Drug Transporters Expressed in the Human Placenta and Models for Studying Maternal‐Fetal Drug Transfer

The inhibitory effect of antiretroviral drugs on the L-carnitine uptake in human placenta

(2019) Rona Karahoda et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Fetal Physiologically Based Pharmacokinetic Models: Systems Information on the Growth and Composition of Fetal Organs

(2018) Khaled Abduljalil et al.   CLINICAL PHARMACOKINETICS

Physiologically Based Pharmacokinetic Modeling in Pregnancy: A Systematic Review of Published Models

(2018) André Dallmann et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Interindividual Regulation of the Breast Cancer Resistance Protein/ABCG2Transporter in Term Human Placentas

(2018) Kristin M. Bircsak et al.   DRUG METABOLISM AND DISPOSITION

Glucocorticoids modulate multidrug resistance transporters in the first trimester human placenta

(2018) Phetcharawan Lye et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Organic Cation Transporter 3 Facilitates Fetal Exposure to Metformin During Pregnancy

(2018) Nora Lee et al.   MOLECULAR PHARMACOLOGY

Regulation of human placental drug transporters in HCV infection and their influence on direct acting antiviral medications

(2018) Emily Pfeifer et al.   PLACENTA

Role of the efflux transporters BCRP and MRP1 in human placental bio-disposition of pravastatin

(2018) Marjan Afrouzian et al.   BIOCHEMICAL PHARMACOLOGY

Prediction of human fetal pharmacokinetics usingex vivohuman placenta perfusion studies and physiologically based models

(2016) Maïlys De Sousa Mendes et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

A Physiologically-Based Pharmacokinetic Model to Predict Human Fetal Exposure for a Drug Metabolized by Several CYP450 Pathways

(2016) Maïlys De Sousa Mendes et al.   CLINICAL PHARMACOKINETICS

The xenoestrogens, bisphenol A and para-nonylphenol, decrease the expression of the ABCG2 transporter protein in human term placental explant cultures

(2016) E. Sieppi et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Animal Models to Study Placental Development and Function throughout Normal and Dysfunctional Human Pregnancy

(2016) Peta Grigsby   SEMINARS IN REPRODUCTIVE MEDICINE

Integration of Life-Stage Physiologically Based Pharmacokinetic Models with Adverse Outcome Pathways and Environmental Exposure Models to Screen for Environmental Hazards

(2016) Hisham El-Masri et al.   TOXICOLOGICAL SCIENCES

Mercury toxicokinetics of the healthy human term placenta involve amino acid transporters and ABC transporters

(2016) Elisabeth Straka et al.   TOXICOLOGY

Development of a 3D Printed, Bioengineered Placenta Model to Evaluate the Role of Trophoblast Migration in Preeclampsia

(2016) Che-Ying Kuo et al.   ACS Biomaterials-Science & Engineering

Development of a 3D Printed, Bioengineered Placenta Model to Evaluate the Role of Trophoblast Migration in Preeclampsia

(2016) Che-Ying Kuo et al.   ACS Biomaterials Science & Engineering

Impact of Bacterial and Viral Challenge on Multidrug Resistance in First- and Third-Trimester Human Placenta

(2015) Phetcharawan Lye et al.   AMERICAN JOURNAL OF PATHOLOGY

Human Ontogeny of Drug Transporters: Review and Recommendations of the Pediatric Transporter Working Group

(2015) KLR Brouwer et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Maternal bacterial infections impact expression of drug transporters in human placenta

(2015) Vanja Petrovic et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Organic Anion Transporter 4-Mediated Transport of Olmesartan at Basal Plasma Membrane of Human Placental Barrier

(2015) Saki Noguchi et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Glyburide Transport Across the Human Placenta

(2015) Rachelle A. Schwartz et al.   OBSTETRICS AND GYNECOLOGY

Immunolocalization of ABC drug transporters in human placenta from normal and gestational diabetic pregnancies

(2015) Danuta Kozłowska-Rup et al.   Ginekologia Polska

Expression of lipoxin A4, TNFα and IL-1β in maternal peripheral blood, umbilical cord blood and placenta, and their significance in pre-eclampsia

(2014) Wei Dong et al.   HYPERTENSION IN PREGNANCY

Effect of oxygen on multidrug resistance in term human placenta

(2014) M. Javam et al.   PLACENTA

Cytokine Levels in Gestational Diabetes Mellitus: a Systematic Review of the Literature

(2013) Caio Perez Gomes et al.   AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY

Assessment of an in vitro transport model using BeWo b30 cells to predict placental transfer of compounds

(2013) Hequn Li et al.   ARCHIVES OF TOXICOLOGY

Organic Cation Transporter 3 (OCT3/SLC22A3) and Multidrug and Toxin Extrusion 1 (MATE1/SLC47A1) Transporter in the Placenta and Fetal Tissues: Expression Profile and Fetus Protective Role at Different Stages of Gestation1

(2013) Davoud Ahmadimoghaddam et al.   BIOLOGY OF REPRODUCTION

Placental P-glycoprotein is unaffected by timing of antenatal glucocorticoid therapy but reduced in SGA preterm infants

(2013) N.A. Hodyl et al.   PLACENTA

Effect of oxygen on multidrug resistance in the first trimester human placenta

(2013) P. Lye et al.   PLACENTA

Transfer of metformin across the rat placenta is mediated by organic cation transporter 3 (OCT3/SLC22A3) and multidrug and toxin extrusion 1 (MATE1/SLC47A1) protein

(2013) Davoud Ahmadimoghaddam et al.   REPRODUCTIVE TOXICOLOGY

Regional expression of the BCRP/ABCG2 transporter in term human placentas

(2013) Naureen Memon et al.   REPRODUCTIVE TOXICOLOGY

Developmental expression of drug metabolizing enzymes: Impact on disposition in neonates and young children

(2012) R.N. Hines   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Development of Pbpk Models for Pfoa and Pfos for Human Pregnancy and Lactation Life Stages

(2012) Anne E. Loccisano et al.   JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A-CURRENT ISSUES

Placental drug transporters and their role in fetal protection

(2012) M. Iqbal et al.   PLACENTA

Placental transfer and metabolism: An overview of the experimental models utilizing human placental tissue

(2012) Päivi Myllynen et al.   TOXICOLOGY IN VITRO

The Human Placental Perfusion Model: A Systematic Review and Development of a Model to Predict In Vivo Transfer of Therapeutic Drugs

(2011) J R Hutson et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

ATP-Binding Cassette Transporter Expression in Human Placenta as a Function of Pregnancy Condition

(2011) C. W. Mason et al.   DRUG METABOLISM AND DISPOSITION

Profound changes in drug metabolism enzymes and possible effects on drug therapy in neonates and children

(2011) Saskia N de Wildt   Expert Opinion on Drug Metabolism & Toxicology

Studying placental transfer of highly purified non-dioxin-like PCBs in two models of the placental barrier

(2011) S. Correia Carreira et al.   PLACENTA

Physiologically Based Pharmacokinetic Modeling of Fetal and Neonatal Manganese Exposure in Humans: Describing Manganese Homeostasis during Development

(2011) Miyoung Yoon et al.   TOXICOLOGICAL SCIENCES

Hypoxia-Mediated Down-Regulation of OCTN2 and PPARα Expression in Human Placentas and in BeWo Cells

(2010) Ting-Ting Chang et al.   MOLECULAR PHARMACEUTICS

Modulation of human placental P-glycoprotein expression and activity by MDR1 gene polymorphisms

(2009) Sarah J. Hemauer et al.   BIOCHEMICAL PHARMACOLOGY

Estradiol and Progesterone-Mediated Regulation of P-gp in P-gp Overexpressing Cells (NCI-ADR-RES) and Placental Cells (JAR)

(2009) Lisa D. Coles et al.   MOLECULAR PHARMACEUTICS

Modeling placental transport: Correlation of in vitro BeWo cell permeability and ex vivo human placental perfusion

(2009) Marie Sønnegaard Poulsen et al.   TOXICOLOGY IN VITRO

Organic Anion Transporter 2 (SLC22A7) Is a Facilitative Transporter of cGMP

(2008) C. D. Cropp et al.   MOLECULAR PHARMACOLOGY

The Role of Placental Breast Cancer Resistance Protein in the Efflux of Glyburide across the Human Placenta

(2008) E. Pollex et al.   PLACENTA

Breast Cancer Resistance Protein: Mediating the Trans-placental Transfer of Glyburide across the Human Placenta

(2007) C. Gedeon et al.   PLACENTA