alpha-Synuclein and intracellular trafficking: impact on the spreading of Parkinson’s disease pathology

Ubiquitination of α-synuclein and autophagy in Parkinson's disease

(2014) Simone Engelender   Autophagy

Dopamine-Mediated Oxidation of Methionine 127 in α-Synuclein Causes Cytotoxicity and Oligomerization of α-Synuclein

(2013) Kazuhiro Nakaso et al.   PLoS One

Neuron-to-neuron transmission of α-synuclein fibrils through axonal transport

(2012) Eric C. Freundt et al.   ANNALS OF NEUROLOGY

Bacterial in-cell NMR of human α-synuclein: a disordered monomer by nature?: Figure 1

(2012) Andres Binolfi et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Impact of N-Terminal Acetylation of α-Synuclein on Its Random Coil and Lipid Binding Properties

(2012) Alexander S. Maltsev et al.   BIOCHEMISTRY

R-SNARE ykt6 resides in membrane-associated protease-resistant protein particles and modulates cell cycle progression when over-expressed

(2012) Nandhakumar Thayanidhi et al.   BIOLOGY OF THE CELL

Rab4 and Rab5 GTPase are required for directional mobility of endocytic vesicles in astrocytes

(2012) Maja Potokar et al.   GLIA

Characterization of Semisynthetic and NaturallyNα-Acetylated α-Synucleinin Vitroand in Intact Cells

(2012) Bruno Fauvet et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Accumulation of Toxic  -Synuclein Oligomer within Endoplasmic Reticulum Occurs in  -Synucleinopathy In Vivo

(2012) E. Colla et al.   JOURNAL OF NEUROSCIENCE

Endoplasmic Reticulum Stress Is Important for the Manifestations of  -Synucleinopathy In Vivo

(2012) E. Colla et al.   JOURNAL OF NEUROSCIENCE

 -Synuclein Inhibits Intersynaptic Vesicle Mobility and Maintains Recycling-Pool Homeostasis

(2012) D. Scott et al.   JOURNAL OF NEUROSCIENCE

N-terminal acetylation of α-synuclein induces increased transient helical propensity and decreased aggregation rates in the intrinsically disordered monomer

(2012) Lijuan Kang et al.   PROTEIN SCIENCE

Pathological  -Synuclein Transmission Initiates Parkinson-like Neurodegeneration in Nontransgenic Mice

(2012) K. C. Luk et al.   SCIENCE

Human α-synuclein modulates vesicle trafficking through its interaction with prenylated Rab acceptor protein 1

(2011) Hak Joo Lee et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

A deadly spread: cellular mechanisms of α-synuclein transfer

(2011) J A Steiner et al.   CELL DEATH AND DIFFERENTIATION

α-Synuclein in Parkinson disease and other neurodegenerative disorders

(2011) Michael Eller et al.   CLINICAL CHEMISTRY AND LABORATORY MEDICINE

Systematic Discovery of Rab GTPases with Synaptic Functions in Drosophila

(2011) Chih-Chiang Chan et al.   CURRENT BIOLOGY

α-Synuclein propagates from mouse brain to grafted dopaminergic neurons and seeds aggregation in cultured human cells

(2011) Christian Hansen et al.   JOURNAL OF CLINICAL INVESTIGATION

Allostery in a Disordered Protein: Oxidative Modifications to α-Synuclein Act Distally To Regulate Membrane Binding

(2011) Eva Sevcsik et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

α-Synuclein occurs physiologically as a helically folded tetramer that resists aggregation

(2011) Tim Bartels et al.   NATURE

Exogenous α-Synuclein Fibrils Induce Lewy Body Pathology Leading to Synaptic Dysfunction and Neuron Death

(2011) Laura A. Volpicelli-Daley et al.   NEURON

Role of Rab GTPases in Membrane Traffic and Cell Physiology

(2011) Alex H. Hutagalung et al.   PHYSIOLOGICAL REVIEWS

A soluble  -synuclein construct forms a dynamic tetramer

(2011) W. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

In vivo demonstration that  -synuclein oligomers are toxic

(2011) B. Winner et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Thousands of Rab GTPases for the Cell Biologist

(2011) Yoan Diekmann et al.   PLoS Computational Biology

SNARE protein redistribution and synaptic failure in a transgenic mouse model of Parkinson’s disease

(2010) Pablo Garcia-Reitböck et al.   BRAIN

α-Synuclein sequesters arachidonic acid to modulate SNARE-mediated exocytosis

(2010) Frédéric Darios et al.   EMBO REPORTS

Aggregation of α-Synuclein in S. cerevisiae is Associated with Defects in Endosomal Trafficking and Phospholipid Biosynthesis

(2010) James H. Soper et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

A Pathologic Cascade Leading to Synaptic Dysfunction in  -Synuclein-Induced Neurodegeneration

(2010) D. A. Scott et al.   JOURNAL OF NEUROSCIENCE

Are synucleinopathies prion-like disorders?

(2010) Elodie Angot et al.   LANCET NEUROLOGY

α-Synuclein Delays Endoplasmic Reticulum (ER)-to-Golgi Transport in Mammalian Cells by Antagonizing ER/Golgi SNAREs

(2010) Nandhakumar Thayanidhi et al.   MOLECULAR BIOLOGY OF THE CELL

Who was the man who discovered the “Lewy bodies”?

(2010) Antonio M. Rodrigues e Silva et al.   MOVEMENT DISORDERS

Increased Expression of α-Synuclein Reduces Neurotransmitter Release by Inhibiting Synaptic Vesicle Reclustering after Endocytosis

(2010) Venu M. Nemani et al.   NEURON

 -Synuclein Promotes SNARE-Complex Assembly in Vivo and in Vitro

(2010) J. Burre et al.   SCIENCE

Pre-fibrillar α-synuclein variants with impaired β-structure increase neurotoxicity in Parkinson's disease models

(2009) Damla Pinar Karpinar et al.   EMBO JOURNAL

Rab11a and HSP90 Regulate Recycling of Extracellular  -Synuclein

(2009) J. Liu et al.   JOURNAL OF NEUROSCIENCE

The PRIAMO study: A multicenter assessment of nonmotor symptoms and their impact on quality of life in Parkinson's disease

(2009) Paolo Barone et al.   MOVEMENT DISORDERS

Cellular prion protein mediates impairment of synaptic plasticity by amyloid-β oligomers

(2009) Juha Laurén et al.   NATURE

VPS41, a protein involved in lysosomal trafficking, is protective in Caenorhabditis elegans and mammalian cellular models of Parkinson's disease

(2009) Qingmin Ruan et al.   NEUROBIOLOGY OF DISEASE

Inclusion formation and neuronal cell death through neuron-to-neuron transmission of  -synuclein

(2009) P. Desplats et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural Mechanisms for Regulation of Membrane Traffic by Rab GTPases

(2009) Meng-Tse Gabe Lee et al.   TRAFFIC

A review of Parkinson's disease

(2008) C. A. Davie   BRITISH MEDICAL BULLETIN

Circular dichroism (CD) spectroscopy of the assembly and disassembly of SNAREs: The proteins involved in membrane fusion in cells

(2008) Jeremy D. Cook et al.   CHEMICAL PHYSICS LETTERS

A systematic RNAi screen reveals involvement of endocytic pathway in neuronal dysfunction in α-synuclein transgenic C . elegans

(2008) Tomoki Kuwahara et al.   HUMAN MOLECULAR GENETICS

Parkinson's disease: clinical features and diagnosis

(2008) J Jankovic   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

α-Synuclein–induced Aggregation of Cytoplasmic Vesicles in Saccharomyces cerevisiae

(2008) James H. Soper et al.   MOLECULAR BIOLOGY OF THE CELL

Transplanted dopaminergic neurons develop PD pathologic changes: A second case report

(2008) Jeffrey H. Kordower et al.   MOVEMENT DISORDERS

Lewy bodies in grafted neurons in subjects with Parkinson's disease suggest host-to-graft disease propagation

(2008) Jia-Yi Li et al.   NATURE MEDICINE

Lewy body–like pathology in long-term embryonic nigral transplants in Parkinson's disease

(2008) Jeffrey H Kordower et al.   NATURE MEDICINE

Absence of α-synuclein affects dopamine metabolism and synaptic markers in the striatum of aging mice

(2008) Abdelmojib Al-Wandi et al.   NEUROBIOLOGY OF AGING

Hypothesis-based RNAi screening identifies neuroprotective genes in a Parkinson's disease model

(2008) S. Hamamichi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

α-Synuclein and Polyunsaturated Fatty Acids Promote Clathrin-Mediated Endocytosis and Synaptic Vesicle Recycling

(2008) Tziona Ben Gedalya et al.   TRAFFIC

C. elegans Model Identifies Genetic Modifiers of α-Synuclein Inclusion Formation During Aging

(2008) Tjakko J. van Ham et al.   PLoS Genetics