splitGFP Technology Reveals Dose-Dependent ER-Mitochondria Interface Modulation by α-Synuclein A53T and A30P Mutants

The VAPB-PTPIP51 endoplasmic reticulum-mitochondria tethering proteins are present in neuronal synapses and regulate synaptic activity

(2019) Patricia Gómez-Suaga et al.   Acta Neuropathologica Communications

Pathogenic alpha-synuclein aggregates preferentially bind to mitochondria and affect cellular respiration

(2019) Xinhe Wang et al.   Acta Neuropathologica Communications

Synapsins regulate α-synuclein functions

(2019) Merav Atias et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Functional cooperation of α-synuclein and VAMP2 in synaptic vesicle recycling

(2019) Jichao Sun et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Human VPS13A is associated with multiple organelles and influences mitochondrial morphology and lipid droplet motility

(2019) Wondwossen M Yeshaw et al.   eLife

Alpha-synuclein mitochondrial interaction leads to irreversible translocation and complex I impairment

(2018) Jimena H. Martínez et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Tau localises within mitochondrial sub-compartments and its caspase cleavage affects ER-mitochondria interactions and cellular Ca 2+ handling

(2018) Domenico Cieri et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

TOM70 Sustains Cell Bioenergetics by Promoting IP3R3-Mediated ER to Mitochondria Ca 2+ Transfer

(2018) Riccardo Filadi et al.   CURRENT BIOLOGY

α-synuclein oligomers interact with ATP synthase and open the permeability transition pore in Parkinson’s disease

(2018) Marthe H. R. Ludtmann et al.   Nature Communications

The Close Encounter Between Alpha-Synuclein and Mitochondria

(2018) Mattia Vicario et al.   Frontiers in Neuroscience

Asiatic Acid Prevents Oxidative Stress and Apoptosis by Inhibiting the Translocation of α-Synuclein Into Mitochondria

(2018) Hongqun Ding et al.   Frontiers in Neuroscience

Pα-syn* mitotoxicity is linked to MAPK activation and involves tau phosphorylation and aggregation at the mitochondria

(2018) Diego Grassi et al.   NEUROBIOLOGY OF DISEASE

Dopamine induces soluble α-synuclein oligomers and nigrostriatal degeneration

(2017) Danielle E Mor et al.   NATURE NEUROSCIENCE

FATE1 antagonizes calcium‐ and drug‐induced apoptosis by uncoupling ER and mitochondria

(2016) Mabrouka Doghman‐Bouguerra et al.   EMBO REPORTS

Reduced mitochondrial Ca2+ transients stimulate autophagy in human fibroblasts carrying the 13514A>G mutation of the ND5 subunit of NADH dehydrogenase

(2015) V Granatiero et al.   CELL DEATH AND DIFFERENTIATION

Proteinopathies, a core concept for understanding and ultimately treating degenerative disorders?

(2015) Thomas A. Bayer   EUROPEAN NEUROPSYCHOPHARMACOLOGY

A new role for α-synuclein in Parkinson's disease: Alteration of ER-mitochondrial communication

(2015) Cristina Guardia-Laguarta et al.   MOVEMENT DISORDERS

Single-molecule FRET studies on alpha-synuclein oligomerization of Parkinson’s disease genetically related mutants

(2015) Laura Tosatto et al.   Scientific Reports

Soluble, Prefibrillar α-Synuclein Oligomers Promote Complex I-dependent, Ca2+-induced Mitochondrial Dysfunction

(2014) Eric S. Luth et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

 -Synuclein Is Localized to Mitochondria-Associated ER Membranes

(2014) C. Guardia-Laguarta et al.   JOURNAL OF NEUROSCIENCE

Region specific mitochondrial impairment in mice with widespread overexpression of alpha-synuclein

(2014) Sudhakar Raja Subramaniam et al.   NEUROBIOLOGY OF DISEASE

Systematic Comparison of the Effects of Alpha-synuclein Mutations on Its Oligomerization and Aggregation

(2014) Diana F. Lázaro et al.   PLoS Genetics

The nuclear accumulation of alpha-synuclein is mediated by importin alpha and promotes neurotoxicity by accelerating the cell cycle

(2013) Kai-Li Ma et al.   NEUROPHARMACOLOGY

Update on novel familial forms of Parkinson's disease and multiple system atrophy

(2013) Shinsuke Fujioka et al.   PARKINSONISM & RELATED DISORDERS

α-Synuclein Controls Mitochondrial Calcium Homeostasis by Enhancing Endoplasmic Reticulum-Mitochondria Interactions

(2012) Tito Calì et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Fiji: an open-source platform for biological-image analysis

(2012) Johannes Schindelin et al.   NATURE METHODS

Amyloid-like Aggregates Sequester Numerous Metastable Proteins with Essential Cellular Functions

(2011) Heidi Olzscha et al.   CELL

Direct Membrane Association Drives Mitochondrial Fission by the Parkinson Disease-associated Protein α-Synuclein

(2011) Ken Nakamura et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

High Cleavage Efficiency of a 2A Peptide Derived from Porcine Teschovirus-1 in Human Cell Lines, Zebrafish and Mice

(2011) Jin Hee Kim et al.   PLoS One

In vivo demonstration that  -synuclein oligomers are toxic

(2011) B. Winner et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Interaction between α-synuclein and tau in Parkinson's disease

(2010) Kurt A. Jellinger   EXPERIMENTAL NEUROLOGY

α-Synuclein impairs macroautophagy: implications for Parkinson’s disease

(2010) Ashley R. Winslow et al.   JOURNAL OF CELL BIOLOGY

Ca2+ Hot Spots on the Mitochondrial Surface Are Generated by Ca2+ Mobilization from Stores, but Not by Activation of Store-Operated Ca2+ Channels

(2010) Marta Giacomello et al.   MOLECULAR CELL

Imaging Interorganelle Contacts and Local Calcium Dynamics at the ER-Mitochondrial Interface

(2010) György Csordás et al.   MOLECULAR CELL

 -Synuclein Promotes SNARE-Complex Assembly in Vivo and in Vitro

(2010) J. Burre et al.   SCIENCE

Mitochondrial trafficking of APP and alpha synuclein: Relevance to mitochondrial dysfunction in Alzheimer's and Parkinson's diseases

(2009) Latha Devi et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

The genetics of Parkinson's syndromes: a critical review

(2009) John Hardy et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

α-Synuclein modulation of Ca2+signaling in human neuroblastoma (SH-SY5Y) cells

(2009) Nishani T. Hettiarachchi et al.   JOURNAL OF NEUROCHEMISTRY

Nuclear and neuritic distribution of serine-129 phosphorylated α-synuclein in transgenic mice

(2009) H. Schell et al.   NEUROSCIENCE

Exogenous  -synuclein fibrils seed the formation of Lewy body-like intracellular inclusions in cultured cells

(2009) K. C. Luk et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mitochondrial association of alpha-synuclein causes oxidative stress

(2008) M. S. Parihar et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Mitochondrial translocation of α-synuclein is promoted by intracellular acidification

(2008) Nelson B. Cole et al.   EXPERIMENTAL CELL RESEARCH

Mitochondrial Import and Accumulation of α-Synuclein Impair Complex I in Human Dopaminergic Neuronal Cultures and Parkinson Disease Brain

(2008) Latha Devi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Calcium-sensitive photoproteins

(2008) Marisa Brini   METHODS

Mitochondrial localization of alpha-synuclein protein in alpha-synuclein overexpressing cells

(2008) Shaik Shavali et al.   NEUROSCIENCE LETTERS

Structure of membrane-bound  -synuclein from site-directed spin labeling and computational refinement

(2008) C. C. Jao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA