Physiologically Based Pharmacokinetic Models Are Effective Support for Pediatric Drug Development
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Title
Physiologically Based Pharmacokinetic Models Are Effective Support for Pediatric Drug Development
Authors
Keywords
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Journal
AAPS PHARMSCITECH
Volume 22, Issue 6, Pages -
Publisher
Springer Science and Business Media LLC
Online
2021-07-27
DOI
10.1208/s12249-021-02076-w
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Note: Only part of the references are listed.- Physiologically‐Based Pharmacokinetic Modeling of Remdesivir and Its Metabolites to Support Dose Selection for the Treatment of Pediatric Patients With COVID‐19
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- The Predictive Value of Glomerular Filtration Rate-Based Scaling of Pediatric Clearance and Doses for Drugs Eliminated by Glomerular Filtration with Varying Protein-Binding Properties
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- Physiologically‐Based Pharmacokinetic Modeling Characterizes the CYP3A‐Mediated Drug‐Drug Interaction Between Fluconazole and Sildenafil in Infants
- (2020) Sara N. Salerno et al. CLINICAL PHARMACOLOGY & THERAPEUTICS
- Pediatric Pharmacokinetics and Dose Predictions: A Report of a Satellite Meeting to the 10th Juvenile Toxicity Symposium
- (2020) Bianca D. Groen et al. CTS-Clinical and Translational Science
- A Physiologically Based Pharmacokinetic Model of Ertapenem in Pediatric Patients with Renal Impairment
- (2020) Lingling Ye et al. JOURNAL OF PHARMACEUTICAL SCIENCES
- Prediction of lisinopril pediatric dose from the reference adult dose by employing a physiologically based pharmacokinetic model
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- Estimating human ADME properties, pharmacokinetic parameters and likely clinical dose in drug discovery
- (2019) Adam J. Lucas et al. Expert Opinion on Drug Discovery
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- (2019) Youwei Bi et al. JOURNAL OF CLINICAL PHARMACOLOGY
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- Developmental Pharmacodynamics and Modeling in Pediatric Drug Development
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- Integration of Ontogeny Into a Physiologically Based Pharmacokinetic Model for Monoclonal Antibodies in Premature Infants
- (2019) Paul R. V. Malik et al. JOURNAL OF CLINICAL PHARMACOLOGY
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- (2016) Elisa A. M. Calvier et al. CLINICAL PHARMACOKINETICS
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- (2016) B Prasad et al. CLINICAL PHARMACOLOGY & THERAPEUTICS
- Pharmacometric Approaches to Personalize Use of Primarily Renally Eliminated Antibiotics in Preterm and Term Neonates
- (2016) Mélanie Wilbaux et al. JOURNAL OF CLINICAL PHARMACOLOGY
- Prediction of Clearance in Neonates and Infants (≤ 3 Months of Age) for Drugs That Are Glucuronidated: A Comparative Study Between Allometric Scaling and Physiologically Based Pharmacokinetic Modeling
- (2016) Iftekhar Mahmood et al. JOURNAL OF CLINICAL PHARMACOLOGY
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- (2016) Geoffrey T Tucker PHARMACEUTICAL RESEARCH
- Meta-analysis of hepatic cytochrome P450 ontogeny to underwrite the prediction of pediatric pharmacokinetics using physiologically based pharmacokinetic modeling
- (2015) Vijay V. Upreti et al. JOURNAL OF CLINICAL PHARMACOLOGY
- A Systematic Evaluation of the Use of Physiologically Based Pharmacokinetic Modeling for Cross-Species Extrapolation
- (2015) Christoph Thiel et al. JOURNAL OF PHARMACEUTICAL SCIENCES
- Albumin and Uptake of Drugs in Cells: Additional Validation Exercises of a Recently Published Equation that Quantifies the Albumin-Facilitated Uptake Mechanism(s) in Physiologically Based Pharmacokinetic and Pharmacodynamic Modeling Research
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- Prediction of Drug Clearance in Children: an Evaluation of the Predictive Performance of Several Models
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- (2014) Khaled Abduljalil et al. AAPS Journal
- A Re-evaluation and Validation of Ontogeny Functions for Cytochrome P450 1A2 and 3A4 Based on In Vivo Data
- (2014) Farzaneh Salem et al. CLINICAL PHARMACOKINETICS
- First Dose in Neonates: Are Juvenile Mice, Adults and In Vitro–In Silico Data Predictive of Neonatal Pharmacokinetics of Fluconazole
- (2014) Wei Zhao et al. CLINICAL PHARMACOKINETICS
- A Physiologically Based Pharmacokinetic Model for Voriconazole Disposition Predicts Intestinal First-pass Metabolism in Children
- (2014) Nicole R. Zane et al. CLINICAL PHARMACOKINETICS
- Physiologically based pharmacokinetic modeling of CYP3A4 induction by rifampicin in human: Influence of time between substrate and inducer administration
- (2014) Guillaume Baneyx et al. EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
- Predicting carrier-mediated hepatic disposition of rosuvastatin in man by scaling from individual transfected cell-lines in vitro using absolute transporter protein quantification and PBPK modeling
- (2014) Sieto Bosgra et al. EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
- Drug Labeling and Exposure in Neonates
- (2013) Matthew M. Laughon et al. JAMA Pediatrics
- Physiologically Based Pharmacokinetics Joined With In Vitro–In Vivo Extrapolation of ADME: A Marriage Under the Arch of Systems Pharmacology
- (2012) A Rostami-Hodjegan CLINICAL PHARMACOLOGY & THERAPEUTICS
- Neonatal and Pediatric Clinical Pharmacology
- (2012) John N. van den Anker et al. PEDIATRIC CLINICS OF NORTH AMERICA
- Modelling and simulation as research tools in paediatric drug development
- (2011) Francesco Bellanti et al. EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY
- Factors and Mechanisms for Pharmacokinetic Differences between Pediatric Population and Adults
- (2011) Eva Fernandez et al. Pharmaceutics
- Interspecies Scaling for the Prediction of Drug Clearance in Children
- (2010) Iftekhar Mahmood CLINICAL PHARMACOKINETICS
- The Need for Modeling and Simulation to Design Clinical Investigations in Children
- (2010) Pravin R. Jadhav et al. JOURNAL OF CLINICAL PHARMACOLOGY
- Resurgence in the use of physiologically based pharmacokinetic models in pediatric clinical pharmacology: parallel shift in incorporating the knowledge of biological elements and increased applicability to drug development and clinical practice
- (2010) Trevor N. Johnson et al. PEDIATRIC ANESTHESIA
- Population-Based Mechanistic Prediction of Oral Drug Absorption
- (2009) Masoud Jamei et al. AAPS Journal
- A Framework for Assessing Inter-individual Variability in Pharmacokinetics Using Virtual Human Populations and Integrating General Knowledge of Physical Chemistry, Biology, Anatomy, Physiology and Genetics: A Tale of ‘Bottom-Up’ vs ‘Top-Down’ Recognition of Covariates
- (2009) Masoud Jamei et al. Drug Metabolism and Pharmacokinetics
- Developmental Changes in Human Liver CYP2D6 Expression
- (2008) J. C. Stevens et al. DRUG METABOLISM AND DISPOSITION
- The problems in scaling adult drug doses to children
- (2007) T N Johnson ARCHIVES OF DISEASE IN CHILDHOOD
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