Functional and metabolic impairment in cigarette smoke-exposed macrophages is tied to oxidative stress

Cigarette smoke activates CFTR through ROS-stimulated cAMP signaling in human bronchial epithelial cells

(2018) Francis H. Wong et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Lumacaftor (VX-809) restores the ability of CF macrophages to phagocytose and kill Pseudomonas aeruginosa

(2018) Roxanna Barnaby et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Sustained high glucose exposure sensitizes macrophage responses to cytokine stimuli but reduces their phagocytic activity

(2018) Sofia Pavlou et al.   BMC IMMUNOLOGY

Detection of mitochondria-generated reactive oxygen species in cells using multiple probes and methods: Potentials, pitfalls, and the future

(2018) Gang Cheng et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Comprehensive comparative compositional study of the vapour phase of cigarette mainstream tobacco smoke and tobacco heating product aerosol

(2018) Benjamin Savareear et al.   JOURNAL OF CHROMATOGRAPHY A

A Neutralizing Aptamer to TGFBR2 and miR-145 Antagonism Rescue Cigarette Smoke- and TGF-β-Mediated CFTR Expression

(2018) Rajib K. Dutta et al.   MOLECULAR THERAPY

VX-445–Tezacaftor–Ivacaftor in Patients with Cystic Fibrosis and One or Two Phe508del Alleles

(2018) Dominic Keating et al.   NEW ENGLAND JOURNAL OF MEDICINE

VX-659–Tezacaftor–Ivacaftor in Patients with Cystic Fibrosis and One or Two Phe508del Alleles

(2018) Jane C. Davies et al.   NEW ENGLAND JOURNAL OF MEDICINE

Cystic fibrosis transmembrane conductance regulator (CFTR) modulators have differential effects on cystic fibrosis macrophage function

(2018) Shuzhong Zhang et al.   Scientific Reports

Tezacaftor–Ivacaftor in Residual-Function Heterozygotes with Cystic Fibrosis

(2017) Steven M. Rowe et al.   NEW ENGLAND JOURNAL OF MEDICINE

Tezacaftor–Ivacaftor in Patients with Cystic Fibrosis Homozygous for Phe508del

(2017) Jennifer L. Taylor-Cousar et al.   NEW ENGLAND JOURNAL OF MEDICINE

Macrophage Immunometabolism: Where Are We (Going)?

(2017) Jan Van den Bossche et al.   TRENDS IN IMMUNOLOGY

Pulmonary microRNA profiling: implications in upper lobe predominant lung disease

(2017) David A. Armstrong et al.   Clinical Epigenetics

Macrophage phagocytosis cracking the defect code in COPD

(2017) Jamil Jubrail et al.   Biomedical Journal

Ezrin links CFTR to TLR4 signaling to orchestrate anti-bacterial immune response in macrophages

(2017) Caterina Di Pietro et al.   Scientific Reports

The Effect of Colonization with Potentially Pathogenic Microorganisms on Efferocytosis in Chronic Obstructive Pulmonary Disease

(2016) Sandra Hodge et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Metabolic Reprogramming Mediated by the mTORC2-IRF4 Signaling Axis Is Essential for Macrophage Alternative Activation

(2016) Stanley Ching-Cheng Huang et al.   IMMUNITY

Mainstream Smoke Levels of Volatile Organic Compounds in 50 U.S. Domestic Cigarette Brands Smoked With the ISO and Canadian Intense Protocols

(2016) Daniel Y. Pazo et al.   NICOTINE & TOBACCO RESEARCH

Mitochondrial Dysfunction Prevents Repolarization of Inflammatory Macrophages

(2016) Jan Van den Bossche et al.   Cell Reports

Pilot evaluation of ivacaftor for chronic bronchitis

(2016) George M Solomon et al.   Lancet Respiratory Medicine

Lumacaftor–Ivacaftor in Patients with Cystic Fibrosis Homozygous for Phe508del CFTR

(2015) Claire E. Wainwright et al.   NEW ENGLAND JOURNAL OF MEDICINE

Second-Hand Cigarette Smoke Impairs Bacterial Phagocytosis in Macrophages by Modulating CFTR Dependent Lipid-Rafts

(2015) Inzer Ni et al.   PLoS One

Benefits of High-Dose N-Acetylcysteine to Exacerbation-Prone Patients With COPD

(2014) Hoi Nam Tse et al.   CHEST

Cigarette Smoke-induced Ca2+Release Leads to Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Dysfunction

(2014) Julia E. Rasmussen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A MicroRNA Processing Defect in Smokers' Macrophages Is Linked to SUMOylation of the Endonuclease DICER

(2014) Thomas J. Gross et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

mTOR- and HIF-1 -mediated aerobic glycolysis as metabolic basis for trained immunity

(2014) S.-C. Cheng et al.   SCIENCE

Cigarette smoke and CFTR: implications in the pathogenesis of COPD

(2013) Andras Rab et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Cigarette Smoke Induces Systemic Defects in Cystic Fibrosis Transmembrane Conductance Regulator Function

(2013) S. Vamsee Raju et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Optimal Complement-Mediated Phagocytosis ofPseudomonas aeruginosaby Monocytes Is Cystic Fibrosis Transmembrane Conductance Regulator–Dependent

(2013) Pauline B. Van de Weert–van Leeuwen et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Acquired Cystic Fibrosis Transmembrane Conductance Regulator Dysfunction in the Lower Airways in COPD

(2013) Mark T. Dransfield et al.   CHEST

Phagocytic Dysfunction of Human Alveolar Macrophages and Severity of Chronic Obstructive Pulmonary Disease

(2013) Charles S. Berenson et al.   JOURNAL OF INFECTIOUS DISEASES

CFTR Is Involved in the Fine Tuning of Intracellular Redox Status

(2012) Christophe Duranton et al.   AMERICAN JOURNAL OF PATHOLOGY

Defective Phagocytosis in Airways Disease

(2012) Louise E. Donnelly et al.   CHEST

CFTR is the primary known apical glutathione transporter involved in cigarette smoke-induced adaptive responses in the lung

(2012) Neal S. Gould et al.   FREE RADICAL BIOLOGY AND MEDICINE

Cigarette smoke exposure induces CFTR internalization and insolubility, leading to airway surface liquid dehydration

(2011) Lucy A. Clunes et al.   FASEB JOURNAL

A CFTR Potentiator in Patients with Cystic Fibrosis and theG551DMutation

(2011) Bonnie W. Ramsey et al.   NEW ENGLAND JOURNAL OF MEDICINE

Targeting Nrf2 Signaling Improves Bacterial Clearance by Alveolar Macrophages in Patients with COPD and in a Mouse Model

(2011) C. J. Harvey et al.   Science Translational Medicine

Effect of VX-770 in Persons with Cystic Fibrosis and the G551D-CFTRMutation

(2010) Frank J. Accurso et al.   NEW ENGLAND JOURNAL OF MEDICINE

Defective macrophage phagocytosis of bacteria in COPD

(2009) A. E. Taylor et al.   EUROPEAN RESPIRATORY JOURNAL

Nontypeable Haemophilus influenzae Clearance by Alveolar Macrophages Is Impaired by Exposure to Cigarette Smoke

(2009) P. Marti-Lliteras et al.   INFECTION AND IMMUNITY

Azithromycin Improves Macrophage Phagocytic Function and Expression of Mannose Receptor in Chronic Obstructive Pulmonary Disease

(2008) Sandra Hodge et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE