Impact of Hepatic CYP3A4 Ontogeny Functions on Drug–Drug Interaction Risk in Pediatric Physiologically‐Based Pharmacokinetic/Pharmacodynamic Modeling: Critical Literature Review and Ivabradine Case Study

Implementation of a Physiologically Based Pharmacokinetic Modeling Approach to Guide Optimal Dosing Regimens for Imatinib and Potential Drug Interactions in Paediatrics

(2020) Jeffry Adiwidjaja et al.   Frontiers in Pharmacology

The Influence of Drug Properties and Ontogeny of Transporters on Pediatric Renal Clearance through Glomerular Filtration and Active Secretion: a Simulation-Based Study

(2020) Sînziana Cristea et al.   AAPS Journal

Simultaneous Ivabradine Parent-Metabolite PBPK/PD Modelling Using a Bayesian Estimation Method

(2020) Jennifer Lang et al.   AAPS Journal

Pediatric Dose Selection and Utility of PBPK in Determining Dose

(2018) Ian E. Templeton et al.   AAPS Journal

Physiologically Based Pharmacokinetic Model Qualification and Reporting Procedures for Regulatory Submissions: A Consortium Perspective

(2018) Mohamad Shebley et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Development of a PBPK Model for Mefloquine and its Application alongside a Clinical Effectiveness Model to Select an Optimal Dose for Prevention of Malaria in Young Caucasian Children

(2018) Trevor N. Johnson et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Characterization of Intestinal and Hepatic CYP3A-Mediated Metabolism of Midazolam in Children Using a Physiological Population Pharmacokinetic Modelling Approach

(2018) Janneke M. Brussee et al.   PHARMACEUTICAL RESEARCH

Pediatric Drug-Drug Interaction Studies: Barriers and Opportunities

(2018) Sara N. Salerno et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Physiologically Based Pharmacokinetic Modeling in Regulatory Science: An Update From the U.S. Food and Drug Administration’s Office of Clinical Pharmacology

(2018) Manuela Grimstein et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Physiologically Based Pharmacokinetic Predictions of Tramadol Exposure Throughout Pediatric Life: an Analysis of the Different Clearance Contributors with Emphasis on CYP2D6 Maturation

(2015) Huybrecht T’jollyn et al.   AAPS Journal

Meta-analysis of hepatic cytochrome P450 ontogeny to underwrite the prediction of pediatric pharmacokinetics using physiologically based pharmacokinetic modeling

(2015) Vijay V. Upreti et al.   JOURNAL OF CLINICAL PHARMACOLOGY

Application of a Bayesian approach to physiological modelling of mavoglurant population pharmacokinetics

(2015) Thierry Wendling et al.   JOURNAL OF PHARMACOKINETICS AND PHARMACODYNAMICS

Model-based approaches for ivabradine development in paediatric population, part I: study preparation assessment

(2015) Sophie Peigné et al.   JOURNAL OF PHARMACOKINETICS AND PHARMACODYNAMICS

Model-based approaches for ivabradine development in paediatric population, part II: PK and PK/PD assessment

(2015) Sophie Peigné et al.   JOURNAL OF PHARMACOKINETICS AND PHARMACODYNAMICS

A Re-evaluation and Validation of Ontogeny Functions for Cytochrome P450 1A2 and 3A4 Based on In Vivo Data

(2014) Farzaneh Salem et al.   CLINICAL PHARMACOKINETICS

Predicting the Effect of Cytochrome P450 Inhibitors on Substrate Drugs: Analysis of Physiologically Based Pharmacokinetic Modeling Submissions to the US Food and Drug Administration

(2014) Christian Wagner et al.   CLINICAL PHARMACOKINETICS

A Physiologically Based Pharmacokinetic Model for Voriconazole Disposition Predicts Intestinal First-pass Metabolism in Children

(2014) Nicole R. Zane et al.   CLINICAL PHARMACOKINETICS

Development and Application of a Mechanistic Pharmacokinetic Model for Simvastatin and its Active Metabolite Simvastatin Acid Using an Integrated Population PBPK Approach

(2014) Nikolaos Tsamandouras et al.   PHARMACEUTICAL RESEARCH

Combining the ‘bottom up’ and ‘top down’ approaches in pharmacokinetic modelling: fitting PBPK models to observed clinical data

(2013) Nikolaos Tsamandouras et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Age Related Changes in Fractional Elimination Pathways for Drugs: Assessing the Impact of Variable Ontogeny on Metabolic Drug-Drug Interactions

(2013) Farzaneh Salem et al.   JOURNAL OF CLINICAL PHARMACOLOGY

Do Children Have the Same Vulnerability to Metabolic Drug-Drug Interactions as Adults? A Critical Analysis of the Literature

(2013) Farzaneh Salem et al.   JOURNAL OF CLINICAL PHARMACOLOGY

Physiologically Based Pharmacokinetic Modeling of Intestinal First-Pass Metabolism of CYP3A Substrates with High Intestinal Extraction

(2011) M. Gertz et al.   DRUG METABOLISM AND DISPOSITION

Proper lumping in systems biology models

(2009) A. Dokoumetzidis et al.   IET Systems Biology