A Systematic Evaluation of the Use of Physiologically Based Pharmacokinetic Modeling for Cross-Species Extrapolation

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Title
A Systematic Evaluation of the Use of Physiologically Based Pharmacokinetic Modeling for Cross-Species Extrapolation
Authors
Keywords
physiologically based pharmacokinetic (PBPK) modeling, Cross-species extrapolation, Systems pharmacology, First-in-man, Virtual liver, Pharmacokinetic/pharmacodynamic models, Bioinformatics, CYP enzymes, Computational biology, Simulations
Journal
JOURNAL OF PHARMACEUTICAL SCIENCES
Volume 104, Issue 1, Pages 191-206
Publisher
Elsevier BV
Online
2014-11-13
DOI
10.1002/jps.24214

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