Microfluidic-Based 3D Engineered Microvascular Networks and Their Applications in Vascularized Microtumor Models

Use of porous membranes in tissue barrier and co-culture models

(2018) Henry H. Chung et al.   LAB ON A CHIP

Flat and microstructured polymeric membranes in organs-on-chips

(2018) Thijs Pasman et al.   Journal of the Royal Society Interface

A vascularized and perfused organ-on-a-chip platform for large-scale drug screening applications

(2017) Duc T. T. Phan et al.   LAB ON A CHIP

Vascular heterogeneity and specialization in development and disease

(2017) Michael Potente et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Tumor cell intravasation

(2016) Serena P. H. Chiang et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Engineered Microvessels for the Study of Human Disease

(2016) Samuel G. Rayner et al.   JOURNAL OF BIOMECHANICAL ENGINEERING-TRANSACTIONS OF THE ASME

Quantification of angiogenic sprouting under different growth factors in a microfluidic platform

(2016) Cristina Del Amo et al.   JOURNAL OF BIOMECHANICS

Elastomeric free-form blood vessels for interconnecting organs on chip systems

(2016) Weijia Zhang et al.   LAB ON A CHIP

Interstitial flow regulates the angiogenic response and phenotype of endothelial cells in a 3D culture model

(2016) Sudong Kim et al.   LAB ON A CHIP

Implementing oxygen control in chip-based cell and tissue culture systems

(2016) Pieter E. Oomen et al.   LAB ON A CHIP

Engineering anastomosis between living capillary networks and endothelial cell-lined microfluidic channels

(2016) Xiaolin Wang et al.   LAB ON A CHIP

Biodegradable scaffold with built-in vasculature for organ-on-a-chip engineering and direct surgical anastomosis

(2016) Boyang Zhang et al.   NATURE MATERIALS

Morphogenesis of 3D vascular networks is regulated by tensile forces

(2016) Dekel Rosenfeld et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Distinct Contributions of Astrocytes and Pericytes to Neuroinflammation Identified in a 3D Human Blood-Brain Barrier on a Chip

(2016) Anna Herland et al.   PLoS One

A Reversibly Sealed, Easy Access, Modular (SEAM) Microfluidic Architecture to Establish In Vitro Tissue Interfaces

(2016) Vinay V. Abhyankar et al.   PLoS One

Intrinsic FGF2 and FGF5 promotes angiogenesis of human aortic endothelial cells in 3D microfluidic angiogenesis system

(2016) Ha-Rim Seo et al.   Scientific Reports

3D microtumors in vitro supported by perfused vascular networks

(2016) Agua Sobrino et al.   Scientific Reports

3D culture broadly regulates tumor cell hypoxia response and angiogenesis via pro-inflammatory pathways

(2015) Peter DelNero et al.   BIOMATERIALS

Recreating blood-brain barrier physiology and structure on chip: A novel neurovascular microfluidic bioreactor

(2015) Jacquelyn A. Brown et al.   Biomicrofluidics

Advantages and challenges of microfluidic cell culture in polydimethylsiloxane devices

(2015) Skarphedinn Halldorsson et al.   BIOSENSORS & BIOELECTRONICS

Long-term maintenance of a microfluidic 3D human liver sinusoid

(2015) Ljupcho Prodanov et al.   BIOTECHNOLOGY AND BIOENGINEERING

Organs-on-chips at the frontiers of drug discovery

(2015) Eric W. Esch et al.   NATURE REVIEWS DRUG DISCOVERY

In Vitro Recapitulation of Functional Microvessels for the Study of Endothelial Shear Response, Nitric Oxide and [Ca2+]i

(2015) Xiang Li et al.   PLoS One

Engineering of a Biomimetic Pericyte-Covered 3D Microvascular Network

(2015) Jaerim Kim et al.   PLoS One

3D Bioprinting of Vascularized, Heterogeneous Cell-Laden Tissue Constructs

(2014) David B. Kolesky et al.   ADVANCED MATERIALS

Microfluidic techniques for development of 3D vascularized tissue

(2014) Anwarul Hasan et al.   BIOMATERIALS

A microfluidic platform for quantitative analysis of cancer angiogenesis and intravasation

(2014) Hyunjae Lee et al.   Biomicrofluidics

Implantable microfluidic device for the formation of three-dimensional vasculature by human endothelial progenitor cells

(2014) Jin Kim et al.   BIOTECHNOLOGY AND BIOPROCESS ENGINEERING

Live-Cell Imaging of Invasion and Intravasation in an Artificial Microvessel Platform

(2014) Andrew D. Wong et al.   CANCER RESEARCH

Multiple endothelial cells constitute the tip of developing blood vessels and polarize to promote lumen formation

(2014) J. C. Pelton et al.   DEVELOPMENT

A three-dimensional in vitro model of tumor cell intravasation

(2014) Seema M. Ehsan et al.   Integrative Biology

Generation of 3D functional microvascular networks with human mesenchymal stem cells in microfluidic systems

(2014) Jessie S. Jeon et al.   Integrative Biology

A multidisciplinary study usingin vivotumor models and microfluidic cell-on-chip approach to explore the cross-talk between cancer and immune cells

(2014) Fabrizio Mattei et al.   Journal of Immunotoxicology

Engineering interconnected 3D vascular networks in hydrogels using molded sodium alginate lattice as the sacrificial template

(2014) Xue-Ying Wang et al.   LAB ON A CHIP

Oxygen control with microfluidics

(2014) Martin D. Brennan et al.   LAB ON A CHIP

Hydrogel bioprinted microchannel networks for vascularization of tissue engineering constructs

(2014) Luiz E. Bertassoni et al.   LAB ON A CHIP

A polydimethylsiloxane–polycarbonate hybrid microfluidic device capable of generating perpendicular chemical and oxygen gradients for cell culture studies

(2014) Chia-Wen Chang et al.   LAB ON A CHIP

Microfluidic organs-on-chips

(2014) Sangeeta N Bhatia et al.   NATURE BIOTECHNOLOGY

Fluid shear stress threshold regulates angiogenic sprouting

(2014) P. A. Galie et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Human 3D vascularized organotypic microfluidic assays to study breast cancer cell extravasation

(2014) Jessie S. Jeon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Flow shear stress regulates endothelial barrier function and expression of angiogenic factors in a 3D microfluidic tumor vascular model

(2014) Cara F Buchanan et al.   Cell Adhesion & Migration

Recapitulating physiological and pathological shear stress and oxygen to model vasculature in health and disease

(2014) Hasan Erbil Abaci et al.   Scientific Reports

Application of a microfluidic chip-based 3D co-culture to test drug sensitivity for individualized treatment of lung cancer

(2013) Zhiyun Xu et al.   BIOMATERIALS

Differential arrest and adhesion of tumor cells and microbeads in the microvasculature

(2013) Peng Guo et al.   Biomechanics and Modeling in Mechanobiology

Blood flow and arterial endothelial dysfunction: Mechanisms and implications

(2013) Abdul I. Barakat   COMPTES RENDUS PHYSIQUE

Human kidney proximal tubule-on-a-chip for drug transport and nephrotoxicity assessment

(2013) Kyung-Jin Jang et al.   Integrative Biology

Mechanisms of tumor cell extravasation in an in vitro microvascular network platform

(2013) Michelle B. Chen et al.   Integrative Biology

Complementary effects of ciclopirox olamine, a prolyl hydroxylase inhibitor and sphingosine 1-phosphate on fibroblasts and endothelial cells in driving capillary sprouting

(2013) Sei Hien Lim et al.   Integrative Biology

Quantification of Blood-Brain Barrier Solute Permeability and Brain Transport by Multiphoton Microscopy

(2013) Lingyan Shi et al.   JOURNAL OF BIOMECHANICAL ENGINEERING-TRANSACTIONS OF THE ASME

A systems biology view of blood vessel growth and remodelling

(2013) Elizabeth A. Logsdon et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

A microfluidic platform for generating large-scale nearly identical human microphysiological vascularized tissue arrays

(2013) Yu-Hsiang Hsu et al.   LAB ON A CHIP

Microfluidics embedded within extracellular matrix to define vascular architectures and pattern diffusive gradients

(2013) Brendon M. Baker et al.   LAB ON A CHIP

Three-dimensional co-cultures of human endothelial cells and embryonic stem cell-derived pericytes inside a microfluidic device

(2013) Andries D. van der Meer et al.   LAB ON A CHIP

Engineering of functional, perfusable 3D microvascular networks on a chip

(2013) Sudong Kim et al.   LAB ON A CHIP

Microfabrication of human organs-on-chips

(2013) Dongeun Huh et al.   Nature Protocols

Biomimetic model to reconstitute angiogenic sprouting morphogenesis in vitro

(2013) D.-H. T. Nguyen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Generation of functionally competent and durable engineered blood vessels from human induced pluripotent stem cells

(2013) R. Samuel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

In Vitro Perfused Human Capillary Networks

(2013) Monica L. Moya et al.   TISSUE ENGINEERING PART C-METHODS

Control of Perfusable Microvascular Network Morphology Using a Multiculture Microfluidic System

(2013) Jordan A. Whisler et al.   TISSUE ENGINEERING PART C-METHODS

Three-Dimensional Microfluidic Collagen Hydrogels for Investigating Flow-Mediated Tumor-Endothelial Signaling and Vascular Organization

(2013) Cara F. Buchanan et al.   TISSUE ENGINEERING PART C-METHODS

Innovations in preclinical biology: ex vivo engineering of a human kidney tissue microperfusion system

(2013) Edward J Kelly et al.   Stem Cell Research & Therapy

Impact of Endothelial Cells on 3D Cultured Smooth Muscle Cells in a Biomimetic Hydrogel

(2012) Yunxiao Liu et al.   ACS Applied Materials & Interfaces

Multilayered Blood Capillary Analogs in Biodegradable Hydrogels for In Vitro Drug Permeability Assays

(2012) Hiroaki Yoshida et al.   ADVANCED FUNCTIONAL MATERIALS

Comparison of Biocompatibility and Adsorption Properties of Different Plastics for Advanced Microfluidic Cell and Tissue Culture Models

(2012) Paul M. van Midwoud et al.   ANALYTICAL CHEMISTRY

Biophysical control of invasive tumor cell behavior by extracellular matrix microarchitecture

(2012) Shawn P. Carey et al.   BIOMATERIALS

Tubeless microfluidic angiogenesis assay with three-dimensional endothelial-lined microvessels

(2012) Lauren L. Bischel et al.   BIOMATERIALS

Stem cell-derived endothelial cells for cardiovascular disease: a therapeutic perspective

(2012) Daniel M. Reed et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Anastomosis of endothelial sprouts forms new vessels in a tissue analogue of angiogenesis

(2012) Jonathan W. Song et al.   Integrative Biology

Mechanism of a flow-gated angiogenesis switch: early signaling events at cell–matrix and cell–cell junctions

(2012) Vernella Vickerman et al.   Integrative Biology

Collagen-nanofiber hydrogel composites promote contact guidance of human lymphatic microvascular endothelial cells and directed capillary tube formation

(2012) Filip Laco et al.   JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A

Artificial lymphatic drainage systems for vascularized microfluidic scaffolds

(2012) Keith H. K. Wong et al.   JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A

In vitro formation and characterization of a perfusable three-dimensional tubular capillary network in microfluidic devices

(2012) Ju Hun Yeon et al.   LAB ON A CHIP

Characterization of a microfluidic in vitro model of the blood-brain barrier (μBBB)

(2012) Ross Booth et al.   LAB ON A CHIP

Human gut-on-a-chip inhabited by microbial flora that experiences intestinal peristalsis-like motions and flow

(2012) Hyun Jung Kim et al.   LAB ON A CHIP

Full range physiological mass transport control in 3D tissue cultures

(2012) Yu-Hsiang Hsu et al.   LAB ON A CHIP

Rapid casting of patterned vascular networks for perfusable engineered three-dimensional tissues

(2012) Jordan S. Miller et al.   NATURE MATERIALS

Perivascular-Like Cells Contribute to the Stability of the Vascular Network of Osteogenic Tissue Formed from Cell Sheet-Based Constructs

(2012) Luís F. Mendes et al.   PLoS One

In vitro microvessels for the study of angiogenesis and thrombosis

(2012) Y. Zheng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Three-dimensional microfluidic model for tumor cell intravasation and endothelial barrier function

(2012) I. K. Zervantonakis et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Sprouting Angiogenesis under a Chemical Gradient Regulated by Interactions with an Endothelial Monolayer in a Microfluidic Platform

(2011) Gi Seok Jeong et al.   ANALYTICAL CHEMISTRY

SAM-based cell transfer to photopatterned hydrogels for microengineering vascular-like structures

(2011) Nasser Sadr et al.   BIOMATERIALS

A novel in vitro angiogenesis model based on a microfluidic device

(2011) XiaoZhen Dai et al.   CHINESE SCIENCE BULLETIN

Patterning cells and shear flow conditions: Convenient observation of endothelial cell remoulding, enhanced production of angiogenesis factors and drug response

(2011) Li Wang et al.   LAB ON A CHIP

In vitro 3D collective sprouting angiogenesis under orchestrated ANG-1 and VEGF gradients

(2011) Yoojin Shin et al.   LAB ON A CHIP

The requirement for fibroblasts in angiogenesis: fibroblast-derived matrix proteins are essential for endothelial cell lumen formation

(2011) Andrew C. Newman et al.   MOLECULAR BIOLOGY OF THE CELL

Tumor angiogenesis: molecular pathways and therapeutic targets

(2011) Sara M Weis et al.   NATURE MEDICINE

Molecular control of endothelial cell behaviour during blood vessel morphogenesis

(2011) Shane P. Herbert et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Interstitial flow influences direction of tumor cell migration through competing mechanisms

(2011) W. J. Polacheck et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Fluid forces control endothelial sprouting

(2011) J. W. Song et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Perspective on Cancer Cell Metastasis

(2011) C. L. Chaffer et al.   SCIENCE

Characterization of In Vitro Endothelial Linings Grown Within Microfluidic Channels

(2011) Mandy B. Esch et al.   TISSUE ENGINEERING PART A

Microvascular Mural Cell Functionality of Human Embryonic Stem Cell-Derived Mesenchymal Cells

(2011) Nolan L. Boyd et al.   TISSUE ENGINEERING PART A

Cell Migration and Invasion Assays as Tools for Drug Discovery

(2011) Keren I. Hulkower et al.   Pharmaceutics

Technique for Real-Time Measurements of Endothelial Permeability in a Microfluidic Membrane Chip Using Laser-Induced Fluorescence Detection

(2010) Edmond W. K. Young et al.   ANALYTICAL CHEMISTRY

Effect of mechanical factors on the function of engineered human blood microvessels in microfluidic collagen gels

(2010) Gavrielle M. Price et al.   BIOMATERIALS

A circular cross-section PDMS microfluidics system for replication of cardiovascular flow conditions

(2010) Lindsey K. Fiddes et al.   BIOMATERIALS

Endothelial cell behaviour within a microfluidic mimic of the flow channels of a modular tissue engineered construct

(2010) Omar F. Khan et al.   BIOMEDICAL MICRODEVICES

Visualizing extravasation dynamics of metastatic tumor cells

(2010) K. Stoletov et al.   JOURNAL OF CELL SCIENCE

A fast and simple method to fabricate circular microchannels in polydimethylsiloxane (PDMS)

(2010) Mohamed Abdelgawad et al.   LAB ON A CHIP

Tumor Microvasculature and Microenvironment: Novel Insights Through Intravital Imaging in Pre-Clinical Models

(2010) DAI FUKUMURA et al.   MICROCIRCULATION

Reconstituting Organ-Level Lung Functions on a Chip

(2010) D. Huh et al.   SCIENCE

Geometrically Controlled Endothelial Tubulogenesis in Micropatterned Gels

(2010) Srivatsan Raghavan et al.   TISSUE ENGINEERING PART A

Hard Top Soft Bottom Microfluidic Devices for Cell Culture and Chemical Analysis

(2009) Geeta Mehta et al.   ANALYTICAL CHEMISTRY

Effects of VEGF temporal and spatial presentation on angiogenesis

(2009) Eduardo A. Silva et al.   BIOMATERIALS

Spheroid-based drug screen: considerations and practical approach

(2009) Juergen Friedrich et al.   Nature Protocols

Cell migration into scaffolds under co-culture conditions in a microfluidic platform

(2008) Seok Chung et al.   LAB ON A CHIP

Non-invasive measurement of solute permeability in cerebral microvessels of the rat

(2008) Wei Yuan et al.   MICROVASCULAR RESEARCH

The Effect of Matrix Density on the Regulation of 3-D Capillary Morphogenesis

(2007) Cyrus M. Ghajar et al.   BIOPHYSICAL JOURNAL