The role of the immune system in Alzheimer’s disease

APOE ɛ4 Allele Testing and Risk of Alzheimer Disease

(2021) Parichita Choudhury et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Restoring metabolism of myeloid cells reverses cognitive decline in ageing

(2021) Paras S. Minhas et al.   NATURE

Safety and efficacy of tilavonemab in progressive supranuclear palsy: a phase 2, randomised, placebo-controlled trial

(2021) Günter U Höglinger et al.   LANCET NEUROLOGY

Donanemab in Early Alzheimer’s Disease

(2021) Mark A. Mintun et al.   NEW ENGLAND JOURNAL OF MEDICINE

APOE immunotherapy reduces cerebral amyloid angiopathy and amyloid plaques while improving cerebrovascular function

(2021) Monica Xiong et al.   Science Translational Medicine

Meningeal lymphatics affect microglia responses and anti-Aβ immunotherapy

(2021) Sandro Da Mesquita et al.   NATURE

Isoform-dependent APOE secretion modulates neuroinflammation

(2021) Philip Hasel et al.   Nature Reviews Neurology

Fatty acid metabolism in the progression and resolution of CNS disorders

(2020) Jeroen F.J. Bogie et al.   ADVANCED DRUG DELIVERY REVIEWS

Exercise-induced re-programming of age-related metabolic changes in microglia is accompanied by a reduction in senescent cells

(2020) Virginia Mela et al.   BRAIN BEHAVIOR AND IMMUNITY

Microglia, Lifestyle Stress, and Neurodegeneration

(2020) Charlotte Madore et al.   IMMUNITY

The Role of Macrophage Migration Inhibitory Factor in Alzheimer′s Disease: Conventionally Pathogenetic or Unconventionally Protective?

(2020) Maria Cristina Petralia et al.   MOLECULES

Clonally expanded CD8 T cells patrol the cerebrospinal fluid in Alzheimer’s disease

(2020) David Gate et al.   NATURE

Human and mouse single-nucleus transcriptomics reveal TREM2-dependent and TREM2-independent cellular responses in Alzheimer’s disease

(2020) Yingyue Zhou et al.   NATURE MEDICINE

The multiplex model of the genetics of Alzheimer’s disease

(2020) Rebecca Sims et al.   NATURE NEUROSCIENCE

Alzheimer’s Disease: From Amyloid to Autoimmune Hypothesis

(2020) Yuri I. Arshavsky   NEUROSCIENTIST

PLCG2 protective variant p.P522R modulates tau pathology and disease progression in patients with mild cognitive impairment

(2020) Luca Kleineidam et al.   ACTA NEUROPATHOLOGICA

Accuracy of Biomarker Testing for Neuropathologically Defined Alzheimer Disease in Older Adults With Dementia

(2020) Howard A. Fink et al.   ANNALS OF INTERNAL MEDICINE

CD8+ T-cells infiltrate Alzheimer’s disease brains and regulate neuronal- and synapse-related gene expression in APP-PS1 transgenic mice

(2020) M.S. Unger et al.   BRAIN BEHAVIOR AND IMMUNITY

Enhancing protective microglial activities with a dual function TREM 2 antibody to the stalk region

(2020) Kai Schlepckow et al.   EMBO Molecular Medicine

Blood and Cerebrospinal Fluid Autoantibody to Aβ Levels in Patients with Alzheimer’s Disease: a Meta-Analysis Study

(2020) Xiao-Wan Li et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Blood phosphorylated tau 181 as a biomarker for Alzheimer's disease: a diagnostic performance and prediction modelling study using data from four prospective cohorts

(2020) Thomas K Karikari et al.   LANCET NEUROLOGY

APOE4 leads to blood–brain barrier dysfunction predicting cognitive decline

(2020) Axel Montagne et al.   NATURE

Large-scale proteomic analysis of Alzheimer’s disease brain and cerebrospinal fluid reveals early changes in energy metabolism associated with microglia and astrocyte activation

(2020) Erik C. B. Johnson et al.   NATURE MEDICINE

Effect of ApoE isoforms on mitochondria in Alzheimer disease

(2020) Junxiang Yin et al.   NEUROLOGY

M2b macrophage subset decrement as an indicator of cognitive function in Alzheimer's disease

(2020) Sun‐Wung Hsieh et al.   PSYCHIATRY AND CLINICAL NEUROSCIENCES

β-Amyloid Clustering around ASC Fibrils Boosts Its Toxicity in Microglia

(2020) Lea L. Friker et al.   Cell Reports

A randomized, controlled clinical trial of plasma exchange with albumin replacement for Alzheimer's disease: Primary results of the AMBAR Study

(2020) Mercè Boada et al.   Alzheimers & Dementia

Impaired glymphatic function and clearance of tau in an Alzheimer’s disease model

(2020) Ian F Harrison et al.   BRAIN

The Physiology, Pathology, and Potential Therapeutic Applications of the TREM2 Signaling Pathway

(2020) Aleksandra Deczkowska et al.   CELL

Higher CSF sTREM2 and microglia activation are associated with slower rates of beta‐amyloid accumulation

(2020) Michael Ewers et al.   EMBO Molecular Medicine

The role of innate immunity in Alzheimer's disease

(2020) Hannah E. Ennerfelt et al.   IMMUNOLOGICAL REVIEWS

Discriminative Accuracy of Plasma Phospho-tau217 for Alzheimer Disease vs Other Neurodegenerative Disorders

(2020) Sebastian Palmqvist et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Depletion of NK Cells Improves Cognitive Function in the Alzheimer Disease Mouse Model

(2020) Yuanyue Zhang et al.   JOURNAL OF IMMUNOLOGY

Synergy between amyloid-β and tau in Alzheimer’s disease

(2020) Marc Aurel Busche et al.   NATURE NEUROSCIENCE

Immunological Features of Non-neuronal Brain Cells: Implications for Alzheimer’s Disease Immunotherapy

(2020) Giulia Castellani et al.   TRENDS IN IMMUNOLOGY

Tissue-Resident NK Cells: Development, Maturation, and Clinical Relevance

(2020) Elaheh Hashemi et al.   Cancers

Influenza vaccine combined with moderate-dose PD1 blockade reduces amyloid-β accumulation and improves cognition in APP/PS1 mice

(2020) Zhiwei Xing et al.   BRAIN BEHAVIOR AND IMMUNITY

Impact of TREM2R47H variant on tau pathology–induced gliosis and neurodegeneration

(2020) Maud Gratuze et al.   JOURNAL OF CLINICAL INVESTIGATION

Complement in neurological disorders and emerging complement-targeted therapeutics

(2020) Marinos C. Dalakas et al.   Nature Reviews Neurology

Translating genetic risk of Alzheimer’s disease into mechanistic insight and drug targets

(2020) Annerieke Sierksma et al.   SCIENCE

Microglia modulate neurodegeneration in Alzheimer’s and Parkinson’s diseases

(2020) Tim Bartels et al.   SCIENCE

Microglia and lipids: how metabolism controls brain innate immunity

(2020) Bruno Chausse et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Danger-Sensing/Patten Recognition Receptors and Neuroinflammation in Alzheimer’s Disease

(2020) Anna Chiarini et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The NLRP3 inflammasome inhibitor OLT1177 rescues cognitive impairment in a mouse model of Alzheimer’s disease

(2020) Niklas Lonnemann et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Glial cells and adaptive immunity in frontotemporal dementia with tau pathology

(2020) Iain J Hartnell et al.   BRAIN

Quantitative proteomics reveals distinct composition of amyloid plaques in Alzheimer's disease

(2019) Feng Xiong et al.   Alzheimers & Dementia

Iron accumulation in microglia triggers a cascade of events that leads to altered metabolism and compromised function in APP/PS1 mice

(2019) Allison McIntosh et al.   BRAIN PATHOLOGY

PET imaging of microglia by targeting macrophage colony-stimulating factor 1 receptor (CSF1R)

(2019) Andrew G. Horti et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Oxidative stress, dysfunctional glucose metabolism and Alzheimer disease

(2019) D. Allan Butterfield et al.   NATURE REVIEWS NEUROSCIENCE

The complexity of neuroinflammation at single-cell resolution

(2019) Ravikiran M. Raju et al.   Nature Reviews Neurology

Neutrophil adhesion in brain capillaries reduces cortical blood flow and impairs memory function in Alzheimer’s disease mouse models

(2019) Jean C. Cruz Hernández et al.   NATURE NEUROSCIENCE

ApoE attenuates unresolvable inflammation by complex formation with activated C1q

(2019) Changjun Yin et al.   NATURE MEDICINE

Genetic meta-analysis of diagnosed Alzheimer’s disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing

(2019) Brian W. Kunkle et al.   NATURE GENETICS

Neuroinflammation in mild cognitive impairment and Alzheimer’s disease: A meta-analysis

(2019) Steven Bradburn et al.   AGEING RESEARCH REVIEWS

Aggregated Tau activates NLRP3–ASC inflammasome exacerbating exogenously seeded and non-exogenously seeded Tau pathology in vivo

(2019) Ilie-Cosmin Stancu et al.   ACTA NEUROPATHOLOGICA

Opposite microglial activation stages upon loss of PGRN or TREM2 result in reduced cerebral glucose metabolism

(2019) Julia K Götzl et al.   EMBO Molecular Medicine

Intravenous immunoglobulins for Alzheimer’s disease and mild cognitive impairment due to Alzheimer’s disease: A systematic review with meta-analysis

(2019) Jia Liu et al.   Expert Review of Neurotherapeutics

Single-cell transcriptomic analysis of Alzheimer’s disease

(2019) Hansruedi Mathys et al.   NATURE

MCC950 closes the active conformation of NLRP3 to an inactive state

(2019) Ana Tapia-Abellán et al.   Nature Chemical Biology

Kainic acid Induces production and aggregation of amyloid β-protein and memory deficits by activating inflammasomes in NLRP3- and NF-κB-stimulated pathways

(2019) Yang Ruan et al.   Aging-US

Persistent neuropathological effects 14 years following amyloid-β immunization in Alzheimer’s disease

(2019) James A R Nicoll et al.   BRAIN

A Breakdown in Metabolic Reprogramming Causes Microglia Dysfunction in Alzheimer's Disease

(2019) Sung Hoon Baik et al.   Cell Metabolism

Monocytes in the Peripheral Clearance of Amyloid-β and Alzheimer’s Disease

(2019) Huifang Guo et al.   JOURNAL OF ALZHEIMERS DISEASE

A genetics-led approach defines the drug target landscape of 30 immune-related traits

(2019) Hai Fang et al.   NATURE GENETICS

TREM2 function impedes tau seeding in neuritic plaques

(2019) Cheryl E. G. Leyns et al.   NATURE NEUROSCIENCE

TREM2 Acts Downstream of CD33 in Modulating Microglial Pathology in Alzheimer’s Disease

(2019) Ana Griciuc et al.   NEURON

Microglia in Brain Development, Homeostasis, and Neurodegeneration

(2019) Christopher J. Bohlen et al.   Annual Review of Genetics

CSF1R inhibitor JNJ-40346527 attenuates microglial proliferation and neurodegeneration in P301S mice

(2019) Renzo Mancuso et al.   BRAIN

Sodium oligomannate therapeutically remodels gut microbiota and suppresses gut bacterial amino acids-shaped neuroinflammation to inhibit Alzheimer’s disease progression

(2019) Xinyi Wang et al.   CELL RESEARCH

Roles for the adaptive immune system in Parkinson’s and Alzheimer’s diseases

(2019) Cecilia S Lindestam Arlehamn et al.   CURRENT OPINION IN IMMUNOLOGY

Chromatin activity at GWAS loci identifies T cell states driving complex immune diseases

(2019) Blagoje Soskic et al.   NATURE GENETICS

Increased soluble TREM2 in cerebrospinal fluid is associated with reduced cognitive and clinical decline in Alzheimer’s disease

(2019) Michael Ewers et al.   Science Translational Medicine

Complement C3 Is Activated in Human AD Brain and Is Required for Neurodegeneration in Mouse Models of Amyloidosis and Tauopathy

(2019) Tiffany Wu et al.   Cell Reports

Multicenter Alzheimer's and Parkinson's disease immune biomarker verification study

(2019) Frederic Brosseron et al.   Alzheimers & Dementia

DAMPs, PAMPs, and LAMPs in Immunity and Sterile Inflammation

(2019) Joel Zindel et al.   Annual Review of Pathology-Mechanisms of Disease

Alzheimer Disease: An Update on Pathobiology and Treatment Strategies

(2019) Justin M. Long et al.   CELL

The complement cascade in Alzheimer’s disease: a systematic review and meta-analysis

(2019) Saffire H. Krance et al.   MOLECULAR PSYCHIATRY

NLRP3 inflammasome activation drives tau pathology

(2019) Christina Ising et al.   NATURE

B cells in autoimmune and neurodegenerative central nervous system diseases

(2019) Joseph J. Sabatino et al.   NATURE REVIEWS NEUROSCIENCE

Amyloid-β-independent regulators of tau pathology in Alzheimer disease

(2019) Rik van der Kant et al.   NATURE REVIEWS NEUROSCIENCE

Plasma Clusterin as a Potential Biomarker for Alzheimer’s Disease-A Systematic Review and Meta-analysis

(2019) XinRui Shi et al.   Current Alzheimer Research

Anti-Amyloid-β Monoclonal Antibodies for Alzheimer’s Disease: Pitfalls and Promise

(2018) Christopher H. van Dyck   BIOLOGICAL PSYCHIATRY

Inflammatory microglia are glycolytic and iron retentive and typify the microglia in APP/PS1 mice

(2018) R. Holland et al.   BRAIN BEHAVIOR AND IMMUNITY

Macrophage migration inhibitory factor: A multifaceted cytokine implicated in multiple neurological diseases

(2018) Marcel F. Leyton-Jaimes et al.   EXPERIMENTAL NEUROLOGY

High-Dimensional Single-Cell Mapping of Central Nervous System Immune Cells Reveals Distinct Myeloid Subsets in Health, Aging, and Disease

(2018) Dunja Mrdjen et al.   IMMUNITY

TREM2-activating antibodies abrogate the negative pleiotropic effects of the Alzheimer’s disease variant TREM2R47Hon murine myeloid cell function

(2018) Qingwen Cheng et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Blood will out: vascular contributions to Alzheimer’s disease

(2018) Sidney Strickland   JOURNAL OF CLINICAL INVESTIGATION

Peripherally derived macrophages can engraft the brain independent of irradiation and maintain an identity distinct from microglia

(2018) James C. Cronk et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Humanized TREM2 mice reveal microglia-intrinsic and -extrinsic effects of R47H polymorphism

(2018) Wilbur M. Song et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Fibrinogen in neurological diseases: mechanisms, imaging and therapeutics

(2018) Mark A. Petersen et al.   NATURE REVIEWS NEUROSCIENCE

Extravascular CD3+ T Cells in Brains of Alzheimer Disease Patients Correlate with Tau but Not with Amyloid Pathology: An Immunohistochemical Study

(2018) Mario Merlini et al.   Neurodegenerative Diseases

APOE4 Causes Widespread Molecular and Cellular Alterations Associated with Alzheimer’s Disease Phenotypes in Human iPSC-Derived Brain Cell Types

(2018) Yuan-Ta Lin et al.   NEURON

TREM2 Is a Receptor for β-Amyloid that Mediates Microglial Function

(2018) Yingjun Zhao et al.   NEURON

Multiscale Analysis of Independent Alzheimer’s Cohorts Finds Disruption of Molecular, Genetic, and Clinical Networks by Human Herpesvirus

(2018) Ben Readhead et al.   NEURON

Anti-herpetic Medications and Reduced Risk of Dementia in Patients with Herpes Simplex Virus Infections—a Nationwide, Population-Based Cohort Study in Taiwan

(2018) Nian-Sheng Tzeng et al.   Neurotherapeutics

Tau and neuroinflammation: What impact for Alzheimer's Disease and Tauopathies?

(2018) Cyril Laurent et al.   Biomedical Journal

Region-specific depletion of synaptic mitochondria in the brains of patients with Alzheimer’s disease

(2018) Eleanor K. Pickett et al.   ACTA NEUROPATHOLOGICA

Tau Oligomers and Fibrils Induce Activation of Microglial Cells

(2018) Inelia Morales et al.   JOURNAL OF ALZHEIMERS DISEASE

Oxidative Stress in CD90+ T-cells of AβPP/PS-1 Transgenic Mice

(2018) Renã A.S. Robinson et al.   JOURNAL OF ALZHEIMERS DISEASE

A Complex Proinflammatory Role for Peripheral Monocytes in Alzheimer's Disease

(2018) Marina Saresella et al.   JOURNAL OF ALZHEIMERS DISEASE

Functional aspects of meningeal lymphatics in ageing and Alzheimer’s disease

(2018) Sandro Da Mesquita et al.   NATURE

Inflammasome signalling in brain function and neurodegenerative disease

(2018) Michael T. Heneka et al.   NATURE REVIEWS NEUROSCIENCE

CSF biomarkers of neuroinflammation and cerebrovascular dysfunction in early Alzheimer disease

(2018) Shorena Janelidze et al.   NEUROLOGY

An updated Alzheimer hypothesis: Complement C3 and risk of Alzheimer's disease—A cohort study of 95,442 individuals

(2018) Katrine Laura Rasmussen et al.   Alzheimers & Dementia

CSF progranulin increases in the course of Alzheimer's disease and is associated with sTREM2, neurodegeneration and cognitive decline

(2018) Marc Suárez‐Calvet et al.   EMBO Molecular Medicine

Efficacy, Acceptability, and Safety of Intravenous Immunoglobulin Administration for Mild-To-Moderate Alzheimer’s Disease: A Systematic Review and Meta-Analysis

(2018) Makoto Okuya et al.   JOURNAL OF ALZHEIMERS DISEASE

Targeting neuro–immune communication in neurodegeneration: Challenges and opportunities

(2018) Aleksandra Deczkowska et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The glymphatic pathway in neurological disorders

(2018) Martin Kaag Rasmussen et al.   LANCET NEUROLOGY

Fibrin-targeting immunotherapy protects against neuroinflammation and neurodegeneration

(2018) Jae Kyu Ryu et al.   NATURE IMMUNOLOGY

Complement C3aR Inactivation Attenuates Tau Pathology and Reverses an Immune Network Deregulated in Tauopathy Models and Alzheimer’s Disease

(2018) Alexandra Litvinchuk et al.   NEURON

The Meningeal Lymphatic System: A New Player in Neurophysiology

(2018) Sandro Da Mesquita et al.   NEURON

The TREM2-APOE Pathway Drives the Transcriptional Phenotype of Dysfunctional Microglia in Neurodegenerative Diseases

(2017) Susanne Krasemann et al.   IMMUNITY

Macrophage Migration Inhibitory Factor is Associated with Biomarkers of Alzheimer’s Disease Pathology and Predicts Cognitive Decline in Mild Cognitive Impairment and Mild Dementia

(2017) Aikaterini Oikonomidi et al.   JOURNAL OF ALZHEIMERS DISEASE

CNS inflammation and neurodegeneration

(2017) Tanuja Chitnis et al.   JOURNAL OF CLINICAL INVESTIGATION

Understanding the functions and relationships of the glymphatic system and meningeal lymphatics

(2017) Antoine Louveau et al.   JOURNAL OF CLINICAL INVESTIGATION

Microglia in Alzheimer’s disease

(2017) Heela Sarlus et al.   JOURNAL OF CLINICAL INVESTIGATION

Soluble TREM2 induces inflammatory responses and enhances microglial survival

(2017) Li Zhong et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Peripheral inflammatory markers in Alzheimer’s disease: a systematic review and meta-analysis of 175 studies

(2017) Ka Sing P Lai et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Cerebrospinal Fluid Clearance in Alzheimer Disease Measured with Dynamic PET

(2017) Mony J. de Leon et al.   JOURNAL OF NUCLEAR MEDICINE

Mitochondrial depletion in CD4 + and CD19 + peripheral lymphocytes in early stage Alzheimer’s disease

(2017) Gökhan Terzioğlu et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Complement in the fundamental processes of the cell

(2017) Owen A. Hawksworth et al.   MOLECULAR IMMUNOLOGY

NLRP3 Inflammasome Inhibitor Ameliorates Amyloid Pathology in a Mouse Model of Alzheimer’s Disease

(2017) Jun Yin et al.   MOLECULAR NEUROBIOLOGY

ApoE4 markedly exacerbates tau-mediated neurodegeneration in a mouse model of tauopathy

(2017) Yang Shi et al.   NATURE

Microglia-derived ASC specks cross-seed amyloid-β in Alzheimer’s disease

(2017) Carmen Venegas et al.   NATURE

Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease

(2017) Rebecca Sims et al.   NATURE GENETICS

The role of peripheral immune cells in the CNS in steady state and disease

(2017) Marco Prinz et al.   NATURE NEUROSCIENCE

Peripheral administration of the soluble TNF inhibitor XPro1595 modifies brain immune cell profiles, decreases beta-amyloid plaque load, and rescues impaired long-term potentiation in 5xFAD mice

(2017) Kathryn P. MacPherson et al.   NEUROBIOLOGY OF DISEASE

Elucidating the Role of TREM2 in Alzheimer’s Disease

(2017) Jason D. Ulrich et al.   NEURON

Amino Acid Catabolism in Alzheimer’s Disease Brain: Friend or Foe?

(2017) Jeddidiah W. D. Griffin et al.   Oxidative Medicine and Cellular Longevity

The mystery behind membrane insertion: a review of the complement membrane attack complex

(2017) Charles Bayly-Jones et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Complement C3 deficiency protects against neurodegeneration in aged plaque-rich APP/PS1 mice

(2017) Qiaoqiao Shi et al.   Science Translational Medicine

Human and nonhuman primate meninges harbor lymphatic vessels that can be visualized noninvasively by MRI

(2017) Martina Absinta et al.   eLife

Test of the 'glymphatic' hypothesis demonstrates diffusive and aquaporin-4-independent solute transport in rodent brain parenchyma

(2017) Alex J Smith et al.   eLife

T Lymphocytes and Inflammatory Mediators in the Interplay between Brain and Blood in Alzheimer’s Disease: Potential Pools of New Biomarkers

(2017) Anna Mietelska-Porowska et al.   Journal of Immunology Research

In Vivo Imaging of Human Neuroinflammation

(2016) Daniel S. Albrecht et al.   ACS Chemical Neuroscience

Distinct inflammatory phenotypes of microglia and monocyte-derived macrophages in Alzheimer's disease models: effects of aging and amyloid pathology

(2016) Elodie Martin et al.   AGING CELL

Hippocampal T cell infiltration promotes neuroinflammation and cognitive decline in a mouse model of tauopathy

(2016) Cyril Laurent et al.   BRAIN

Regulatory T cells delay disease progression in Alzheimer-like pathology

(2016) Cira Dansokho et al.   BRAIN

Early and protective microglial activation in Alzheimer’s disease: a prospective study using18F-DPA-714 PET imaging

(2016) Lorraine Hamelin et al.   BRAIN

Clusterin levels are increased in Alzheimer's disease and influence the regional distribution of Aβ

(2016) J. Scott Miners et al.   BRAIN PATHOLOGY

Progranulin Deficiency Promotes Circuit-Specific Synaptic Pruning by Microglia via Complement Activation

(2016) Hansen Lui et al.   CELL

The amyloid hypothesis of Alzheimer's disease at 25 years

(2016) Dennis J Selkoe et al.   EMBO Molecular Medicine

Complement Biomarkers as Predictors of Disease Progression in Alzheimer’s Disease

(2016) Svetlana Hakobyan et al.   JOURNAL OF ALZHEIMERS DISEASE

Bacterial Amyloid and DNA are Important Constituents of Senile Plaques: Further Evidence of the Spirochetal and Biofilm Nature of Senile Plaques

(2016) Judith Miklossy   JOURNAL OF ALZHEIMERS DISEASE

TREM2-mediated early microglial response limits diffusion and toxicity of amyloid plaques

(2016) Yaming Wang et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Danger-associated molecular patterns in Alzheimer’s disease

(2016) Carmen Venegas et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Large Soluble Oligomers of Amyloid β-Protein from Alzheimer Brain Are Far Less Neuroactive Than the Smaller Oligomers to Which They Dissociate

(2016) Ting Yang et al.   JOURNAL OF NEUROSCIENCE

11 C-ER176, a Radioligand for 18-kDa Translocator Protein, Has Adequate Sensitivity to Robustly Image All Three Affinity Genotypes in Human Brain

(2016) Masamichi Ikawa et al.   JOURNAL OF NUCLEAR MEDICINE

Human memory B cells

(2016) M Seifert et al.   LEUKEMIA

Microglial Polarization and Inflammatory Mediators After Intracerebral Hemorrhage

(2016) Zhen Zhang et al.   MOLECULAR NEUROBIOLOGY

Origin, fate and dynamics of macrophages at central nervous system interfaces

(2016) Tobias Goldmann et al.   NATURE IMMUNOLOGY

PD-1 immune checkpoint blockade reduces pathology and improves memory in mouse models of Alzheimer's disease

(2016) Kuti Baruch et al.   NATURE MEDICINE

Lymphatics in Neurological Disorders: A Neuro-Lympho-Vascular Component of Multiple Sclerosis and Alzheimer’s Disease?

(2016) Antoine Louveau et al.   NEURON

TREM2 Binds to Apolipoproteins, Including APOE and CLU/APOJ, and Thereby Facilitates Uptake of Amyloid-Beta by Microglia

(2016) Felix L. Yeh et al.   NEURON

The adaptive immune system restrains Alzheimer’s disease pathogenesis by modulating microglial function

(2016) Samuel E. Marsh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Complement and microglia mediate early synapse loss in Alzheimer mouse models

(2016) S. Hong et al.   SCIENCE

Early changes in CSF sTREM2 in dominantly inherited Alzheimers disease occur after amyloid deposition and neuronal injury

(2016) M. Suarez-Calvet et al.   Science Translational Medicine

Physiological amyloid-beta clearance in the periphery and its therapeutic potential for Alzheimer’s disease

(2015) Yang Xiang et al.   ACTA NEUROPATHOLOGICA

APOEε2 is associated with milder clinical and pathological Alzheimer disease

(2015) Alberto Serrano-Pozo et al.   ANNALS OF NEUROLOGY

Reactive microglia drive tau pathology and contribute to the spreading of pathological tau in the brain

(2015) Nicole Maphis et al.   BRAIN

Therapeutic effects of glatiramer acetate and grafted CD115+monocytes in a mouse model of Alzheimer’s disease

(2015) Yosef Koronyo et al.   BRAIN

Apolipoprotein E Is a Ligand for Triggering Receptor Expressed on Myeloid Cells 2 (TREM2)

(2015) Yuka Atagi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A dural lymphatic vascular system that drains brain interstitial fluid and macromolecules

(2015) Aleksanteri Aspelund et al.   JOURNAL OF EXPERIMENTAL MEDICINE

T Cells—Protective or Pathogenic in Alzheimer’s Disease?

(2015) Róisín M. McManus et al.   Journal of Neuroimmune Pharmacology

Interactions between mitochondria and the transcription factor myocyte enhancer factor 2 (MEF2) regulate neuronal structural and functional plasticity and metaplasticity

(2015) Janaina Brusco et al.   JOURNAL OF PHYSIOLOGY-LONDON

Structural and functional features of central nervous system lymphatic vessels

(2015) Antoine Louveau et al.   NATURE

Neutrophils promote Alzheimer's disease–like pathology and cognitive decline via LFA-1 integrin

(2015) Elena Zenaro et al.   NATURE MEDICINE

Depletion of microglia and inhibition of exosome synthesis halt tau propagation

(2015) Hirohide Asai et al.   NATURE NEUROSCIENCE

Clearance systems in the brain—implications for Alzheimer disease

(2015) Jenna M. Tarasoff-Conway et al.   Nature Reviews Neurology

Revisiting the Mechanisms of CNS Immune Privilege

(2015) Antoine Louveau et al.   TRENDS IN IMMUNOLOGY

A Single-Cell Gene-Expression Profile Reveals Inter-Cellular Heterogeneity within Human Monocyte Subsets

(2015) Susanne T. Gren et al.   PLoS One

VEGFR signaling during lymphatic vascular development: From progenitor cells to functional vessels

(2014) Genevieve A. Secker et al.   DEVELOPMENTAL DYNAMICS

An RNA-Sequencing Transcriptome and Splicing Database of Glia, Neurons, and Vascular Cells of the Cerebral Cortex

(2014) Y. Zhang et al.   JOURNAL OF NEUROSCIENCE

Impairment of Glymphatic Pathway Function Promotes Tau Pathology after Traumatic Brain Injury

(2014) Jeffrey J. Iliff et al.   JOURNAL OF NEUROSCIENCE

CNS Repair Requires Both Effector and Regulatory T Cells with Distinct Temporal and Spatial Profiles

(2014) C. Raposo et al.   JOURNAL OF NEUROSCIENCE

Pathogenesis of multiple sclerosis: insights from molecular and metabolic imaging

(2014) Olga Ciccarelli et al.   LANCET NEUROLOGY

Progranulin protects against amyloid β deposition and toxicity in Alzheimer's disease mouse models

(2014) S Sakura Minami et al.   NATURE MEDICINE

Evidence for lymphatic Aβ clearance in Alzheimer's transgenic mice

(2014) Miguel Pappolla et al.   NEUROBIOLOGY OF DISEASE

Dysfunction of phospholipase Cγ in immune disorders and cancer

(2014) Hans Koss et al.   TRENDS IN BIOCHEMICAL SCIENCES

The amyloid cascade-inflammatory hypothesis of Alzheimer disease: implications for therapy

(2013) Patrick L. McGeer et al.   ACTA NEUROPATHOLOGICA

DAMPs and autophagy

(2013) Qiuhong Zhang et al.   Autophagy

CD4 T cells in immunity and immunotherapy of Alzheimer's disease

(2013) Alon Monsonego et al.   IMMUNOLOGY

Diverse novel functions of neutrophils in immunity, inflammation, and beyond

(2013) Attila Mócsai   JOURNAL OF EXPERIMENTAL MEDICINE

IFN-  Production by Amyloid  -Specific Th1 Cells Promotes Microglial Activation and Increases Plaque Burden in a Mouse Model of Alzheimer's Disease

(2013) T. C. Browne et al.   JOURNAL OF IMMUNOLOGY

Cleavage of GSK-3β by calpain counteracts the inhibitory effect of Ser9 phosphorylation on GSK-3β activity induced by H2O2

(2013) Ye Feng et al.   JOURNAL OF NEUROCHEMISTRY

Activated Cyclin-Dependent Kinase 5 Promotes Microglial Phagocytosis of Fibrillar β-Amyloid by Up-regulating Lipoprotein Lipase Expression

(2013) Yuanhui Ma et al.   MOLECULAR & CELLULAR PROTEOMICS

The microglial sensome revealed by direct RNA sequencing

(2013) Suzanne E Hickman et al.   NATURE NEUROSCIENCE

Inflammatory Proteins in Plasma Are Associated with Severity of Alzheimer’s Disease

(2013) Rufina Leung et al.   PLoS One

Naturally occurring autoantibodies interfere with β-amyloid metabolism and improve cognition in a transgenic mouse model of Alzheimer’s disease 24 h after single treatment

(2013) D Mengel et al.   Translational Psychiatry

The Complement System: An Unexpected Role in Synaptic Pruning During Development and Disease

(2012) Alexander H. Stephan et al.   Annual Review of Neuroscience

Mitochondrial fission proteins in peripheral blood lymphocytes are potential biomarkers for Alzheimer’s disease

(2012) S. Wang et al.   EUROPEAN JOURNAL OF NEUROLOGY

Peripheral Mitochondrial Dysfunction in Alzheimer’s Disease: Focus on Lymphocytes

(2012) Kristina Leuner et al.   MOLECULAR NEUROBIOLOGY

CCL2 affects β-amyloidosis and progressive neurocognitive dysfunction in a mouse model of Alzheimer's disease

(2012) Tomomi Kiyota et al.   NEUROBIOLOGY OF AGING

A Paravascular Pathway Facilitates CSF Flow Through the Brain Parenchyma and the Clearance of Interstitial Solutes, Including Amyloid  

(2012) J. J. Iliff et al.   Science Translational Medicine

Innate immunosenescence: Effect of aging on cells and receptors of the innate immune system in humans

(2012) Rafael Solana et al.   SEMINARS IN IMMUNOLOGY

Age-Related Comparisons of Evolution of the Inflammatory Response After Intracerebral Hemorrhage in Rats

(2012) Starlee Lively et al.   Translational Stroke Research

Plasma Clusterin and the Risk of Alzheimer Disease

(2011) Elisabeth M. C. Schrijvers   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Naturally Occurring Autoantibodies against  -Amyloid: Investigating Their Role in Transgenic Animal and In Vitro Models of Alzheimer's Disease

(2011) R. Dodel et al.   JOURNAL OF NEUROSCIENCE

The Translocator Protein

(2011) A. M. Scarf et al.   JOURNAL OF NUCLEAR MEDICINE

Inhibiting the C5–C5a receptor axis

(2011) Trent M. Woodruff et al.   MOLECULAR IMMUNOLOGY

Phagocytic activity of neuronal progenitors regulates adult neurogenesis

(2011) Zhenjie Lu et al.   NATURE CELL BIOLOGY

A Meta-Analysis of Cytokines in Alzheimer's Disease

(2010) Walter Swardfager et al.   BIOLOGICAL PSYCHIATRY

Increased activity of Th-17 and Th-9 lymphocytes and a skewing of the post-thymic differentiation pathway are seen in Alzheimer’s disease

(2010) Marina Saresella et al.   BRAIN BEHAVIOR AND IMMUNITY

Efficient Phagocytosis Requires Triacylglycerol Hydrolysis by Adipose Triglyceride Lipase

(2010) Prakash G. Chandak et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Complement: a key system for immune surveillance and homeostasis

(2010) Daniel Ricklin et al.   NATURE IMMUNOLOGY

Regulation of Tau Pathology by the Microglial Fractalkine Receptor

(2010) Kiran Bhaskar et al.   NEURON

Neutrophil Elastase, Proteinase 3, and Cathepsin G as Therapeutic Targets in Human Diseases

(2010) B. Korkmaz et al.   PHARMACOLOGICAL REVIEWS

Autoantibodies against β-amyloid are common in Alzheimer's disease and help control plaque burden

(2009) Alexander Kellner et al.   ANNALS OF NEUROLOGY

Blood Monocytes: Development, Heterogeneity, and Relationship with Dendritic Cells

(2009) Cedric Auffray et al.   Annual Review of Immunology

High glucose, unsaturated and saturated fatty acids differentially regulate expression of ATP-binding cassette transporters ABCA1 and ABCG1 in human macrophages

(2009) Richard Mauerer et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

Soluble cell adhesion molecules in monocytes of Alzheimer’s disease and mild cognitive impairment

(2009) Tanja Hochstrasser et al.   EXPERIMENTAL GERONTOLOGY

Exaggerated inflammation, impaired host defense, and neuropathology in progranulin-deficient mice

(2009) Fangfang Yin et al.   JOURNAL OF EXPERIMENTAL MEDICINE

CD36 ligands promote sterile inflammation through assembly of a Toll-like receptor 4 and 6 heterodimer

(2009) Cameron R Stewart et al.   NATURE IMMUNOLOGY

Aβ-specific Th2 cells provide cognitive and pathological benefits to Alzheimer's mice without infiltrating the CNS

(2009) Chuanhai Cao et al.   NEUROBIOLOGY OF DISEASE

Systemic inflammation and disease progression in Alzheimer disease

(2009) C. Holmes et al.   NEUROLOGY

Selective targeting of perivascular macrophages for clearance of  -amyloid in cerebral amyloid angiopathy

(2009) C. A. Hawkes et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Lysophosphatidic acid receptor activation affects the C13NJ microglia cell line proteome leading to alterations in glycolysis, motility, and cytoskeletal architecture

(2009) Eva Bernhart et al.   PROTEOMICS

A peptide containing residues 26–44 of tau protein impairs mitochondrial oxidative phosphorylation acting at the level of the adenine nucleotide translocator

(2008) A. Atlante et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Complement C3 Deficiency Leads to Accelerated Amyloid   Plaque Deposition and Neurodegeneration and Modulation of the Microglia/Macrophage Phenotype in Amyloid Precursor Protein Transgenic Mice

(2008) M. Maier et al.   JOURNAL OF NEUROSCIENCE

Macrophage migration inhibitory factor in mild cognitive impairment and Alzheimer’s disease

(2008) Julius Popp et al.   JOURNAL OF PSYCHIATRIC RESEARCH