedicine

(2020) Ajay Vikram Singh et al.   Advanced Healthcare Materials

Models of the blood-brain barrier using iPSC-derived cells

(2020) Louise Delsing et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Untethered control of functional origami microrobots with distributed actuation

(2020) Larissa S. Novelino et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Chiral gold nanoparticles enantioselectively rescue memory deficits in a mouse model of Alzheimer’s disease

(2020) Ke Hou et al.   Nature Communications

Engineering E. coli for Magnetic Control and the Spatial Localization of Functions

(2020) Mary Aubry et al.   ACS Synthetic Biology

Medical Micro/Nanorobots in Precision Medicine

(2020) Fernando Soto et al.   Advanced Science

Machine-Learning-Based Approach to Decode the Influence of Nanomaterial Properties on Their Interaction with Cells

(2020) Ajay Vikram Singh et al.   ACS Applied Materials & Interfaces

A Recurrent Neural Network model to predict blood–brain barrier permeability

(2020) Shrooq Alsenan et al.   COMPUTATIONAL BIOLOGY AND CHEMISTRY

Emerging paradigm against global antimicrobial resistance via bioprospecting of mushroom into novel nanotherapeutics development

(2020) Aprajita Tiwari Pandey et al.   TRENDS IN FOOD SCIENCE & TECHNOLOGY

Advances and opportunities for hiPSC-derived models of the blood-brain barrier

(2020) Hannah S Seo et al.   Current Opinion in Chemical Engineering

Transcytosis to Cross the Blood Brain Barrier, New Advancements and Challenges

(2019) Victor M. Pulgar   Frontiers in Neuroscience

Bioinspired neuron-like electronics

(2019) Xiao Yang et al.   NATURE MATERIALS

Advances in Microfluidic Blood–Brain Barrier (BBB) Models

(2019) Arianna Oddo et al.   TRENDS IN BIOTECHNOLOGY

Human iPSC-Derived Blood-Brain Barrier Chips Enable Disease Modeling and Personalized Medicine Applications

(2019) Gad D. Vatine et al.   Cell Stem Cell

Pericytes and Neurovascular Function in the Healthy and Diseased Brain

(2019) Lachlan S. Brown et al.   Frontiers in Cellular Neuroscience

Improved Classification of Blood-Brain-Barrier Drugs Using Deep Learning

(2019) Rui Miao et al.   Scientific Reports

Tumor-Derived Extracellular Vesicles Breach the Intact Blood–Brain Barrier via Transcytosis

(2019) Golnaz Morad et al.   ACS Nano

Blood brain barrier permeability prediction using machine learning techniques: An update

(2019) Deeksha Saxena et al.   CURRENT PHARMACEUTICAL BIOTECHNOLOGY

An isogenic neurovascular unit model comprised of human induced pluripotent stem cell-derived brain microvascular endothelial cells, pericytes, astrocytes, and neurons

(2019) Scott G. Canfield et al.   Fluids and Barriers of the CNS

Multifunctional magnetic hairbot for untethered osteogenesis, ultrasound contrast imaging and drug delivery

(2019) Ajay Vikram Singh et al.   BIOMATERIALS

Micro-nanorobots: important considerations when developing novel drug delivery platforms

(2019) Ajay Vikram Singh et al.   Expert Opinion on Drug Delivery

Blood brain barrier: A tissue engineered microfluidic chip

(2019) Sikkandhar Musafargani et al.   JOURNAL OF NEUROSCIENCE METHODS

3D Printing of Highly Stretchable, Shape-Memory, and Self-Healing Elastomer toward Novel 4D Printing

(2018) Xiao Kuang et al.   ACS Applied Materials & Interfaces

Ferritin Nanocarrier Traverses the Blood Brain Barrier and Kills Glioma

(2018) Kelong Fan et al.   ACS Nano

Use of porous membranes in tissue barrier and co-culture models

(2018) Henry H. Chung et al.   LAB ON A CHIP

In vitro anti-cancer activity and pharmacokinetic evaluation of curcumin-loaded lipid nanocapsules

(2018) Giovanna Lollo et al.   Materials Science & Engineering C-Materials for Biological Applications

An in vivo model of functional and vascularized human brain organoids

(2018) Abed AlFatah Mansour et al.   NATURE BIOTECHNOLOGY

Generation of human vascularized brain organoids

(2018) Missy T. Pham et al.   NEUROREPORT

Lipid nanocarriers loaded with natural compounds: Potential new therapies for age related neurodegenerative diseases?

(2018) Telma Bezerra Soares et al.   PROGRESS IN NEUROBIOLOGY

Dual-Modality Surface-Enhanced Resonance Raman Scattering and Multispectral Optoacoustic Tomography Nanoparticle Approach for Brain Tumor Delineation

(2018) Volker Neuschmelting et al.   Small

Human Cortex Spheroid with a Functional Blood Brain Barrier for High-Throughput Neurotoxicity Screening and Disease Modeling

(2018) Goodwell Nzou et al.   Scientific Reports

Comparison of a Rat Primary Cell-Based Blood-Brain Barrier Model With Epithelial and Brain Endothelial Cell Lines: Gene Expression and Drug Transport

(2018) Szilvia Veszelka et al.   Frontiers in Molecular Neuroscience

Ultraparamagnetic Cells Formed through Intracellular Oxidation and Chelation of Paramagnetic Iron

(2018) Pradeep Ramesh et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

In Silico Prediction of Blood-Brain Barrier Permeability of Compounds by Machine Learning and Resampling Methods

(2018) Zhuang Wang et al.   ChemMedChem

In-vitro blood–brain barrier modeling: A review of modern and fast-advancing technologies

(2018) Farzane Sivandzade et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Planning chemical syntheses with deep neural networks and symbolic AI

(2018) Marwin H. S. Segler et al.   NATURE

Inverse molecular design using machine learning: Generative models for matter engineering

(2018) Benjamin Sanchez-Lengeling et al.   SCIENCE

Apolipoprotein E Peptide-Directed Chimeric Polymersomes Mediate an Ultrahigh-Efficiency Targeted Protein Therapy for Glioblastoma

(2018) Yu Jiang et al.   ACS Nano

Phototheranostics: Active Targeting of Orthotopic Glioma Using Biomimetic Proteolipid Nanoparticles

(2018) Yali Jia et al.   ACS Nano

Induced Pluripotent Stem Cells and Their Use in Human Models of Disease and Development

(2018) Peter Karagiannis et al.   PHYSIOLOGICAL REVIEWS

An isogenic blood-brain barrier model comprising brain endothelial cells, astrocytes, and neurons derived from human induced pluripotent stem cells

(2017) Scott G. Canfield et al.   JOURNAL OF NEUROCHEMISTRY

Neutrophil-mediated anticancer drug delivery for suppression of postoperative malignant glioma recurrence

(2017) Jingwei Xue et al.   Nature Nanotechnology

Blood-brain-barrier spheroids as an in vitro screening platform for brain-penetrating agents

(2017) Choi-Fong Cho et al.   Nature Communications

QSAR model for blood-brain barrier permeation

(2017) Andrey A. Toropov et al.   JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS

Development and Function of the Blood-Brain Barrier in the Context of Metabolic Control

(2017) Roberta Haddad-Tóvolli et al.   Frontiers in Neuroscience

Establishment of a Human Blood-Brain Barrier Co-culture Model Mimicking the Neurovascular Unit Using Induced Pluri- and Multipotent Stem Cells

(2017) Antje Appelt-Menzel et al.   Stem Cell Reports

Machine learning in materials informatics: recent applications and prospects

(2017) Rampi Ramprasad et al.   npj Computational Materials

A Low Permeability Microfluidic Blood-Brain Barrier Platform with Direct Contact between Perfusable Vascular Network and Astrocytes

(2017) Seokyoung Bang et al.   Scientific Reports

Nanomedicines: From Bench to Bedside and Beyond

(2016) Henry Havel et al.   AAPS Journal

Predict drug permeability to blood–brain-barrier from clinical phenotypes: drug side effects and drug indications

(2016) Zhen Gao et al.   BIOINFORMATICS

Modeling Development and Disease with Organoids

(2016) Hans Clevers   CELL

Stem Cell Models of Human Brain Development

(2016) Iva Kelava et al.   Cell Stem Cell

In vitro models of the blood–brain barrier: An overview of commonly used brain endothelial cell culture models and guidelines for their use

(2016) Hans C Helms et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Nanoparticle-mediated brain drug delivery: Overcoming blood–brain barrier to treat neurodegenerative diseases

(2016) Cláudia Saraiva et al.   JOURNAL OF CONTROLLED RELEASE

Brain and Retinal Pericytes: Origin, Function and Role

(2016) Andrea Trost et al.   Frontiers in Cellular Neuroscience

High Precision Imaging of Microscopic Spread of Glioblastoma with a Targeted Ultrasensitive SERRS Molecular Imaging Probe

(2016) Ruimin Huang et al.   Theranostics

Materials and technologies for soft implantable neuroprostheses

(2016) Stéphanie P. Lacour et al.   Nature Reviews Materials

MRI Virtual Biopsy and Treatment of Brain Metastatic Tumors with Targeted Nanobioconjugates: Nanoclinic in the Brain

(2015) Rameshwar Patil et al.   ACS Nano

Neuronopathic lysosomal storage disorders: Approaches to treat the central nervous system

(2015) Maurizio Scarpa et al.   BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM

Collagen-based brain microvasculature model in vitro using three-dimensional printed template

(2015) Jeong Ah Kim et al.   Biomicrofluidics

Conductive 3D microstructures by direct 3D printing of polymer/carbon nanotube nanocomposites via liquid deposition modeling

(2015) Giovanni Postiglione et al.   COMPOSITES PART A-APPLIED SCIENCE AND MANUFACTURING

The dynamic blood-brain barrier

(2015) James Keaney et al.   FEBS Journal

Self-assembled 20-nm 64 Cu-micelles enhance accumulation in rat glioblastoma

(2015) Jai Woong Seo et al.   JOURNAL OF CONTROLLED RELEASE

3D printed microfluidics for biological applications

(2015) Chee Meng Benjamin Ho et al.   LAB ON A CHIP

Inkjet printing for biosensor fabrication: combining chemistry and technology for advanced manufacturing

(2015) Jia Li et al.   LAB ON A CHIP

The Molecular Constituents of the Blood–Brain Barrier

(2015) Brian Wai Chow et al.   TRENDS IN NEUROSCIENCES

The Blood–Brain Barrier

(2015) Richard Daneman et al.   Cold Spring Harbor Perspectives in Biology

Acute Effects of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) or Paraquat on Core Temperature in C57BL/6J Mice

(2015) Yun Jiao et al.   Journal of Parkinsons Disease

Fiber Encapsulation Additive Manufacturing: An Enabling Technology for 3D Printing of Electromechanical Devices and Robotic Components

(2015) Matt Saari et al.   3D Printing and Additive Manufacturing

Transporters at CNS Barrier Sites: Obstacles or Opportunities for Drug Delivery?

(2014) Lucy Sanchez-Covarrubias et al.   CURRENT PHARMACEUTICAL DESIGN

Biological and medical applications of a brain-on-a-chip

(2014) David Pamies et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Controlling many differential-drive robots with uniform control inputs

(2014) Aaron Becker et al.   INTERNATIONAL JOURNAL OF ROBOTICS RESEARCH

Preclinical research: Make mouse studies work

(2014) Steve Perrin   NATURE

Microfluidic organs-on-chips

(2014) Sangeeta N Bhatia et al.   NATURE BIOTECHNOLOGY

In Vitro Cerebrovascular Modeling in the 21st Century: Current and Prospective Technologies

(2014) Christopher A. Palmiotti et al.   PHARMACEUTICAL RESEARCH

Cell-Culture Models of the Blood–Brain Barrier

(2014) Yarong He et al.   STROKE

Mechanisms of cooperation in cancer nanomedicine: towards systems nanotechnology

(2014) Sabine Hauert et al.   TRENDS IN BIOTECHNOLOGY

Nano-QSAR modeling for predicting biological activity of diverse nanomaterials

(2014) Kunwar P. Singh et al.   RSC Advances

A retinoic acid-enhanced, multicellular human blood-brain barrier model derived from stem cell sources

(2014) Ethan S. Lippmann et al.   Scientific Reports

Drug delivery to the central nervous system by polymeric nanoparticles: What do we know?

(2013) Jörg Kreuter   ADVANCED DRUG DELIVERY REVIEWS

Glioma targeting and blood–brain barrier penetration by dual-targeting doxorubincin liposomes

(2013) Jian-Qing Gao et al.   BIOMATERIALS

Potential Use of Polymeric Nanoparticles for Drug Delivery Across the Blood-Brain Barrier

(2013) G. Tosi et al.   CURRENT MEDICINAL CHEMISTRY

Phenotypic Spectrum of Glucose Transporter Type 1 Deficiency Syndrome (Glut1 DS)

(2013) Toni S. Pearson et al.   Current Neurology and Neuroscience Reports

Endothelial Cell Heterogeneity

(2013) W. C. Aird   Cold Spring Harbor Perspectives in Medicine

Drug Transport across the Blood–Brain Barrier

(2012) William M Pardridge   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Derivation of blood-brain barrier endothelial cells from human pluripotent stem cells

(2012) Ethan S Lippmann et al.   NATURE BIOTECHNOLOGY

Modern methods for delivery of drugs across the blood–brain barrier

(2011) Yan Chen et al.   ADVANCED DRUG DELIVERY REVIEWS

Characterization and evaluation of chitosan nanoparticles for dopamine brain delivery

(2011) Adriana Trapani et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Truncation of monocyte chemoattractant protein 1 by plasmin promotes blood-brain barrier disruption

(2011) Y. Yao et al.   JOURNAL OF CELL SCIENCE

Formulation development and systematic optimization of solid lipid nanoparticles of quercetin for improved brain delivery

(2011) Sanju Dhawan et al.   JOURNAL OF PHARMACY AND PHARMACOLOGY

Delivery of siRNA to the mouse brain by systemic injection of targeted exosomes

(2011) Lydia Alvarez-Erviti et al.   NATURE BIOTECHNOLOGY

Interactive role of human immunodeficiency virus type 1 (HIV-1) clade-specific Tat protein and cocaine in blood-brain barrier dysfunction: Implications for HIV-1–associated neurocognitive disorder

(2010) Nimisha Gandhi et al.   JOURNAL OF NEUROVIROLOGY

Structure and function of the blood–brain barrier

(2009) N. Joan Abbott et al.   NEUROBIOLOGY OF DISEASE

CNS Delivery Via Adsorptive Transcytosis

(2008) Françoise Hervé et al.   AAPS Journal

Human Brain Microvascular Endothelial Cells and Umbilical Vein Endothelial Cells Differentially Facilitate Leukocyte Recruitment and Utilize Chemokines for T Cell Migration

(2008) Shumei Man et al.   Clinical & Developmental Immunology