Lung-on-a-chip: the future of respiratory disease models and pharmacological studies

Human iPSC-Derived Blood-Brain Barrier Chips Enable Disease Modeling and Personalized Medicine Applications

(2019) Gad D. Vatine et al.   Cell Stem Cell

Nanofiber membrane supported lung-on-a-chip microdevice for anti-cancer drug testing

(2018) Xingyuan Yang et al.   LAB ON A CHIP

Microfluidic lung airway-on-a-chip with arrayable suspended gels for studying epithelial and smooth muscle cell interactions

(2018) Mouhita Humayun et al.   LAB ON A CHIP

Microfabrication of liver and heart tissues for drug development

(2018) Grace E. Brown et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Personalized Cancer Medicine: An Organoid Approach

(2018) Hamidreza Aboulkheyr Es et al.   TRENDS IN BIOTECHNOLOGY

Stem cell-based Lung-on-Chips: The best of both worlds?

(2018) Janna C. Nawroth et al.   ADVANCED DRUG DELIVERY REVIEWS

A Biomimetic Human Gut-on-a-Chip for Modeling Drug Metabolism in Intestine

(2018) Yaqiong Guo et al.   ARTIFICIAL ORGANS

Use of 3D organoids and lung-on-a-chip methods to study lung development, regeneration and disease

(2018) Konstantinos Gkatzis et al.   EUROPEAN RESPIRATORY JOURNAL

A 3D human lung-on-a-chip model for nanotoxicity testing

(2018) Min Zhang et al.   Toxicology Research

Organ-on-a-chip devices advance to market

(2017) Boyang Zhang et al.   LAB ON A CHIP

Disease Modeling in Stem Cell-Derived 3D Organoid Systems

(2017) Devanjali Dutta et al.   TRENDS IN MOLECULAR MEDICINE

Human Organ Chip Models Recapitulate Orthotopic Lung Cancer Growth, Therapeutic Responses, and Tumor Dormancy In Vitro

(2017) Bryan A. Hassell et al.   Cell Reports

Assessment of whole blood thrombosis in a microfluidic device lined by fixed human endothelium

(2016) Abhishek Jain et al.   BIOMEDICAL MICRODEVICES

Microfluidic blood-brain barrier model provides in vivo-like barrier properties for drug permeability screening

(2016) Ying I. Wang et al.   BIOTECHNOLOGY AND BIOENGINEERING

Modeling Development and Disease with Organoids

(2016) Hans Clevers   CELL

The Flaws and Human Harms of Animal Experimentation

(2015) AYSHA AKHTAR   CAMBRIDGE QUARTERLY OF HEALTHCARE ETHICS

A lung-on-a-chip array with an integrated bio-inspired respiration mechanism

(2015) Andreas O. Stucki et al.   LAB ON A CHIP

Small airway-on-a-chip enables analysis of human lung inflammation and drug responses in vitro

(2015) Kambez H Benam et al.   NATURE METHODS

Organs-on-chips at the frontiers of drug discovery

(2015) Eric W. Esch et al.   NATURE REVIEWS DRUG DISCOVERY

Mimicking the niche of lung epithelial stem cells and characterization of several effectors of their in vitro behavior

(2015) Ahmed E. Hegab et al.   Stem Cell Research

Notch2 Is Required for Inflammatory Cytokine-Driven Goblet Cell Metaplasia in the Lung

(2015) Henry Danahay et al.   Cell Reports

In vitro generation of human pluripotent stem cell derived lung organoids

(2015) Briana R Dye et al.   eLife

Cystic fibrosis

(2015) Felix Ratjen et al.   Nature Reviews Disease Primers

Role of Mechanical Cues in Cell Differentiation and Proliferation: A 3D Numerical Model

(2015) Seyed Jamaleddin Mousavi et al.   PLoS One

Lung Stem Cell Differentiation in Mice Directed by Endothelial Cells via a BMP4-NFATc1-Thrombospondin-1 Axis

(2014) Joo-Hyeon Lee et al.   CELL

Branching morphogenesis of immortalized human bronchial epithelial cells in three-dimensional culture

(2014) Aadil Kaisani et al.   DIFFERENTIATION

The potential of microfluidic lung epithelial wounding: towards in vivo-like alveolar microinjuries

(2014) M. Felder et al.   Integrative Biology

Human airway musculature on a chip: an in vitro model of allergic asthmatic bronchoconstriction and bronchodilation

(2014) Alexander Peyton Nesmith et al.   LAB ON A CHIP

A biomimetic multicellular model of the airways using primary human cells

(2014) Katelyn L. Sellgren et al.   LAB ON A CHIP

Microfluidic organs-on-chips

(2014) Sangeeta N Bhatia et al.   NATURE BIOTECHNOLOGY

Organogenesis in a dish: Modeling development and disease using organoid technologies

(2014) M. A. Lancaster et al.   SCIENCE

Generation of Alveolar Epithelial Spheroids via Isolated Progenitor Cells from Human Pluripotent Stem Cells

(2014) Shimpei Gotoh et al.   Stem Cell Reports

Application of a microfluidic chip-based 3D co-culture to test drug sensitivity for individualized treatment of lung cancer

(2013) Zhiyun Xu et al.   BIOMATERIALS

Human kidney proximal tubule-on-a-chip for drug transport and nephrotoxicity assessment

(2013) Kyung-Jin Jang et al.   Integrative Biology

Gut-on-a-Chip microenvironment induces human intestinal cells to undergo villus differentiation

(2013) Hyun Jung Kim et al.   Integrative Biology

Humoral immunity and delayed-type hypersensitivity in healthy subjects treated for 30days with MK-7123, a selective CXCR2 antagonist

(2013) Michael Seiberling et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Type 2 alveolar cells are stem cells in adult lung

(2013) Christina E. Barkauskas et al.   JOURNAL OF CLINICAL INVESTIGATION

The Pulmonary Side of Reflux Disease: from Heartburn to Lung Fibrosis

(2013) Marco E. Allaix et al.   JOURNAL OF GASTROINTESTINAL SURGERY

BET Protein Function Is Required for Inflammation: Brd2 Genetic Disruption and BET Inhibitor JQ1 Impair Mouse Macrophage Inflammatory Responses

(2013) A. C. Belkina et al.   JOURNAL OF IMMUNOLOGY

Microfluidic heart on a chip for higher throughput pharmacological studies

(2013) Ashutosh Agarwal et al.   LAB ON A CHIP

Microfabrication of human organs-on-chips

(2013) Dongeun Huh et al.   Nature Protocols

On chip porous polymer membranes for integration of gastrointestinal tract epithelium with microfluidic ‘body-on-a-chip’ devices

(2012) Mandy Brigitte Esch et al.   BIOMEDICAL MICRODEVICES

BBB ON CHIP: microfluidic platform to mechanically and biochemically modulate blood-brain barrier function

(2012) L. M. Griep et al.   BIOMEDICAL MICRODEVICES

Characterization of a microfluidic in vitro model of the blood-brain barrier (μBBB)

(2012) Ross Booth et al.   LAB ON A CHIP

Human gut-on-a-chip inhabited by microbial flora that experiences intestinal peristalsis-like motions and flow

(2012) Hyun Jung Kim et al.   LAB ON A CHIP

Directed differentiation of human pluripotent stem cells into mature airway epithelia expressing functional CFTR protein

(2012) Amy P Wong et al.   NATURE BIOTECHNOLOGY

Placebo-Controlled Trial of Tofacitinib Monotherapy in Rheumatoid Arthritis

(2012) Roy Fleischmann et al.   NEW ENGLAND JOURNAL OF MEDICINE

Monitoringin vitrothrombus formation with novel microfluidic devices

(2012) Erik Westein et al.   PLATELETS

A Human Disease Model of Drug Toxicity–Induced Pulmonary Edema in a Lung-on-a-Chip Microdevice

(2012) Dongeun Huh et al.   Science Translational Medicine

Evaluation of seven drug metabolisms and clearances by cryopreserved human primary hepatocytes cultivated in microfluidic biochips

(2012) Régis Baudoin et al.   XENOBIOTICA

Prothrombotic effects of tumor necrosis factor alpha in vivo are amplified by the absence of TNF-alpha receptor subtype 1 and require TNF-alpha receptor subtype 2

(2012) Joachim Pircher et al.   ARTHRITIS RESEARCH & THERAPY

Acute Exacerbations of Chronic Obstructive Pulmonary Disease

(2011) Mona Bafadhel et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

In Vivo Fluorescence Imaging of Large-Vessel Thrombosis in Mice

(2011) Brian C. Cooley   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Endothelial Cells Are Central Orchestrators of Cytokine Amplification during Influenza Virus Infection

(2011) John R. Teijaro et al.   CELL

Notch-Dependent Differentiation of Adult Airway Basal Stem Cells

(2011) Jason R. Rock et al.   Cell Stem Cell

Biomimetic tissues on a chip for drug discovery

(2011) Amir M. Ghaemmaghami et al.   DRUG DISCOVERY TODAY

Asthma exacerbations: Origin, effect, and prevention

(2011) David J. Jackson et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Ensembles of engineered cardiac tissues for physiological and pharmacological study: Heart on a chip

(2011) Anna Grosberg et al.   LAB ON A CHIP

Microfluidic devices as tools for mimicking the in vivo environment

(2011) Karina Ziółkowska et al.   NEW JOURNAL OF CHEMISTRY

Multipotent Capacity of Immortalized Human Bronchial Epithelial Cells

(2011) Oliver Delgado et al.   PLoS One

From 3D cell culture to organs-on-chips

(2011) Dongeun Huh et al.   TRENDS IN CELL BIOLOGY

Microfluidic Cardiac Cell Culture Model (μCCCM)

(2010) Guruprasad A. Giridharan et al.   ANALYTICAL CHEMISTRY

Integration ofin silicoandin vitroplatforms for pharmacokinetic–pharmacodynamic modeling

(2010) Jong Hwan Sung et al.   Expert Opinion on Drug Metabolism & Toxicology

Ciliary dysfunction and ultrastructural abnormalities are features of severe asthma

(2010) Biju Thomas et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Geometric cues for directing the differentiation of mesenchymal stem cells

(2010) K. A. Kilian et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Reconstituting Organ-Level Lung Functions on a Chip

(2010) D. Huh et al.   SCIENCE

Evaluation of a microfluidic based cell culture platform with primary human hepatocytes for the prediction of hepatic clearance in human

(2009) P. Chao et al.   BIOCHEMICAL PHARMACOLOGY

TRPV4 Channels Mediate Cyclic Strain–Induced Endothelial Cell Reorientation Through Integrin-to-Integrin Signaling

(2009) Charles K. Thodeti et al.   CIRCULATION RESEARCH

A micro cell culture analog (µCCA) with 3-D hydrogel culture of multiple cell lines to assess metabolism-dependent cytotoxicity of anti-cancer drugs

(2009) Jong Hwan Sung et al.   LAB ON A CHIP

A multi-layer microfluidic device for efficient culture and analysis of renal tubular cells

(2009) Kyung-Jin Jang et al.   LAB ON A CHIP

Dynamics of Liquid Plugs of Buffer and Surfactant Solutions in a Micro-Engineered Pulmonary Airway Model

(2009) Hossein Tavana et al.   LANGMUIR

Basal cells as stem cells of the mouse trachea and human airway epithelium

(2009) J. R. Rock et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A novel system for evaluation of drug mixtures for potential efficacy in treating multidrug resistant cancers

(2008) Daniel A. Tatosian et al.   BIOTECHNOLOGY AND BIOENGINEERING

The JAK-3 inhibitor CP-690550 is a potent anti-inflammatory agent in a murine model of pulmonary eosinophilia

(2008) Elizabeth Kudlacz et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Etiology of asthma exacerbations

(2008) Annemarie Sykes et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Severe childhood asthma: a common international approach?

(2008) Andrew Bush et al.   LANCET

Development of a Microscale Cell Culture Analog To Probe Naphthalene Toxicity

(2004) Kwanchanok Viravaidya et al.   BIOTECHNOLOGY PROGRESS

The Design and Fabrication of Three-Chamber Microscale Cell Culture Analog Devices with Integrated Dissolved Oxygen Sensors

(2004) Aaron Sin et al.   BIOTECHNOLOGY PROGRESS