Matrix Remodeling in Pulmonary Fibrosis and Emphysema

Versican V1 Overexpression Induces a Myofibroblast-Like Phenotype in Cultured Fibroblasts

(2015) Jon M. Carthy et al.   PLoS One

Matrix Biology of Idiopathic Pulmonary Fibrosis

(2014) Victor J. Thannickal et al.   AMERICAN JOURNAL OF PATHOLOGY

Proteoglycans Maintain Lung Stability in an Elastase-Treated Mouse Model of Emphysema

(2014) Ayuko Takahashi et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Diverse functions of matrix metalloproteinases during fibrosis

(2014) M. Giannandrea et al.   Disease Models & Mechanisms

Fibrotic extracellular matrix activates a profibrotic positive feedback loop

(2014) Matthew W. Parker et al.   JOURNAL OF CLINICAL INVESTIGATION

Fibrosis: ultimate and proximate causes

(2014) Victor J. Thannickal et al.   JOURNAL OF CLINICAL INVESTIGATION

A Novel Proteolytic Cascade Generates an Extracellular Matrix-Derived Chemoattractant in Chronic Neutrophilic Inflammation

(2014) A. Gaggar et al.   JOURNAL OF IMMUNOLOGY

Remodelling the extracellular matrix in development and disease

(2014) Caroline Bonnans et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Reversal of Persistent Fibrosis in Aging by Targeting Nox4-Nrf2 Redox Imbalance

(2014) L. Hecker et al.   Science Translational Medicine

Lung fibrotic tenascin-C upregulation is associated with other extracellular matrix proteins and induced by TGFβ1

(2014) Susanna Estany et al.   BMC Pulmonary Medicine

Differential effects of fluticasone on extracellular matrix production by airway and parenchymal fibroblasts in severe COPD

(2013) Corry-Anke Brandsma et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Glycosyltransferases and Glycosaminoglycans in Bleomycin and Transforming Growth Factor-β1–Induced Pulmonary Fibrosis

(2013) Narayanan Venkatesan et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Serum lysyl oxidase-like 2 levels and idiopathic pulmonary fibrosis disease progression

(2013) J. W. Chien et al.   EUROPEAN RESPIRATORY JOURNAL

Control of alternative splicing in immune responses: many regulators, many predictions, much still to learn

(2013) Nicole M. Martinez et al.   IMMUNOLOGICAL REVIEWS

Inhibition of mechanosensitive signaling in myofibroblasts ameliorates experimental pulmonary fibrosis

(2013) Yong Zhou et al.   JOURNAL OF CLINICAL INVESTIGATION

Extracellular matrix proteins: A positive feedback loop in lung fibrosis?

(2013) Marjolein E. Blaauboer et al.   MATRIX BIOLOGY

Myofibroblast expression in airways and alveoli is affected by smoking and COPD

(2013) Henna M Karvonen et al.   RESPIRATORY RESEARCH

Low α2β1 Integrin Function Enhances the Proliferation of Fibroblasts from Patients with Idiopathic Pulmonary Fibrosis by Activation of the β-Catenin Pathway

(2012) Hong Xia et al.   AMERICAN JOURNAL OF PATHOLOGY

Recent Developments in Myofibroblast Biology

(2012) Boris Hinz et al.   AMERICAN JOURNAL OF PATHOLOGY

Matrix Stiffness–Induced Myofibroblast Differentiation Is Mediated by Intrinsic Mechanotransduction

(2012) Xiangwei Huang et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Extracellular matrix composition in COPD

(2012) Raquel Annoni et al.   EUROPEAN RESPIRATORY JOURNAL

Pulmonary fibrosis: patterns and perpetrators

(2012) Paul W. Noble et al.   JOURNAL OF CLINICAL INVESTIGATION

TGFβ signalling in context

(2012) Joan Massagué   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The pathogenesis of COPD and IPF: Distinct horns of the same devil?

(2012) Marco Chilosi et al.   RESPIRATORY RESEARCH

An Official ATS/ERS/JRS/ALAT Statement: Idiopathic Pulmonary Fibrosis: Evidence-based Guidelines for Diagnosis and Management

(2011) Ganesh Raghu et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Fibronectin Extra Domain-A Promotes Hepatic Stellate Cell Motility but Not Differentiation Into Myofibroblasts

(2011) Abby L. Olsen et al.   GASTROENTEROLOGY

Transforming growth factor-β1 polymorphisms and chronic obstructive pulmonary disease: a meta-analysis

(2011) L. Zhang et al.   INTERNATIONAL JOURNAL OF TUBERCULOSIS AND LUNG DISEASE

Small-Airway Obstruction and Emphysema in Chronic Obstructive Pulmonary Disease

(2011) John E. McDonough et al.   NEW ENGLAND JOURNAL OF MEDICINE

Multiple stromal populations contribute to pulmonary fibrosis without evidence for epithelial to mesenchymal transition

(2011) J. R. Rock et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

 -Arrestin Deficiency Protects Against Pulmonary Fibrosis in Mice and Prevents Fibroblast Invasion of Extracellular Matrix

(2011) A. K. Lovgren et al.   Science Translational Medicine

Overview of the Matrisome--An Inventory of Extracellular Matrix Constituents and Functions

(2011) R. O. Hynes et al.   Cold Spring Harbor Perspectives in Biology

Tenascin-C deficiency attenuates TGF-β-mediated fibrosis following murine lung injury

(2010) William A. Carey et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Cigarette smoke-induced lung emphysema in mice is associated with prolyl endopeptidase, an enzyme involved in collagen breakdown

(2010) Saskia Braber et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Increased deposition of chondroitin/dermatan sulfate glycosaminoglycan and upregulation of β1,3-glucuronosyltransferase I in pulmonary fibrosis

(2010) Narayanan Venkatesan et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Prostaglandin E2Inhibits Human Lung Fibroblast Chemotaxis through Disparate Actions on Different E-Prostanoid Receptors

(2010) Ying-Ji Li et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Matrix Metalloproteinases: Regulators of the Tumor Microenvironment

(2010) Kai Kessenbrock et al.   CELL

EDA-containing cellular fibronectin induces fibroblast differentiation through binding to α4β7 integrin receptor and MAPK/Erk 1/2-dependent signaling

(2010) Martin Kohan et al.   FASEB JOURNAL

Thy-1-Integrin αvβ5Interactions Inhibit Lung Fibroblast Contraction-induced Latent Transforming Growth Factor-β1 Activation and Myofibroblast Differentiation

(2010) Yong Zhou et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A new lock-step mechanism of matrix remodelling based on subcellular contractile events

(2010) L. F. Castella et al.   JOURNAL OF CELL SCIENCE

Enhanced Deposition of Low-Molecular-Weight Hyaluronan in Lungs of Cigarette Smoke–Exposed Mice

(2009) Ken R. Bracke et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Proteoglycans: from structural compounds to signaling molecules

(2009) Liliana Schaefer et al.   CELL AND TISSUE RESEARCH

Neutrophils contain prolyl endopeptidase and generate the chemotactic peptide, PGP, from collagen

(2009) Philip J. O'Reilly et al.   JOURNAL OF NEUROIMMUNOLOGY

Chronic obstructive pulmonary disease in non-smokers

(2009) Sundeep S Salvi et al.   LANCET

Exposures and Idiopathic Lung Disease

(2009) Varsha Taskar et al.   SEMINARS IN RESPIRATORY AND CRITICAL CARE MEDICINE

EGF antagonizes TGF-β-induced tropoelastin expression in lung fibroblasts via stabilization of Smad corepressor TGIF

(2008) Shenghong Yang et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Lung Fibroblast Repair Functions in Patients with Chronic Obstructive Pulmonary Disease Are Altered by Multiple Mechanisms

(2008) Shinsaku Togo et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Molecular pathogenesis of emphysema

(2008) Laimute Taraseviciene-Stewart et al.   JOURNAL OF CLINICAL INVESTIGATION

Pathological integrin signaling enhances proliferation of primary lung fibroblasts from patients with idiopathic pulmonary fibrosis

(2008) Hong Xia et al.   JOURNAL OF EXPERIMENTAL MEDICINE

An Essential Role for Fibronectin Extra Type III Domain A in Pulmonary Fibrosis

(2007) Andrés F. Muro et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE