Diverse novel functions of neutrophils in immunity, inflammation, and beyond

Infiltrated Neutrophils Acquire Novel Chemokine Receptor Expression and Chemokine Responsiveness in Chronic Inflammatory Lung Diseases

(2014) D. Hartl et al.   JOURNAL OF IMMUNOLOGY

A Novel Role for Neutrophils As Critical Activators of NK Cells

(2014) R. Sporri et al.   JOURNAL OF IMMUNOLOGY

Neutrophils Recruited to Sites of Infection Protect from Virus Challenge by Releasing Neutrophil Extracellular Traps

(2013) Craig N. Jenne et al.   Cell Host & Microbe

Neutrophils control the magnitude and spread of the immune response in a thromboxane A2-mediated process

(2013) Chiao-Wen Yang et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Genomic responses in mouse models poorly mimic human inflammatory diseases

(2013) Junhee Seok et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

NETs Are a Source of Citrullinated Autoantigens and Stimulate Inflammatory Responses in Rheumatoid Arthritis

(2013) R. Khandpur et al.   Science Translational Medicine

Neutrophil Function: From Mechanisms to Disease

(2012) Borko Amulic et al.   Annual Review of Immunology

Antibacterial effect of microvesicles released from human neutrophilic granulocytes

(2012) C. I. Timar et al.   BLOOD

Endocytosis of soluble immune complexes leads to their clearance by Fc RIIIB but induces neutrophil extracellular traps via Fc RIIA in vivo

(2012) K. Chen et al.   BLOOD

Tissue factor-positive neutrophils bind to injured endothelial wall and initiate thrombus formation

(2012) R. Darbousset et al.   BLOOD

Properties of mouse and human IgG receptors and their contribution to disease models

(2012) P. Bruhns   BLOOD

Tumor-associated neutrophils: friend or foe?

(2012) Z. G. Fridlender et al.   CARCINOGENESIS

Neutrophils Exert Protection in the Early Tuberculous Granuloma by Oxidative Killing of Mycobacteria Phagocytosed from Infected Macrophages

(2012) Chao-Tsung Yang et al.   Cell Host & Microbe

Neutrophil Extracellular Traps Mediate a Host Defense Response to Human Immunodeficiency Virus-1

(2012) Tatsuya Saitoh et al.   Cell Host & Microbe

Intravascular Neutrophil Extracellular Traps Capture Bacteria from the Bloodstream during Sepsis

(2012) Braedon McDonald et al.   Cell Host & Microbe

Auto-Antigenic Protein-DNA Complexes Stimulate Plasmacytoid Dendritic Cells to Promote Atherosclerosis

(2012) Yvonne Döring et al.   CIRCULATION

Lack of Neutrophil-Derived CRAMP Reduces Atherosclerosis in Mice

(2012) Yvonne Döring et al.   CIRCULATION RESEARCH

A hypomorphic mutation in the Gfi1 transcriptional repressor results in a novel form of neutropenia

(2012) Diana Ordoñez-Rueda et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Neutrophils Transport Antigen from the Dermis to the Bone Marrow, Initiating a Source of Memory CD8+ T Cells

(2012) Darragh Duffy et al.   IMMUNITY

Leukotriene B4-Driven Neutrophil Recruitment to the Skin Is Essential for Allergic Skin Inflammation

(2012) Michiko K. Oyoshi et al.   IMMUNITY

The role of neutrophils in autoimmune diseases

(2012) Tamás Németh et al.   IMMUNOLOGY LETTERS

Neutrophil extracellular traps: Is immunity the second function of chromatin?

(2012) Volker Brinkmann et al.   JOURNAL OF CELL BIOLOGY

Neutrophil depletion impairs natural killer cell maturation, function, and homeostasis

(2012) Baptiste N. Jaeger et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Pericytes support neutrophil subendothelial cell crawling and breaching of venular walls in vivo

(2012) Doris Proebstl et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Monocytes, neutrophils, and platelets cooperate to initiate and propagate venous thrombosis in mice in vivo

(2012) Marie-Luise von Brühl et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Editorial: Nyet to NETs,n? A pause for healthy skepticism

(2012) William M. Nauseef   JOURNAL OF LEUKOCYTE BIOLOGY

Requirements for NADPH oxidase and myeloperoxidase in neutrophil extracellular trap formation differ depending on the stimulus

(2012) Heather Parker et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Capillary and arteriolar pericytes attract innate leukocytes exiting through venules and 'instruct' them with pattern-recognition and motility programs

(2012) Konstantin Stark et al.   NATURE IMMUNOLOGY

Neutrophils mediate insulin resistance in mice fed a high-fat diet through secreted elastase

(2012) Saswata Talukdar et al.   NATURE MEDICINE

Infection-induced NETosis is a dynamic process involving neutrophil multitasking in vivo

(2012) Bryan G Yipp et al.   NATURE MEDICINE

Crosstalk between neutrophils, B-1a cells and plasmacytoid dendritic cells initiates autoimmune diabetes

(2012) Julien Diana et al.   NATURE MEDICINE

Cancers predispose neutrophils to release extracellular DNA traps that contribute to cancer-associated thrombosis

(2012) M. Demers et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

NADPH Oxidase Inhibits the Pathogenesis of Systemic Lupus Erythematosus

(2012) A. M. Campbell et al.   Science Translational Medicine

Inflammatory Mechanisms in Obesity

(2011) Margaret F. Gregor et al.   Annual Review of Immunology

Human Fc RIIA induces anaphylactic and allergic reactions

(2011) F. Jonsson et al.   BLOOD

Killing by neutrophil extracellular traps: fact or folklore?

(2011) R. Menegazzi et al.   BLOOD

Tumor Entrained Neutrophils Inhibit Seeding in the Premetastatic Lung

(2011) Zvi Granot et al.   CANCER CELL

Tumor-Associated Neutrophils: New Targets for Cancer Therapy

(2011) A. D. Gregory et al.   CANCER RESEARCH

Peculiarities of cell death mechanisms in neutrophils

(2011) B Geering et al.   CELL DEATH AND DIFFERENTIATION

Pathophysiology of anaphylaxis

(2011) Bilal Q. Khan et al.   Current Opinion in Allergy and Clinical Immunology

Angiotensin II mediates urotensin II expression by hypoxia in cultured cardiac fibroblast

(2011) Kou-Gi Shyu et al.   EUROPEAN JOURNAL OF CLINICAL INVESTIGATION

Mouse neutrophils are professional antigen-presenting cells programmed to instruct Th1 and Th17 T-cell differentiation

(2011) D. S. Abi Abdallah et al.   INTERNATIONAL IMMUNOLOGY

Mouse and human neutrophils induce anaphylaxis

(2011) Friederike Jönsson et al.   JOURNAL OF CLINICAL INVESTIGATION

A subset of neutrophils in human systemic inflammation inhibits T cell responses through Mac-1

(2011) Janesh Pillay et al.   JOURNAL OF CLINICAL INVESTIGATION

Critical role of the neutrophil-associated high-affinity receptor for IgE in the pathogenesis of experimental cerebral malaria

(2011) Adeline Porcherie et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Regulation of neutrophils by interferon-γ limits lung inflammation during tuberculosis infection

(2011) Bisweswar Nandi et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Myeloperoxidase associated with neutrophil extracellular traps is active and mediates bacterial killing in the presence of hydrogen peroxide

(2011) Heather Parker et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Phagosome dynamics during phagocytosis by neutrophils

(2011) Pontus Nordenfelt et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Neutrophil extracellular traps promote deep vein thrombosis in mice

(2011) A. BRILL et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Failure to detect production of IL-10 by activated human neutrophils

(2011) Martin S Davey et al.   NATURE IMMUNOLOGY

The junctional adhesion molecule JAM-C regulates polarized transendothelial migration of neutrophils in vivo

(2011) Abigail Woodfin et al.   NATURE IMMUNOLOGY

B cell–helper neutrophils stimulate the diversification and production of immunoglobulin in the marginal zone of the spleen

(2011) Irene Puga et al.   NATURE IMMUNOLOGY

Neutrophils in the pathogenesis and manifestations of SLE

(2011) Mariana J. Kaplan   Nature Reviews Rheumatology

Neutrophil-Derived Cathelicidin Protects from Neointimal Hyperplasia

(2011) O. Soehnlein et al.   Science Translational Medicine

Neutrophils Activate Plasmacytoid Dendritic Cells by Releasing Self-DNA-Peptide Complexes in Systemic Lupus Erythematosus

(2011) R. Lande et al.   Science Translational Medicine

Netting Neutrophils Are Major Inducers of Type I IFN Production in Pediatric Systemic Lupus Erythematosus

(2011) G. S. Garcia-Romo et al.   Science Translational Medicine

Role of Neutrophil Apoptosis in the Resolution of Inflammation

(2011) Driss El Kebir et al.   TheScientificWorldJOURNAL

Regulating neutrophil apoptosis: new players enter the game

(2011) Véronique Witko-Sarsat et al.   TRENDS IN IMMUNOLOGY

Neutrophil clearance: when the party is over, clean-up begins

(2011) Donna L. Bratton et al.   TRENDS IN IMMUNOLOGY

Neutrophils in tuberculosis: friend or foe?

(2011) David M. Lowe et al.   TRENDS IN IMMUNOLOGY

Distinct Infiltration of Neutrophils in Lesion Shoulders in ApoE−/− Mice

(2010) Pierre Rotzius et al.   AMERICAN JOURNAL OF PATHOLOGY

Macrophages, Inflammation, and Insulin Resistance

(2010) Jerrold M. Olefsky et al.   Annual Review of Physiology

High Neutrophil Numbers in Human Carotid Atherosclerotic Plaques Are Associated With Characteristics of Rupture-Prone Lesions

(2010) Mihaela G. Ionita et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Human neutrophils interact with both 6-sulfo LacNAc+ DC and NK cells to amplify NK-derived IFN : role of CD18, ICAM-1, and ICAM-3

(2010) C. Costantini et al.   BLOOD

CCR7 is involved in the migration of neutrophils to lymph nodes

(2010) C. Beauvillain et al.   BLOOD

In vivo labeling with 2H2O reveals a human neutrophil lifespan of 5.4 days

(2010) J. Pillay et al.   BLOOD

Hyperlipidemia-Triggered Neutrophilia Promotes Early Atherosclerosis

(2010) Maik Drechsler et al.   CIRCULATION

Neutrophils, from Marrow to Microbes

(2010) Niels Borregaard   IMMUNITY

Basophils Orchestrate Chronic Allergic Dermatitis and Protective Immunity against Helminths

(2010) Caspar Ohnmacht et al.   IMMUNITY

Neutrophils responsive to endogenous IFN-β regulate tumor angiogenesis and growth in a mouse tumor model

(2010) Jadwiga Jablonska et al.   JOURNAL OF CLINICAL INVESTIGATION

Pathological role of interleukin 17 in mice subjected to repeated BCG vaccination after infection withMycobacterium tuberculosis

(2010) Andrea Cruz et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The defensive alliance between neutrophils and NK cells as a novel arm of innate immunity

(2010) Claudio Costantini et al.   JOURNAL OF LEUKOCYTE BIOLOGY

The interferon-α signature of systemic lupus erythematosus

(2010) G. Obermoser et al.   LUPUS

An interferon-inducible neutrophil-driven blood transcriptional signature in human tuberculosis

(2010) Matthew P. R. Berry et al.   NATURE

Invariant NKT cells modulate the suppressive activity of IL-10-secreting neutrophils differentiated with serum amyloid A

(2010) Carmela De Santo et al.   NATURE IMMUNOLOGY

Reciprocal coupling of coagulation and innate immunity via neutrophil serine proteases

(2010) Steffen Massberg et al.   NATURE MEDICINE

Neutrophil elastase–mediated degradation of IRS-1 accelerates lung tumor growth

(2010) A McGarry Houghton et al.   NATURE MEDICINE

Histamine deficiency promotes inflammation-associated carcinogenesis through reduced myeloid maturation and accumulation of CD11b+Ly6G+ immature myeloid cells

(2010) Xiang Dong Yang et al.   NATURE MEDICINE

Breaching multiple barriers: leukocyte motility through venular walls and the interstitium

(2010) Sussan Nourshargh et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Impairment of neutrophil extracellular trap degradation is associated with lupus nephritis

(2010) A. Hakkim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Extracellular DNA traps promote thrombosis

(2010) T. A. Fuchs et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Intravascular Danger Signals Guide Neutrophils to Sites of Sterile Inflammation

(2010) B. McDonald et al.   SCIENCE

Neutrophil-Derived CCL3 Is Essential for the Rapid Recruitment of Dendritic Cells to the Site of Leishmania major Inoculation in Resistant Mice

(2010) Mélanie Charmoy et al.   PLoS Pathogens

Increased Hepatic Myeloperoxidase Activity in Obese Subjects with Nonalcoholic Steatohepatitis

(2009) Sander S. Rensen et al.   AMERICAN JOURNAL OF PATHOLOGY

Polarization of Tumor-Associated Neutrophil Phenotype by TGF-β: “N1” versus “N2” TAN

(2009) Zvi G. Fridlender et al.   CANCER CELL

Activation of dendritic cells by polymorphonuclear neutrophils

(2009) Sarah Boudaly   Frontiers in Bioscience-Landmark

Coactivation of Syk Kinase and MyD88 Adaptor Protein Pathways by Bacteria Promotes Regulatory Properties of Neutrophils

(2009) Xiaoming Zhang et al.   IMMUNITY

Direct and alternative antimicrobial mechanisms of neutrophil-derived granule proteins

(2009) Oliver Soehnlein   JOURNAL OF MOLECULAR MEDICINE-JMM

Netting neutrophils in autoimmune small-vessel vasculitis

(2009) Kai Kessenbrock et al.   NATURE MEDICINE

Alarmins link neutrophils and dendritic cells

(2009) De Yang et al.   TRENDS IN IMMUNOLOGY

BK channels in innate immune functions of neutrophils and macrophages

(2008) K. Essin et al.   BLOOD

Basophils Play a Pivotal Role in Immunoglobulin-G-Mediated but Not Immunoglobulin-E-Mediated Systemic Anaphylaxis

(2008) Yusuke Tsujimura et al.   IMMUNITY

Neutrophils transiently infiltrate intra-abdominal fat early in the course of high-fat feeding

(2008) Vered Elgazar-Carmon et al.   JOURNAL OF LIPID RESEARCH

IMMUNOLOGY: Neutrophil Soldiers or Trojan Horses?

(2008) B. John et al.   SCIENCE

In Vivo Imaging Reveals an Essential Role for Neutrophils in Leishmaniasis Transmitted by Sand Flies

(2008) N. C. Peters et al.   SCIENCE

Regulation of B-cell-activating factor (BAFF)/B lymphocyte stimulator (BLyS) expression in human neutrophils

(2007) Patrizia Scapini et al.   IMMUNOLOGY LETTERS