Review: Sporadic Parkinson's disease: development and distribution ofα-synuclein pathology

Propagation of alpha-synuclein pathology: hypotheses, discoveries, and yet unresolved questions from experimental and human brain studies

(2015) Toshiki Uchihara et al.   ACTA NEUROPATHOLOGICA

α-synuclein pathology accumulates in sacral spinal visceral sensory pathways

(2015) Veronique G. VanderHorst et al.   ANNALS OF NEUROLOGY

Vagotomy and subsequent risk of Parkinson's disease

(2015) Elisabeth Svensson et al.   ANNALS OF NEUROLOGY

The preclinical phase of the pathological process underlying sporadic Alzheimer’s disease

(2015) Heiko Braak et al.   BRAIN

Alteration of Upstream Autophagy-Related Proteins (ULK1, ULK2, Beclin1, VPS34 and AMBRA1) in Lewy Body Disease

(2015) Yasuo Miki et al.   BRAIN PATHOLOGY

Alpha-Synuclein Pathology in Sensory Nerve Terminals of the Upper Aerodigestive Tract of Parkinson’s Disease Patients

(2015) Liancai Mu et al.   DYSPHAGIA

Correlation Between Structural and Functional Retinal Changes in Parkinson Disease

(2015) Manpreet Kaur et al.   JOURNAL OF NEURO-OPHTHALMOLOGY

Targeting α-synuclein for treatment of Parkinson's disease: mechanistic and therapeutic considerations

(2015) Benjamin Dehay et al.   LANCET NEUROLOGY

Crystals of a toxic core

(2015) Michel Goedert et al.   NATURE

α-Synuclein strains cause distinct synucleinopathies after local and systemic administration

(2015) W. Peelaerts et al.   NATURE

Structure of the toxic core of α-synuclein from invisible crystals

(2015) Jose A. Rodriguez et al.   NATURE

Spreading of α-synuclein in the face of axonal transport deficits in Parkinson's disease: A speculative synthesis

(2015) Jennifer T. Lamberts et al.   NEUROBIOLOGY OF DISEASE

α-Synuclein pathology in the cranial and spinal nerves in Lewy body disease

(2015) Keiko Nakamura et al.   NEUROPATHOLOGY

Alpha-synuclein immunoreactivity patterns in the enteric nervous system

(2015) Iban Aldecoa et al.   NEUROSCIENCE LETTERS

Alzheimer's and Parkinson's diseases: The prion concept in relation to assembled A , tau, and  -synuclein

(2015) M. Goedert   SCIENCE

Parkinson's disease as a member of Prion-like disorders

(2015) Maria Eugenia Herva et al.   VIRUS RESEARCH

Viral capsid assembly as a model for protein aggregation diseases: Active processes catalyzed by cellular assembly machines comprising novel drug targets

(2015) Rita Marreiros et al.   VIRUS RESEARCH

Parkinson-causing α-synuclein missense mutations shift native tetramers to monomers as a mechanism for disease initiation

(2015) Ulf Dettmer et al.   Nature Communications

Role of Different Alpha-Synuclein Strains in Synucleinopathies, Similarities with other Neurodegenerative Diseases

(2015) Ronald Melki   Journal of Parkinsons Disease

Distribution of α-synuclein in the spinal cord and dorsal root ganglia in an autopsy cohort of elderly persons

(2015) Hiroyuki Sumikura et al.   Acta Neuropathologica Communications

Alpha-synuclein in peripheral tissues and body fluids as a biomarker for Parkinson's disease - a systematic review

(2014) N. Malek et al.   ACTA NEUROLOGICA SCANDINAVICA

Direct evidence of Parkinson pathology spread from the gastrointestinal tract to the brain in rats

(2014) Staffan Holmqvist et al.   ACTA NEUROPATHOLOGICA

Cutaneous neuropathy in Parkinson’s disease: a window into brain pathology

(2014) Kathrin Doppler et al.   ACTA NEUROPATHOLOGICA

Preventing α-synuclein aggregation: The role of the small heat-shock molecular chaperone proteins

(2014) Dezerae Cox et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Prion-like Mechanisms in the Pathogenesis of Tauopathies and Synucleinopathies

(2014) Michel Goedert et al.   Current Neurology and Neuroscience Reports

Mortality in Parkinson's disease: A 38-year follow-up study

(2014) Bernadette Pinter et al.   MOVEMENT DISORDERS

Intramuscular injection of  -synuclein induces CNS  -synuclein pathology and a rapid-onset motor phenotype in transgenic mice

(2014) A. N. Sacino et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Alpha-synuclein spreading in Parkinson’s disease

(2014) Ariadna Recasens et al.   Frontiers in Neuroanatomy

Alpha-synuclein biology in Lewy body diseases

(2014) Woojin Scott Kim et al.   Alzheimers Research & Therapy

α-Synuclein Immunotherapy Blocks Uptake and Templated Propagation of Misfolded α-Synuclein and Neurodegeneration

(2014) Hien T. Tran et al.   Cell Reports

Considerations on the role of environmental toxins in idiopathic Parkinson’s disease pathophysiology

(2014) Francisco Pan-Montojo et al.   Translational Neurodegeneration

Accumulation of α-synuclein in the bowel of patients in the pre-clinical phase of Parkinson’s disease

(2013) David Hilton et al.   ACTA NEUROPATHOLOGICA

Transfer of human α-synuclein from the olfactory bulb to interconnected brain regions in mice

(2013) Nolwen L. Rey et al.   ACTA NEUROPATHOLOGICA

Lewy body extracts from Parkinson disease brains trigger α-synuclein pathology and neurodegeneration in mice and monkeys

(2013) Ariadna Recasens et al.   ANNALS OF NEUROLOGY

α-Synuclein: The Long Distance Runner

(2013) Sonia George et al.   BRAIN PATHOLOGY

Atypical parkinsonism

(2013) Maria Stamelou et al.   CURRENT OPINION IN NEUROLOGY

Caudo-rostral brain spreading of α-synuclein through vagal connections

(2013) Ayse Ulusoy et al.   EMBO Molecular Medicine

Idiopathic REM sleep behaviour disorder in the development of Parkinson's disease

(2013) Bradley F Boeve   LANCET NEUROLOGY

Parkinson's Disease and Alpha Synuclein: Is Parkinson's Disease a Prion-Like Disorder?

(2013) C. Warren Olanow et al.   MOVEMENT DISORDERS

Properties of native brain α-synuclein

(2013) Jacqueline Burré et al.   NATURE

Self-propagation of pathogenic protein aggregates in neurodegenerative diseases

(2013) Mathias Jucker et al.   NATURE

Defining the Native State of α-Synuclein

(2013) Dennis Selkoe et al.   Neurodegenerative Diseases

The spectrum of nonmotor symptoms in early Parkinson disease

(2013) T. K. Khoo et al.   NEUROLOGY

Dietary fat intake, pesticide use, and Parkinson's disease

(2013) Freya Kamel et al.   PARKINSONISM & RELATED DISORDERS

Modeling Lewy pathology propagation in Parkinson's disease

(2013) Kelvin C. Luk et al.   PARKINSONISM & RELATED DISORDERS

Viruses and neurodegeneration

(2013) Li Zhou et al.   Virology Journal

Structural and functional characterization of two alpha-synuclein strains

(2013) Luc Bousset et al.   Nature Communications

The Role of Autophagy in Parkinson's Disease

(2013) M. A. Lynch-Day et al.   Cold Spring Harbor Perspectives in Medicine

Spinal cord lesions in sporadic Parkinson’s disease

(2012) Kelly Del Tredici et al.   ACTA NEUROPATHOLOGICA

Neuropathologic substrates of Parkinson disease dementia

(2012) David J. Irwin et al.   ANNALS OF NEUROLOGY

Fibrillar α-Synuclein and Huntingtin Exon 1 Assemblies Are Toxic to the Cells

(2012) Laura Pieri et al.   BIOPHYSICAL JOURNAL

Critical Role of Truncated α-Synuclein and Aggregates in Parkinson's Disease and Incidental Lewy Body Disease

(2012) Kavita Prasad et al.   BRAIN PATHOLOGY

Evaluation of the Braak hypothesis: how far can it explain the pathogenesis of Parkinson's disease?

(2012) Glenda Halliday et al.   Expert Review of Neurotherapeutics

α-Synuclein in Central Nervous System and from Erythrocytes, Mammalian Cells, andEscherichia coliExists Predominantly as Disordered Monomer

(2012) Bruno Fauvet et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Targeting the Chameleon: a Focused Look at α-Synuclein and Its Roles in Neurodegeneration

(2012) Blanca A. Silva et al.   MOLECULAR NEUROBIOLOGY

Molecular Chaperones, Alpha-Synuclein, and Neurodegeneration

(2012) Stephan N. Witt   MOLECULAR NEUROBIOLOGY

Infectious Agents and Neurodegeneration

(2012) Giovanna De Chiara et al.   MOLECULAR NEUROBIOLOGY

The Lewy Body in Parkinson’s Disease and Related Neurodegenerative Disorders

(2012) Koichi Wakabayashi et al.   MOLECULAR NEUROBIOLOGY

Exosomal cell-to-cell transmission of alpha synuclein oligomers

(2012) Karin M Danzer et al.   Molecular Neurodegeneration

Lewy pathology and neurodegeneration in premotor Parkinson's disease

(2012) Kelly Del Tredici et al.   MOVEMENT DISORDERS

Identifying prodromal Parkinson's disease: Pre-Motor disorders in Parkinson's disease

(2012) Ronald B. Postuma et al.   MOVEMENT DISORDERS

The significance of defining preclinical or prodromal Parkinson's disease

(2012) C. Warren Olanow et al.   MOVEMENT DISORDERS

Olfactory dysfunction in Parkinson disease

(2012) Richard L. Doty   Nature Reviews Neurology

100 years of Lewy pathology

(2012) Michel Goedert et al.   Nature Reviews Neurology

The many faces of α-synuclein: from structure and toxicity to therapeutic target

(2012) Hilal A. Lashuel et al.   NATURE REVIEWS NEUROSCIENCE

Alpha-synuclein transgenic mice display age-related slowing of gastrointestinal motility associated with transgene expression in the vagal system

(2012) Ali Reza Noorian et al.   NEUROBIOLOGY OF DISEASE

Lewy pathology is not the first sign of degeneration in vulnerable neurons in Parkinson disease

(2012) J. M. Milber et al.   NEUROLOGY

Alpha-synuclein aggregates in epicardial fat tissue in living subjects without parkinsonism

(2012) Judith Navarro-Otano et al.   PARKINSONISM & RELATED DISORDERS

Beyond α-synuclein transfer: pathology propagation in Parkinson's disease

(2012) Christian Hansen et al.   TRENDS IN MOLECULAR MEDICINE

Environmental toxins trigger PD-like progression via increased alpha-synuclein release from enteric neurons in mice

(2012) Francisco Pan-Montojo et al.   Scientific Reports

Does a prion-like mechanism play a major role in the apparent spread of α-synuclein pathology?

(2012) Amanda N Sacino et al.   Alzheimers Research & Therapy

Neuropathology underlying clinical variability in patients with synucleinopathies

(2011) Glenda M. Halliday et al.   ACTA NEUROPATHOLOGICA

α-Synuclein misfolding and Parkinson's disease

(2011) Leonid Breydo et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Pale Neurites, Premature α-Synuclein Aggregates with Centripetal Extension from Axon Collaterals

(2011) Toshiro Kanazawa et al.   BRAIN PATHOLOGY

A deadly spread: cellular mechanisms of α-synuclein transfer

(2011) J A Steiner et al.   CELL DEATH AND DIFFERENTIATION

α-Synuclein propagates from mouse brain to grafted dopaminergic neurons and seeds aggregation in cultured human cells

(2011) Christian Hansen et al.   JOURNAL OF CLINICAL INVESTIGATION

Dementia in Parkinson's disease: a 20-year neuropsychological study (Sydney Multicentre Study)

(2011) W. G. J. Reid et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

View point: Etiology in Parkinson's disease. Dual hit or spreading intoxication

(2011) Heinz Reichmann   JOURNAL OF THE NEUROLOGICAL SCIENCES

Autonomic involvement in Parkinson's disease: Pathology, pathophysiology, clinical features and possible peripheral biomarkers

(2011) Maria G. Cersosimo et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

A critical appraisal of the premotor symptoms of Parkinson's disease: Potential usefulness in early diagnosis and design of neuroprotective trials

(2011) Anthony E. Lang   MOVEMENT DISORDERS

Milestones in Parkinson's disease-Clinical and pathologic features

(2011) Glenda Halliday et al.   MOVEMENT DISORDERS

Alpha-synuclein in colonic submucosa in early untreated Parkinson's disease

(2011) Kathleen M. Shannon et al.   MOVEMENT DISORDERS

α-Synuclein occurs physiologically as a helically folded tetramer that resists aggregation

(2011) Tim Bartels et al.   NATURE

Exogenous α-Synuclein Fibrils Induce Lewy Body Pathology Leading to Synaptic Dysfunction and Neuron Death

(2011) Laura A. Volpicelli-Daley et al.   NEURON

Lewy body-related α-synucleinopathy in the spinal cord of cases with incidental Lewy body disease

(2011) Takuya Tamura et al.   NEUROPATHOLOGY

Unmyelinated axons are more vulnerable to degeneration than myelinated axons of the cardiac nerve in Parkinson's disease

(2011) S. Orimo et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Patterns of alpha-synuclein pathology in incidental cases and clinical subtypes of Parkinson's disease

(2011) Wilma D.J. van de Berg et al.   PARKINSONISM & RELATED DISORDERS

Increased Intestinal Permeability Correlates with Sigmoid Mucosa alpha-Synuclein Staining and Endotoxin Exposure Markers in Early Parkinson's Disease

(2011) Christopher B. Forsyth et al.   PLoS One

Can Parkinson's disease pathology be propagated from one neuron to another?

(2011) Christopher J.R. Dunning et al.   PROGRESS IN NEUROBIOLOGY

Cell type specific sequestration of choline acetyltransferase and tyrosine hydroxylase within Lewy bodies

(2010) Brittany N. Dugger et al.   ACTA NEUROPATHOLOGICA

Multi-organ distribution of phosphorylated α-synuclein histopathology in subjects with Lewy body disorders

(2010) Thomas G. Beach et al.   ACTA NEUROPATHOLOGICA

Lewy pathology in the submandibular gland of individuals with incidental Lewy body disease and sporadic Parkinson’s disease

(2010) Kelly Del Tredici et al.   ACTA NEUROPATHOLOGICA

Proteinase K-resistant α-synuclein is deposited in presynapses in human Lewy body disease and A53T α-synuclein transgenic mice

(2010) Kunikazu Tanji et al.   ACTA NEUROPATHOLOGICA

When Does Parkinson Disease Start?

(2010) Rodolfo Savica et al.   ARCHIVES OF NEUROLOGY

Extensive enteric nervous system abnormalities in mice transgenic for artificial chromosomes containing Parkinson disease-associated α-synuclein gene mutations precede central nervous system changes

(2010) Yien-Ming Kuo et al.   HUMAN MOLECULAR GENETICS

Pathogenic Lysosomal Depletion in Parkinson's Disease

(2010) B. Dehay et al.   JOURNAL OF NEUROSCIENCE

Are synucleinopathies prion-like disorders?

(2010) Elodie Angot et al.   LANCET NEUROLOGY

When does Parkinson's disease begin?

(2010) Carles Gaig et al.   MOVEMENT DISORDERS

Alpha-synuclein immunoreactivity in minor salivary gland biopsies of Parkinson's disease patients

(2010) Maria Graciela Cersósimo et al.   MOVEMENT DISORDERS

What are the most important nonmotor symptoms in patients with Parkinson's disease and are we missing them?

(2010) David A. Gallagher et al.   MOVEMENT DISORDERS

Evidence in favor of Braak staging of Parkinson's disease

(2010) Dennis W. Dickson et al.   MOVEMENT DISORDERS

Molecular and clinical prodrome of Parkinson disease: implications for treatment

(2010) Anthony H. V. Schapira et al.   Nature Reviews Neurology

Gastrointestinal dysfunction in Parkinson’s disease

(2010) Ronald F. Pfeiffer   PARKINSONISM & RELATED DISORDERS

Progression of Parkinson's Disease Pathology Is Reproduced by Intragastric Administration of Rotenone in Mice

(2010) Francisco Pan-Montojo et al.   PLoS One

The propagation of prion-like protein inclusions in neurodegenerative diseases

(2010) Michel Goedert et al.   TRENDS IN NEUROSCIENCES

Unified staging system for Lewy body disorders: correlation with nigrostriatal degeneration, cognitive impairment and motor dysfunction

(2009) Thomas G. Beach et al.   ACTA NEUROPATHOLOGICA

Parkinson Disease With Dementia

(2009) Marwan N. Sabbagh et al.   ALZHEIMER DISEASE & ASSOCIATED DISORDERS

Parkinson's Disease

(2009) Christopher H. Hawkes et al.   Annals of the New York Academy of Sciences

Hyposialorrhea as an early manifestation of Parkinson disease

(2009) M.G. Cersósimo et al.   AUTONOMIC NEUROSCIENCE-BASIC & CLINICAL

Lewy Body Pathology in Normal Elderly Subjects

(2009) William R. Markesbery et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Parkinson's disease: Before the motor symptoms and beyond

(2009) Amos D. Korczyn et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Neuropathological assessment of Parkinson's disease: refining the diagnostic criteria

(2009) Dennis W Dickson et al.   LANCET NEUROLOGY

Incidental Lewy body disease restricted to the heart and stellate ganglia

(2009) Yasuo Miki et al.   MOVEMENT DISORDERS

Lesions outside the CNS in Parkinson's disease

(2009) Ruth Djaldetti et al.   MOVEMENT DISORDERS

Alterations in lysosomal and proteasomal markers in Parkinson's disease: Relationship to alpha-synuclein inclusions

(2009) Yaping Chu et al.   NEUROBIOLOGY OF DISEASE

The locus ceruleus norepinephrine system: Functional organization and potential clinical significance

(2009) E. E. Benarroch   NEUROLOGY

Diagnosis and the premotor phase of Parkinson disease

(2009) E. Tolosa et al.   NEUROLOGY

Neuropathology of non-motor features of Parkinson disease

(2009) Dennis W. Dickson et al.   PARKINSONISM & RELATED DISORDERS

A timeline for Parkinson's disease

(2009) Christopher H. Hawkes et al.   PARKINSONISM & RELATED DISORDERS

Inclusion formation and neuronal cell death through neuron-to-neuron transmission of  -synuclein

(2009) P. Desplats et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Highly pathogenic H5N1 influenza virus can enter the central nervous system and induce neuroinflammation and neurodegeneration

(2009) H. Jang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pathogenesis of Parkinson's disease: emerging role of molecular chaperones

(2009) Rina Bandopadhyay et al.   TRENDS IN MOLECULAR MEDICINE

Evidence that incidental Lewy body disease is pre-symptomatic Parkinson’s disease

(2008) Dennis W. Dickson et al.   ACTA NEUROPATHOLOGICA

The olfactory vector hypothesis of neurodegenerative disease: Is it viable?

(2008) Richard L. Doty   ANNALS OF NEUROLOGY

Incidental Lewy Body Disease and Preclinical Parkinson Disease

(2008) Anthony DelleDonne et al.   ARCHIVES OF NEUROLOGY

Sensory deficit in Parkinson's disease: evidence of a cutaneous denervation

(2008) M. Nolano et al.   BRAIN

Autophagy in the Pathogenesis of Disease

(2008) Beth Levine et al.   CELL

Non-motor symptoms in Parkinson’s disease

(2008) W. Poewe   EUROPEAN JOURNAL OF NEUROLOGY

Lewy Body Pathology Involves Cutaneous Nerves

(2008) Masako Ikemura et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Incidence and Extent of Lewy Body-Related α-Synucleinopathy in Aging Human Olfactory Bulb

(2008) Renpei Sengoku et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Olfactory pathogenesis of idiopathic Parkinson disease revisited

(2008) Alicja Lerner et al.   MOVEMENT DISORDERS

The Sydney multicenter study of Parkinson's disease: The inevitability of dementia at 20 years

(2008) Mariese A. Hely et al.   MOVEMENT DISORDERS

Neural control of the gastrointestinal tract: Implications for Parkinson disease

(2008) Maria G. Cersosimo et al.   MOVEMENT DISORDERS

Research in motion: the enigma of Parkinson's disease pathology spread

(2008) Patrik Brundin et al.   NATURE REVIEWS NEUROSCIENCE

Red Blood Cells Are the Major Source of Alpha-Synuclein in Blood

(2008) Robin Barbour et al.   Neurodegenerative Diseases

Alpha-synuclein-immunopositive myenteric neurons and vagal preganglionic terminals: Autonomic pathway implicated in Parkinson's disease?

(2008) R.J. Phillips et al.   NEUROSCIENCE