Organ-on-a-Chip: A New Paradigm for Drug Development

Engineering Microphysiological Immune System Responses on Chips

(2020) Chris P. Miller et al.   TRENDS IN BIOTECHNOLOGY

Robotic fluidic coupling and interrogation of multiple vascularized organ chips

(2020) Richard Novak et al.   Nature Biomedical Engineering

Quantitative prediction of human pharmacokinetic responses to drugs via fluidically coupled vascularized organ chips

(2020) Anna Herland et al.   Nature Biomedical Engineering

Extensive Remodeling of the Immune Microenvironment in B Cell Acute Lymphoblastic Leukemia

(2020) Matthew T. Witkowski et al.   CANCER CELL

Tackling rare diseases: Clinical trials on chips

(2020) Sandra H Blumenrath et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Dissecting the immunosuppressive tumor microenvironments in Glioblastoma-on-a-Chip for optimized PD-1 immunotherapy

(2020) Xin Cui et al.   eLife

CRISPR/Cas9 edited hiPSC-based vascular tissues to model aging and disease-dependent impairment

(2019) Aylin Acun et al.   TISSUE ENGINEERING PART A

Flow-enhanced vascularization and maturation of kidney organoids in vitro

(2019) Kimberly A. Homan et al.   NATURE METHODS

A Platform for Generation of Chamber-Specific Cardiac Tissues and Disease Modeling

(2019) Yimu Zhao et al.   CELL

A bioprinted human-glioblastoma-on-a-chip for the identification of patient-specific responses to chemoradiotherapy

(2019) Hee-Gyeong Yi et al.   Nature Biomedical Engineering

In vitro aged, hiPSC-origin engineered heart tissue models with age-dependent functional deterioration to study myocardial infarction

(2019) Aylin Acun et al.   Acta Biomaterialia

Engineered heart tissue models from hiPSC-derived cardiomyocytes and cardiac ECM for disease modeling and drug testing applications

(2019) Idit Goldfracht et al.   Acta Biomaterialia

Therapeutic Potential of Patient iPSC-Derived iMelanocytes in Autologous Transplantation

(2019) Li-Ping Liu et al.   Cell Reports

Human iPSC-Derived Blood-Brain Barrier Chips Enable Disease Modeling and Personalized Medicine Applications

(2019) Gad D. Vatine et al.   Cell Stem Cell

Impact of organ-on-a-chip technology on pharmaceutical R&D costs

(2019) Nora Franzen et al.   DRUG DISCOVERY TODAY

Organoids-on-a-chip

(2019) Sunghee Estelle Park et al.   SCIENCE

Multi-organ system for the evaluation of efficacy and off-target toxicity of anticancer therapeutics

(2019) Christopher W. McAleer et al.   Science Translational Medicine

Integrating Organs-on-Chips: Multiplexing, Scaling, Vascularization, and Innervation

(2019) DoYeun Park et al.   TRENDS IN BIOTECHNOLOGY

Patient-derived pancreas-on-a-chip to model cystic fibrosis-related disorders

(2019) Kyu Shik Mun et al.   Nature Communications

Human-gut-microbiome on a chip

(2019) Roberta Poceviciute et al.   Nature Biomedical Engineering

A human-on-a-chip approach to tackling rare diseases

(2019) Camilly P. Pires de Mello et al.   DRUG DISCOVERY TODAY

Merging organoid and organ-on-a-chip technology to generate complex multi-layer tissue models in a human retina-on-a-chip platform

(2019) Kevin Achberger et al.   eLife

A biomimetic pancreatic cancer on-chip reveals endothelial ablation via ALK7 signaling

(2019) Duc-Huy T. Nguyen et al.   Science Advances

An isogenic hiPSC-derived BBB-on-a-chip

(2019) Pedram Motallebnejad et al.   Biomicrofluidics

Reproducing human and cross-species drug toxicities using a Liver-Chip

(2019) Kyung-Jin Jang et al.   Science Translational Medicine

Mussel-inspired 3D fiber scaffolds for heart-on-a-chip toxicity studies of engineered nanomaterials

(2018) Seungkuk Ahn et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Physiologically Based Pharmacokinetic and Pharmacodynamic Analysis Enabled by Microfluidically Linked Organs-on-Chips

(2018) Rachelle Prantil-Baun et al.   Annual Review of Pharmacology and Toxicology

A nephron model for study of drug-induced acute kidney injury and assessment of drug-induced nephrotoxicity

(2018) Yueyang Qu et al.   BIOMATERIALS

Hacking macrophage-associated immunosuppression for regulating glioblastoma angiogenesis

(2018) Xin Cui et al.   BIOMATERIALS

Maximizing the impact of microphysiological systems with in vitro–in vivo translation

(2018) Murat Cirit et al.   LAB ON A CHIP

Understanding the tumor immune microenvironment (TIME) for effective therapy

(2018) Mikhail Binnewies et al.   NATURE MEDICINE

Human bone perivascular niche-on-a-chip for studying metastatic colonization

(2018) Alessandro Marturano-Kruik et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Spontaneous 3D Bone-On-a-Chip for Bone Metastasis Study of Breast Cancer Cells

(2018) Sijie Hao et al.   Small

Fibrotic microtissue array to predict anti-fibrosis drug efficacy

(2018) Mohammadnabi Asmani et al.   Nature Communications

Contractile Work Contributes to Maturation of Energy Metabolism in hiPSC-Derived Cardiomyocytes

(2018) Bärbel M. Ulmer et al.   Stem Cell Reports

A Biomimetic Human Gut-on-a-Chip for Modeling Drug Metabolism in Intestine

(2018) Yaqiong Guo et al.   ARTIFICIAL ORGANS

Three-dimensional (3D) tetra-culture brain on chip platform for organophosphate toxicity screening

(2018) Youngmi Koo et al.   Scientific Reports

Advances in organ-on-a-chip engineering

(2018) Boyang Zhang et al.   Nature Reviews Materials

Recent Advances in Body-on-a-Chip Systems

(2018) Jong Hwan Sung et al.   ANALYTICAL CHEMISTRY

Towards the development of human immune-system-on-a-chip platforms

(2018) Alessandro Polini et al.   DRUG DISCOVERY TODAY

A 3D human placenta-on-a-chip model to probe nanoparticle exposure at the placental barrier

(2018) Fangchao Yin et al.   TOXICOLOGY IN VITRO

Toward improved myocardial maturity in an organ-on-chip platform with immature cardiac myocytes

(2017) Sean P Sheehy et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Organ-on-a-chip devices advance to market

(2017) Boyang Zhang et al.   LAB ON A CHIP

Drug development in the era of precision medicine

(2017) Sarah A. Dugger et al.   NATURE REVIEWS DRUG DISCOVERY

Multisensor-integrated organs-on-chips platform for automated and continual in situ monitoring of organoid behaviors

(2017) Yu Shrike Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ex Vivo Profiling of PD-1 Blockade Using Organotypic Tumor Spheroids

(2017) Russell W. Jenkins et al.   Cancer Discovery

Human Organ Chip Models Recapitulate Orthotopic Lung Cancer Growth, Therapeutic Responses, and Tumor Dormancy In Vitro

(2017) Bryan A. Hassell et al.   Cell Reports

Mature induced-pluripotent-stem-cell-derived human podocytes reconstitute kidney glomerular-capillary-wall function on a chip

(2017) Samira Musah et al.   Nature Biomedical Engineering

Design and Construction of a Multi-Organ Microfluidic Chip Mimicking the in vivo Microenvironment of Lung Cancer Metastasis

(2016) Zhiyun Xu et al.   ACS Applied Materials & Interfaces

On-Chip Construction of Liver Lobule-like Microtissue and Its Application for Adverse Drug Reaction Assay

(2016) Chao Ma et al.   ANALYTICAL CHEMISTRY

Bioprinting 3D microfibrous scaffolds for engineering endothelialized myocardium and heart-on-a-chip

(2016) Yu Shrike Zhang et al.   BIOMATERIALS

Design and demonstration of a pumpless 14 compartment microphysiological system

(2016) Paula G. Miller et al.   BIOTECHNOLOGY AND BIOENGINEERING

Pneumatic-aided micro-molding for flexible fabrication of homogeneous and heterogeneous cell-laden microgels

(2016) Chao Ma et al.   LAB ON A CHIP

Beating heart on a chip: a novel microfluidic platform to generate functional 3D cardiac microtissues

(2016) Anna Marsano et al.   LAB ON A CHIP

A microphysiological model of the human placental barrier

(2016) Cassidy Blundell et al.   LAB ON A CHIP

Instrumented cardiac microphysiological devices via multimaterial three-dimensional printing

(2016) Johan U. Lind et al.   NATURE MATERIALS

Modeling Hematopoiesis and Responses to Radiation Countermeasures in a Bone Marrow-on-a-Chip

(2016) Yu-suke Torisawa et al.   TISSUE ENGINEERING PART C-METHODS

Identification of Drug–Drug InteractionsIn Vitro: A Case Study Evaluating the Effects of Sofosbuvir and Amiodarone on hiPSC-Derived Cardiomyocytes

(2016) Daniel C. Millard et al.   TOXICOLOGICAL SCIENCES

High-Throughput Assessment of Drug Cardiac Safety Using a High-Speed Impedance Detection Technology-Based Heart-on-a-Chip

(2016) Xi Zhang et al.   Micromachines

Tissue chips to aid drug development and modeling for rare diseases

(2016) Lucie A. Low et al.   Expert Opinion on Orphan Drugs

Matched-Comparative Modeling of Normal and Diseased Human Airway Responses Using a Microengineered Breathing Lung Chip

(2016) Kambez H. Benam et al.   Cell Systems

Modeling Barrier Tissues In Vitro: Methods, Achievements, and Challenges

(2016) Courtney M. Sakolish et al.   EBioMedicine

Facilitating the commercialization and use of organ platforms generated by the microphysiological systems (Tissue Chip) program through public–private partnerships

(2016) Christine A. Livingston et al.   Computational and Structural Biotechnology Journal

Preclinical Mouse Cancer Models: A Maze of Opportunities and Challenges

(2015) Chi-Ping Day et al.   CELL

Human-on-a-chip design strategies and principles for physiologically based pharmacokinetics/pharmacodynamics modeling

(2015) Hasan Erbil Abaci et al.   Integrative Biology

A four-organ-chip for interconnected long-term co-culture of human intestine, liver, skin and kidney equivalents

(2015) Ilka Maschmeyer et al.   LAB ON A CHIP

Small airway-on-a-chip enables analysis of human lung inflammation and drug responses in vitro

(2015) Kambez H Benam et al.   NATURE METHODS

Organs-on-chips at the frontiers of drug discovery

(2015) Eric W. Esch et al.   NATURE REVIEWS DRUG DISCOVERY

Central Nervous System and its Disease Models on a Chip

(2015) YoonYoung Yi et al.   TRENDS IN BIOTECHNOLOGY

Human iPSC-based Cardiac Microphysiological System For Drug Screening Applications

(2015) Anurag Mathur et al.   Scientific Reports

Microfluidic organs-on-chips

(2014) Sangeeta N Bhatia et al.   NATURE BIOTECHNOLOGY

Lessons learned from the fate of AstraZeneca's drug pipeline: a five-dimensional framework

(2014) David Cook et al.   NATURE REVIEWS DRUG DISCOVERY

Engineering a 3D vascular network in hydrogel for mimicking a nephron

(2013) Xuan Mu et al.   LAB ON A CHIP

Deconstructing the Drug Development Process: The New Face of Innovation

(2010) K I Kaitin   CLINICAL PHARMACOLOGY & THERAPEUTICS

A microfluidic device for a pharmacokinetic–pharmacodynamic (PK–PD) model on a chip

(2010) Jong Hwan Sung et al.   LAB ON A CHIP

Reconstituting Organ-Level Lung Functions on a Chip

(2010) D. Huh et al.   SCIENCE

Towards a human-on-chip: Culturing multiple cell types on a chip with compartmentalized microenvironments

(2009) Chi Zhang et al.   LAB ON A CHIP

A micro cell culture analog (µCCA) with 3-D hydrogel culture of multiple cell lines to assess metabolism-dependent cytotoxicity of anti-cancer drugs

(2009) Jong Hwan Sung et al.   LAB ON A CHIP