Advanced human-relevant in vitro pulmonary platforms for respiratory therapeutics

Long-term follow-up of recovered patients with COVID-19

(2021) Monica Cortinovis et al.   LANCET

Disulfide disruption reverses mucus dysfunction in allergic airway disease

(2021) Leslie E. Morgan et al.   Nature Communications

Focused targeting of inhaled magnetic aerosols in reconstructed in vitro airway models

(2021) Yan Ostrovski et al.   JOURNAL OF BIOMECHANICS

Novel three-dimensional biochip pulmonary sarcoidosis model

(2021) Tess M. Calcagno et al.   PLoS One

Biofilm formation in the lung contributes to virulence and drug tolerance of Mycobacterium tuberculosis

(2021) Poushali Chakraborty et al.   Nature Communications

Robotics, microfluidics, nanotechnology and AI in the synthesis and evaluation of liposomes and polymeric drug delivery systems

(2021) Egor Egorov et al.   Drug Delivery and Translational Research

A Bioinspired in vitro Lung Model to Study Particokinetics of Nano-/Microparticles Under Cyclic Stretch and Air-Liquid Interface Conditions

(2021) Ali Doryab et al.   Frontiers in Bioengineering and Biotechnology

Second-generation lung-on-a-chip with an array of stretchable alveoli made with a biological membrane

(2021) Pauline Zamprogno et al.   Communications Biology

Lung-on-a-chip: the future of respiratory disease models and pharmacological studies

(2020) Jesus Shrestha et al.   CRITICAL REVIEWS IN BIOTECHNOLOGY

Advancing human in vitro pulmonary disease models in preclinical research: opportunities for lung-on-chips

(2020) Arbel Artzy-Schnirman et al.   Expert Opinion on Drug Delivery

In Silico Optimization of Fiber-Shaped Aerosols in Inhalation Therapy for Augmented Targeting and Deposition across the Respiratory Tract

(2020) Lihi Shachar-Berman et al.   Pharmaceutics

In situ-Like Aerosol Inhalation Exposure for Cytotoxicity Assessment Using Airway-on-Chips Platforms

(2020) Shani Elias-Kirma et al.   Frontiers in Bioengineering and Biotechnology

Therapeutic RNA Strategies for Chronic Obstructive Pulmonary Disease

(2020) Dan Mei et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Systemic modified messenger RNA for replacement therapy in alpha 1-antitrypsin deficiency

(2020) Ahmad Karadagi et al.   Scientific Reports

In vitro, ex vivo and in vivo methods of lung absorption for inhaled drugs

(2020) Masahiro Sakagami   ADVANCED DRUG DELIVERY REVIEWS

A Micro-Engineered Airway Lung-Chip Models Key Features of Viral-Induced Exacerbation of Asthma

(2020) Janna C Nawroth et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Inhaled Liposomal Antimicrobial Delivery in Lung Infections

(2020) Matteo Bassetti et al.   DRUGS

Nanotechnology-based disinfectants and sensors for SARS-CoV-2

(2020) Sepehr Talebian et al.   Nature Nanotechnology

An mRNA Vaccine against SARS-CoV-2 — Preliminary Report

(2020) Lisa A. Jackson et al.   NEW ENGLAND JOURNAL OF MEDICINE

COVID-19-associated acute respiratory distress syndrome: is a different approach to management warranted?

(2020) Eddy Fan et al.   Lancet Respiratory Medicine

Mortality in COVID-19 patients with acute respiratory distress syndrome and corticosteroids use: a systematic review and meta-analysis

(2020) Syed Shahzad Hasan et al.   Expert Review of Respiratory Medicine

Nanoparticle-based thymulin gene therapy therapeutically reverses key pathology of experimental allergic asthma

(2020) Adriana L. da Silva et al.   Science Advances

3D alveolar in vitro model based on epithelialized biomimetically curved culture membranes

(2020) D. Baptista et al.   BIOMATERIALS

Development of a dynamic in vitro stretch model of the alveolar interface with aerosol delivery

(2020) Daniele Cei et al.   BIOTECHNOLOGY AND BIOENGINEERING

The lasting misery of coronavirus long-haulers

(2020) Michael Marshall   NATURE

Organs-on-chips: into the next decade

(2020) Lucie A. Low et al.   NATURE REVIEWS DRUG DISCOVERY

Inhaled RNA Therapy: From Promise to Reality

(2020) Michael Y.T. Chow et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Pathophysiology of COVID-19-associated acute respiratory distress syndrome: a multicentre prospective observational study

(2020) Giacomo Grasselli et al.   Lancet Respiratory Medicine

3D curvature-instructed endothelial flow response and tissue vascularization

(2020) Christian Mandrycky et al.   Science Advances

A Biomimetic, Copolymeric Membrane for Cell‐Stretch Experiments with Pulmonary Epithelial Cells at the Air‐Liquid Interface

(2020) Ali Doryab et al.   ADVANCED FUNCTIONAL MATERIALS

Decoding (patho-)physiology of the lung by advanced in vitro models for developing novel anti-infectives therapies

(2020) Carlos Victor Montefusco-Pereira et al.   DRUG DISCOVERY TODAY

The Advisory Committee on Immunization Practices’ Interim Recommendation for Use of Pfizer-BioNTech COVID-19 Vaccine — United States, December 2020

(2020) Sara E. Oliver et al.   MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT

Mechanical Stimulation: A Crucial Element of Organ-on-Chip Models

(2020) Clare L. Thompson et al.   Frontiers in Bioengineering and Biotechnology

Organ-on-a-Chip: A New Paradigm for Drug Development

(2020) Chao Ma et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Generation of lung organoids from human pluripotent stem cells in vitro

(2019) Alyssa J. Miller et al.   Nature Protocols

Recent Developments in mRNA-Based Protein Supplementation Therapy to Target Lung Diseases

(2019) Itishri Sahu et al.   MOLECULAR THERAPY

Amikacin Liposome Inhalation Suspension: A Review in Mycobacterium avium Complex Lung Disease

(2019) Matt Shirley   DRUGS

Organ-on-a-chip technology: turningt its potential for clinical benefit into reality

(2019) Malcolm Haddrick et al.   DRUG DISCOVERY TODAY

Gene and Base Editing as a Therapeutic Option for Cystic Fibrosis—Learning from Other Diseases

(2019) Karen Mention et al.   Genes

Antibiotics versus biofilm: an emerging battleground in microbial communities

(2019) Divakar Sharma et al.   Antimicrobial Resistance and Infection Control

Triple co-culture of human alveolar epithelium, endothelium and macrophages for studying the interaction of nanocarriers with the air-blood barrier

(2019) Ana Costa et al.   Acta Biomaterialia

Evolution of Bioengineered Lung Models: Recent Advances and Challenges in Tissue Mimicry for Studying the Role of Mechanical Forces in Cell Biology

(2019) Ali Doryab et al.   ADVANCED FUNCTIONAL MATERIALS

Functional and metabolic impairment in cigarette smoke-exposed macrophages is tied to oxidative stress

(2019) Daniel S. Aridgides et al.   Scientific Reports

Targeting inhaled fibers to the pulmonary acinus: Opportunities for augmented delivery from in silico simulations

(2019) Lihi Shachar-Berman et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

H2020 funding for respiratory research: scaling up for the prevention and treatment of lung diseases

(2019) Constantine I. Vardavas et al.   EUROPEAN RESPIRATORY JOURNAL

Update on the Pathogenesis of Chronic Obstructive Pulmonary Disease

(2019) Alvar Agustí et al.   NEW ENGLAND JOURNAL OF MEDICINE

Advanced in vitro lung-on-chip platforms for inhalation assays: From prospect to pipeline

(2019) Arbel Artzy-Schnirman et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Multimodal Precision Imaging of Pulmonary Nanoparticle Delivery in Mice: Dynamics of Application, Spatial Distribution, and Dosimetry

(2019) Lin Yang et al.   Small

Current developments and applications of microfluidic technology toward clinical translation of nanomedicines

(2018) Dongfei Liu et al.   ADVANCED DRUG DELIVERY REVIEWS

Engineered cell and tissue models of pulmonary fibrosis

(2018) Aswin Sundarakrishnan et al.   ADVANCED DRUG DELIVERY REVIEWS

Tumor targeting via EPR: Strategies to enhance patient responses

(2018) Susanne K. Golombek et al.   ADVANCED DRUG DELIVERY REVIEWS

Breaking the In Vitro Barrier in Respiratory Medicine. Engineered Microphysiological Systems for Chronic Obstructive Pulmonary Disease and Beyond

(2018) Kambez H. Benam et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Incorporating mechanical strain in organs-on-a-chip: Lung and skin

(2018) Olivier T. Guenat et al.   Biomicrofluidics

Biomimetics of the pulmonary environment in vitro: A microfluidics perspective

(2018) Janna Tenenbaum-Katan et al.   Biomicrofluidics

Dual-ligand modified liposomes provide effective local targeted delivery of lung-cancer drug by antibody and tumor lineage-homing cell-penetrating peptide

(2018) Congcong Lin et al.   DRUG DELIVERY

Current approaches to the discovery of novel inhaled medicines

(2018) Peter Strong et al.   DRUG DISCOVERY TODAY

Organ/body-on-a-chip based on microfluidic technology for drug discovery

(2018) Hiroshi Kimura et al.   Drug Metabolism and Pharmacokinetics

An efficient computational fluid-particle dynamics method to predict deposition in a simplified approximation of the deep lung

(2018) P.G. Koullapis et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

One (sub-)acinus for all: Fate of inhaled aerosols in heterogeneous pulmonary acinar structures

(2018) Philipp Hofemeier et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Optimising experimental research in respiratory diseases: an ERS statement

(2018) Philippe Bonniaud et al.   EUROPEAN RESPIRATORY JOURNAL

A guide to polarized airway epithelial models for studies of host-pathogen interactions

(2018) Shakir Hasan et al.   FEBS Journal

Targeted Drug Delivery to Upper Airways Using a Pulsed Aerosol Bolus and Inhaled Volume Tracking Method

(2018) Yan Ostrovski et al.   FLOW TURBULENCE AND COMBUSTION

CFTR modulator theratyping: Current status, gaps and future directions

(2018) John Paul Clancy et al.   Journal of Cystic Fibrosis

Targeting pulmonary tuberculosis using nanocarrier-based dry powder inhalation: current status and futuristic need

(2018) Tulshidas S. Patil et al.   JOURNAL OF DRUG TARGETING

Nanofiber membrane supported lung-on-a-chip microdevice for anti-cancer drug testing

(2018) Xingyuan Yang et al.   LAB ON A CHIP

Human lung epithelial cell cultures for analysis of inhaled toxicants: Lessons learned and future directions

(2018) Pieter S. Hiemstra et al.   TOXICOLOGY IN VITRO

Human Organ Chip Models Recapitulate Orthotopic Lung Cancer Growth, Therapeutic Responses, and Tumor Dormancy In Vitro

(2018) Bryan A. Hassell et al.   Cell Reports

Patisiran: First Global Approval

(2018) Sheridan M. Hoy   DRUGS

Engineering biofunctional in vitro vessel models using a multilayer bioprinting technique

(2018) Jan Schöneberg et al.   Scientific Reports

Medium throughput breathing human primary cell alveolus-on-chip model

(2018) Janick D. Stucki et al.   Scientific Reports

Microfluidic-Based 3D Engineered Microvascular Networks and Their Applications in Vascularized Microtumor Models

(2018) Xiaolin Wang et al.   Micromachines

A 3D human lung-on-a-chip model for nanotoxicity testing

(2018) Min Zhang et al.   Toxicology Research

Advances in organ-on-a-chip engineering

(2018) Boyang Zhang et al.   Nature Reviews Materials

Nucleic Acid-Based Therapeutics for Pulmonary Diseases

(2018) Jing Chen et al.   AAPS PHARMSCITECH

Organ-on-chip models: Implications in drug discovery and clinical applications

(2018) Rahul Mittal et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Lung delivery of nanoliposomal salbutamol sulphate dry powder inhalation for facilitated asthma therapy

(2018) Sandip Honmane et al.   JOURNAL OF LIPOSOME RESEARCH

Targeting inhaled aerosol delivery to upper airways in children: Insight from computational fluid dynamics (CFD)

(2018) Prashant Das et al.   PLoS One

Challenges Associated with the Pulmonary Delivery of Therapeutic Dry Powders for Preclinical Testing

(2018) Dominique N. Price et al.   KONA Powder and Particle Journal

Cell and tissue-based in vitro models for improving the development of oral inhalation drug products

(2017) Marius Hittinger et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

The instructive extracellular matrix of the lung: basic composition and alterations in chronic lung disease

(2017) Gerald Burgstaller et al.   EUROPEAN RESPIRATORY JOURNAL

A new combination therapy for asthma using dual-function dexamethasone-conjugated polyethylenimine and vitamin D binding protein siRNA

(2017) M Choi et al.   GENE THERAPY

Novel Drug Delivery Systems Tailored for Improved Administration of Glucocorticoids

(2017) Fred Lühder et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

A comprehensive screening platform for aerosolizable protein formulations for intranasal and pulmonary drug delivery

(2017) Martina Röhm et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

The History of Therapeutic Aerosols: A Chronological Review

(2017) Stephen W. Stein et al.   Journal of Aerosol Medicine and Pulmonary Drug Delivery

Streamline crossing: An essential mechanism for aerosol dispersion in the pulmonary acinus

(2017) Rami Fishler et al.   JOURNAL OF BIOMECHANICS

Organ-on-a-chip devices advance to market

(2017) Boyang Zhang et al.   LAB ON A CHIP

Chronic obstructive pulmonary disease

(2017) Klaus F Rabe et al.   LANCET

Modeling Physiological Events in 2D vs. 3D Cell Culture

(2017) Kayla Duval et al.   PHYSIOLOGY

Microbial volatile communication in human organotypic lung models

(2017) Layla J. Barkal et al.   Nature Communications

Human Organ Chip Models Recapitulate Orthotopic Lung Cancer Growth, Therapeutic Responses, and Tumor Dormancy In Vitro

(2017) Bryan A. Hassell et al.   Cell Reports

Liposomal Formulations in Clinical Use: An Updated Review

(2017) Upendra Bulbake et al.   Pharmaceutics

Matrix Remodeling in Pulmonary Fibrosis and Emphysema

(2016) Tejaswini Kulkarni et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

State-of-the-Art Review of 3D Bioprinting for Cardiovascular Tissue Engineering

(2016) Bin Duan   ANNALS OF BIOMEDICAL ENGINEERING

Lung morphometry: the link between structure and function

(2016) Ewald R. Weibel   CELL AND TISSUE RESEARCH

The role of anisotropic expansion for pulmonary acinar aerosol deposition

(2016) Philipp Hofemeier et al.   JOURNAL OF BIOMECHANICS

Pulmonary administration of small interfering RNA: The route to go?

(2016) M.J.R. Ruigrok et al.   JOURNAL OF CONTROLLED RELEASE

Global, regional, and national causes of under-5 mortality in 2000–15: an updated systematic analysis with implications for the Sustainable Development Goals

(2016) Li Liu et al.   LANCET

Cells and Culture Systems Used to Model the Small Airway Epithelium

(2016) Rudra Bhowmick et al.   LUNG

Liposome Delivery Systems for Inhalation: A Critical Review Highlighting Formulation Issues and Anticancer Applications

(2016) Mindaugas Rudokas et al.   MEDICAL PRINCIPLES AND PRACTICE

A Review of Three-Dimensional Printing in Tissue Engineering

(2016) Nick A. Sears et al.   TISSUE ENGINEERING PART B-REVIEWS

Onivyde for the therapy of multiple solid tumors

(2016) Haijun Zhang   OncoTargets and Therapy

Soft Interaction in Liposome Nanocarriers for Therapeutic Drug Delivery

(2016) Domenico Lombardo et al.   Nanomaterials

Matched-Comparative Modeling of Normal and Diseased Human Airway Responses Using a Microengineered Breathing Lung Chip

(2016) Kambez H. Benam et al.   Cell Systems

Preclinical safety and efficacy models for pulmonary drug delivery of antimicrobials with focus on in vitro models

(2015) Marius Hittinger et al.   ADVANCED DRUG DELIVERY REVIEWS

Inhaled anti-infective chemotherapy for respiratory tract infections: Successes, challenges and the road ahead

(2015) Tony Velkov et al.   ADVANCED DRUG DELIVERY REVIEWS

On the Tricks Alveolar Epithelial Cells Play to Make a Good Lung

(2015) Ewald R. Weibel   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

An Official American Thoracic Society/European Respiratory Society Statement: Research Questions in Chronic Obstructive Pulmonary Disease

(2015) Bartolome R. Celli et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Diseases of Pulmonary Surfactant Homeostasis

(2015) Jeffrey A. Whitsett et al.   Annual Review of Pathology-Mechanisms of Disease

Engineered In Vitro Disease Models

(2015) Kambez H. Benam et al.   Annual Review of Pathology-Mechanisms of Disease

Dynamics of Lung Defense in Pneumonia: Resistance, Resilience, and Remodeling

(2015) Lee J. Quinton et al.   Annual Review of Physiology

Progress and future of in vitro models to study translocation of nanoparticles

(2015) Hedwig M. Braakhuis et al.   ARCHIVES OF TOXICOLOGY

Biomimetics of fetal alveolar flow phenomena using microfluidics

(2015) Janna Tenenbaum-Katan et al.   Biomicrofluidics

Barriers to new drug development in respiratory disease

(2015) Peter J. Barnes et al.   EUROPEAN RESPIRATORY JOURNAL

Chronic pulmonary disease withMycobacterium abscessuscomplex is a biofilm infection

(2015) Tavs Qvist et al.   EUROPEAN RESPIRATORY JOURNAL

Liposomes as nanomedical devices

(2015) Giuseppina Bozzuto et al.   International Journal of Nanomedicine

Pulmonary drug delivery: a review on nanocarriers for antibacterial chemotherapy

(2015) M. Moreno-Sastre et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Revisiting pulmonary acinar particle transport: convection, sedimentation, diffusion, and their interplay

(2015) Philipp Hofemeier et al.   JOURNAL OF APPLIED PHYSIOLOGY

A lung-on-a-chip array with an integrated bio-inspired respiration mechanism

(2015) Andreas O. Stucki et al.   LAB ON A CHIP

Small airway-on-a-chip enables analysis of human lung inflammation and drug responses in vitro

(2015) Kambez H Benam et al.   NATURE METHODS

Organs-on-chips at the frontiers of drug discovery

(2015) Eric W. Esch et al.   NATURE REVIEWS DRUG DISCOVERY

Highly compacted biodegradable DNA nanoparticles capable of overcoming the mucus barrier for inhaled lung gene therapy

(2015) Panagiotis Mastorakos et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Aerosolized Medications for Gene and Peptide Therapy

(2015) B. L. Laube   Respiratory Care

Particle dynamics and deposition in true-scale pulmonary acinar models

(2015) Rami Fishler et al.   Scientific Reports

Engineering an in vitro air-blood barrier by 3D bioprinting

(2015) Lenke Horváth et al.   Scientific Reports

Carrier interactions with the biological barriers of the lung: Advanced in vitro models and challenges for pulmonary drug delivery

(2014) Cristiane de Souza Carvalho et al.   ADVANCED DRUG DELIVERY REVIEWS

Critical analysis of 3-D organoid in vitro cell culture models for high-throughput drug candidate toxicity assessments

(2014) Anna Astashkina et al.   ADVANCED DRUG DELIVERY REVIEWS

Microfluidic shear stress-regulated surfactant secretion in alveolar epithelial type II cells in vitro

(2014) Sanjeev Kumar Mahto et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Efficient Bioactive Delivery of Aerosolized Drugs to Human Pulmonary Epithelial Cells Cultured in Air–Liquid Interface Conditions

(2014) Anke-Gabriele Lenz et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Modeling the lung: Design and development of tissue engineered macro- and micro-physiologic lung models for research use

(2014) Joan E Nichols et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

The potential of microfluidic lung epithelial wounding: towards in vivo-like alveolar microinjuries

(2014) M. Felder et al.   Integrative Biology

A biomimetic multicellular model of the airways using primary human cells

(2014) Katelyn L. Sellgren et al.   LAB ON A CHIP

Microfluidic platforms for advanced risk assessments of nanomaterials

(2014) Sanjeev Kumar Mahto et al.   Nanotoxicology

Microfluidic organs-on-chips

(2014) Sangeeta N Bhatia et al.   NATURE BIOTECHNOLOGY

Perfusion decellularization of whole organs

(2014) Jacques P Guyette et al.   Nature Protocols

Effective pulmonary delivery of an aerosolized plasmid DNA vaccine via surface acoustic wave nebulization

(2014) Anushi E Rajapaksa et al.   RESPIRATORY RESEARCH

Mimicking exposures to acute and lifetime concentrations of inhaled silver nanoparticles by two different in vitro approaches

(2014) Fabian Herzog et al.   Beilstein Journal of Nanotechnology

Application of liposomes in medicine and drug delivery

(2014) Hadis Daraee et al.   Artificial Cells Nanomedicine and Biotechnology

Delivery of inhalation drugs to children for asthma and other respiratory diseases

(2013) Philip Chi Lip Kwok et al.   ADVANCED DRUG DELIVERY REVIEWS

The role of bacterial biofilms in chronic infections

(2013) Thomas Bjarnsholt   APMIS

In vitro, in vivo and ex vivo models for studying particle deposition and drug absorption of inhaled pharmaceuticals

(2013) Kamrun Nahar et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Targeting Aerosol Deposition to and Within the Lung Airways Using Excipient Enhanced Growth

(2013) Geng Tian et al.   Journal of Aerosol Medicine and Pulmonary Drug Delivery

Acinus-on-a-chip: A microfluidic platform for pulmonary acinar flows

(2013) Rami Fishler et al.   JOURNAL OF BIOMECHANICS

Biomimetic model to reconstitute angiogenic sprouting morphogenesis in vitro

(2013) D.-H. T. Nguyen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Genomic responses in mouse models poorly mimic human inflammatory diseases

(2013) Junhee Seok et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Production and Assessment of Decellularized Pig and Human Lung Scaffolds

(2013) Joan E. Nichols et al.   TISSUE ENGINEERING PART A

Aerosol therapy in children: challenges and solutions

(2013) Arzu Ari et al.   Expert Review of Respiratory Medicine

Defective Phagocytosis in Airways Disease

(2012) Louise E. Donnelly et al.   CHEST

The role of liposome size on the type of immune response induced in BALB/c mice against leishmaniasis: rgp63 as a model antigen

(2012) Ali Badiee et al.   EXPERIMENTAL PARASITOLOGY

Organs-on-chips: breaking the in vitro impasse

(2012) Andries D. van der Meer et al.   Integrative Biology

Inhaled chemotherapy in lung cancer: future concept of nanomedicine

(2012) Paul Zarogoulidis et al.   International Journal of Nanomedicine

Aerosol Deposition in Health and Disease

(2012) Chantal Darquenne   Journal of Aerosol Medicine and Pulmonary Drug Delivery

Respiratory microflows in the pulmonary acinus

(2012) Josué Sznitman   JOURNAL OF BIOMECHANICS

In vitro microvessels for the study of angiogenesis and thrombosis

(2012) Y. Zheng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Human Disease Model of Drug Toxicity–Induced Pulmonary Edema in a Lung-on-a-Chip Microdevice

(2012) Dongeun Huh et al.   Science Translational Medicine

In silico models of aerosol delivery to the respiratory tract — Development and applications

(2011) P. Worth Longest et al.   ADVANCED DRUG DELIVERY REVIEWS

Liposome-encapsulated dexamethasone attenuates ventilator-induced lung inflammation

(2011) MA Hegeman et al.   BRITISH JOURNAL OF PHARMACOLOGY

Animal models of asthma: value, limitations and opportunities for alternative approaches

(2011) Anthony M. Holmes et al.   DRUG DISCOVERY TODAY

Pre-clinical evaluation of three non-viral gene transfer agents for cystic fibrosis after aerosol delivery to the ovine lung

(2011) G McLachlan et al.   GENE THERAPY

New insights into the immunology of chronic obstructive pulmonary disease

(2011) Guy G Brusselle et al.   LANCET

Expression of therapeutic proteins after delivery of chemically modified mRNA in mice

(2011) Michael S D Kormann et al.   NATURE BIOTECHNOLOGY

Guidelines for aerosol devices in infants, children and adults: which to choose, why and how to achieve effective aerosol therapy

(2011) Arzu Ari et al.   Expert Review of Respiratory Medicine

An in vitro triple cell co-culture model with primary cells mimicking the human alveolar epithelial barrier

(2010) Andrea D. Lehmann et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

The extracellular matrix at a glance

(2010) C. Frantz et al.   JOURNAL OF CELL SCIENCE

Aerosol drug delivery: developments in device design and clinical use

(2010) Myrna B Dolovich et al.   LANCET

What can in vitro models of COPD tell us?

(2010) D.I. Krimmer et al.   PULMONARY PHARMACOLOGY & THERAPEUTICS

Reconstituting Organ-Level Lung Functions on a Chip

(2010) D. Huh et al.   SCIENCE

Can Animal Models of Disease Reliably Inform Human Studies?

(2010) H. Bart van der Worp et al.   PLOS MEDICINE

Hydrogels as extracellular matrix mimics for 3D cell culture

(2009) Mark W. Tibbitt et al.   BIOTECHNOLOGY AND BIOENGINEERING

The extracellular matrix in development and morphogenesis: A dynamic view

(2009) Tania Rozario et al.   DEVELOPMENTAL BIOLOGY

Defective macrophage phagocytosis of bacteria in COPD

(2009) A. E. Taylor et al.   EUROPEAN RESPIRATORY JOURNAL

Preclinical models for pulmonary drug delivery

(2009) Cláudia A Fernandes et al.   Expert Opinion on Drug Delivery

Dynamics of Liquid Plugs of Buffer and Surfactant Solutions in a Micro-Engineered Pulmonary Airway Model

(2009) Hossein Tavana et al.   LANGMUIR

Phase II study of liposomal cisplatin (Lipoplatin™) plus gemcitabine versus cisplatin plus gemcitabine as first line treatment in inoperable (stage IIIB/IV) non-small cell lung cancer

(2009) N. Mylonakis et al.   LUNG CANCER

An overview of pulmonary surfactant in the neonate: Genetics, metabolism, and the role of surfactant in health and disease

(2009) Paul O. Nkadi et al.   MOLECULAR GENETICS AND METABOLISM

Mucus-penetrating nanoparticles for drug and gene delivery to mucosal tissues

(2008) Samuel K. Lai et al.   ADVANCED DRUG DELIVERY REVIEWS

Interactions of nanoparticles with pulmonary structures and cellular responses

(2008) Christian Mühlfeld et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

The Pathology of Chronic Obstructive Pulmonary Disease

(2008) James C. Hogg et al.   Annual Review of Pathology-Mechanisms of Disease

How to make an alveolus

(2008) E. R. Weibel   EUROPEAN RESPIRATORY JOURNAL

In vitrocell culture models for the assessment of pulmonary drug disposition

(2008) Jennifer L Sporty et al.   Expert Opinion on Drug Metabolism & Toxicology

Severe childhood asthma: a common international approach?

(2008) Andrew Bush et al.   LANCET