Physiological amyloid-beta clearance in the periphery and its therapeutic potential for Alzheimer’s disease

Neuroinflammation in Alzheimer's disease

(2015) Michael T Heneka et al.   LANCET NEUROLOGY

Structural and functional features of central nervous system lymphatic vessels

(2015) Antoine Louveau et al.   NATURE

Clearance systems in the brain—implications for Alzheimer disease

(2015) Jenna M. Tarasoff-Conway et al.   Nature Reviews Neurology

Amyloid-β efflux from the central nervous system into the plasma

(2014) Kaleigh Filisa Roberts et al.   ANNALS OF NEUROLOGY

Clearance of Amyloid-Beta in Alzheimer’s Disease: Shifting the Action Site from Center to Periphery

(2014) Yu-Hui Liu et al.   MOLECULAR NEUROBIOLOGY

Association Between Serum Amyloid-Beta and Renal Functions: Implications for Roles of Kidney in Amyloid-Beta Clearance

(2014) Yu-Hui Liu et al.   MOLECULAR NEUROBIOLOGY

Young blood reverses age-related impairments in cognitive function and synaptic plasticity in mice

(2014) Saul A Villeda et al.   NATURE MEDICINE

Lessons from immunotherapy for Alzheimer disease

(2014) Yan-Jiang Wang   Nature Reviews Neurology

Phase 3 Trials of Solanezumab for Mild-to-Moderate Alzheimer's Disease

(2014) Rachelle S. Doody et al.   NEW ENGLAND JOURNAL OF MEDICINE

Specific antibody binding to the APP672–699 region shifts APP processing from α- to β-cleavage

(2014) S Li et al.   Cell Death & Disease

The Bradykinin B1 Receptor Regulates Aβ Deposition and Neuroinflammation in Tg-SwDI Mice

(2013) Giselle F. Passos et al.   AMERICAN JOURNAL OF PATHOLOGY

Sustained peripheral depletion of amyloid-β with a novel form of neprilysin does not affect central levels of amyloid-β

(2013) Simon J. Henderson et al.   BRAIN

Enhanced Proteolytic Clearance of Plasma A  by Peripherally Administered Neprilysin Does Not Result in Reduced Levels of Brain A  in Mice

(2013) J. R. Walker et al.   JOURNAL OF NEUROSCIENCE

CD33 Alzheimer's disease locus: altered monocyte function and amyloid biology

(2013) Elizabeth M Bradshaw et al.   NATURE NEUROSCIENCE

Withania somnifera reverses Alzheimer's disease pathology by enhancing low-density lipoprotein receptor-related protein in liver

(2012) N. Sehgal et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Paravascular Pathway Facilitates CSF Flow Through the Brain Parenchyma and the Clearance of Interstitial Solutes, Including Amyloid  

(2012) J. J. Iliff et al.   Science Translational Medicine

Roles of p75NTR in the pathogenesis of Alzheimer's disease: A novel therapeutic target

(2011) Fan Zeng et al.   BIOCHEMICAL PHARMACOLOGY

Autoreactive-Aβ antibodies promote APP β-secretase processing

(2011) Juan Deng et al.   JOURNAL OF NEUROCHEMISTRY

Osteoarthritis accelerates and exacerbates Alzheimer's disease pathology in mice

(2011) Stephanos Kyrkanides et al.   Journal of Neuroinflammation

The ageing systemic milieu negatively regulates neurogenesis and cognitive function

(2011) Saul A. Villeda et al.   NATURE

Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease

(2011) Adam C Naj et al.   NATURE GENETICS

Circulating neprilysin clears brain amyloid

(2010) Yinxing Liu et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

A  Immunotherapy: Intracerebral Sequestration of A  by an Anti-A  Monoclonal Antibody 266 with High Affinity to Soluble A 

(2009) K. Yamada et al.   JOURNAL OF NEUROSCIENCE

Expression of Neprilysin in Skeletal Muscle Reduces Amyloid Burden in a Transgenic Mouse Model of Alzheimer Disease

(2009) Yinxing Liu et al.   MOLECULAR THERAPY

Systemic inflammation and disease progression in Alzheimer disease

(2009) C. Holmes et al.   NEUROLOGY

Peripherally expressed neprilysin reduces brain amyloid burden: A novel approach for treating Alzheimer's disease

(2008) Hanjun Guan et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Intramuscular delivery of a single chain antibody gene reduces brain Aβ burden in a mouse model of Alzheimer's disease

(2007) Yan-Jiang Wang et al.   NEUROBIOLOGY OF AGING