Alpha-Synuclein Oligomers—Neurotoxic Molecules in Parkinson's Disease and Other Lewy Body Disorders
Published 2016 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Alpha-Synuclein Oligomers—Neurotoxic Molecules in Parkinson's Disease and Other Lewy Body Disorders
Authors
Keywords
-
Journal
Frontiers in Neuroscience
Volume 10, Issue -, Pages -
Publisher
Frontiers Media SA
Online
2016-09-05
DOI
10.3389/fnins.2016.00408
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Suppression of Map Kinases Inhibits Microglial Activation and Attenuates Neuronal Cell Death Induced by α-Synuclein Protofibrils
- (2017) H. Wilms et al. INTERNATIONAL JOURNAL OF IMMUNOPATHOLOGY AND PHARMACOLOGY
- Intracellular soluble α-synuclein oligomers reduce pyramidal cell excitability
- (2016) Timothy J. Kaufmann et al. JOURNAL OF PHYSIOLOGY-LONDON
- Structural disorder of monomeric α-synuclein persists in mammalian cells
- (2016) Francois-Xavier Theillet et al. NATURE
- α-Synuclein binds to TOM20 and inhibits mitochondrial protein import in Parkinson’s disease
- (2016) Roberto Di Maio et al. Science Translational Medicine
- α -synuclein conformational antibodies fused to penetratin are effective in models of Lewy body disease
- (2016) Brian Spencer et al. Annals of Clinical and Translational Neurology
- Age-dependent defects of alpha-synuclein oligomer uptake in microglia and monocytes
- (2015) Corinna Bliederhaeuser et al. ACTA NEUROPATHOLOGICA
- -synuclein and synapsin III cooperatively regulate synaptic function in dopamine neurons
- (2015) M. Zaltieri et al. JOURNAL OF CELL SCIENCE
- Single-molecule FRET studies on alpha-synuclein oligomerization of Parkinson’s disease genetically related mutants
- (2015) Laura Tosatto et al. Scientific Reports
- The Synaptic Function of α-Synuclein
- (2015) Jacqueline Burré Journal of Parkinsons Disease
- Direct evidence of Parkinson pathology spread from the gastrointestinal tract to the brain in rats
- (2014) Staffan Holmqvist et al. ACTA NEUROPATHOLOGICA
- Next-generation active immunization approach for synucleinopathies: implications for Parkinson’s disease clinical trials
- (2014) Markus Mandler et al. ACTA NEUROPATHOLOGICA
- Accumulation of oligomer-prone α-synuclein exacerbates synaptic and neuronal degeneration in vivo
- (2014) Edward Rockenstein et al. BRAIN
- Detection of disease-associated α-synuclein in the cerebrospinal fluid: a feasibility study
- (2014) Ursula Unterberger et al. CLINICAL NEUROPATHOLOGY
- Reducing C-Terminal-Truncated Alpha-Synuclein by Immunotherapy Attenuates Neurodegeneration and Propagation in Parkinson's Disease-Like Models
- (2014) D. Games et al. JOURNAL OF NEUROSCIENCE
- Cerebrospinal fluid lysosomal enzymes and alpha-synuclein in Parkinson's disease
- (2014) Lucilla Parnetti et al. MOVEMENT DISORDERS
- Immunotherapy targeting α-synuclein protofibrils reduced pathology in (Thy-1)-h[A30P] α-synuclein mice
- (2014) Veronica Lindström et al. NEUROBIOLOGY OF DISEASE
- Correction: Formation of Toxic Oligomeric α-Synuclein Species in Living Cells
- (2014) Tiago Fleming Outeiro et al. PLoS One
- A Generic Method for Design of Oligomer-Specific Antibodies
- (2014) Kristoffer Brännström et al. PLoS One
- Levels of cerebrospinal fluid α-synuclein oligomers are increased in Parkinson’s disease with dementia and dementia with Lewy bodies compared to Alzheimer’s disease
- (2014) Oskar Hansson et al. Alzheimers Research & Therapy
- Elevated levels of cerebrospinal fluid α-synuclein oligomers in healthy asymptomatic LRRK2 mutation carriers
- (2014) Jan O. Aasly et al. Frontiers in Aging Neuroscience
- Off-pathwayα-synuclein oligomers seem to alterα-synuclein turnover in a cell model but lack seeding capabilityin vivo
- (2013) Therese Fagerqvist et al. AMYLOID-JOURNAL OF PROTEIN FOLDING DISORDERS
- G51D α-synuclein mutation causes a novel Parkinsonian-pyramidal syndrome
- (2013) Suzanne Lesage et al. ANNALS OF NEUROLOGY
- In VivoCross-linking Reveals Principally Oligomeric Forms of α-Synuclein and β-Synuclein in Neurons and Non-neural Cells
- (2013) Ulf Dettmer et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- α-Synuclein Membrane Association Is Regulated by the Rab3a Recycling Machinery and Presynaptic Activity
- (2013) Robert H. C. Chen et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Monoclonal antibodies selective for α-synuclein oligomers/protofibrils recognize brain pathology in Lewy body disorders and α-synuclein transgenic mice with the disease-causing A30P mutation
- (2013) Therese Fagerqvist et al. JOURNAL OF NEUROCHEMISTRY
- α-Synuclein Vaccination Prevents the Accumulation of Parkinson Disease-Like Pathologic Inclusions in Striatum in Association With Regulatory T Cell Recruitment in a Rat Model
- (2013) Vanesa Sanchez-Guajardo et al. JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY
- Alpha-synuclein p.H50Q, a novel pathogenic mutation for Parkinson's disease
- (2013) Silke Appel-Cresswell et al. MOVEMENT DISORDERS
- Properties of native brain α-synuclein
- (2013) Jacqueline Burré et al. NATURE
- A novel -synuclein missense mutation in Parkinson disease
- (2013) C. Proukakis et al. NEUROLOGY
- Large -synuclein oligomers inhibit neuronal SNARE-mediated vesicle docking
- (2013) B.-K. Choi et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- The genetics and neuropathology of Parkinson’s disease
- (2012) Henry Houlden et al. ACTA NEUROPATHOLOGICA
- Alpha-synuclein aggregation involves a bafilomycin A1-sensitive autophagy pathway
- (2012) Jochen Klucken et al. Autophagy
- α-Synuclein in Central Nervous System and from Erythrocytes, Mammalian Cells, andEscherichia coliExists Predominantly as Disordered Monomer
- (2012) Bruno Fauvet et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Elevated Levels of α-Synuclein Oligomer in the Cerebrospinal Fluid of Drug-Naïve Patients with Parkinson's Disease
- (2012) Min Jeong Park et al. Journal of Clinical Neurology
- Extracellular Alpha-Synuclein Oligomers Modulate Synaptic Transmission and Impair LTP Via NMDA-Receptor Activation
- (2012) M. J. Diogenes et al. JOURNAL OF NEUROSCIENCE
- Accumulation of Toxic -Synuclein Oligomer within Endoplasmic Reticulum Occurs in -Synucleinopathy In Vivo
- (2012) E. Colla et al. JOURNAL OF NEUROSCIENCE
- Endoplasmic Reticulum Stress Is Important for the Manifestations of -Synucleinopathy In Vivo
- (2012) E. Colla et al. JOURNAL OF NEUROSCIENCE
- Antibody-Aided Clearance of Extracellular -Synuclein Prevents Cell-to-Cell Aggregate Transmission
- (2012) E.-J. Bae et al. JOURNAL OF NEUROSCIENCE
- Exosomal cell-to-cell transmission of alpha synuclein oligomers
- (2012) Karin M Danzer et al. Molecular Neurodegeneration
- Exosomes: Vehicles for the Transfer of Toxic Proteins Associated with Neurodegenerative Diseases?
- (2012) Shayne A. Bellingham et al. Frontiers in Physiology
- CSF levels of oligomeric alpha-synuclein and beta-amyloid as biomarkers for neurodegenerative disease
- (2011) Michael R. Sierks et al. Integrative Biology
- α-Synuclein propagates from mouse brain to grafted dopaminergic neurons and seeds aggregation in cultured human cells
- (2011) Christian Hansen et al. JOURNAL OF CLINICAL INVESTIGATION
- α-Synuclein occurs physiologically as a helically folded tetramer that resists aggregation
- (2011) Tim Bartels et al. NATURE
- Passive Immunization Reduces Behavioral and Neuropathological Deficits in an Alpha-Synuclein Transgenic Model of Lewy Body Disease
- (2011) Eliezer Masliah et al. PLoS One
- In vivo demonstration that -synuclein oligomers are toxic
- (2011) B. Winner et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- The lipid peroxidation products 4-oxo-2-nonenal and 4-hydroxy-2-nonenal promote the formation of α-synuclein oligomers with distinct biochemical, morphological, and functional properties
- (2010) Thomas Näsström et al. FREE RADICAL BIOLOGY AND MEDICINE
- Direct Transfer of α-Synuclein from Neuron to Astroglia Causes Inflammatory Responses in Synucleinopathies
- (2010) He-Jin Lee et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Cell-Produced -Synuclein Is Secreted in a Calcium-Dependent Manner by Exosomes and Impacts Neuronal Survival
- (2010) E. Emmanouilidou et al. JOURNAL OF NEUROSCIENCE
- Mitochondrial alpha-synuclein accumulation impairs complex I function in dopaminergic neurons and results in increased mitophagy in vivo
- (2010) Shankar J. Chinta et al. NEUROSCIENCE LETTERS
- EGCG remodels mature α-synuclein and amyloid-β fibrils and reduces cellular toxicity
- (2010) Jan Bieschke et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- -Synuclein Promotes SNARE-Complex Assembly in Vivo and in Vitro
- (2010) J. Burre et al. SCIENCE
- Methionine oxidation stabilizes non-toxic oligomers of α-synuclein through strengthening the auto-inhibitory intra-molecular long-range interactions
- (2009) Wenbo Zhou et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
- Detection of elevated levels of soluble -synuclein oligomers in post-mortem brain extracts from patients with dementia with Lewy bodies
- (2009) K. E. Paleologou et al. BRAIN
- Pre-fibrillar α-synuclein variants with impaired β-structure increase neurotoxicity in Parkinson's disease models
- (2009) Damla Pinar Karpinar et al. EMBO JOURNAL
- Alpha-synuclein overexpression and aggregation exacerbates impairment of mitochondrial functions by augmenting oxidative stress in human neuroblastoma cells
- (2009) Mordhwaj S. Parihar et al. INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
- At Low Concentrations, 3,4-Dihydroxyphenylacetic Acid (DOPAC) Binds Non-Covalently to α-Synuclein and Prevents Its Fibrillation
- (2009) Wenbo Zhou et al. JOURNAL OF MOLECULAR BIOLOGY
- Seeding induced by α-synuclein oligomers provides evidence for spreading of α-synuclein pathology
- (2009) Karin M. Danzer et al. JOURNAL OF NEUROCHEMISTRY
- The lipid peroxidation metabolite 4-oxo-2-nonenal cross-links α-synuclein causing rapid formation of stable oligomers
- (2008) Tomas Näsström et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Smoking and Parkinson's disease: Does nicotine affect α-synuclein fibrillation?
- (2008) Dong-Pyo Hong et al. BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS
- Structural Characteristics of α-Synuclein Oligomers Stabilized by the Flavonoid Baicalein
- (2008) Dong-Pyo Hong et al. JOURNAL OF MOLECULAR BIOLOGY
- Dopamine neurons implanted into people with Parkinson's disease survive without pathology for 14 years
- (2008) Ivar Mendez et al. NATURE MEDICINE
- Lewy bodies in grafted neurons in subjects with Parkinson's disease suggest host-to-graft disease propagation
- (2008) Jia-Yi Li et al. NATURE MEDICINE
- Lewy body–like pathology in long-term embryonic nigral transplants in Parkinson's disease
- (2008) Jeffrey H Kordower et al. NATURE MEDICINE
- EGCG redirects amyloidogenic polypeptides into unstructured, off-pathway oligomers
- (2008) Dagmar E Ehrnhoefer et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
Publish scientific posters with Peeref
Peeref publishes scientific posters from all research disciplines. Our Diamond Open Access policy means free access to content and no publication fees for authors.
Learn MoreCreate your own webinar
Interested in hosting your own webinar? Check the schedule and propose your idea to the Peeref Content Team.
Create Now