VEGFR signaling during lymphatic vascular development: From progenitor cells to functional vessels

Receptor Tyrosine Kinases Endocytosis in Endothelium

(2014) Xi Zhang et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

AIP1 Mediates Vascular Endothelial Cell Growth Factor Receptor-3–Dependent Angiogenic and Lymphangiogenic Responses

(2014) Huanjiao Jenny Zhou et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Slit2N and Robo4 regulate lymphangiogenesis through the VEGF-C/VEGFR-3 pathway

(2014) Jinlong Yu et al.   Cell Communication and Signaling

CCBE1 Enhances Lymphangiogenesis via A Disintegrin and Metalloprotease With Thrombospondin Motifs-3–Mediated Vascular Endothelial Growth Factor-C Activation

(2014) Michael Jeltsch et al.   CIRCULATION

Ccbe1 regulates Vegfc-mediated induction of Vegfr3 signaling during embryonic lymphangiogenesis

(2014) L. Le Guen et al.   DEVELOPMENT

Vegfd can compensate for loss of Vegfc in zebrafish facial lymphatic sprouting

(2014) J. W. Astin et al.   DEVELOPMENT

Lymphatic function is required prenatally for lung inflation at birth

(2014) Zoltán Jakus et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The docking protein FRS2  is a critical regulator of VEGF receptors signaling

(2014) P.-Y. Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Temporal and spatial regulation of epsin abundance and VEGFR3 signaling are required for lymphatic valve formation and function

(2014) X. Liu et al.   Science Signaling

Lymphatic Vessels Are Essential for the Removal of Cholesterol from Peripheral Tissues by SR-BI-Mediated Transport of HDL

(2013) Hwee Ying Lim et al.   Cell Metabolism

Mutation in Vascular Endothelial Growth Factor-C, a Ligand for Vascular Endothelial Growth Factor Receptor-3, Is Associated With Autosomal Dominant Milroy-Like Primary Lymphedema

(2013) Kristiana Gordon et al.   CIRCULATION RESEARCH

Getting out and about: the emergence and morphogenesis of the vertebrate lymphatic vasculature

(2013) K. Koltowska et al.   DEVELOPMENT

A novel multistep mechanism for initial lymphangiogenesis in mouse embryos based on ultramicroscopy

(2013) René Hägerling et al.   EMBO JOURNAL

Platelets mediate lymphovenous hemostasis to maintain blood-lymphatic separation throughout life

(2013) Paul R. Hess et al.   JOURNAL OF CLINICAL INVESTIGATION

Lymphatic vasculature mediates macrophage reverse cholesterol transport in mice

(2013) Catherine Martel et al.   JOURNAL OF CLINICAL INVESTIGATION

Vascular Endothelial Growth Factor-d Modulates Caliber and Function of Initial Lymphatics in the Dermis

(2013) Sophie Paquet-Fifield et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Caveolae as plasma membrane sensors, protectors and organizers

(2013) Robert G. Parton et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Vascular Endothelial Growth Factor Receptor-2 Promotes the Development of the Lymphatic Vasculature

(2013) Michael T. Dellinger et al.   PLoS One

Structural and mechanistic insights into VEGF receptor 3 ligand binding and activation

(2013) V.-M. Leppanen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Lymphatic endothelial progenitors bud from the cardinal vein and intersomitic vessels in mammalian embryos

(2012) Y. Yang et al.   BLOOD

Developmental and Pathological Angiogenesis

(2011) Alicia S. Chung et al.   Annual Review of Cell and Developmental Biology

CCBE1 Is Essential for Mammalian Lymphatic Vascular Development and Enhances the Lymphangiogenic Effect of Vascular Endothelial Growth Factor-C In Vivo

(2011) Frank L. Bos et al.   CIRCULATION RESEARCH

Segmental territories along the cardinal veins generate lymph sacs via a ballooning mechanism during embryonic lymphangiogenesis in mice

(2011) Mathias François et al.   DEVELOPMENTAL BIOLOGY

Mechanoinduction of lymph vessel expansion

(2011) Lara Planas-Paz et al.   EMBO JOURNAL

Prox1 dosage controls the number of lymphatic endothelial cell progenitors and the formation of the lymphovenous valves

(2011) R. S. Srinivasan et al.   GENES & DEVELOPMENT

Lymphatic vascular morphogenesis in development, physiology, and disease

(2011) Stefan Schulte-Merker et al.   JOURNAL OF CELL BIOLOGY

Protein Tyrosine Phosphatase PTPN14 Is a Regulator of Lymphatic Function and Choanal Development in Humans

(2010) Audrey C. Au et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Lymphangiogenesis: Molecular Mechanisms and Future Promise

(2010) Tuomas Tammela et al.   CELL

VEGFR-3 ligand-binding and kinase activity are required for lymphangiogenesis but not for angiogenesis

(2010) Luqing Zhang et al.   CELL RESEARCH

Endothelial Cell Adhesion to the Extracellular Matrix Induces c-Src–Dependent VEGFR-3 Phosphorylation Without the Activation of the Receptor Intrinsic Kinase Activity

(2010) Federico Galvagni et al.   CIRCULATION RESEARCH

VEGF receptor 2/-3 heterodimers detected in situ by proximity ligation on angiogenic sprouts

(2010) Ingrid Nilsson et al.   EMBO JOURNAL

Claudin-like protein 24 interacts with the VEGFR-2 and VEGFR-3 pathways and regulates lymphatic vessel development

(2010) P. Saharinen et al.   GENES & DEVELOPMENT

Neuropilin-2 mediates VEGF-C–induced lymphatic sprouting together with VEGFR3

(2010) Yunling Xu et al.   JOURNAL OF CELL BIOLOGY

Ephrin-B2 regulates VEGFR2 function in developmental and tumour angiogenesis

(2010) Suphansa Sawamiphak et al.   NATURE

Ephrin-B2 controls VEGF-induced angiogenesis and lymphangiogenesis

(2010) Yingdi Wang et al.   NATURE

FOXC2 controls formation and maturation of lymphatic collecting vessels through cooperation with NFATc1

(2009) Camilla Norrmén et al.   JOURNAL OF CELL BIOLOGY

Mutations in CCBE1 cause generalized lymph vessel dysplasia in humans

(2009) Marielle Alders et al.   NATURE GENETICS

ccbe1 is required for embryonic lymphangiogenesis and venous sprouting

(2009) Benjamin M Hogan et al.   NATURE GENETICS

Macrophages regulate salt-dependent volume and blood pressure by a vascular endothelial growth factor-C–dependent buffering mechanism

(2009) Agnes Machnik et al.   NATURE MEDICINE

Deletion of Vascular Endothelial Growth Factor C (VEGF-C) and VEGF-D Is Not Equivalent to VEGF Receptor 3 Deletion in Mouse Embryos

(2008) P. Haiko et al.   MOLECULAR AND CELLULAR BIOLOGY

Robo4 stabilizes the vascular network by inhibiting pathologic angiogenesis and endothelial hyperpermeability

(2008) Christopher A Jones et al.   NATURE MEDICINE