A Framework for Assessing Inter-individual Variability in Pharmacokinetics Using Virtual Human Populations and Integrating General Knowledge of Physical Chemistry, Biology, Anatomy, Physiology and Genetics: A Tale of ‘Bottom-Up’ vs ‘Top-Down’ Recognition of Covariates

Quantitative analysis of highly homologous proteins: the challenge of assaying the “CYP-ome” by mass spectrometry

(2008) Elmar Langenfeld et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Physiology-Based Simulations of a Pathological Condition

(2008) Andrea N Edginton et al.   CLINICAL PHARMACOKINETICS

Emerging Evidence of the Impact of Kidney Disease on Drug Metabolism and Transport

(2008) TD Nolin et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Pharmacokinetics/Genotype Associations for Major Cytochrome P450 Enzymes in Native and First- and Third-generation Japanese Populations: Comparison With Korean, Chinese, and Caucasian Populations

(2008) SP Myrand et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Genetic Variants of the Organic Cation Transporter 2 Influence the Disposition of Metformin

(2008) IS Song et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Cytochrome P450 Turnover: Regulation of Synthesis and Degradation, Methods for Determining Rates, and Implications for the Prediction of Drug Interactions

(2008) Jiansong Yang et al.   CURRENT DRUG METABOLISM

Modeling, Prediction, and in Vitro in Vivo Correlation of CYP3A4 Induction

(2008) M. Shou et al.   DRUG METABOLISM AND DISPOSITION

Covariation of Human Microsomal Protein Per Gram of Liver with Age: Absence of Influence of Operator and Sample Storage May Justify Interlaboratory Data Pooling

(2008) Z. E. Barter et al.   DRUG METABOLISM AND DISPOSITION

Potential role of intestinal first-pass metabolism in the prediction of drug–drug interactions

(2008) Aleksandra Galetin et al.   Expert Opinion on Drug Metabolism & Toxicology

Pharmacokinetic predictions in children by using the physiologically based pharmacokinetic modelling

(2008) F. Bouzom et al.   FUNDAMENTAL & CLINICAL PHARMACOLOGY

Physiologically Based Pharmacokinetic Modeling to Predict Transporter-Mediated Clearance and Distribution of Pravastatin in Humans

(2008) T. Watanabe et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Distinction between Human Cytochrome P450 (CYP) Isoforms and Identification of New Phosphorylation Sites by Mass Spectrometry

(2008) Gorden Redlich et al.   JOURNAL OF PROTEOME RESEARCH

Interplay Between Intestinal pH, Transit Time and Feed Status on the In Vivo Performance of pH Responsive Ileo-Colonic Release Systems

(2008) Valentine C. Ibekwe et al.   PHARMACEUTICAL RESEARCH

Metabolism and related human risk factors for hepatic damage by usnic acid containing nutritional supplements

(2008) R. S. Foti et al.   XENOBIOTICA

A regulatory viewpoint on transporter-based drug interactions

(2008) L. Zhang et al.   XENOBIOTICA

Pre-clinical pharmacokinetics of UK-453,061, a novel non-nucleoside reverse transcriptase inhibitor (NNRTI), and use ofin silicophysiologically based prediction tools to predict the oral pharmacokinetics of UK-453,061 in man

(2008) G. Allan et al.   XENOBIOTICA

Mechanism-Based Concepts of Size and Maturity in Pharmacokinetics

(2007) B.J. Anderson et al.   Annual Review of Pharmacology and Toxicology

Pharmacokinetics in Drug Discovery

(2007) Ana Ruiz-Garcia et al.   JOURNAL OF PHARMACEUTICAL SCIENCES