Journal
AGEING RESEARCH REVIEWS
Volume 50, Issue -, Pages 89-101Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.arr.2019.01.012
Keywords
Parkinson's disease; alpha-Synuclein; Prion-like behavior; Neurodegeneration; Neurobiology
Categories
Funding
- Agence Nationale de la Recherche [ANR-16-CE16-0019-01]
- Fondation pour la Recherche Medicale [FRM-2016-DEQ20160334896]
- Fondation Vaincre Alzheimer [FR-16020]
- Association France Alzheimer [AAPSM2017] [1674]
- Agence Nationale de la Recherche (ANR) [ANR-16-CE16-0019] Funding Source: Agence Nationale de la Recherche (ANR)
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Parkinson's disease (PD) is the second most common neurodegenerative disorder after Alzheimer's disease. PD is characterized by the loss of dopaminergic neurons, primarily in brain regions that control motor functions, thereby leading to motor impairments in the patients. Pathological aggregated forms of the synaptic protein, alpha-synuclein (alpha-syn), are involved in the generation and progression of PD. In PD brains, alpha-syn accumulates inside neurons and propagates from cell-to-cell in a prion-like manner. In this review, we discuss the in vitro and in vivo models used to study the prion-like properties of alpha-syn and related findings. In particular, we focus on the different mechanisms of alpha-syn spreading, which could be relevant for the development of alternative therapeutic approaches for PD treatment.
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