Early synaptic dysfunction in Parkinson's disease: Insights from animal models

Paraquat-and Rotenone-Induced Models of Parkinson's Disease

(2017) R. Nisticò et al.   INTERNATIONAL JOURNAL OF IMMUNOPATHOLOGY AND PHARMACOLOGY

Exposure to low-dose rotenone precipitates synaptic plasticity alterations in PINK1 heterozygous knockout mice

(2016) G. Martella et al.   NEUROBIOLOGY OF DISEASE

Neuronal hyperactivity - A key defect in Alzheimer's disease?

(2015) Marc Aurel Busche et al.   BIOESSAYS

Leucine-rich Repeat Kinase 2 (LRRK2) Pharmacological Inhibition Abates α-Synuclein Gene-induced Neurodegeneration

(2015) João P. L. Daher et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

shRNA targeting α-synuclein prevents neurodegeneration in a Parkinson’s disease model

(2015) Alevtina D. Zharikov et al.   JOURNAL OF CLINICAL INVESTIGATION

Balancing the basal ganglia circuitry: A possible new role for dopamine D2 receptors in health and disease

(2015) Maxime Cazorla et al.   MOVEMENT DISORDERS

Progressive dopaminergic alterations and mitochondrial abnormalities in LRRK2 G2019S knock-in mice

(2015) M. Yue et al.   NEUROBIOLOGY OF DISEASE

An update on the rotenone models of Parkinson's disease: Their ability to reproduce the features of clinical disease and model gene–environment interactions

(2015) Michaela E. Johnson et al.   NEUROTOXICOLOGY

Impaired intracellular trafficking defines early Parkinson's disease

(2015) Benjamin H.M. Hunn et al.   TRENDS IN NEUROSCIENCES

Interneuronal Nitric Oxide Signaling Mediates Post-synaptic Long-Term Depression of Striatal Glutamatergic Synapses

(2015) Igor V. Rafalovich et al.   Cell Reports

LRRK2 overexpression alters glutamatergic presynaptic plasticity, striatal dopamine tone, postsynaptic signal transduction, motor activity and memory

(2014) Dayne A. Beccano-Kelly et al.   HUMAN MOLECULAR GENETICS

Discovery and Preclinical Profiling of 3-[4-(Morpholin-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl]benzonitrile (PF-06447475), a Highly Potent, Selective, Brain Penetrant, and in Vivo Active LRRK2 Kinase Inhibitor

(2014) Jaclyn L. Henderson et al.   JOURNAL OF MEDICINAL CHEMISTRY

Synucleins Regulate the Kinetics of Synaptic Vesicle Endocytosis

(2014) K. J. Vargas et al.   JOURNAL OF NEUROSCIENCE

Leucine-Rich Repeat Kinase 2 Binds to Neuronal Vesicles through Protein Interactions Mediated by Its C-Terminal WD40 Domain

(2014) G. Piccoli et al.   MOLECULAR AND CELLULAR BIOLOGY

The role of the LRRK2 gene in Parkinsonism

(2014) Jie-Qiong Li et al.   Molecular Neurodegeneration

LRRK2 regulates synaptogenesis and dopamine receptor activation through modulation of PKA activity

(2014) Loukia Parisiadou et al.   NATURE NEUROSCIENCE

Direct and indirect pathways of basal ganglia: a critical reappraisal

(2014) Paolo Calabresi et al.   NATURE NEUROSCIENCE

Basal ganglia subcircuits distinctively encode the parsing and concatenation of action sequences

(2014) Xin Jin et al.   NATURE NEUROSCIENCE

Extracellular α-synuclein—a novel and crucial factor in Lewy body diseases

(2014) He-Jin Lee et al.   Nature Reviews Neurology

Phenotypic characterization of recessive gene knockout rat models of Parkinson's disease

(2014) Kuldip D. Dave et al.   NEUROBIOLOGY OF DISEASE

Reorganization of corticostriatal circuits in healthy G2019S LRRK2 carriers

(2014) R. C. Helmich et al.   NEUROLOGY

Dopamine D2 Receptors Regulate the Anatomical and Functional Balance of Basal Ganglia Circuitry

(2014) Maxime Cazorla et al.   NEURON

Parkin and PINK1: much more than mitophagy

(2014) Leslie A. Scarffe et al.   TRENDS IN NEUROSCIENCES

Synaptic function is modulated by LRRK2 and glutamate release is increased in cortical neurons of G2019S LRRK2 knock-in mice

(2014) Dayne A. Beccano-Kelly et al.   Frontiers in Cellular Neuroscience

The behavioural and neuropathological impact of intranigral AAV-α-synuclein is exacerbated by systemic infusion of the Parkinson's disease-associated pesticide, rotenone, in rats

(2013) Pádraig Mulcahy et al.   BEHAVIOURAL BRAIN RESEARCH

PINK1heterozygous mutations induce subtle alterations in dopamine-dependent synaptic plasticity

(2013) Graziella Madeo et al.   MOVEMENT DISORDERS

“Lazy” nigrostriatal synapses in the heterozygous PINK1 mouse model of familial Parkinson's disease

(2013) Paolo Calabresi et al.   MOVEMENT DISORDERS

Concurrent activation of striatal direct and indirect pathways during action initiation

(2013) Guohong Cui et al.   NATURE

Advances in the genetics of Parkinson disease

(2013) Joanne Trinh et al.   Nature Reviews Neurology

Region-specific deficits in dopamine, but not norepinephrine, signaling in a novel A30P α-synuclein BAC transgenic mouse

(2013) Tonya N. Taylor et al.   NEUROBIOLOGY OF DISEASE

Treadmill exercise reverses dendritic spine loss in direct and indirect striatal medium spiny neurons in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) mouse model of Parkinson's disease

(2013) William A. Toy et al.   NEUROBIOLOGY OF DISEASE

Deficits in dopaminergic transmission precede neuron loss and dysfunction in a new Parkinson model

(2013) S. Janezic et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Enemy within: Propagation of Aberrant Corticostriatal Learning to Cortical Function in Parkinson’s Disease

(2013) Jeff A. Beeler et al.   Frontiers in Neurology

Considerations Regarding the Etiology and Future Treatment of Autosomal Recessive Versus Idiopathic Parkinson Disease

(2012) Tohru Kitada et al.   Current Treatment Options in Neurology

Extracellular Alpha-Synuclein Oligomers Modulate Synaptic Transmission and Impair LTP Via NMDA-Receptor Activation

(2012) M. J. Diogenes et al.   JOURNAL OF NEUROSCIENCE

Systematic Mutagenesis of  -Synuclein Reveals Distinct Sequence Requirements for Physiological and Pathological Activities

(2012) J. Burre et al.   JOURNAL OF NEUROSCIENCE

LRRK2 Controls an EndoA Phosphorylation Cycle in Synaptic Endocytosis

(2012) Samer Matta et al.   NEURON

Impaired neurotransmission caused by overexpression of  -synuclein in nigral dopamine neurons

(2012) M. Lundblad et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An extracellular mechanism that can explain the neurotoxic effects of α-synuclein aggregates in the brain

(2012) C. Pacheco et al.   Frontiers in Physiology

Early, severe and bilateral loss of LTP and LTD-like plasticity in motor cortex (M1) in de novo Parkinson’s disease

(2011) Asha Kishore et al.   CLINICAL NEUROPHYSIOLOGY

Dopamine promotes formation and secretion of non-fibrillar alpha-synuclein oligomers

(2011) He-Jin Lee et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

LRRK2 Controls Synaptic Vesicle Storage and Mobilization within the Recycling Pool

(2011) G. Piccoli et al.   JOURNAL OF NEUROSCIENCE

Elevated tonic extracellular dopamine concentration and altered dopamine modulation of synaptic activity precede dopamine loss in the striatum of mice overexpressing human α-synuclein

(2011) Hoa A. Lam et al.   JOURNAL OF NEUROSCIENCE RESEARCH

A tale on animal models of Parkinson's disease

(2011) Erwan Bezard et al.   MOVEMENT DISORDERS

Mechanisms underlying altered striatal synaptic plasticity in old A53T-α synuclein overexpressing mice

(2011) Alessandro Tozzi et al.   NEUROBIOLOGY OF AGING

The L-type channel antagonist isradipine is neuroprotective in a mouse model of Parkinson's disease

(2011) E. Ilijic et al.   NEUROBIOLOGY OF DISEASE

Aberrant striatal synaptic plasticity in monogenic parkinsonisms

(2011) G. Madeo et al.   NEUROSCIENCE

Synaptopathy: dysfunction of synaptic function?

(2010) Nils Brose et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

α-Synuclein Transgenic Mice Reveal Compensatory Increases in Parkinson's Disease-Associated Proteins DJ-1 and Parkin and Have Enhanced α-Synuclein and PINK1 Levels After Rotenone Treatment

(2010) Sonia George et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

LRRK2 Kinase Regulates Synaptic Morphology through Distinct Substrates at the Presynaptic and Postsynaptic Compartments of the Drosophila Neuromuscular Junction

(2010) S. Lee et al.   JOURNAL OF NEUROSCIENCE

Enhanced Striatal Dopamine Transmission and Motor Performance with LRRK2 Overexpression in Mice Is Eliminated by Familial Parkinson's Disease Mutation G2019S

(2010) X. Li et al.   JOURNAL OF NEUROSCIENCE

Cell-Produced  -Synuclein Is Secreted in a Calcium-Dependent Manner by Exosomes and Impacts Neuronal Survival

(2010) E. Emmanouilidou et al.   JOURNAL OF NEUROSCIENCE

Distinct Levels of Dopamine Denervation Differentially Alter Striatal Synaptic Plasticity and NMDA Receptor Subunit Composition

(2010) V. Paille et al.   JOURNAL OF NEUROSCIENCE

Mapping preclinical compensation in Parkinson's disease: An imaging genomics approach

(2010) Bart F.L. van Nuenen et al.   MOVEMENT DISORDERS

Impaired dopaminergic neurotransmission and microtubule-associated protein tau alterations in human LRRK2 transgenic mice

(2010) H.L. Melrose et al.   NEUROBIOLOGY OF DISEASE

Progression of subtle motor signs in PINK1 mutation carriers with mild dopaminergic deficit

(2010) C. Eggers et al.   NEUROLOGY

Increased Expression of α-Synuclein Reduces Neurotransmitter Release by Inhibiting Synaptic Vesicle Reclustering after Endocytosis

(2010) Venu M. Nemani et al.   NEURON

Genetic Animal Models of Parkinson's Disease

(2010) Ted M. Dawson et al.   NEURON

LRRK2 in Parkinson’s disease: genetic and clinical studies from patients

(2009) Udhaya Kumari et al.   FEBS Journal

Leucine-rich repeat kinase 2 interacts with Parkin, DJ-1 and PINK-1 in a Drosophila melanogaster model of Parkinson's disease

(2009) K. Venderova et al.   HUMAN MOLECULAR GENETICS

Parkin Protects against LRRK2 G2019S Mutant-Induced Dopaminergic Neurodegeneration in Drosophila

(2009) C.-H. Ng et al.   JOURNAL OF NEUROSCIENCE

Mutant LRRK2 R1441G BAC transgenic mice recapitulate cardinal features of Parkinson's disease

(2009) Yanping Li et al.   NATURE NEUROSCIENCE

α-Synuclein and LRRK2: Partners in Crime

(2009) Youren Tong et al.   NEURON

Striatal spine plasticity in Parkinson's disease: pathological or not?

(2009) Y. Smith et al.   PARKINSONISM & RELATED DISORDERS

R1441C mutation in LRRK2 impairs dopaminergic neurotransmission in mice

(2009) Y. Tong et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Animal models of Parkinson’s disease progression

(2008) Gloria E. Meredith et al.   ACTA NEUROPATHOLOGICA

Genomic investigation of α-synuclein multiplication and parkinsonism

(2008) Owen A. Ross et al.   ANNALS OF NEUROLOGY

Dopaminergic denervation and spine loss in the striatum of MPTP-treated monkeys

(2008) Rosa M. Villalba et al.   EXPERIMENTAL NEUROLOGY

Motor cortical physiology in patients and asymptomatic carriers of parkin gene mutations

(2008) Susanne A. Schneider et al.   MOVEMENT DISORDERS

Striatal and extrastriatal dopamine in the basal ganglia: An overview of its anatomical organization in normal and Parkinsonian brains

(2008) Yoland Smith et al.   MOVEMENT DISORDERS

Parkinson's disease and pesticides: a toxicological perspective

(2008) J HATCHER et al.   TRENDS IN PHARMACOLOGICAL SCIENCES