First dose in neonates: pharmacokinetic bridging study from juvenile mice to neonates for drugs metabolized by CYP3A

Recently Registered Midazolam Doses for Preterm Neonates Do Not Lead to Equal Exposure: A Population Pharmacokinetic Model

(2019) Swantje Völler et al.   JOURNAL OF CLINICAL PHARMACOLOGY

Model qualification of the PK-Sim® pediatric module for pediatric exposure assessment of CYP450 metabolized compounds

(2019) Yejin Esther Yun et al.   JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A-CURRENT ISSUES

Pharmacokinetics of midazolam and its major metabolite 1‐hydroxymidazolam in the ball python ( Python regius ) after intracardiac and intramuscular administrations

(2019) Cédric B. Larouche et al.   JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS

Preterm Physiologically Based Pharmacokinetic Model. Part II: Applications of the Model to Predict Drug Pharmacokinetics in the Preterm Population

(2019) Khaled Abduljalil et al.   CLINICAL PHARMACOKINETICS

Extrapolation of Drug Clearance in Children ≤ 2 Years of Age from Empirical Models Using Data from Children (> 2 Years) and Adults

(2019) Iftekhar Mahmood   Drugs in research & development

Prediction of Human Pharmacokinetics of Ulixertinib, a Novel ERK1/2 Inhibitor from Mice, Rats, and Dogs Pharmacokinetics

(2018) Ponnayyan Sulochana Suresh et al.   EUROPEAN JOURNAL OF DRUG METABOLISM AND PHARMACOKINETICS

A Comparative Study Between Allometric Scaling and Physiologically Based Pharmacokinetic Modeling for the Prediction of Drug Clearance From Neonates to Adolescents

(2018) Iftekhar Mahmood et al.   JOURNAL OF CLINICAL PHARMACOLOGY

Immune and Metabolic Shifts During Neonatal Development Reprogram Liver Identity and Function

(2018) Brenda Naemi Nakagaki et al.   JOURNAL OF HEPATOLOGY

Clindamycin Pharmacokinetics and Safety in Preterm and Term Infants

(2016) Daniel Gonzalez et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Prediction of Clearance in Neonates and Infants (≤ 3 Months of Age) for Drugs That Are Glucuronidated: A Comparative Study Between Allometric Scaling and Physiologically Based Pharmacokinetic Modeling

(2016) Iftekhar Mahmood et al.   JOURNAL OF CLINICAL PHARMACOLOGY

Pharmacokinetics in neonatal prescribing: evidence base, paradigms and the future

(2015) Kate O'Hara et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Prediction of Antimalarial Drug Clearance in Children: A Comparison of Three Different Interspecies Scaling Methods

(2015) Iftekhar Mahmood et al.   EUROPEAN JOURNAL OF DRUG METABOLISM AND PHARMACOKINETICS

First Dose in Neonates: Are Juvenile Mice, Adults and In Vitro–In Silico Data Predictive of Neonatal Pharmacokinetics of Fluconazole

(2014) Wei Zhao et al.   CLINICAL PHARMACOKINETICS

Use of Opportunistic Clinical Data and a Population Pharmacokinetic Model to Support Dosing of Clindamycin for Premature Infants to Adolescents

(2014) D Gonzalez et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Predicting the “First dose in children” of CYP3A-metabolized drugs: Evaluation of scaling approaches and insights into the CYP3A7-CYP3A4 switch at young ages

(2014) Ashley Strougo et al.   JOURNAL OF CLINICAL PHARMACOLOGY

Pharmacokinetics and pharmacodynamics of midazolam after intravenous and intramuscular administration in alpacas

(2013) Turi K. Aarnes et al.   AMERICAN JOURNAL OF VETERINARY RESEARCH

Population pharmacokinetics of clindamycin orally and intravenously administered in patients with osteomyelitis

(2012) Naïm Bouazza et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Approaches for predicting human pharmacokinetics using interspecies pharmacokinetic scaling

(2011) Hee Eun Kang et al.   ARCHIVES OF PHARMACAL RESEARCH

Towards a Better Prediction of Peak Concentration, Volume of Distribution and Half-Life after Oral Drug Administration in Man, Using Allometry

(2011) Vikash K. Sinha et al.   CLINICAL PHARMACOKINETICS

Interspecies Scaling for the Prediction of Drug Clearance in Children

(2010) Iftekhar Mahmood   CLINICAL PHARMACOKINETICS

A Model-Based Approach to Dose Selection in Early Pediatric Development

(2010) M Cella et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

The role of population PK–PD modelling in paediatric clinical research

(2010) Roosmarijn F. W. De Cock et al.   EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY

A maturation model for midazolam clearance

(2010) Brian J. Anderson et al.   PEDIATRIC ANESTHESIA

What is the right dose for children?

(2009) Massimo Cella et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Predicting Oral Clearance in Humans

(2009) Vikash K Sinha et al.   CLINICAL PHARMACOKINETICS

Pharmacokinetic Allometric Scaling of Antibodies: Application to the First-In-Human Dose Estimation

(2009) Iftekhar Mahmood   JOURNAL OF PHARMACEUTICAL SCIENCES

Computing normalised prediction distribution errors to evaluate nonlinear mixed-effect models: The npde add-on package for R

(2008) Emmanuelle Comets et al.   COMPUTER METHODS AND PROGRAMS IN BIOMEDICINE

Human renal function maturation: a quantitative description using weight and postmenstrual age

(2008) Malin M. Rhodin et al.   PEDIATRIC NEPHROLOGY

A Systematic Review of Studies That Aim to Determine Which Outcomes to Measure in Clinical Trials in Children

(2008) Ian Sinha et al.   PLOS MEDICINE

Children Are Not Just Small Adults: The Urgent Need for High-Quality Trial Evidence in Children

(2008) Terry P Klassen et al.   PLOS MEDICINE