State-of-the-Art Review on Physiologically Based Pharmacokinetic Modeling in Pediatric Drug Development

Mechanistic Physiologically Based Pharmacokinetic (PBPK) Model of the Heart Accounting for Inter-Individual Variability: Development and Performance Verification

(2018) Zofia Tylutki et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Pediatric Development of Bosentan Facilitated by Modeling and Simulation

(2017) Jochen Zisowsky et al.   PEDIATRIC DRUGS

A Physiologically Based Pharmacokinetic Model for Ganciclovir and Its Prodrug Valganciclovir in Adults and Children

(2016) V. Lukacova et al.   AAPS Journal

Bottom-up Meets Top-down: Complementary Physiologically Based Pharmacokinetic and Population Pharmacokinetic Modeling for Regulatory Approval of a Dosing Algorithm of Valganciclovir in Very Young Children

(2016) K Jorga et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Ontogeny of Hepatic Drug Transporters as Quantified by LC-MS/MS Proteomics

(2016) B Prasad et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Age-Dependent Absolute Abundance of Hepatic Carboxylesterases (CES1 and CES2) by LC-MS/MS Proteomics: Application to PBPK Modeling of Oseltamivir In Vivo Pharmacokinetics in Infants

(2016) Mikael Boberg et al.   DRUG METABOLISM AND DISPOSITION

Does age affect gastric emptying time? A model-based meta-analysis of data from premature neonates through to adults

(2015) Jennifer J. Bonner et al.   BIOPHARMACEUTICS & DRUG DISPOSITION

Physiologically based pharmacokinetic modeling in drug discovery and development: A pharmaceutical industry perspective

(2015) HM Jones et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Modeling and simulation in pediatric drug therapy: Application of pharmacometrics to define the right dose for children

(2015) AA Vinks et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Assessment of Age-Related Changes in Pediatric Gastrointestinal Solubility

(2015) Anil R. Maharaj et al.   PHARMACEUTICAL RESEARCH

Development of physiologically based pharmacokinetic model to evaluate the relative systemic exposure to quetiapine after administration of IR and XR formulations to adults, children and adolescents

(2014) Trevor N. Johnson et al.   BIOPHARMACEUTICS & DRUG DISPOSITION

Dosing in Children: A Critical Review of the Pharmacokinetic Allometric Scaling and Modelling Approaches in Paediatric Drug Development and Clinical Settings

(2014) Iftekhar Mahmood   CLINICAL PHARMACOKINETICS

Use of Opportunistic Clinical Data and a Population Pharmacokinetic Model to Support Dosing of Clindamycin for Premature Infants to Adolescents

(2014) D Gonzalez et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Clinical Pharmacology in Neonates: Small Size, Huge Variability

(2014) Karel Allegaert et al.   Neonatology

Mechanisms to Provide Safe and Effective Drugs for Children

(2014) M. M. Laughon et al.   PEDIATRICS

A Workflow Example of PBPK Modeling to Support Pediatric Research and Development: Case Study with Lorazepam

(2013) A. R. Maharaj et al.   AAPS Journal

The Integration of Allometry and Virtual Populations to Predict Clearance and Clearance Variability in Pediatric Populations over the Age of 6 Years

(2013) Andrea N. Edginton et al.   CLINICAL PHARMACOKINETICS

Response to “Physiologically Based Pharmacokinetic Modeling at the Extremes of Age”

(2012) O Della Casa Alberighi et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Physiologically Based Pharmacokinetic (PBPK) Modeling in Children

(2012) J S Barrett et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Regulatory Experience With Physiologically Based Pharmacokinetic Modeling for Pediatric Drug Trials

(2012) R Leong et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Applications of minimal physiologically-based pharmacokinetic models

(2012) Yanguang Cao et al.   JOURNAL OF PHARMACOKINETICS AND PHARMACODYNAMICS

First dose in children: physiological insights into pharmacokinetic scaling approaches and their implications in paediatric drug development

(2012) Ashley Strougo et al.   JOURNAL OF PHARMACOKINETICS AND PHARMACODYNAMICS

Clinical Practice Guidelines by the Infectious Diseases Society of America for the Treatment of Methicillin-Resistant Staphylococcus aureus Infections in Adults and Children: Executive Summary

(2011) Catherine Liu et al.   CLINICAL INFECTIOUS DISEASES

Development of a Physiologically Based Model for Oseltamivir and Simulation of Pharmacokinetics in Neonates and Infants

(2011) Neil Parrott et al.   CLINICAL PHARMACOKINETICS

Physiologically Based Pharmacokinetic Modeling: Methodology, Applications, and Limitations with a Focus on Its Role in Pediatric Drug Development

(2011) Feras Khalil et al.   JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY

Pharmacokinetics of Intravenous Lorazepam in Pediatric Patients with and without Status Epilepticus

(2011) James M. Chamberlain et al.   JOURNAL OF PEDIATRICS

Sirolimus for the treatment of complicated vascular anomalies in children

(2011) Adrienne M. Hammill et al.   PEDIATRIC BLOOD & CANCER

Knowledge-driven approaches for the guidance of first-in-children dosing

(2010) Andrea N. Edginton   PEDIATRIC ANESTHESIA

Resurgence in the use of physiologically based pharmacokinetic models in pediatric clinical pharmacology: parallel shift in incorporating the knowledge of biological elements and increased applicability to drug development and clinical practice

(2010) Trevor N. Johnson et al.   PEDIATRIC ANESTHESIA

Antibiotic Management of Staphylococcus aureus Infections in US Children's Hospitals, 1999-2008

(2010) J. C. Herigon et al.   PEDIATRICS

Clinical Trial Simulations in Pediatric Patients Using Realistic Covariates: Application to Teduglutide, a Glucagon-Like Peptide-2 Analog in Neonates and Infants With Short-Bowel Syndrome

(2009) M S Mouksassi et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Human renal function maturation: a quantitative description using weight and postmenstrual age

(2008) Malin M. Rhodin et al.   PEDIATRIC NEPHROLOGY