Synaptopathies: synaptic dysfunction in neurological disorders - A review from students to students

Hippocampal long-term depression is facilitated by the acquisition and updating of memory of spatial auditory content and requires mGlu5 activation

(2017) Birte Dietz et al.   NEUROPHARMACOLOGY

Synaptic Amyloid-β Oligomers Precede p-Tau and Differentiate High Pathology Control Cases

(2016) Tina Bilousova et al.   AMERICAN JOURNAL OF PATHOLOGY

MMP-9 in translation: from molecule to brain physiology, pathology, and therapy

(2016) Behnam Vafadari et al.   JOURNAL OF NEUROCHEMISTRY

Glycinergic Neurotransmission: A Potent Regulator of Embryonic Motor Neuron Dendritic Morphology and Synaptic Plasticity

(2016) M. J. Fogarty et al.   JOURNAL OF NEUROSCIENCE

Development of epilepsy after ischaemic stroke

(2016) Asla Pitkänen et al.   LANCET NEUROLOGY

Comorbidities of epilepsy: current concepts and future perspectives

(2016) Mark R Keezer et al.   LANCET NEUROLOGY

Adenosinergic signaling in epilepsy

(2016) Detlev Boison   NEUROPHARMACOLOGY

Evidence for the progression through S-phase in the ectopic cell cycle re-entry of neurons in Alzheimer disease

(2016) David J. Bonda et al.   Aging-US

Human autoantibodies to amphiphysin induce defective presynaptic vesicle dynamics and composition

(2015) Christian Werner et al.   BRAIN

Aging in Down Syndrome and the Development of Alzheimer's Disease Neuropathology

(2015) Elizabeth Head et al.   Current Alzheimer Research

Presynaptic active zones in invertebrates and vertebrates

(2015) F. Ackermann et al.   EMBO REPORTS

miR-132/212 deficiency impairs tau metabolism and promotes pathological aggregationin vivo

(2015) Pascal Y. Smith et al.   HUMAN MOLECULAR GENETICS

HDAC inhibitor–dependent transcriptome and memory reinstatement in cognitive decline models

(2015) Eva Benito et al.   JOURNAL OF CLINICAL INVESTIGATION

Serotonergic dysfunction in the A53T alpha-synuclein mouse model of Parkinson's disease

(2015) Janina Deusser et al.   JOURNAL OF NEUROCHEMISTRY

The Parkinson's Disease-Associated Mutation LRRK2-G2019S Impairs Synaptic Plasticity in Mouse Hippocampus

(2015) E. S. Sweet et al.   JOURNAL OF NEUROSCIENCE

Disturbed Neuronal ER-Golgi Sorting of Unassembled Glycine Receptors Suggests Altered Subcellular Processing Is a Cause of Human Hyperekplexia

(2015) N. Schaefer et al.   JOURNAL OF NEUROSCIENCE

Differential Effect of Neuropeptides on Excitatory Synaptic Transmission in Human Epileptic Hippocampus

(2015) M. Ledri et al.   JOURNAL OF NEUROSCIENCE

Conserved epigenomic signals in mice and humans reveal immune basis of Alzheimer’s disease

(2015) Elizabeta Gjoneska et al.   NATURE

Critical role of acetylation in tau-mediated neurodegeneration and cognitive deficits

(2015) Sang-Won Min et al.   NATURE MEDICINE

Social deficits in IRSp53 mutant mice improved by NMDAR and mGluR5 suppression

(2015) Woosuk Chung et al.   NATURE NEUROSCIENCE

Molecular mechanisms of epilepsy

(2015) Kevin Staley   NATURE NEUROSCIENCE

Pathway-driven discovery of epilepsy genes

(2015) Jeffrey Noebels   NATURE NEUROSCIENCE

Weeding out bad waves: towards selective cannabinoid circuit control in epilepsy

(2015) Ivan Soltesz et al.   NATURE REVIEWS NEUROSCIENCE

Aβ42 oligomers selectively disrupt neuronal calcium release

(2015) Cristian Lazzari et al.   NEUROBIOLOGY OF AGING

Region-specific alterations of AMPA receptor phosphorylation and signaling pathways in the pilocarpine model of epilepsy

(2015) Mark William Lopes et al.   NEUROCHEMISTRY INTERNATIONAL

A Peptide Uncoupling BDNF Receptor TrkB from Phospholipase Cγ1 Prevents Epilepsy Induced by Status Epilepticus

(2015) Bin Gu et al.   NEURON

The Roles of PINK1, Parkin, and Mitochondrial Fidelity in Parkinson’s Disease

(2015) Alicia M. Pickrell et al.   NEURON

Increased extracellular levels of glutamate in the hippocampus of chronically epileptic rats

(2015) M. Soukupova et al.   NEUROSCIENCE

Neuronal stress signaling and eIF2α phosphorylation as molecular links between Alzheimer's disease and diabetes

(2015) Mychael V. Lourenco et al.   PROGRESS IN NEUROBIOLOGY

Matrix Metalloproteinase-9 as a Novel Player in Synaptic Plasticity and Schizophrenia: Table 1.

(2015) Katarzyna Lepeta et al.   SCHIZOPHRENIA BULLETIN

Impaired intracellular trafficking defines early Parkinson's disease

(2015) Benjamin H.M. Hunn et al.   TRENDS IN NEUROSCIENCES

Neonatal seizures alter NMDA glutamate receptor GluN2A and 3A subunit expression and function in hippocampal CA1 neurons

(2015) Chengwen Zhou et al.   Frontiers in Cellular Neuroscience

Soluble amyloid-β oligomers as synaptotoxins leading to cognitive impairment in Alzheimer’s disease

(2015) Sergio T. Ferreira et al.   Frontiers in Cellular Neuroscience

Structural Components of Synaptic Plasticity and Memory Consolidation

(2015) Craig H. Bailey et al.   Cold Spring Harbor Perspectives in Biology

Astrocytes Control Synapse Formation, Function, and Elimination

(2015) Won-Suk Chung et al.   Cold Spring Harbor Perspectives in Biology

Epileptogenesis

(2015) Asla Pitkänen et al.   Cold Spring Harbor Perspectives in Medicine

d-serine levels in Alzheimer’s disease: implications for novel biomarker development

(2015) C Madeira et al.   Translational Psychiatry

Clinical course of poststroke epilepsy: a retrospective nested case-control study

(2015) Johan Zelano et al.   Brain and Behavior

Glycine receptor antibodies in PERM and related syndromes: characteristics, clinical features and outcomes

(2014) Alexander Carvajal-González et al.   BRAIN

Accumulation of oligomer-prone α-synuclein exacerbates synaptic and neuronal degeneration in vivo

(2014) Edward Rockenstein et al.   BRAIN

The Molecular and Systems Biology of Memory

(2014) Eric R. Kandel et al.   CELL

A Trial of D-Cycloserine to Treat Stereotypies in Older Adolescents and Young Adults With Autism Spectrum Disorder

(2014) Maria Urbano et al.   CLINICAL NEUROPHARMACOLOGY

Impairment of GABA release in the hippocampus at the time of the first spontaneous seizure in the pilocarpine model of temporal lobe epilepsy

(2014) Marie Soukupová et al.   EXPERIMENTAL NEUROLOGY

Local Pruning of Dendrites and Spines by Caspase-3-Dependent and Proteasome-Limited Mechanisms

(2014) A. Erturk et al.   JOURNAL OF NEUROSCIENCE

Oligomeric Aβ-induced synaptic dysfunction in Alzheimer’s disease

(2014) Shichun Tu et al.   Molecular Neurodegeneration

The Intersection of Amyloid Beta and Tau at Synapses in Alzheimer’s Disease

(2014) Tara L. Spires-Jones et al.   NEURON

Dysregulation of group-I metabotropic glutamate (mGlu) receptor mediated signalling in disorders associated with Intellectual Disability and Autism

(2014) Simona D’Antoni et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Two Phase 3 Trials of Bapineuzumab in Mild-to-Moderate Alzheimer's Disease

(2014) Stephen Salloway et al.   NEW ENGLAND JOURNAL OF MEDICINE

Phase 3 Trials of Solanezumab for Mild-to-Moderate Alzheimer's Disease

(2014) Rachelle S. Doody et al.   NEW ENGLAND JOURNAL OF MEDICINE

Hyaluronan-based extracellular matrix under conditions of homeostatic plasticity

(2014) J. C. Valenzuela et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Unbiased screen for interactors of leucine-rich repeat kinase 2 supports a common pathway for sporadic and familial Parkinson disease

(2014) A. Beilina et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Overproduction of Upper-Layer Neurons in the Neocortex Leads to Autism-like Features in Mice

(2014) Wei-Qun Fang et al.   Cell Reports

Contribution of Aberrant GluK2-Containing Kainate Receptors to Chronic Seizures in Temporal Lobe Epilepsy

(2014) Angélique Peret et al.   Cell Reports

The Genetic Landscapes of Autism Spectrum Disorders

(2013) Guillaume Huguet et al.   Annual Review of Genomics and Human Genetics

Genotype-phenotype correlations in hyperekplexia: apnoeas, learning difficulties and speech delay

(2013) R. H. Thomas et al.   BRAIN

Increased metalloprotease activity in the epileptogenic lesion—Lobectomy reduces metalloprotease activity and urokinase-type uPAR circulating levels

(2013) Thereza Quirico-Santos et al.   BRAIN RESEARCH

TNF-α Mediates PKR-Dependent Memory Impairment and Brain IRS-1 Inhibition Induced by Alzheimer’s β-Amyloid Oligomers in Mice and Monkeys

(2013) Mychael V. Lourenco et al.   Cell Metabolism

Alteration of the microRNA network during the progression of Alzheimer's disease

(2013) Pierre Lau et al.   EMBO Molecular Medicine

Morphological changes among hippocampal dentate granule cells exposed to early kindling-epileptogenesis

(2013) Shatrunjai P. Singh et al.   HIPPOCAMPUS

A Direct Interaction between Leucine-rich Repeat Kinase 2 and Specific β-Tubulin Isoforms Regulates Tubulin Acetylation

(2013) Bernard M. H. Law et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Deregulation of excitatory neurotransmission underlying synapse failure in Alzheimer's disease

(2013) Andrea C. Paula-Lima et al.   JOURNAL OF NEUROCHEMISTRY

Pathophysiological Mechanisms of Dominant and Recessive GLRA1 Mutations in Hyperekplexia

(2013) S.-K. Chung et al.   JOURNAL OF NEUROSCIENCE

Impaired D-Serine-Mediated Cotransmission Mediates Cognitive Dysfunction in Epilepsy

(2013) K. Klatte et al.   JOURNAL OF NEUROSCIENCE

How to Scale Down Postsynaptic Strength

(2013) V. Tatavarty et al.   JOURNAL OF NEUROSCIENCE

Excess of rare novel loss-of-function variants in synaptic genes in schizophrenia and autism spectrum disorders

(2013) E M Kenny et al.   MOLECULAR PSYCHIATRY

Overexpression of Down syndrome cell adhesion molecule impairs precise synaptic targeting

(2013) Vedrana Cvetkovska et al.   NATURE NEUROSCIENCE

Suppression of eIF2α kinases alleviates Alzheimer's disease–related plasticity and memory deficits

(2013) Tao Ma et al.   NATURE NEUROSCIENCE

CaMKII phosphorylation of neuroligin-1 regulates excitatory synapses

(2013) Michael A Bemben et al.   NATURE NEUROSCIENCE

NMDA receptor subunit diversity: impact on receptor properties, synaptic plasticity and disease

(2013) Pierre Paoletti et al.   NATURE REVIEWS NEUROSCIENCE

Microglial derived tumor necrosis factor-α drives Alzheimer's disease-related neuronal cell cycle events

(2013) Kiran Bhaskar et al.   NEUROBIOLOGY OF DISEASE

Dscam Expression Levels Determine Presynaptic Arbor Sizes in Drosophila Sensory Neurons

(2013) Jung Hwan Kim et al.   NEURON

Transient Inhibition of TrkB Kinase after Status Epilepticus Prevents Development of Temporal Lobe Epilepsy

(2013) Gumei Liu et al.   NEURON

Metabotropic Glutamate Receptor 5 Is a Coreceptor for Alzheimer Aβ Oligomer Bound to Cellular Prion Protein

(2013) Ji Won Um et al.   NEURON

RAB7L1 Interacts with LRRK2 to Modify Intraneuronal Protein Sorting and Parkinson’s Disease Risk

(2013) David A. MacLeod et al.   NEURON

Neurons generated by direct conversion of fibroblasts reproduce synaptic phenotype caused by autism-associated neuroligin-3 mutation

(2013) S. Chanda et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A  induces astrocytic glutamate release, extrasynaptic NMDA receptor activation, and synaptic loss

(2013) M. Talantova et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Deficits in dopaminergic transmission precede neuron loss and dysfunction in a new Parkinson model

(2013) S. Janezic et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

LRRK2: an éminence grise of Wnt-mediated neurogenesis?

(2013) Daniel C. Berwick et al.   Frontiers in Cellular Neuroscience

Molecular mechanisms driving homeostatic plasticity of neurotransmitter release

(2013) Vesna Lazarevic et al.   Frontiers in Cellular Neuroscience

Extracellular matrix inhibits structural and functional plasticity of dendritic spines in the adult visual cortex

(2013) L. de Vivo et al.   Nature Communications

Deciphering Alzheimer Disease

(2013) D. Selkoe et al.   Cold Spring Harbor Perspectives in Medicine

The Role of Autophagy in Parkinson's Disease

(2013) M. A. Lynch-Day et al.   Cold Spring Harbor Perspectives in Medicine

Progressive Encephalomyelitis With Rigidity and Myoclonus

(2013) Joana Damásio et al.   JAMA Neurology

Apolipoprotein E4 effects in Alzheimer’s disease are mediated by synaptotoxic oligomeric amyloid-β

(2012) Robert M. Koffie et al.   BRAIN

Synaptopathies: diseases of the synaptome

(2012) Seth GN Grant   CURRENT OPINION IN NEUROBIOLOGY

Mice with reduced NMDA receptor expression: more consistent with autism than schizophrenia?

(2012) M. J. Gandal et al.   GENES BRAIN AND BEHAVIOR

APOE genotype alters glial activation and loss of synaptic markers in mice

(2012) Yuangui Zhu et al.   GLIA

A Retroelement Modifies Pre-mRNA Splicing

(2012) Kristina Becker et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Development and Characterization of a New Parkinson's Disease Model Resulting from Impaired Autophagy

(2012) I. Ahmed et al.   JOURNAL OF NEUROSCIENCE

Absence of amyloid β oligomers at the postsynapse and regulated synaptic Zn2+ in cognitively intact aged individuals with Alzheimer’s disease neuropathology

(2012) Nicole L Bjorklund et al.   Molecular Neurodegeneration

Living on the edge with too many mouths to feed: Why dopamine neurons die

(2012) J. Paul Bolam et al.   MOVEMENT DISORDERS

Autistic-like social behaviour in Shank2-mutant mice improved by restoring NMDA receptor function

(2012) Hyejung Won et al.   NATURE

An epigenetic blockade of cognitive functions in the neurodegenerating brain

(2012) Johannes Gräff et al.   NATURE

Regulation of neuronal GABAB receptor functions by subunit composition

(2012) Martin Gassmann et al.   NATURE REVIEWS NEUROSCIENCE

Novel missense mutations in the glycine receptor β subunit gene (GLRB) in startle disease

(2012) Victoria M. James et al.   NEUROBIOLOGY OF DISEASE

LRRK2 Controls an EndoA Phosphorylation Cycle in Synaptic Endocytosis

(2012) Samer Matta et al.   NEURON

Shared Synaptic Pathophysiology in Syndromic and Nonsyndromic Rodent Models of Autism

(2012) S. J. Baudouin et al.   SCIENCE

Multiplex Targeted Sequencing Identifies Recurrently Mutated Genes in Autism Spectrum Disorders

(2012) B. J. O'Roak et al.   SCIENCE

Caspase-3 in the central nervous system: beyond apoptosis

(2012) Marcello D’Amelio et al.   TRENDS IN NEUROSCIENCES

From Abnormal Hippocampal Synaptic Plasticity in Down Syndrome Mouse Models to Cognitive Disability in Down Syndrome

(2012) Nathan Cramer et al.   NEURAL PLASTICITY

The Synaptic Protein Neuroligin-1 Interacts with the Amyloid β-Peptide. Is There a Role in Alzheimer’s Disease?

(2011) Margarita C. Dinamarca et al.   BIOCHEMISTRY

Paper 2: EUROCAT public health indicators for congenital anomalies in Europe

(2011) Babak Khoshnood et al.   BIRTH DEFECTS RESEARCH PART A-CLINICAL AND MOLECULAR TERATOLOGY

Novel mutation in GLRB in a large family with hereditary hyperekplexia

(2011) M Al-Owain et al.   CLINICAL GENETICS

Synapse adhesion: a dynamic equilibrium conferring stability and flexibility

(2011) Deanna L Benson et al.   CURRENT OPINION IN NEUROBIOLOGY

What Can We Learn about Autism from Studying Fragile X Syndrome?

(2011) Dejan B. Budimirovic et al.   DEVELOPMENTAL NEUROSCIENCE

An autism-associated point mutation in the neuroligin cytoplasmic tail selectively impairs AMPA receptor-mediated synaptic transmission in hippocampus

(2011) Mark R Etherton et al.   EMBO JOURNAL

Direct Membrane Association Drives Mitochondrial Fission by the Parkinson Disease-associated Protein α-Synuclein

(2011) Ken Nakamura et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Down Syndrome Critical Region Regulates Retinogeniculate Refinement

(2011) M. Blank et al.   JOURNAL OF NEUROSCIENCE

Extensive Remodeling of the Presynaptic Cytomatrix upon Homeostatic Adaptation to Network Activity Silencing

(2011) V. Lazarevic et al.   JOURNAL OF NEUROSCIENCE

LRRK2 Controls Synaptic Vesicle Storage and Mobilization within the Recycling Pool

(2011) G. Piccoli et al.   JOURNAL OF NEUROSCIENCE

Amyloid- /Fyn-Induced Synaptic, Network, and Cognitive Impairments Depend on Tau Levels in Multiple Mouse Models of Alzheimer's Disease

(2011) E. D. Roberson et al.   JOURNAL OF NEUROSCIENCE

Mutations causing syndromic autism define an axis of synaptic pathophysiology

(2011) Benjamin D. Auerbach et al.   NATURE

Resolving controversies on the path to Alzheimer's therapeutics

(2011) Dennis J Selkoe   NATURE MEDICINE

Functional dependence of neuroligin on a new non-PDZ intracellular domain

(2011) Seth L Shipman et al.   NATURE NEUROSCIENCE

Aβ1–42 inhibition of LTP is mediated by a signaling pathway involving caspase-3, Akt1 and GSK-3β

(2011) Jihoon Jo et al.   NATURE NEUROSCIENCE

Soluble amyloid  -protein dimers isolated from Alzheimer cortex directly induce Tau hyperphosphorylation and neuritic degeneration

(2011) M. Jin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Low-resolution structure of a vesicle disrupting  -synuclein oligomer that accumulates during fibrillation

(2011) L. Giehm et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

In vivo demonstration that  -synuclein oligomers are toxic

(2011) B. Winner et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

LRRK2 signaling pathways: the key to unlocking neurodegeneration?

(2011) Daniel C. Berwick et al.   TRENDS IN CELL BIOLOGY

The Postsynaptic Organization of Synapses

(2011) M. Sheng et al.   Cold Spring Harbor Perspectives in Biology

Homeostatic Synaptic Plasticity: Local and Global Mechanisms for Stabilizing Neuronal Function

(2011) G. Turrigiano   Cold Spring Harbor Perspectives in Biology

Metabotropic Glutamate Receptors: Physiology, Pharmacology, and Disease

(2010) Colleen M. Niswender et al.   Annual Review of Pharmacology and Toxicology

Synaptopathy: dysfunction of synaptic function?

(2010) Nils Brose et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Oligomerized Aβ25–35 induces increased tyrosine phosphorylation of NMDA receptor subunit 2A in rat hippocampal CA1 subfield

(2010) Gui-Mei Wu et al.   BRAIN RESEARCH

Dendritic Function of Tau Mediates Amyloid-β Toxicity in Alzheimer's Disease Mouse Models

(2010) Lars M. Ittner et al.   CELL

Caspase-3 Activation via Mitochondria Is Required for Long-Term Depression and AMPA Receptor Internalization

(2010) Zheng Li et al.   CELL

Progressive accumulation of amyloid-β oligomers in Alzheimer’s disease and in amyloid precursor protein transgenic mice is accompanied by selective alterations in synaptic scaffold proteins

(2010) Emiley Pham et al.   FEBS Journal

EGCG functions through estrogen receptor-mediated activation of ADAM10 in the promotion of non-amyloidogenic processing of APP

(2010) Jamie Winderbaum Fernandez et al.   FEBS LETTERS

Overexpression of the cell adhesion protein neuroligin-1 induces learning deficits and impairs synaptic plasticity by altering the ratio of excitation to inhibition in the hippocampus

(2010) Regina Dahlhaus et al.   HIPPOCAMPUS

Phenylbutyrate rescues dendritic spine loss associated with memory deficits in a mouse model of Alzheimer disease

(2010) Ana Ricobaraza et al.   HIPPOCAMPUS

Apolipoprotein E4 Causes Age- and Tau-Dependent Impairment of GABAergic Interneurons, Leading to Learning and Memory Deficits in Mice

(2010) Y. Andrews-Zwilling et al.   JOURNAL OF NEUROSCIENCE

Role of Presenilins in Neuronal Calcium Homeostasis

(2010) H. Zhang et al.   JOURNAL OF NEUROSCIENCE

Neuroligin-1 Deletion Results in Impaired Spatial Memory and Increased Repetitive Behavior

(2010) J. Blundell et al.   JOURNAL OF NEUROSCIENCE

Cognitive deficits and associated neurological complications in individuals with Down's syndrome

(2010) Ira T Lott et al.   LANCET NEUROLOGY

Characterization of the proteome, diseases and evolution of the human postsynaptic density

(2010) Àlex Bayés et al.   NATURE NEUROSCIENCE

Synaptic dysfunction in genetic models of Parkinson's disease: A role for autophagy?

(2010) Edward D. Plowey et al.   NEUROBIOLOGY OF DISEASE

Detection of elevated levels of  -synuclein oligomers in CSF from patients with Parkinson disease

(2010) T. Tokuda et al.   NEUROLOGY

Deleterious Effects of Amyloid β Oligomers Acting as an Extracellular Scaffold for mGluR5

(2010) Marianne Renner et al.   NEURON

Metaplasticity at Single Glutamatergic Synapses

(2010) Ming-Chia Lee et al.   NEURON

Glutamate Receptor Ion Channels: Structure, Regulation, and Function

(2010) S. F. Traynelis et al.   PHARMACOLOGICAL REVIEWS

GTPase Activity Plays a Key Role in the Pathobiology of LRRK2

(2010) Yulan Xiong et al.   PLoS Genetics

A Specific Enzyme-Linked Immunosorbent Assay for Measuring β-Amyloid Protein Oligomers in Human Plasma and Brain Tissue of Patients With Alzheimer Disease

(2009) Weiming Xia et al.   ARCHIVES OF NEUROLOGY

Nurturing brain plasticity: impact of environmental enrichment

(2009) L Baroncelli et al.   CELL DEATH AND DIFFERENTIATION

MicroRNA-132 Potentiates Cholinergic Anti-Inflammatory Signaling by Targeting Acetylcholinesterase

(2009) Iftach Shaked et al.   IMMUNITY

Functional Complementation of Glra1spd-ot, a Glycine Receptor Subunit Mutant, by Independently Expressed C-Terminal Domains

(2009) C. Villmann et al.   JOURNAL OF NEUROSCIENCE

Matrix Metalloproteinase-9 Controls NMDA Receptor Surface Diffusion through Integrin  1 Signaling

(2009) P. Michaluk et al.   JOURNAL OF NEUROSCIENCE

The "Down Syndrome Critical Region" Is Sufficient in the Mouse Model to Confer Behavioral, Neurophysiological, and Synaptic Phenotypes Characteristic of Down Syndrome

(2009) N. P. Belichenko et al.   JOURNAL OF NEUROSCIENCE

Clonazepam is an effective treatment for hyperekplexia due to a SLC6A5 (GlyT2) mutation

(2009) Mirte J. Bakker et al.   MOVEMENT DISORDERS

Cellular prion protein mediates impairment of synaptic plasticity by amyloid-β oligomers

(2009) Juha Laurén et al.   NATURE

Brain extracellular matrix affects AMPA receptor lateral mobility and short-term synaptic plasticity

(2009) Renato Frischknecht et al.   NATURE NEUROSCIENCE

The origin and evolution of synapses

(2009) Tomás J. Ryan et al.   NATURE REVIEWS NEUROSCIENCE

DSCAM and DSCAML1 Function in Self-Avoidance in Multiple Cell Types in the Developing Mouse Retina

(2009) Peter G. Fuerst et al.   NEURON

The crosstalk of hyaluronan-based extracellular matrix and synapses

(2009) Renato Frischknecht et al.   Neuron Glia Biology

Phenylbutyrate Ameliorates Cognitive Deficit and Reduces Tau Pathology in an Alzheimer's Disease Mouse Model

(2009) Ana Ricobaraza et al.   NEUROPSYCHOPHARMACOLOGY

Inhibitors of Class 1 Histone Deacetylases Reverse Contextual Memory Deficits in a Mouse Model of Alzheimer's Disease

(2009) Mark Kilgore et al.   NEUROPSYCHOPHARMACOLOGY

Aneuploidy: From a Physiological Mechanism of Variance to Down Syndrome

(2009) Mara Dierssen et al.   PHYSIOLOGICAL REVIEWS

Fibrillar amyloid-  burden in cognitively normal people at 3 levels of genetic risk for Alzheimer's disease

(2009) E. M. Reiman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Perineuronal Nets Protect Fear Memories from Erasure

(2009) N. Gogolla et al.   SCIENCE

Enrich the environment to empower the brain

(2009) Alessandro Sale et al.   TRENDS IN NEUROSCIENCES

Down Syndrome Fibroblast Model of Alzheimer-Related Endosome Pathology

(2008) Anne M. Cataldo et al.   AMERICAN JOURNAL OF PATHOLOGY

Gene therapy in epilepsy

(2008) Véronique Riban et al.   EPILEPSIA

Molecular and cellular basis of epileptogenesis in symptomatic epilepsy

(2008) Asla Pitkänen et al.   EPILEPSY & BEHAVIOR

LRRK2 regulates synaptic vesicle endocytosis

(2008) Narae Shin et al.   EXPERIMENTAL CELL RESEARCH

Molecular responses of the Ts65Dn and Ts1Cje mouse models of Down syndrome to MK-801

(2008) A. Siddiqui et al.   GENES BRAIN AND BEHAVIOR

 -Amyloid1-42 Induces Neuronal Death through the p75 Neurotrophin Receptor

(2008) A. Sotthibundhu et al.   JOURNAL OF NEUROSCIENCE

Smaller Dendritic Spines, Weaker Synaptic Transmission, but Enhanced Spatial Learning in Mice Lacking Shank1

(2008) A. Y. Hung et al.   JOURNAL OF NEUROSCIENCE

A  Oligomers Induce Neuronal Cell Cycle Events in Alzheimer's Disease

(2008) N. H. Varvel et al.   JOURNAL OF NEUROSCIENCE

Vesicular trafficking and secretion of matrix metalloproteinases-2, -9 and tissue inhibitor of metalloproteinases-1 in neuronal cells

(2008) Oualid Sbai et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Amyloid-β protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory

(2008) Ganesh M Shankar et al.   NATURE MEDICINE

Calcium Channel Regulation and Presynaptic Plasticity

(2008) William A. Catterall et al.   NEURON

Astrocytes in the Epileptic Brain

(2008) Jonathon Wetherington et al.   NEURON

Diffusion in Brain Extracellular Space

(2008) Eva Syková et al.   PHYSIOLOGICAL REVIEWS

Alzheimer's disease-type neuronal tau hyperphosphorylation induced by Aβ oligomers

(2007) Fernanda G. De Felice et al.   NEUROBIOLOGY OF AGING