Changes in Individual Drug-Independent System Parameters during Virtual Paediatric Pharmacokinetic Trials: Introducing Time-Varying Physiology into a Paediatric PBPK Model

Age Related Changes in Fractional Elimination Pathways for Drugs: Assessing the Impact of Variable Ontogeny on Metabolic Drug-Drug Interactions

(2013) Farzaneh Salem et al.   JOURNAL OF CLINICAL PHARMACOLOGY

A Neonatal Amikacin Covariate Model Can Be Used to Predict Ontogeny of Other Drugs Eliminated Through Glomerular Filtration in Neonates

(2013) Roosmarijn F. W. De Cock et al.   PHARMACEUTICAL RESEARCH

Covariate Pharmacokinetic Model Building in Oncology and its Potential Clinical Relevance

(2012) Markus Joerger   AAPS Journal

Scaling of pharmacokinetics across paediatric populations: the lack of interpolative power of allometric models

(2012) Massimo Cella et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Anatomical, Physiological and Metabolic Changes with Gestational Age during Normal Pregnancy

(2012) Khaled Abduljalil et al.   CLINICAL PHARMACOKINETICS

First dose in children: physiological insights into pharmacokinetic scaling approaches and their implications in paediatric drug development

(2012) Ashley Strougo et al.   JOURNAL OF PHARMACOKINETICS AND PHARMACODYNAMICS

A seven-day study of the pharmacokinetics of intravenous levetiracetam in neonates: marked changes in pharmacokinetics occur during the first week of life

(2012) Cynthia M. Sharpe et al.   PEDIATRIC RESEARCH

Paediatric drug development: are population models predictive of pharmacokinetics across paediatric populations?

(2011) Massimo Cella et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Age-Related Changes in Pharmacokinetics

(2011) Shaojun Shi et al.   CURRENT DRUG METABOLISM

Profound changes in drug metabolism enzymes and possible effects on drug therapy in neonates and children

(2011) Saskia N de Wildt   Expert Opinion on Drug Metabolism & Toxicology

Individualized dosing regimens in children based on population PKPD modelling: Are we ready for it?

(2011) Catherijne A.J. Knibbe et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Developmental pharmacology; filling one knowledge gap in pediatric anesthesiology

(2011) Brian J. Anderson   PEDIATRIC ANESTHESIA

Mechanism based medicine in infancy: complex interplay between developmental pharmacology and pharmacogenetics

(2011) Karel Allegaert   International Journal of Clinical Pharmacy

Pharmacokinetic research in children: an analysis of registered records of clinical trials

(2011) R. F. Viergever et al.   BMJ Open

Developmental pharmacology

(2010) Johannes N. van den Anker   Developmental Disabilities Research Reviews

Developmental pharmacology of tramadol during infancy: ontogeny, pharmacogenetics and elimination clearance

(2010) Karel Allegaert et al.   PEDIATRIC ANESTHESIA

Resurgence in the use of physiologically based pharmacokinetic models in pediatric clinical pharmacology: parallel shift in incorporating the knowledge of biological elements and increased applicability to drug development and clinical practice

(2010) Trevor N. Johnson et al.   PEDIATRIC ANESTHESIA

A maturation model for midazolam clearance

(2010) Brian J. Anderson et al.   PEDIATRIC ANESTHESIA

Intestinal Metabolism and Transport of Drugs in Children: The Effects of Age and Disease

(2009) Trevor N Johnson et al.   JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION

Mechanisms of Cancer Cachexia

(2009) Michael J. Tisdale   PHYSIOLOGICAL REVIEWS

Population Pharmacokinetics of Fluconazole in Young Infants

(2008) K. C. Wade et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Population Pharmacokinetics of Sildenafil in Term Neonates: Evidence of Rapid Maturation of Metabolic Clearance in the Early Postnatal Period

(2008) A Mukherjee et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Improving Pediatric Dosing Through Pediatric Initiatives: What We Have Learned

(2008) W. Rodriguez et al.   PEDIATRICS

Development of CYP2D6 and CYP3A4 in the First Year of Life

(2007) TN Johnson et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS