Review
Pharmacology & Pharmacy
Tongtong Ge, Xiaoxiao Yao, Haisheng Zhao, Wei Yang, Xiaohan Zou, Fanzhen Peng, Bingjin Li, Ranji Cui
Summary: Increasing evidence suggests that dysbiosis of gut microbiota may be involved in the physiological mechanisms of neuropsychiatric disorders, but the exact pathways are still unclear. The complex crosstalk between neuroendocrine and immunological regulation may underlie the mechanisms by which gut microbiota are associated with neuropsychiatric disorders.
PHARMACOLOGICAL RESEARCH
(2021)
Review
Endocrinology & Metabolism
Aishika Datta, Chandrima Saha, Pratiksha Godse, Muskaan Sharma, Deepaneeta Sarmah, Pallab Bhattacharya
Summary: The neuroendocrine system, which is the interaction between the central nervous system and endocrine glands, plays a crucial role in balancing and controlling hormone secretion and functions. Following a stroke, the neuroendocrine pathways and mechanisms often become dysregulated, leading to altered hormone secretion and aberrant receptor expression. This dysregulation of the neuroendocrine activity can directly or indirectly influence post-stroke complications and play a significant role in stroke vulnerability and susceptibility. Therefore, it is important to explore the interrelationships between various neurohormones to better understand stroke and develop potential therapeutics.
TRENDS IN ENDOCRINOLOGY AND METABOLISM
(2023)
Review
Immunology
Thomas Belcher, Christine S. Rollier, Christina Dold, Jonathan D. C. Ross, Calman A. Maclennan
Summary: Gonorrhea is a sexually transmitted infection caused by Neisseria gonorrhoeae, which often does not induce protective immunity in humans. Mouse models suggest that the immune response to gonorrhea is primarily a non-protective Th17 response instead of a protective Th1 response. Human studies show limited immune response to natural infections and no clear evidence of protective immunity.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Medicine, Research & Experimental
Elham Baghbani, Saeed Noorolyai, Dariush Shanehbandi, Ahad Mokhtarzadeh, Leili Aghebati-Maleki, Vahid Khaze Shahgoli, Oronzo Brunetti, Shima Rahmani, Mahdi Abdoli Shadbad, Amir Baghbanzadeh, Nicola Silvestris, Behzad Baradaran
Summary: The immunosuppressive tumor microenvironment is affected by inhibitory immune checkpoints like CD39 and CD73, which can transform the pro-inflammatory environment into an immunosuppressive one by the purinergic signaling pathway. The enzymatic processes of CD39 and CD73 play crucial roles in adjusting the nature and intensity of purinergic signals.
Article
Cardiac & Cardiovascular Systems
Caitlin A. Moran, Lauren F. Collins, Nour Beydoun, Puja K. Mehta, Yetunde Fatade, Ijeoma Isiadinso, Tene T. Lewis, Brittany Weber, Jill Goldstein, Igho Ofotokun, Arshed Quyyumi, May Y. Choi, Kehmia Titanji, Cecile D. Lahiri
Summary: Immune responses differ between men and women, with women more prone to chronic autoimmune diseases. Current ASCVD risk assessment tools underestimate the risk in immune dysregulation populations, especially women. This review focuses on the impact of immune dysregulation on ASCVD and discusses factors contributing to ASCVD in women with immune disorders.
CIRCULATION RESEARCH
(2022)
Review
Cell & Tissue Engineering
Ying Wang, Jiankai Fang, Benming Liu, Changshun Shao, Yufang Shi
Summary: This passage discusses the characteristics and functions of MSCs under different pathological conditions and emphasizes their interaction with the inflammatory microenvironment. The aim of the study is to provide new insights into the diverse immunoregulatory properties of MSCs during tissue regeneration and therapy.
Review
Fisheries
Ruixue Tong, Luqing Pan, Xin Zhang, Yufen Li
Summary: This review focuses on the role of the neuroendocrine system in regulating the immune system of crustaceans, as well as the impact of environmental stress on pathogen pressure and intestinal immune regulation.
REVIEWS IN AQUACULTURE
(2022)
Article
Clinical Neurology
Anik Banerjee, Louise D. McCullough
Summary: Both biological sex and aging play important roles in the host immune response in ischemic stroke. Older women tend to have poorer functional outcomes compared to men, possibly due to their older age at first stroke and increased comorbidities. In addition, the immune response differs between men and women, potentially contributing to sex differences in poststroke recovery.
Review
Immunology
Amene Saghazadeh, Nima Rezaei
Summary: Poxviruses (PXVs) are viruses that cause smallpox and pox-like infections. In recent decades, PXV outbreaks have occurred in both endemic and non-endemic areas. The cessation of smallpox vaccination is believed to be a major reason for the changing epidemiology of PXV infections. The immune system recognizes PXVs and elicits responses, but PXVs can evade these responses. Discussions on PXV immunization are more prevalent than those on PXV infection.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Review
Oncology
Jannis Wissfeld, Anke Werner, Xin Yan, Nora Ten Bosch, Guoliang Cui
Summary: The tumor microenvironment is composed of various types of cells, and the rapid growth of cancer cells alters nutrient availability and affects immune cell metabolism. Metabolism of nutrients like lipids and amino acids in immune cells regulates cellular signal transduction, immune cell survival, differentiation, and anti-tumor function. This research field is rapidly evolving, and recent studies highlight the roles of lipids and amino acids in T cells, macrophages, and natural killer cells in the tumor microenvironment.
CANCER BIOLOGY & MEDICINE
(2022)
Review
Cell Biology
Rebecca Charles, Philip Eaton
Summary: Cell responses to changes in redox state are mediated by reversible protein modifications, which can alter protein activities or interactions. These modifications are crucial for cells' homeostatic responses to environmental changes in redox state. The dysregulation of these redox regulatory mechanisms can contribute to pathophysiology. This review focuses on the redox control of soluble epoxide hydrolase (sEH), its different oxidative modifications, and their impact on cardiovascular physiology and disease progression during stress.
Article
Neurosciences
Isabella Russo, Luigi Bubacco, Elisa Greggio
Summary: This review summarizes the role of LRRK2 in modulating central and peripheral inflammation in Parkinson's disease and inflammatory disease models. In addition, it discusses the potential benefits of LRRK2 inhibitors and anti-inflammatory drugs in reducing disease risk and progression.
NEUROBIOLOGY OF DISEASE
(2022)
Article
Oncology
Man Liu, Wanming Hu, Yixuan Zhang, Ning Zhang, Luohai Chen, Yuan Lin, Yu Wang, Yanji Luo, Yu Guo, Minhu Chen, Jie Chen
Summary: This study characterizes the immune landscape and its correlation with clinical characteristics in thymic neuroendocrine neoplasms (T-NEN). It identifies CD8(+) tumor-infiltrating lymphocytes (TILs) as a potential marker to predict bone metastasis. The presence of an immune-inflamed landscape in T-NEN suggests that it could be a favorable target for immune checkpoint blockade (ICB) treatment. Further tailor-made clinical trials of ICB in T-NEN are urgently needed.
FRONTIERS IN ONCOLOGY
(2022)
Article
Neurosciences
Zongqi Wang, Gang Chen
Summary: Traumatic brain injury (TBI) is a leading cause of death and disability globally, and survivors often face movement disorders, memory loss, and cognitive impairments. However, the understanding of the underlying pathophysiology of TBI-induced neuroinflammation and neurodegeneration remains limited. Changes in peripheral and central nervous system immunity, as well as alterations in the neurovascular unit (NVU), play crucial roles in the immune regulation process. The NVU, consisting of different cell types, is responsible for maintaining brain homeostasis, and investigating immune changes in the NVU pattern can provide valuable insights into post-TBI pathological processes.
NEUROBIOLOGY OF DISEASE
(2023)
Article
Immunology
Qi Chen, Hao Li, Yusi Liu, Min Zhao
Summary: This study comprehensively analyzed the epigenetic regulation in rheumatoid arthritis (RA) using differential analysis and cross-analysis. The results identified differentially methylated sites, differentially expressed genes, and differentially expressed miRNAs associated with RA. A comprehensive epigenetic regulatory network was constructed, and core regulatory genes were identified. This study provides a new direction for future research on the epigenetic mechanisms of RA.
FRONTIERS IN IMMUNOLOGY
(2022)