Meta-analysis of hepatic cytochrome P450 ontogeny to underwrite the prediction of pediatric pharmacokinetics using physiologically based pharmacokinetic modeling

Addressing phenoconversion: the Achilles' heel of personalized medicine

(2015) Rashmi R. Shah et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Physiologically based pharmacokinetic modeling in drug discovery and development: A pharmaceutical industry perspective

(2015) HM Jones et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Practical Considerations for Dose Selection in Pediatric Patients to Ensure Target Exposure Requirements

(2014) April M. Barbour et al.   AAPS Journal

A Re-evaluation and Validation of Ontogeny Functions for Cytochrome P450 1A2 and 3A4 Based on In Vivo Data

(2014) Farzaneh Salem et al.   CLINICAL PHARMACOKINETICS

The pharmacokinetics of methadone and its metabolites in neonates, infants, and children

(2014) Robert M. Ward et al.   PEDIATRIC ANESTHESIA

Pediatric Drug Formulations: A Review of Challenges and Progress

(2014) V. Ivanovska et al.   PEDIATRICS

Physiology-Based IVIVE Predictions of Tramadol from in Vitro Metabolism Data

(2014) Huybrecht T’jollyn et al.   PHARMACEUTICAL RESEARCH

Neonatal Livers: A Source for the Isolation of Good-Performing Hepatocytes for Cell Transplantation

(2013) Laia Tolosa et al.   CELL TRANSPLANTATION

Developmental Changes in the Expression and Function of Cytochrome P450 3A Isoforms: Evidence from In Vitro and In Vivo Investigations

(2013) Ibrahim Ince et al.   CLINICAL PHARMACOKINETICS

CYP2A6 Genotype but not Age Determines Cotinine Half-Life in Infants and Children

(2013) D A Dempsey et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Profiling biopharmaceutical deciding properties of absorption of lansoprazole enteric-coated tablets using gastrointestinal simulation technology

(2013) Chunnuan Wu et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Determining Population and Developmental Pharmacokinetics of Metronidazole Using Plasma and Dried Blood Spot Samples From Premature Infants

(2013) Michael Cohen-Wolkowiez et al.   PEDIATRIC INFECTIOUS DISEASE JOURNAL

Cytochrome P450 enzymes in drug metabolism: Regulation of gene expression, enzyme activities, and impact of genetic variation

(2013) Ulrich M. Zanger et al.   PHARMACOLOGY & THERAPEUTICS

Physiologically Based Pharmacokinetic (PBPK) Modeling in Children

(2012) J S Barrett et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Regulatory Experience With Physiologically Based Pharmacokinetic Modeling for Pediatric Drug Trials

(2012) R Leong et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

CYP2C19 polymorphism affects single-dose pharmacokinetics of oral pantoprazole in healthy volunteers

(2012) Barbara Gawrońska-Szklarz et al.   EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY

Developmental expression of drug metabolizing enzymes: Impact on disposition in neonates and young children

(2012) R.N. Hines   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Use of dried blood spots for the determination of plasma concentrations of nevirapine and efavirenz

(2012) W. Kromdijk et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Critical Illness Is a Major Determinant of Midazolam Clearance in Children Aged 1 Month to 17 Years

(2012) Ibrahim Ince et al.   THERAPEUTIC DRUG MONITORING

Sensitivity of Intravenous and Oral Alfentanil and Pupillary Miosis as Minimal and Noninvasive Probes for Hepatic and First-Pass CYP3A Induction

(2011) E D Kharasch et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Safety, tolerability and pharmacokinetics of an intravenous bolus of sildenafil in patients with pulmonary arterial hypertension

(2010) Jean-Luc Vachiery et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Impact of the CYP2C19*17 Allele on the Pharmacokinetics of Omeprazole and Pantoprazole in Children: Evidence for a Differential Effect

(2010) G. L. Kearns et al.   DRUG METABOLISM AND DISPOSITION

Human Liver Expression of CYP2C8: Gender, Age, and Genotype Effects

(2010) S. B. Naraharisetti et al.   DRUG METABOLISM AND DISPOSITION

Single-dose, multiple-dose, and population pharmacokinetics of pantoprazole in neonates and preterm infants with a clinical diagnosis of gastroesophageal reflux disease (GERD)

(2010) Robert M. Ward et al.   EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY

Aspects of pharmacokinetics and pharmacodynamics of sufentanil in pediatric practice

(2010) Stefan Lundeberg et al.   PEDIATRIC ANESTHESIA

Human hepatic CYP2B6 developmental expression: The impact of age and genotype

(2009) Edward L. Croom et al.   BIOCHEMICAL PHARMACOLOGY

Population pharmacokinetics of intravenous pantoprazole in paediatric intensive care patients

(2009) Géraldine Pettersen et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Pharmacokinetic assessment of a five-probe cocktail for CYPs 1A2, 2C9, 2C19, 2D6 and 3A

(2009) Sandrine Turpault et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Polymorphism of Human Cytochrome P450 2D6 and Its Clinical Significance

(2009) Shu-Feng Zhou   CLINICAL PHARMACOKINETICS

Hepatic CYP2A6 levels and nicotine metabolism: impact of genetic, physiological, environmental, and epigenetic factors

(2009) Nael Al Koudsi et al.   EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY

The Simcyp®Population-based ADME Simulator

(2009) Masoud Jamei et al.   Expert Opinion on Drug Metabolism & Toxicology

Mass spectrometry-based absolute quantification of microsomal cytochrome P450 2D6 in human liver

(2009) Elmar Langenfeld et al.   PROTEOMICS

Effect of CYP2C19 *2 and *17 mutations on pharmacodynamics and kinetics of proton pump inhibitors in Caucasians

(2008) Nicole G. Hunfeld et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Population Pharmacokinetics of Sildenafil in Term Neonates: Evidence of Rapid Maturation of Metabolic Clearance in the Early Postnatal Period

(2008) A Mukherjee et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Developmental Changes in Human Liver CYP2D6 Expression

(2008) J. C. Stevens et al.   DRUG METABOLISM AND DISPOSITION

Role of NADPH-Cytochrome P450 Reductase and Cytochrome-b5/NADH-b5 Reductase in Variability of CYP3A Activity in Human Liver Microsomes

(2008) L. Gan et al.   DRUG METABOLISM AND DISPOSITION

Antiviral efficacy, tolerability and pharmacokinetics of efavirenz in an unselected cohort of HIV-infected children

(2008) U. Wintergerst et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Pharmacokinetics and Safety of Montelukast Oral Granules in Children 1 to 3 Months of Age With Bronchiolitis

(2008) Gregory L. Kearns et al.   JOURNAL OF CLINICAL PHARMACOLOGY

Single-Dose Pharmacokinetics of Oral and Intravenous Pantoprazole in Children and Adolescents

(2008) Gregory L. Kearns et al.   JOURNAL OF CLINICAL PHARMACOLOGY

Caffeine Citrate Treatment for Extremely Premature Infants With Apnea: Population Pharmacokinetics, Absolute Bioavailability, and Implications for Therapeutic Drug Monitoring

(2008) Bruce G Charles et al.   THERAPEUTIC DRUG MONITORING