A guide to polarized airway epithelial models for studies of host-pathogen interactions

Airway microbiota across age and disease spectrum in cystic fibrosis

(2017) Edith T. Zemanick et al.   EUROPEAN RESPIRATORY JOURNAL

Physiopathological roles of spontaneously released outer membrane vesicles of Bordetella pertussis

(2017) Gianmarco Gasperini et al.   Future Microbiology

Estimates of the global, regional, and national morbidity, mortality, and aetiologies of lower respiratory tract infections in 195 countries: a systematic analysis for the Global Burden of Disease Study 2015

(2017) Christopher Troeger et al.   LANCET INFECTIOUS DISEASES

The microbiota of the respiratory tract: gatekeeper to respiratory health

(2017) Wing Ho Man et al.   NATURE REVIEWS MICROBIOLOGY

Animal models of respiratory syncytial virus infection

(2017) Geraldine Taylor   VACCINE

Pseudomonas aeruginosa ExoU augments neutrophil transepithelial migration

(2017) Michael A. Pazos et al.   PLoS Pathogens

Development of a Primary Human Co-Culture Model of Inflamed Airway Mucosa

(2017) Lael M. Yonker et al.   Scientific Reports

A novel high-throughput assay to quantify the vaccine-induced inhibition of Bordetella pertussis adhesion to airway epithelia

(2016) Elisa Zanaboni et al.   BMC MICROBIOLOGY

Development of an in vitro colonization model to investigateStaphylococcus aureusinteractions with airway epithelia

(2016) Megan R. Kiedrowski et al.   CELLULAR MICROBIOLOGY

Understanding dissemination of Mycobacterium tuberculosis from the lungs during primary infection

(2016) Michelle B. Ryndak et al.   JOURNAL OF MEDICAL MICROBIOLOGY

Corynebacterium accolens Releases Antipneumococcal Free Fatty Acids from Human Nostril and Skin Surface Triacylglycerols

(2016) Lindsey Bomar et al.   mBio

Microfold Cells Actively Translocate Mycobacterium tuberculosis to Initiate Infection

(2016) Vidhya R. Nair et al.   Cell Reports

Haemophilus haemolyticus Interaction with Host Cells Is Different to Nontypeable Haemophilus influenzae and Prevents NTHi Association with Epithelial Cells

(2016) Janessa L. Pickering et al.   Frontiers in Cellular and Infection Microbiology

3D Reconstruction of the Human Airway Mucosa In Vitro as an Experimental Model to Study NTHi Infections

(2016) Pasquale Marrazzo et al.   PLoS One

Analysis of the association between host genetics, smoking, and sputum microbiota in healthy humans

(2016) Mi Young Lim et al.   Scientific Reports

Crumbs3-Mediated Polarity Directs Airway Epithelial Cell Fate through the Hippo Pathway Effector Yap

(2015) Aleksander D. Szymaniak et al.   DEVELOPMENTAL CELL

Modelling staphylococcal pneumonia in a human 3D lung tissue model system delineates toxin-mediated pathology

(2015) S. Mairpady Shambat et al.   Disease Models & Mechanisms

The characterization of the human cell line Calu-3 under different culture conditions and its use as an optimized in vitro model to investigate bronchial epithelial function

(2015) Mateja Erdani Kreft et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Dysbiosis of upper respiratory tract microbiota in elderly pneumonia patients

(2015) Wouter A A de Steenhuijsen Piters et al.   ISME Journal

Bacillus anthracis spores germinate extracellularly at air-liquid interface in an in vitro lung model under serum-free conditions

(2015) J.D. Powell et al.   JOURNAL OF APPLIED MICROBIOLOGY

Respiratory epithelial cells orchestrate pulmonary innate immunity

(2015) Jeffrey A Whitsett et al.   NATURE IMMUNOLOGY

Evaluation of an air–liquid interface cell culture model for studies on the inflammatory and cytotoxic responses to tobacco smoke aerosols

(2015) David Azzopardi et al.   TOXICOLOGY IN VITRO

The changing face of asthma and its relation with microbes

(2015) Chris S. Earl et al.   TRENDS IN MICROBIOLOGY

Haemophilus influenzae induces steroid-resistant inflammatory responses in COPD

(2015) Borja G. Cosío et al.   BMC Pulmonary Medicine

Highly differentiated human airway epithelial cells: a model to study host cell–parasite interactions in pertussis

(2015) Claudia Guevara et al.   Infectious Diseases

Plasticity of Airway Epithelial Cell Transcriptome in Response to Flagellin

(2015) Joan G. Clark et al.   PLoS One

The Importance of Bacterial and Viral Infections Associated with Adult Asthma Exacerbations in Clinical Practice

(2015) Motoyasu Iikura et al.   PLoS One

Mast Cells Protect against Pseudomonas aeruginosa–Induced Lung Injury

(2014) Robert D. Junkins et al.   AMERICAN JOURNAL OF PATHOLOGY

An engineered 3D human airway mucosa model based on an SIS scaffold

(2014) Maria Steinke et al.   BIOMATERIALS

Epithelial barrier function: At the front line of asthma immunology and allergic airway inflammation

(2014) Steve N. Georas et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Nonhuman Primate and Human Challenge Models of Pertussis

(2014) T. J. Merkel et al.   JOURNAL OF INFECTIOUS DISEASES

deltaNp63 Has a Role in Maintaining Epithelial Integrity in Airway Epithelium

(2014) Ari Jon Arason et al.   PLoS One

A Co-Culture Model of the Developing Small Intestine Offers New Insight in the Early Immunomodulation of Enterocytes and Macrophages by Lactobacillus spp. through STAT1 and NF-kB p65 Translocation

(2014) Martin Trapecar et al.   PLoS One

Human Lung Epithelial Cells Contain Mycobacterium tuberculosis in a Late Endosomal Vacuole and Are Efficiently Recognized by CD8+ T Cells

(2014) Melanie J. Harriff et al.   PLoS One

In Vitro Selection and Characterization of New Probiotic Candidates from Table Olive Microbiota

(2014) Cristian Botta et al.   PLoS One

In VitroSpatial and Temporal Analysis of Mycoplasma pneumoniae Colonization of Human Airway Epithelium

(2013) Oliver A. Prince et al.   INFECTION AND IMMUNITY

Growth of human bronchial epithelial cells at an air-liquid interface alters the response to particle exposure

(2013) Andrew J Ghio et al.   Particle and Fibre Toxicology

Epithelial Uptake of Flagella Initiates Proinflammatory Signaling

(2013) Dane Parker et al.   PLoS One

Barrier Disrupting Effects of Alternaria Alternata Extract on Bronchial Epithelium from Asthmatic Donors

(2013) Marina S. Leino et al.   PLoS One

Generation of a human airway epithelium derived basal cell line with multipotent differentiation capacity

(2013) Matthew S Walters et al.   RESPIRATORY RESEARCH

Upper Respiratory Tract Microbial Communities, Acute Otitis Media Pathogens, and Antibiotic Use in Healthy and Sick Children

(2012) Melinda M. Pettigrew et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

The Haemophilus influenzae Sap Transporter Mediates Bacterium-Epithelial Cell Homeostasis

(2012) Forrest K. Raffel et al.   INFECTION AND IMMUNITY

Nonhuman Primate Model of Pertussis

(2012) Jason M. Warfel et al.   INFECTION AND IMMUNITY

Pneumococcal Interactions with Epithelial Cells Are Crucial for Optimal Biofilm Formation and ColonizationIn VitroandIn Vivo

(2012) Laura R. Marks et al.   INFECTION AND IMMUNITY

The Second Type VI Secretion System ofPseudomonas aeruginosaStrain PAO1 Is Regulated by Quorum Sensing and Fur and Modulates Internalization in Epithelial Cells

(2012) Thibault G. Sana et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Interaction of environmental Burkholderia cenocepacia strains with cystic fibrosis and non-cystic fibrosis bronchial epithelial cells in vitro

(2012) A. Bevivino et al.   MICROBIOLOGY-SGM

Directed differentiation of human pluripotent stem cells into mature airway epithelia expressing functional CFTR protein

(2012) Amy P Wong et al.   NATURE BIOTECHNOLOGY

Drug Delivery Characteristics of the Progenitor Bronchial Epithelial Cell Line VA10

(2012) Berglind Eva Benediktsdóttir et al.   PHARMACEUTICAL RESEARCH

The microbiome of the lung

(2012) James M. Beck et al.   Translational Research

Pseudomonas aeruginosa Pili and Flagella Mediate Distinct Binding and Signaling Events at the Apical and Basolateral Surface of Airway Epithelium

(2012) Iwona Bucior et al.   PLoS Pathogens

Dendritic cell functional properties in a three-dimensional tissue model of human lung mucosa

(2011) Anh Thu Nguyen Hoang et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Characterization of the Retrocyclin Analogue RC-101 as a Preventative of Staphylococcus aureus Nasal Colonization

(2011) Ryan P. Lamers et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Tomatidine Inhibits Replication of Staphylococcus aureus Small-Colony Variants in Cystic Fibrosis Airway Epithelial Cells

(2011) Gabriel Mitchell et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Streptococcus pneumoniae exposure is associated with human metapneumovirus seroconversion and increased susceptibility to in vitro HMPV infection

(2011) N.J. Verkaik et al.   CLINICAL MICROBIOLOGY AND INFECTION

Infection of Polarized Airway Epithelial Cells by Normal and Small-Colony Variant Strains of Staphylococcus aureus Is Increased in Cells with Abnormal Cystic Fibrosis Transmembrane Conductance Regulator Function and Is Influenced by NF-κB

(2011) Gabriel Mitchell et al.   INFECTION AND IMMUNITY

Functional Apical Large Conductance, Ca2+-activated, and Voltage-dependent K+Channels Are Required for Maintenance of Airway Surface Liquid Volume

(2011) Dahis Manzanares et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Staphylococcus aureusProtein A Mediates Invasion across Airway Epithelial Cells through Activation of RhoA GTPase Signaling and Proteolytic Activity

(2011) Grace Soong et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The air-liquid interface and use of primary cell cultures are important to recapitulate the transcriptional profile of in vivo airway epithelia

(2010) Alejandro A. Pezzulo et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Do Airway Epithelium Air–Liquid Cultures Represent theIn VivoAirway Epithelium Transcriptome?

(2010) Anna Dvorak et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Chlamydia pneumoniae Infection in Polarized Epithelial Cell Lines

(2010) L. Tormakangas et al.   INFECTION AND IMMUNITY

Selective Translocation of theBordetella pertussisAdenylate Cyclase Toxin across the Basolateral Membranes of Polarized Epithelial Cells

(2010) Joshua C. Eby et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Organotypic 3D cell culture models: using the rotating wall vessel to study host–pathogen interactions

(2010) Jennifer Barrila et al.   NATURE REVIEWS MICROBIOLOGY

Bacillus anthracis Spore Entry into Epithelial Cells Is an Actin-Dependent Process Requiring c-Src and PI3K

(2010) Qiong Xue et al.   PLoS One

Polarized Secretion of Interleukin (IL)-6 and IL-8 by Human Airway Epithelia 16HBE14o- Cells in Response to Cationic Polypeptide Challenge

(2010) Alison Wai-ming Chow et al.   PLoS One

Monolayer Culture Systems with Respiratory Epithelial Cells for Evaluation of Bacterial Invasiveness

(2010) Yoichi Hirakata et al.   TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE

Human primary bronchial lung cell constructs: The new respiratory models

(2010) Kelly BéruBé et al.   TOXICOLOGY

Azithromycin Maintains Airway Epithelial Integrity duringPseudomonas aeruginosaInfection

(2009) Skarphedinn Halldorsson et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Development of animal models for the acute respiratory distress syndrome

(2009) J. A. Bastarache et al.   Disease Models & Mechanisms

Pseudomonas aeruginosa-Mediated Damage Requires Distinct Receptors at the Apical and Basolateral Surfaces of the Polarized Epithelium

(2009) I. Bucior et al.   INFECTION AND IMMUNITY

Hag Mediates Adherence of Moraxella catarrhalis to Ciliated Human Airway Cells

(2009) R. Balder et al.   INFECTION AND IMMUNITY

Clara cell: Progenitor for the bronchiolar epithelium

(2009) Susan D. Reynolds et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Physiology and Function of the Tight Junction

(2009) J. M. Anderson et al.   Cold Spring Harbor Perspectives in Biology

Long-Distance Delivery of Bacterial Virulence Factors by Pseudomonas aeruginosa Outer Membrane Vesicles

(2009) Jennifer M. Bomberger et al.   PLoS Pathogens

Potential dissemination of Bacillus anthracis utilizing human lung epithelial cells

(2008) Brooke H. Russell et al.   CELLULAR MICROBIOLOGY

An amino acid substitution in PBP-3 in Haemophilus influenzae associate with the invasion to bronchial epithelial cells

(2008) Tadashi Okabe et al.   MICROBIOLOGICAL RESEARCH