T Cells—Protective or Pathogenic in Alzheimer’s Disease?

Peripheral Chemokine Receptors, Their Ligands, Cytokines and Alzheimer's Disease

(2017) Marcella Reale et al.   JOURNAL OF ALZHEIMERS DISEASE

Anti-Amyloid-β Immunotherapy in Alzheimer's Disease: Relevance of Transgenic Mouse Studies to Clinical Trials

(2017) Donna M. Wilcock et al.   JOURNAL OF ALZHEIMERS DISEASE

Dramatic Shifts in Circulating CD4 but not CD8 T Cell Subsets in Mild Alzheimer's Disease

(2017) Anis Larbi et al.   JOURNAL OF ALZHEIMERS DISEASE

PD1 Negative and PD1 Positive CD4+ T Regulatory Cells in Mild Cognitive Impairment and Alzheimer's Disease

(2017) Marina Saresella et al.   JOURNAL OF ALZHEIMERS DISEASE

Systemic Immune Responses in Alzheimer's Disease: In Vitro Mononuclear Cell Activation and Cytokine Production

(2017) Mariavaleria Pellicanò et al.   JOURNAL OF ALZHEIMERS DISEASE

Co-stimulation with TNF receptor superfamily 4/25 antibodies enhances in-vivo expansion of CD4+CD25+Foxp3+ T cells (Tregs) in a mouse study for active DNA Aβ42 immunotherapy

(2015) Doris Lambracht-Washington et al.   JOURNAL OF NEUROIMMUNOLOGY

Clinical relevance of specific T-cell activation in the blood and cerebrospinal fluid of patients with mild Alzheimer's disease

(2015) Gero Lueg et al.   NEUROBIOLOGY OF AGING

Co-immunization with DNA and protein mixture: A safe and efficacious immunotherapeutic strategy for Alzheimer's disease in PDAPP mice

(2015) Si Liu et al.   Scientific Reports

Effector molecules released by Th1 but not Th17 cells drive an M1 response in microglia

(2014) Chittappen K. Prajeeth et al.   BRAIN BEHAVIOR AND IMMUNITY

IL-4-Induced Selective Clearance of Oligomeric  -Amyloid Peptide1-42 by Rat Primary Type 2 Microglia

(2014) E. Shimizu et al.   JOURNAL OF IMMUNOLOGY

Body Fluid Cytokine Levels in Mild Cognitive Impairment and Alzheimer’s Disease: a Comparative Overview

(2014) Frederic Brosseron et al.   MOLECULAR NEUROBIOLOGY

Age-associated dysregulation of microglial activation is coupled with enhanced blood-brain barrier permeability and pathology in APP/PS1 mice

(2014) Aedín M. Minogue et al.   NEUROBIOLOGY OF AGING

Classical activation of microglia in CD200-deficient mice is a consequence of blood brain barrier permeability and infiltration of peripheral cells

(2013) Stephanie Denieffe et al.   BRAIN BEHAVIOR AND IMMUNITY

The resolution of neuroinflammation in neurodegeneration: leukocyte recruitment via the choroid plexus

(2013) Michal Schwartz et al.   EMBO JOURNAL

Elevated CNS Inflammation in Patients with Preclinical Alzheimer's Disease

(2013) Nancy L Monson et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

IFN-  Production by Amyloid  -Specific Th1 Cells Promotes Microglial Activation and Increases Plaque Burden in a Mouse Model of Alzheimer's Disease

(2013) T. C. Browne et al.   JOURNAL OF IMMUNOLOGY

Th1 Polarization of T Cells Injected into the Cerebrospinal Fluid Induces Brain Immunosurveillance

(2013) Y. Fisher et al.   JOURNAL OF IMMUNOLOGY

Role of Scavenger Receptors in Glia-Mediated Neuroinflammatory Response Associated with Alzheimer’s Disease

(2013) Francisca Cornejo et al.   MEDIATORS OF INFLAMMATION

Respiratory infection promotes T cell infiltration and amyloid-β deposition in APP/PS1 mice

(2013) Róisín M. McManus et al.   NEUROBIOLOGY OF AGING

Enhanced Chemokine Receptor Expression on Leukocytes of Patients with Alzheimer's Disease

(2013) David Goldeck et al.   PLoS One

Neuroinflammation and Brain Functional Disconnection in Alzheimer’s Disease

(2013) Francesca Baglio et al.   Frontiers in Aging Neuroscience

The adaptive immune system in diseases of the central nervous system

(2012) David C. Wraith et al.   JOURNAL OF CLINICAL INVESTIGATION

Amyloid-β-Induced Astrocytic Phagocytosis is Mediated by CD36, CD47 and RAGE

(2012) Raasay S. Jones et al.   Journal of Neuroimmune Pharmacology

A 1-42-RAGE Interaction Disrupts Tight Junctions of the Blood-Brain Barrier Via Ca2+-Calcineurin Signaling

(2012) S.-Y. Kook et al.   JOURNAL OF NEUROSCIENCE

Inhibition of IL-12/IL-23 signaling reduces Alzheimer's disease–like pathology and cognitive decline

(2012) Johannes vom Berg et al.   NATURE MEDICINE

Clinical and Biomarker Changes in Dominantly Inherited Alzheimer's Disease

(2012) Randall J. Bateman et al.   NEW ENGLAND JOURNAL OF MEDICINE

Capture, crawl, cross: the T cell code to breach the blood–brain barriers

(2012) Britta Engelhardt et al.   TRENDS IN IMMUNOLOGY

DNA immunization with HBsAg-based particles expressing a B cell epitope of amyloid β-peptide attenuates disease progression and prolongs survival in a mouse model of Alzheimer's disease

(2012) Purevdorj B. Olkhanud et al.   VACCINE

Vascular β-amyloid and early astrocyte alterations impair cerebrovascular function and cerebral metabolism in transgenic arcAβ mice

(2011) Mario Merlini et al.   ACTA NEUROPATHOLOGICA

Amyloid Beta Induces Oxidative Stress-Mediated Blood–Brain Barrier Changes in Capillary Amyloid Angiopathy

(2011) Anna Carrano et al.   ANTIOXIDANTS & REDOX SIGNALING

DNA Immunization Against Amyloid beta 42 has High Potential as Safe Therapy for Alzheimer’s Disease as it Diminishes Antigen-Specific Th1 and Th17 Cell Proliferation

(2011) Doris Lambracht-Washington et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Immune profiling of Alzheimer patients

(2011) Mariavaleria Pellicanò et al.   JOURNAL OF NEUROIMMUNOLOGY

Microglial phagocytosis induced by fibrillar β-amyloid is attenuated by oligomeric β-amyloid: implications for Alzheimer's disease

(2011) Xiao-dong Pan et al.   Molecular Neurodegeneration

A potential role for the PD1/PD-L1 pathway in the neuroinflammation of Alzheimer's disease

(2011) Marina Saresella et al.   NEUROBIOLOGY OF AGING

Alterations in the blood brain barrier in ageing cerebral cortex in relationship to Alzheimer-type pathology: A study in the MRC-CFAS population neuropathology cohort

(2011) Andrew P. Viggars et al.   NEUROSCIENCE LETTERS

Amyloid Triggers Extensive Cerebral Angiogenesis Causing Blood Brain Barrier Permeability and Hypervascularity in Alzheimer's Disease

(2011) Kaan E. Biron et al.   PLoS One

The role of antigen presenting cells in multiple sclerosis

(2010) Emily M.L. Chastain et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Activation of mixed glia by Aβ-specific Th1 and Th17 cells and its regulation by Th2 cells

(2010) K. McQuillan et al.   BRAIN BEHAVIOR AND IMMUNITY

Infiltration of Th1 and Th17 cells and activation of microglia in the CNS during the course of experimental autoimmune encephalomyelitis

(2010) Áine C. Murphy et al.   BRAIN BEHAVIOR AND IMMUNITY

Increased activity of Th-17 and Th-9 lymphocytes and a skewing of the post-thymic differentiation pathway are seen in Alzheimer’s disease

(2010) Marina Saresella et al.   BRAIN BEHAVIOR AND IMMUNITY

T cells in multiple sclerosis and experimental autoimmune encephalomyelitis

(2010) J. M. Fletcher et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

IL-17 Enhancement of the IL-6 Signaling Cascade in Astrocytes

(2010) X. Ma et al.   JOURNAL OF IMMUNOLOGY

Microglial Cx3cr1 knockout prevents neuron loss in a mouse model of Alzheimer's disease

(2010) Martin Fuhrmann et al.   NATURE NEUROSCIENCE

Long-Term Follow-Up of Patients Immunized with AN1792: Reduced Functional Decline in Antibody Responders

(2009) Bruno Vellas et al.   Current Alzheimer Research

Amyloid   Interaction with Receptor for Advanced Glycation End Products Up-Regulates Brain Endothelial CCR5 Expression and Promotes T Cells Crossing the Blood-Brain Barrier

(2009) M. Li et al.   JOURNAL OF IMMUNOLOGY

Functional interleukin-17 receptor A is expressed in central nervous system glia and upregulated in experimental autoimmune encephalomyelitis

(2009) Jayasri Sarma et al.   Journal of Neuroinflammation

ZO-1 Stabilizes the Tight Junction Solute Barrier through Coupling to the Perijunctional Cytoskeleton

(2009) Christina M. Van Itallie et al.   MOLECULAR BIOLOGY OF THE CELL

C-C chemokine receptor 6–regulated entry of TH-17 cells into the CNS through the choroid plexus is required for the initiation of EAE

(2009) Andrea Reboldi et al.   NATURE IMMUNOLOGY

Aβ-specific Th2 cells provide cognitive and pathological benefits to Alzheimer's mice without infiltrating the CNS

(2009) Chuanhai Cao et al.   NEUROBIOLOGY OF DISEASE

Vascular amyloid alters astrocytic water and potassium channels in mouse models and humans with Alzheimer's disease

(2009) D.M. Wilcock et al.   NEUROSCIENCE

The blood-brain barrier in brain homeostasis and neurological diseases

(2008) Nicolas Weiss et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

SYMPOSIUM: Clearance of Aβ from the Brain in Alzheimer' Disease: The Role of the Immune System in Clearance of Aβ from the Brain

(2008) Delphine Boche et al.   BRAIN PATHOLOGY

Astrocytes in multiple sclerosis: A product of their environment

(2008) A. Nair et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

A leaky blood-brain barrier, fibrinogen infiltration and microglial reactivity in inflamed Alzheimer’s disease brain

(2008) Jae K. Ryu et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

RNAi-mediated reversible opening of the blood-brain barrier

(2008) Matthew Campbell et al.   JOURNAL OF GENE MEDICINE

Production and functions of IL-17 in microglia

(2008) Jun Kawanokuchi et al.   JOURNAL OF NEUROIMMUNOLOGY

Perivascular Spaces and the Two Steps to Neuroinflammation

(2008) Trevor Owens et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Inflammatory Response in the Hippocampus of PS1M146L/APP751SL Mouse Model of Alzheimer's Disease: Age-Dependent Switch in the Microglial Phenotype from Alternative to Classic

(2008) S. Jimenez et al.   JOURNAL OF NEUROSCIENCE

Long-term effects of Aβ42 immunisation in Alzheimer's disease: follow-up of a randomised, placebo-controlled phase I trial

(2008) Clive Holmes et al.   LANCET

RANTES upregulation in the Alzheimer's disease brain: A possible neuroprotective role

(2008) Debjani Tripathy et al.   NEUROBIOLOGY OF AGING

Peripheral T cells derived from Alzheimer's disease patients overexpress CXCR2 contributing to its transendothelial migration, which is microglial TNF-α-dependent

(2008) Yi-Jun Liu et al.   NEUROBIOLOGY OF AGING

Solutes, but not cells, drain from the brain parenchyma along basement membranes of capillaries and arteries: significance for cerebral amyloid angiopathy and neuroimmunology

(2008) R. O. Carare et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Blood–brain barrier: Ageing and microvascular disease – systematic review and meta-analysis

(2007) Andrew J. Farrall et al.   NEUROBIOLOGY OF AGING