The role of peripheral immune cells in the CNS in steady state and disease

Immune cell trafficking across the barriers of the central nervous system in multiple sclerosis and stroke

(2016) Melissa A. Lopes Pinheiro et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Transcriptional profiling of CD11c-positive microglia accumulating around amyloid plaques in a mouse model for Alzheimer's disease

(2016) Willem Kamphuis et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Transcriptome‐based profiling of yolk sac‐derived macrophages reveals a role for Irf8 in macrophage maturation

(2016) Nora Hagemeyer et al.   EMBO JOURNAL

A case of mistaken identity: CD11c-eYFP+cells in the normal mouse brain parenchyma and neural retina display the phenotype of microglia, not dendritic cells

(2016) Samantha J. Dando et al.   GLIA

Human USP18 deficiency underlies type 1 interferonopathy leading to severe pseudo-TORCH syndrome

(2016) Marije E.C. Meuwissen et al.   JOURNAL OF EXPERIMENTAL MEDICINE

TREM2-mediated early microglial response limits diffusion and toxicity of amyloid plaques

(2016) Yaming Wang et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Unexpected role of interferon-γ in regulating neuronal connectivity and social behaviour

(2016) Anthony J. Filiano et al.   NATURE

Origin, fate and dynamics of macrophages at central nervous system interfaces

(2016) Tobias Goldmann et al.   NATURE IMMUNOLOGY

Translocation and dissemination of commensal bacteria in post-stroke infection

(2016) Dragana Stanley et al.   NATURE MEDICINE

Commensal microbiota affects ischemic stroke outcome by regulating intestinal γδ T cells

(2016) Corinne Benakis et al.   NATURE MEDICINE

Microglia development follows a stepwise program to regulate brain homeostasis

(2016) O. Matcovitch-Natan et al.   SCIENCE

How neuroinflammation contributes to neurodegeneration

(2016) R. M. Ransohoff   SCIENCE

Ly6Chi Monocytes Provide a Link between Antibiotic-Induced Changes in Gut Microbiota and Adult Hippocampal Neurogenesis

(2016) Luisa Möhle et al.   Cell Reports

ATREM1variant alters the accumulation of Alzheimer-related amyloid pathology

(2015) Joseph M. Replogle et al.   ANNALS OF NEUROLOGY

TREM2 Lipid Sensing Sustains the Microglial Response in an Alzheimer’s Disease Model

(2015) Yaming Wang et al.   CELL

Temporal-Spatial Resolution Fate Mapping Reveals Distinct Origins for Embryonic and Adult Microglia in Zebrafish

(2015) Jin Xu et al.   DEVELOPMENTAL CELL

USP18 lack in microglia causes destructive interferonopathy of the mouse brain

(2015) T. Goldmann et al.   EMBO JOURNAL

Cerebral nitric oxide represses choroid plexus NF B-dependent gateway activity for leukocyte trafficking

(2015) K. Baruch et al.   EMBO JOURNAL

Integration of Th17- and Lymphotoxin-Derived Signals Initiates Meningeal-Resident Stromal Cell Remodeling to Propagate Neuroinflammation

(2015) Natalia B. Pikor et al.   IMMUNITY

Genetic Cell Ablation Reveals Clusters of Local Self-Renewing Microglia in the Mammalian Central Nervous System

(2015) Julia Bruttger et al.   IMMUNITY

The Cytokine GM-CSF Drives the Inflammatory Signature of CCR2+ Monocytes and Licenses Autoimmunity

(2015) Andrew L. Croxford et al.   IMMUNITY

Therapeutic antiviral T cells noncytopathically clear persistently infected microglia after conversion into antigen-presenting cells

(2015) Jasmin Herz et al.   JOURNAL OF EXPERIMENTAL MEDICINE

TREM2 deficiency eliminates TREM2+inflammatory macrophages and ameliorates pathology in Alzheimer’s disease mouse models

(2015) Taylor R. Jay et al.   JOURNAL OF EXPERIMENTAL MEDICINE

A dural lymphatic vascular system that drains brain interstitial fluid and macromolecules

(2015) Aleksanteri Aspelund et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Blocking Stroke-Induced Immunodeficiency Increases CNS Antigen-Specific Autoreactivity But Does Not Worsen Functional Outcome after Experimental Stroke

(2015) C. Romer et al.   JOURNAL OF NEUROSCIENCE

B-Lymphocyte-Mediated Delayed Cognitive Impairment following Stroke

(2015) K. P. Doyle et al.   JOURNAL OF NEUROSCIENCE

Role of the innate and adaptive immune responses in the course of multiple sclerosis

(2015) Bernhard Hemmer et al.   LANCET NEUROLOGY

Neuroinflammation in Alzheimer's disease

(2015) Michael T Heneka et al.   LANCET NEUROLOGY

Structural and functional features of central nervous system lymphatic vessels

(2015) Antoine Louveau et al.   NATURE

Neutrophils promote Alzheimer's disease–like pathology and cognitive decline via LFA-1 integrin

(2015) Elena Zenaro et al.   NATURE MEDICINE

CD33 modulates TREM2: convergence of Alzheimer loci

(2015) Gail Chan et al.   NATURE NEUROSCIENCE

Central nervous system myeloid cells as drug targets: current status and translational challenges

(2015) Knut Biber et al.   NATURE REVIEWS DRUG DISCOVERY

Immune interventions in stroke

(2015) Ying Fu et al.   Nature Reviews Neurology

Lack of Widespread BBB Disruption in Alzheimer’s Disease Models: Focus on Therapeutic Antibodies

(2015) Nga Bien-Ly et al.   NEURON

Extensive grey matter pathology in the cerebellum in multiple sclerosis is linked to inflammation in the subarachnoid space

(2015) Owain W. Howell et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Do not judge a cell by its cover—diversity of CNS resident, adjoining and infiltrating myeloid cells in inflammation

(2015) Stefanie M. Brendecke et al.   Seminars in Immunopathology

Cholinergic Pathway Suppresses Pulmonary Innate Immunity Facilitating Pneumonia After Stroke

(2015) Odilo Engel et al.   STROKE

GM-CSF in Neuroinflammation: Licensing Myeloid Cells for Tissue Damage

(2015) Andrew L. Croxford et al.   TRENDS IN IMMUNOLOGY

Microglia Plasticity During Health and Disease: An Immunological Perspective

(2015) Anat Shemer et al.   TRENDS IN IMMUNOLOGY

Revisiting the Mechanisms of CNS Immune Privilege

(2015) Antoine Louveau et al.   TRENDS IN IMMUNOLOGY

Myeloid Cells in Alzheimer's Disease: Culprits, Victims or Innocent Bystanders?

(2015) Melanie Meyer-Luehmann et al.   TRENDS IN NEUROSCIENCES

Microglia Versus Myeloid Cell Nomenclature during Brain Inflammation

(2015) Melanie Greter et al.   Frontiers in Immunology

Oral TNFα Modulation Alters Neutrophil Infiltration, Improves Cognition and Diminishes Tau and Amyloid Pathology in the 3xTgAD Mouse Model

(2015) S. Prasad Gabbita et al.   PLoS One

CD8+MAIT cells infiltrate into the CNS and alterations in their blood frequencies correlate with IL-18 serum levels in multiple sclerosis

(2014) Anne Willing et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Differential roles of microglia and monocytes in the inflamed central nervous system

(2014) Ryo Yamasaki et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Microglia and brain macrophages in the molecular age: from origin to neuropsychiatric disease

(2014) Marco Prinz et al.   NATURE REVIEWS NEUROSCIENCE

IL-17 and GM-CSF Expression Are Antagonistically Regulated by Human T Helper Cells

(2014) R. Noster et al.   Science Translational Medicine

B cells populating the multiple sclerosis brain mature in the draining cervical lymph nodes

(2014) J. N. H. Stern et al.   Science Translational Medicine

Proliferation of parenchymal microglia is the main source of microgliosis after ischaemic stroke

(2013) Ting Li et al.   BRAIN

Integrated Systems Approach Identifies Genetic Nodes and Networks in Late-Onset Alzheimer’s Disease

(2013) Bin Zhang et al.   CELL

Role of Microglia in CNS Autoimmunity

(2013) Tobias Goldmann et al.   Clinical & Developmental Immunology

Tissue-Resident Macrophages Self-Maintain Locally throughout Adult Life with Minimal Contribution from Circulating Monocytes

(2013) Daigo Hashimoto et al.   IMMUNITY

MHC class I–restricted myelin epitopes are cross-presented by Tip-DCs that promote determinant spreading to CD8+ T cells

(2013) Qingyong Ji et al.   NATURE IMMUNOLOGY

Development, maintenance and disruption of the blood-brain barrier

(2013) Birgit Obermeier et al.   NATURE MEDICINE

A new type of microglia gene targeting shows TAK1 to be pivotal in CNS autoimmune inflammation

(2013) Tobias Goldmann et al.   NATURE NEUROSCIENCE

Microglia emerge from erythromyeloid precursors via Pu.1- and Irf8-dependent pathways

(2013) Katrin Kierdorf et al.   NATURE NEUROSCIENCE

Alzheimer’s Disease Risk Gene CD33 Inhibits Microglial Uptake of Amyloid Beta

(2013) Ana Griciuc et al.   NEURON

Bone Marrow Cell Recruitment to the Brain in the Absence of Irradiation or Parabiosis Bias

(2013) Katrin Kierdorf et al.   PLoS One

Using Exome Sequencing to Reveal Mutations in TREM2 Presenting as a Frontotemporal Dementia–like Syndrome Without Bone Involvement

(2013) Rita João Guerreiro et al.   JAMA Neurology

The neurovascular unit as a selective barrier to polymorphonuclear granulocyte (PMN) infiltration into the brain after ischemic injury

(2012) Gaby Enzmann et al.   ACTA NEUROPATHOLOGICA

Adoptive regulatory T-cell therapy protects against cerebral ischemia

(2012) Peiying Li et al.   ANNALS OF NEUROLOGY

Decisions About Dendritic Cells: Past, Present, and Future

(2012) Ralph M. Steinman   Annual Review of Immunology

Neutralization of the IL-17 axis diminishes neutrophil invasion and protects from ischemic stroke

(2012) M. Gelderblom et al.   BLOOD

Regulatory T cells are strong promoters of acute ischemic stroke in mice by inducing dysfunction of the cerebral microvasculature

(2012) C. Kleinschnitz et al.   BLOOD

Brain-Derived Antigens in Lymphoid Tissue of Patients with Acute Stroke

(2012) A. M. Planas et al.   JOURNAL OF IMMUNOLOGY

NLRP3 is activated in Alzheimer’s disease and contributes to pathology in APP/PS1 mice

(2012) Michael T. Heneka et al.   NATURE

Inhibition of IL-12/IL-23 signaling reduces Alzheimer's disease–like pathology and cognitive decline

(2012) Johannes vom Berg et al.   NATURE MEDICINE

The immunology of acute stroke

(2012) Ángel Chamorro et al.   Nature Reviews Neurology

A Lineage of Myeloid Cells Independent of Myb and Hematopoietic Stem Cells

(2012) C. Schulz et al.   SCIENCE

Pathology of Demyelinating Diseases

(2011) Bogdan F.Gh. Popescu et al.   Annual Review of Pathology-Mechanisms of Disease

Th17 Cells Induce Ectopic Lymphoid Follicles in Central Nervous System Tissue Inflammation

(2011) Anneli Peters et al.   IMMUNITY

Flt3L controls the development of radiosensitive dendritic cells in the meninges and choroid plexus of the steady-state mouse brain

(2011) Niroshana Anandasabapathy et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Distinct and Non-Redundant Roles of Microglia and Myeloid Subsets in Mouse Models of Alzheimer's Disease

(2011) A. Mildner et al.   JOURNAL OF NEUROSCIENCE

Regulatory B Cells Limit CNS Inflammation and Neurologic Deficits in Murine Experimental Stroke

(2011) X. Ren et al.   JOURNAL OF NEUROSCIENCE

Mutations in the colony stimulating factor 1 receptor (CSF1R) gene cause hereditary diffuse leukoencephalopathy with spheroids

(2011) Rosa Rademakers et al.   NATURE GENETICS

Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease

(2011) Adam C Naj et al.   NATURE GENETICS

Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease

(2011) Paul Hollingworth et al.   NATURE GENETICS

RORγt drives production of the cytokine GM-CSF in helper T cells, which is essential for the effector phase of autoimmune neuroinflammation

(2011) Laura Codarri et al.   NATURE IMMUNOLOGY

Infiltrating monocytes trigger EAE progression, but do not contribute to the resident microglia pool

(2011) Bahareh Ajami et al.   NATURE NEUROSCIENCE

Heterogeneity of CNS myeloid cells and their roles in neurodegeneration

(2011) Marco Prinz et al.   NATURE NEUROSCIENCE

Functional Innervation of Hepatic iNKT Cells Is Immunosuppressive Following Stroke

(2011) C. H. Y. Wong et al.   SCIENCE

CD11c-expressing cells reside in the juxtavascular parenchyma and extend processes into the glia limitans of the mouse nervous system

(2010) Carolin Prodinger et al.   ACTA NEUROPATHOLOGICA

Early detrimental T-cell effects in experimental cerebral ischemia are neither related to adaptive immunity nor thrombus formation

(2010) C. Kleinschnitz et al.   BLOOD

Tissue macrophages act as cellular chaperones for vascular anastomosis downstream of VEGF-mediated endothelial tip cell induction

(2010) A. Fantin et al.   BLOOD

Human CD14dim Monocytes Patrol and Sense Nucleic Acids and Viruses via TLR7 and TLR8 Receptors

(2010) Jérôme Cros et al.   IMMUNITY

Regulation of learning and memory by meningeal immunity: a key role for IL-4

(2010) Noël C. Derecki et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Inflammatory mechanisms in ischemic stroke: role of inflammatory cells

(2010) Rong Jin et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Selective Chemokine Receptor Usage by Central Nervous System Myeloid Cells in CCR2-Red Fluorescent Protein Knock-In Mice

(2010) Noah Saederup et al.   PLoS One

Fate Mapping Analysis Reveals That Adult Microglia Derive from Primitive Macrophages

(2010) F. Ginhoux et al.   SCIENCE

A Genetic and Functional Relationship between T Cells and Cellular Proliferation in the Adult Hippocampus

(2010) Guo-Jen Huang et al.   PLOS BIOLOGY

Choroid plexus: biology and pathology

(2009) Hartwig Wolburg et al.   ACTA NEUROPATHOLOGICA

Circulating Ly-6C+ myeloid precursors migrate to the CNS and play a pathogenic role during autoimmune demyelinating disease

(2009) I. L. King et al.   BLOOD

CCR2+Ly-6Chi monocytes are crucial for the effector phase of autoimmunity in the central nervous system

(2009) Alexander Mildner et al.   BRAIN

The relation between inflammation and neurodegeneration in multiple sclerosis brains

(2009) Josa M. Frischer et al.   BRAIN

CCR6 regulates EAE pathogenesis by controlling regulatory CD4+T‐cell recruitment to target tissues

(2009) Ricardo Villares et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Adaptive peripheral immune response increases proliferation of neural precursor cells in the adult hippocampus

(2009) Susanne A. Wolf et al.   FASEB JOURNAL

Enhanced hippocampal neurogenesis in the absence of microglia T cell interaction and microglia activation in the murine running wheel model

(2009) Marta Olah et al.   GLIA

Feridex Preloading Permits Tracking of CNS-Resident Macrophages after Transient Middle Cerebral Artery Occlusion

(2009) Erica C Henning et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

B cells produce pathogenic antibodies and impair recovery after spinal cord injury in mice

(2009) Daniel P. Ankeny et al.   JOURNAL OF CLINICAL INVESTIGATION

C-C chemokine receptor 6–regulated entry of TH-17 cells into the CNS through the choroid plexus is required for the initiation of EAE

(2009) Andrea Reboldi et al.   NATURE IMMUNOLOGY

Pivotal role of cerebral interleukin-17–producing γδT cells in the delayed phase of ischemic brain injury

(2009) Takashi Shichita et al.   NATURE MEDICINE

Regulatory T cells are key cerebroprotective immunomodulators in acute experimental stroke

(2009) Arthur Liesz et al.   NATURE MEDICINE

Temporal and Spatial Dynamics of Cerebral Immune Cell Accumulation in Stroke

(2009) Mathias Gelderblom et al.   STROKE

Localizing central nervous system immune surveillance: Meningeal antigen-presenting cells activate T cells during experimental autoimmune encephalomyelitis

(2008) Pia Kivisäkk et al.   ANNALS OF NEUROLOGY

IL17 and IFNγ production by peripheral blood mononuclear cells from clinically isolated syndrome to secondary progressive multiple sclerosis

(2008) Giovanni Frisullo et al.   CYTOKINE

CD11c/EYFP transgene illuminates a discrete network of dendritic cells within the embryonic, neonatal, adult, and injured mouse brain

(2008) Karen Bulloch et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Brain antigens in functionally distinct antigen-presenting cell populations in cervical lymph nodes in MS and EAE

(2008) Marloes van Zwam et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Interleukin-1beta and tumor necrosis factor-alpha are expressed by different subsets of microglia and macrophages after ischemic stroke in mice

(2008) Bettina H Clausen et al.   Journal of Neuroinflammation

Repeated subcutaneous injections of IL12/23 p40 neutralising antibody, ustekinumab, in patients with relapsing-remitting multiple sclerosis: a phase II, double-blind, placebo-controlled, randomised, dose-ranging study

(2008) Benjamin M Segal et al.   LANCET NEUROLOGY

The NALP3 inflammasome is involved in the innate immune response to amyloid-β

(2008) Annett Halle et al.   NATURE IMMUNOLOGY

Interleukin-17 Production in Central Nervous System-Infiltrating T Cells and Glial Cells Is Associated with Active Disease in Multiple Sclerosis

(2007) John S. Tzartos et al.   AMERICAN JOURNAL OF PATHOLOGY