Comparison of cancer cells in 2D vs 3D culture reveals differences in AKT–mTOR–S6K signaling and drug responses

Dynamic Change of Polarity in Primary Cultured Spheroids of Human Colorectal Adenocarcinoma and Its Role in Metastasis

(2016) Hiroaki Okuyama et al.   AMERICAN JOURNAL OF PATHOLOGY

The protective role of autophagy in experimental osteoarthritis, and the therapeutic effects of Torin 1 on osteoarthritis by activating autophagy

(2016) Ni-Tao Cheng et al.   BMC MUSCULOSKELETAL DISORDERS

Vascular endothelial growth factor directly stimulates tumour cell proliferation in non-small cell lung cancer

(2015) AOIFE M. DEVERY et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Inhibition of p70S6K1 Activation by Pdcd4 Overcomes the Resistance to an IGF-1R/IR Inhibitor in Colon Carcinoma Cells

(2015) Y. Zhang et al.   MOLECULAR CANCER THERAPEUTICS

Autophagy protects chondrocytes from glucocorticoids-induced apoptosis via ROS/Akt/FOXO3 signaling

(2015) C. Shen et al.   OSTEOARTHRITIS AND CARTILAGE

Increased complexity in carcinomas: Analyzing and modeling the interaction of human cancer cells with their microenvironment

(2015) Mira Stadler et al.   SEMINARS IN CANCER BIOLOGY

The molecular landscape of colorectal cancer cell lines unveils clinically actionable kinase targets

(2015) Enzo Medico et al.   Nature Communications

eIF3 controls cell size independently of S6K1-activity

(2015) Katharina Schipany et al.   Oncotarget

Periostin in tumor microenvironment is associated with poor prognosis and platinum resistance in epithelial ovarian carcinoma

(2015) Pi-Lin Sung et al.   Oncotarget

Vertical Targeting of AKT and mTOR as Well as Dual Targeting of AKT and MEK Signaling Is Synergistic in Hepatocellular Carcinoma

(2015) Florian Ewald et al.   Journal of Cancer

Modeling human carcinomas: Physiologically relevant 3D models to improve anti-cancer drug development

(2014) Christine Unger et al.   ADVANCED DRUG DELIVERY REVIEWS

Rapid uptake of glucose and lactate, and not hypoxia, induces apoptosis in three-dimensional tumor tissue culture

(2014) Rachel W. Kasinskas et al.   Integrative Biology

A method for estimating the oxygen consumption rate in multicellular tumour spheroids

(2014) D. R. Grimes et al.   Journal of the Royal Society Interface

Three-Dimensional Lung Tumor Microenvironment Modulates Therapeutic Compound Responsiveness In Vitro – Implication for Drug Development

(2014) Jason E. Ekert et al.   PLoS One

Reliable Quantification of Protein Expression and Cellular Localization in Histological Sections

(2014) Michaela Schlederer et al.   PLoS One

A Diverse Array of Cancer-Associated MTOR Mutations Are Hyperactivating and Can Predict Rapamycin Sensitivity

(2014) B. C. Grabiner et al.   Cancer Discovery

Multicellular tumor spheroid models to explore cell cycle checkpoints in 3D

(2013) Jennifer Laurent et al.   BMC CANCER

Amino acid signalling upstream of mTOR

(2013) Jenna L. Jewell et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Impact of the 3D Microenvironment on Phenotype, Gene Expression, and EGFR Inhibition of Colorectal Cancer Cell Lines

(2013) Anna C. Luca et al.   PLoS One

mTORC1 Phosphorylation Sites Encode Their Sensitivity to Starvation and Rapamycin

(2013) S. A. Kang et al.   SCIENCE

Gene Expression Classification of Colon Cancer into Molecular Subtypes: Characterization, Validation, and Prognostic Value

(2013) Laetitia Marisa et al.   PLOS MEDICINE

mTOR Signaling in Growth Control and Disease

(2012) Mathieu Laplante et al.   CELL

A unifying model for mTORC1-mediated regulation of mRNA translation

(2012) Carson C. Thoreen et al.   NATURE

Diagnosing the decline in pharmaceutical R&D efficiency

(2012) Jack W. Scannell et al.   NATURE REVIEWS DRUG DISCOVERY

Pharma Firms Push for Sharing of Cancer Trial Data

(2012) Y. Bhattacharjee   SCIENCE

Modeling Colon Adenocarcinomas in Vitro

(2011) Helmut Dolznig et al.   AMERICAN JOURNAL OF PATHOLOGY

Lipoxygenase mediates invasion of intrametastatic lymphatic vessels and propagates lymph node metastasis of human mammary carcinoma xenografts in mouse

(2011) Dontscho Kerjaschki et al.   JOURNAL OF CLINICAL INVESTIGATION

The Ras-ERK and PI3K-mTOR pathways: cross-talk and compensation

(2011) Michelle C. Mendoza et al.   TRENDS IN BIOCHEMICAL SCIENCES

Characterization of PF-4708671, a novel and highly specific inhibitor of p70 ribosomal S6 kinase (S6K1)

(2010) Laura R. Pearce et al.   BIOCHEMICAL JOURNAL

Multicellular tumor spheroids: An underestimated tool is catching up again

(2010) Franziska Hirschhaeuser et al.   JOURNAL OF BIOTECHNOLOGY

HER2 signaling pathway activation and response of breast cancer cells to HER2-targeting agents is dependent strongly on the 3D microenvironment

(2009) Britta Weigelt et al.   BREAST CANCER RESEARCH AND TREATMENT

Cancer cell angiogenic capability is regulated by 3D culture and integrin engagement

(2009) C. Fischbach et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Comparison of 3D and 2D tumor models reveals enhanced HER2 activation in 3D associated with an increased response to trastuzumab

(2008) M Pickl et al.   ONCOGENE