α-Synuclein fibrils recruit peripheral immune cells in the rat brain prior to neurodegeneration

Tau/α-synuclein ratio and inflammatory proteins in Parkinson's disease: An exploratory study

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T cells from patients with Parkinson’s disease recognize α-synuclein peptides

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Allelic difference in Mhc2ta confers altered microglial activation and susceptibility to α-synuclein-induced dopaminergic neurodegeneration

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α-Synuclein fibril-induced inclusion spread in rats and mice correlates with dopaminergic Neurodegeneration

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Inhibition of the JAK/STAT Pathway Protects Against α-Synuclein-Induced Neuroinflammation and Dopaminergic Neurodegeneration

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Parkinson-associated risk variant in distal enhancer of α-synuclein modulates target gene expression

(2016) Frank Soldner et al.   NATURE

Origin, fate and dynamics of macrophages at central nervous system interfaces

(2016) Tobias Goldmann et al.   NATURE IMMUNOLOGY

New tools for studying microglia in the mouse and human CNS

(2016) Mariko L. Bennett et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An Efficient Procedure for Removal and Inactivation of Alpha-Synuclein Assemblies from Laboratory Materials

(2016) Luc Bousset et al.   Journal of Parkinsons Disease

Non-cell-autonomous Neurotoxicity of α-synuclein Through Microglial Toll-like Receptor 2

(2016) Changyoun Kim et al.   Experimental Neurobiology

Amyloid fibrils are the molecular trigger of inflammation in Parkinson's disease

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Structural and functional features of central nervous system lymphatic vessels

(2015) Antoine Louveau et al.   NATURE

Intrastriatal injection of pre-formed mouse α-synuclein fibrils into rats triggers α-synuclein pathology and bilateral nigrostriatal degeneration

(2015) Katrina L. Paumier et al.   NEUROBIOLOGY OF DISEASE

M1 and M2 immune activation in Parkinson’s Disease: Foe and ally?

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Interleukin-6 May Contribute to Mortality in Parkinson’s Disease Patients: A 4-Year Prospective Study

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Differential roles of microglia and monocytes in the inflamed central nervous system

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Addition of exogenous α-synuclein preformed fibrils to primary neuronal cultures to seed recruitment of endogenous α-synuclein to Lewy body and Lewy neurite–like aggregates

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MHC-I expression renders catecholaminergic neurons susceptible to T-cell-mediated degeneration

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Decontamination of medical devices from pathological amyloid-β-, tau- and α-synuclein aggregates

(2014) Achim Thomzig et al.   Acta Neuropathologica Communications

Phenotypic profile of alternative activation marker CD163 is different in Alzheimer’s and Parkinson’s disease

(2014) Peixuan Pey et al.   Acta Neuropathologica Communications

Minimal Differentiation of Classical Monocytes as They Survey Steady-State Tissues and Transport Antigen to Lymph Nodes

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MHCII Is Required for  -Synuclein-Induced Activation of Microglia, CD4 T Cell Proliferation, and Dopaminergic Neurodegeneration

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The genetics of Parkinson's disease: Progress and therapeutic implications

(2013) Andrew B. Singleton et al.   MOVEMENT DISORDERS

Identification of a unique TGF-β–dependent molecular and functional signature in microglia

(2013) Oleg Butovsky et al.   NATURE NEUROSCIENCE

Neuron-released oligomeric α-synuclein is an endogenous agonist of TLR2 for paracrine activation of microglia

(2013) Changyoun Kim et al.   Nature Communications

Toll-like receptor 4 is required for α-synuclein dependent activation of microglia and astroglia

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Pathological  -Synuclein Transmission Initiates Parkinson-like Neurodegeneration in Nontransgenic Mice

(2012) K. C. Luk et al.   SCIENCE

Toll-Like Receptor 4 Promotes α-Synuclein Clearance and Survival of Nigral Dopaminergic Neurons

(2011) Nadia Stefanova et al.   AMERICAN JOURNAL OF PATHOLOGY

The Fractalkine Receptor but Not CCR2 Is Present on Microglia from Embryonic Development throughout Adulthood

(2011) M. Mizutani et al.   JOURNAL OF IMMUNOLOGY

Exogenous α-Synuclein Fibrils Induce Lewy Body Pathology Leading to Synaptic Dysfunction and Neuron Death

(2011) Laura A. Volpicelli-Daley et al.   NEURON

Common genetic variation in the HLA region is associated with late-onset sporadic Parkinson's disease

(2010) Taye H Hamza et al.   NATURE GENETICS

Microglia Acquire Distinct Activation Profiles Depending on the Degree of α-Synuclein Neuropathology in a rAAV Based Model of Parkinson's Disease

(2010) Vanesa Sanchez-Guajardo et al.   PLoS One