Complement C3 deficiency protects against neurodegeneration in aged plaque-rich APP/PS1 mice

Pharmacological targeting of CSF1R inhibits microglial proliferation and prevents the progression of Alzheimer’s-like pathology

(2016) Adrian Olmos-Alonso et al.   BRAIN

Eliminating microglia in Alzheimer’s mice prevents neuronal loss without modulating amyloid-β pathology

(2016) Elizabeth E. Spangenberg et al.   BRAIN

Astrocyte-Microglia Cross Talk through Complement Activation Modulates Amyloid Pathology in Mouse Models of Alzheimer's Disease

(2016) H. Lian et al.   JOURNAL OF NEUROSCIENCE

C1q propagates microglial activation and neurodegeneration in the visual axis following retinal ischemia/reperfusion injury

(2016) Sean M. Silverman et al.   Molecular Neurodegeneration

Inhibition of the classical pathway of the complement cascade prevents early dendritic and synaptic degeneration in glaucoma

(2016) Pete A. Williams et al.   Molecular Neurodegeneration

Novel allele-dependent role for APOE in controlling the rate of synapse pruning by astrocytes

(2016) Won-Suk Chung et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Complement and microglia mediate early synapse loss in Alzheimer mouse models

(2016) S. Hong et al.   SCIENCE

Complement C3-Deficient Mice Fail to Display Age-Related Hippocampal Decline

(2015) Q. Shi et al.   JOURNAL OF NEUROSCIENCE

NFκB-Activated Astroglial Release of Complement C3 Compromises Neuronal Morphology and Function Associated with Alzheimer’s Disease

(2015) Hong Lian et al.   NEURON

A Commentary On: “NFκB-Activated Astroglial Release of Complement C3 Compromises Neuronal Morphology and Function Associated with Alzheimer’s Disease”. A cautionary note regarding C3aR

(2015) Trent M. Woodruff et al.   Frontiers in Immunology

Altered cognitive performance and synaptic function in the hippocampus of mice lacking C3

(2014) Marta Perez-Alcazar et al.   EXPERIMENTAL NEUROLOGY

Deficiency of complement receptors CR2/CR1 in Cr2-/- mice reduces the extent of secondary brain damage after closed head injury

(2014) Miriam D Neher et al.   Journal of Neuroinflammation

Neurodegeneration by Activation of the Microglial Complement-Phagosome Pathway

(2014) L.-G. Bodea et al.   JOURNAL OF NEUROSCIENCE

Microglial priming in neurodegenerative disease

(2014) V. Hugh Perry et al.   Nature Reviews Neurology

Microglia Promote Learning-Dependent Synapse Formation through Brain-Derived Neurotrophic Factor

(2013) Christopher N. Parkhurst et al.   CELL

Amyloid-β plaque reduction, endogenous antibody delivery and glial activation by brain-targeted, transcranial focused ultrasound

(2013) Jessica F. Jordão et al.   EXPERIMENTAL NEUROLOGY

A quantitative spatiotemporal analysis of microglia morphology during ischemic stroke and reperfusion

(2013) Helena W Morrison et al.   Journal of Neuroinflammation

Synaptic Changes in the Dentate Gyrus of APP/PS1 Transgenic Mice Revealed by Electron Microscopy

(2013) Lidia Alonso-Nanclares et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

A Dramatic Increase of C1q Protein in the CNS during Normal Aging

(2013) A. H. Stephan et al.   JOURNAL OF NEUROSCIENCE

TGF-β signaling regulates neuronal C1q expression and developmental synaptic refinement

(2013) Allison R Bialas et al.   NATURE NEUROSCIENCE

Reduced removal of synaptic terminals from axotomized spinal motoneurons in the absence of complement C3

(2012) Alexander Berg et al.   EXPERIMENTAL NEUROLOGY

Complement component C3 and complement receptor type 3 contribute to the phagocytosis and clearance of fibrillar Aβ by microglia

(2012) Hongjun Fu et al.   GLIA

Microglia Sculpt Postnatal Neural Circuits in an Activity and Complement-Dependent Manner

(2012) Dorothy P. Schafer et al.   NEURON

Complement Inhibition Promotes Endogenous Neurogenesis and Sustained Anti-Inflammatory Neuroprotection following Reperfused Stroke

(2012) Andrew F. Ducruet et al.   PLoS One

C3-dependent mechanism of microglial priming relevant to multiple sclerosis

(2012) V. Ramaglia et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hippocampus-dependent place learning enables spatial flexibility in C57BL6/N mice

(2012) Karl R. Kleinknecht et al.   Frontiers in Behavioral Neuroscience

Histological and Direct Evidence for the Role of Complement in the Neuroinflammation of AD

(2011) Robert Veerhuis   Current Alzheimer Research

Complement in the brain

(2011) Robert Veerhuis et al.   MOLECULAR IMMUNOLOGY

Soluble amyloid  -protein dimers isolated from Alzheimer cortex directly induce Tau hyperphosphorylation and neuritic degeneration

(2011) M. Jin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Complement receptor 3 (CD11b/CD18) is implicated in the elimination of β-amyloid peptides

(2010) Nada Choucair-Jaafar et al.   FUNDAMENTAL & CLINICAL PHARMACOLOGY

Quantifying Synapses: an Immunocytochemistry-based Assay to Quantify Synapse Number

(2010) Dominic M. Ippolito et al.   Jove-Journal of Visualized Experiments

Age-related cognitive decline and nesting behavior in an APPswe/PS1 bigenic model of Alzheimer's disease

(2009) Mohammed Filali et al.   BRAIN RESEARCH

Over expression of amyloid beta-protein reduces the number of neurons in the striatum of APPswe/PS1ΔE9

(2009) Mette Richner et al.   BRAIN RESEARCH

Treatment with a C5aR Antagonist Decreases Pathology and Enhances Behavioral Performance in Murine Models of Alzheimer's Disease

(2009) M. I. Fonseca et al.   JOURNAL OF IMMUNOLOGY

Expression of complement system components during aging and amyloid deposition in APP transgenic mice

(2009) Julia Reichwald et al.   Journal of Neuroinflammation

Oligomeric amyloid   associates with postsynaptic densities and correlates with excitatory synapse loss near senile plaques

(2009) R. M. Koffie et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Widespread Changes in Dendritic Spines in a Model of Alzheimer's Disease

(2008) S. Knafo et al.   CEREBRAL CORTEX

Complement C3 and C4 expression in C1q sufficient and deficient mouse models of Alzheimer’s disease

(2008) Jun Zhou et al.   JOURNAL OF NEUROCHEMISTRY

Complement C3 Deficiency Leads to Accelerated Amyloid   Plaque Deposition and Neurodegeneration and Modulation of the Microglia/Macrophage Phenotype in Amyloid Precursor Protein Transgenic Mice

(2008) M. Maier et al.   JOURNAL OF NEUROSCIENCE

Molecular signatures of neurodegeneration in the cortex of PS1/PS2 double knockout mice

(2008) Károly Mirnics et al.   Molecular Neurodegeneration

Amyloid precursor protein increases cortical neuron size in transgenic mice

(2008) Esther S. Oh et al.   NEUROBIOLOGY OF AGING

Synaptic contact number and size in stratum radiatum CA1 of APP/PS1ΔE9 transgenic mice

(2008) Mark J. West et al.   NEUROBIOLOGY OF AGING

Age-related alterations of Nestin-immunoreactive neurons in rat basal forebrain with aged memory deficit

(2008) Dongpei Li et al.   NEUROCHEMISTRY INTERNATIONAL