Physiologically-Based Pharmacokinetic (PBPK) Modeling of Buprenorphine in Adults, Children and Preterm Neonates

Responses among substance abuse treatment providers to the opioid epidemic in the USA: Variations in buprenorphine and methadone treatment by geography, operational, and payment characteristics, 2007-16

(2020) Justin C. Yang et al.   PLoS One

Comprehensive Parent–Metabolite PBPK/PD Modeling Insights into Nicotine Replacement Therapy Strategies

(2020) Lukas Kovar et al.   CLINICAL PHARMACOKINETICS

Buprenorphine Overdose in Young Children: An Underappreciated Risk

(2019) Meike Lo Re et al.   CLINICAL PEDIATRICS

Predictive Pediatric Modeling and Simulation Using Ontogeny Information

(2019) Ibrahim Ince et al.   JOURNAL OF CLINICAL PHARMACOLOGY

Prediction of Drug–Drug Interactions Between Opioids and Overdosed Benzodiazepines Using Physiologically Based Pharmacokinetic (PBPK) Modeling and Simulation

(2019) Beihong Ji et al.   Drugs in research & development

Pediatric Dose Selection and Utility of PBPK in Determining Dose

(2018) Ian E. Templeton et al.   AAPS Journal

Gestational changes in buprenorphine exposure: A physiologically-based pharmacokinetic analysis

(2018) Hongfei Zhang et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Norbuprenorphine and respiratory depression: Exploratory analyses with new lyophilized buprenorphine and sublingual buprenorphine


(2018) John Strang et al.   INTERNATIONAL JOURNAL OF CLINICAL PHARMACOLOGY AND THERAPEUTICS

Buprenorphine Exposures Among Children and Adolescents Reported to US Poison Control Centers

(2018) Sara Post et al.   PEDIATRICS

Buprenorphine and pain treatment in pediatric patients: an update

(2018) Erendira Vicencio-Rosas et al.   Journal of Pain Research

Voriconazole greatly increases the exposure to oral buprenorphine

(2018) Mari Fihlman et al.   EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY

A Comparative Study Between Allometric Scaling and Physiologically Based Pharmacokinetic Modeling for the Prediction of Drug Clearance From Neonates to Adolescents

(2018) Iftekhar Mahmood et al.   JOURNAL OF CLINICAL PHARMACOLOGY

HMDB 4.0: the human metabolome database for 2018

(2017) David S Wishart et al.   NUCLEIC ACIDS RESEARCH

Advances in the delivery of buprenorphine for opioid dependence

(2017) Richard Rosenthal et al.   Drug Design Development and Therapy

Physiologically Based Pharmacokinetic Prediction of Linezolid and Emtricitabine in Neonates and Infants

(2016) Peng Duan et al.   CLINICAL PHARMACOKINETICS

Evaluation of the Pharmacokinetics of Single- and Multiple-dose Buprenorphine Buccal Film in Healthy Volunteers

(2016) Stephen A. Bai et al.   CLINICAL THERAPEUTICS

Voriconazole more likely than posaconazole increases plasma exposure to sublingual buprenorphine causing a risk of a clinically important interaction

(2016) Mari Fihlman et al.   EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY

Clinical Management of Opioid Use Disorder

(2016) Beth Dunlap et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Predicting the “First dose in children” of CYP3A-metabolized drugs: Evaluation of scaling approaches and insights into the CYP3A7-CYP3A4 switch at young ages

(2014) Ashley Strougo et al.   JOURNAL OF CLINICAL PHARMACOLOGY

Ethics of Drug Studies in the Newborn

(2014) Robert M. Ward et al.   PEDIATRIC DRUGS

A Workflow Example of PBPK Modeling to Support Pediatric Research and Development: Case Study with Lorazepam

(2013) A. R. Maharaj et al.   AAPS Journal

In vitroOATP1B1 and OATP1B3 inhibition is associated with observations of benign clinical unconjugated hyperbilirubinemia

(2013) William J. Chiou et al.   XENOBIOTICA

Fabrication and statistical optimization of a polysaccharide-based sublingual film of buprenorphine hydrochloride for breakthrough pain management: in vitro and in vivo performance

(2013) Gaurav Subhash Yeola et al.   Drug Delivery and Translational Research

Effect of Ketoconazole on the Pharmacokinetic Profile of Buprenorphine following Administration of a Once-Weekly Buprenorphine Transdermal System

(2012) Ram P. Kapil et al.   CLINICAL DRUG INVESTIGATION

Physiologically Based Pharmacokinetic (PBPK) Modeling in Children

(2012) J S Barrett et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Regulatory Experience With Physiologically Based Pharmacokinetic Modeling for Pediatric Drug Trials

(2012) R Leong et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Intravenous buprenorphine and norbuprenorphine pharmacokinetics in humans

(2012) M.A. Huestis et al.   DRUG AND ALCOHOL DEPENDENCE

Once-Weekly Transdermal Buprenorphine Application Results in Sustained and Consistent Steady-State Plasma Levels

(2012) Ram P. Kapil et al.   JOURNAL OF PAIN AND SYMPTOM MANAGEMENT

Management of Opioid Analgesic Overdose

(2012) Edward W. Boyer   NEW ENGLAND JOURNAL OF MEDICINE

Application of PBPK modelling in drug discovery and development at Pfizer

(2011) Hannah M Jones et al.   XENOBIOTICA

Rifampin's Acute Inhibitory and Chronic Inductive Drug Interactions: Experimental and Model-Based Approaches to Drug–Drug Interaction Trial Design

(2010) M L Reitman et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

An in vitro approach to estimate putative inhibition of buprenorphine and norbuprenorphine glucuronidation

(2010) Stephanie Oechsler et al.   INTERNATIONAL JOURNAL OF LEGAL MEDICINE

Buprenorphine TTS for children - a review of the drug’s clinical pharmacology

(2010) Erik Michel et al.   PEDIATRIC ANESTHESIA

Resurgence in the use of physiologically based pharmacokinetic models in pediatric clinical pharmacology: parallel shift in incorporating the knowledge of biological elements and increased applicability to drug development and clinical practice

(2010) Trevor N. Johnson et al.   PEDIATRIC ANESTHESIA

Transdermal buprenorphine – a critical appraisal of its role in pain management

(2010) Guy Hans   Journal of Pain Research

Facilitation of Drug Evaluation in Children by Population Methods and Modelling†

(2009) Michel Tod et al.   CLINICAL PHARMACOKINETICS

The Human UGT1A3 Enzyme Conjugates Norursodeoxycholic Acid into a C23-ester Glucuronide in the Liver

(2009) Jocelyn Trottier et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Clinical update on the pharmacology, efficacy and safety of transdermal buprenorphine

(2008) Hans G. Kress   EUROPEAN JOURNAL OF PAIN

General approach for the calculation of tissue to plasma partition coefficients

(2007) Walter Schmitt   TOXICOLOGY IN VITRO