Pediatric physiology in relation to the pharmacokinetics of monoclonal antibodies

Predicting Escitalopram Exposure to Breastfeeding Infants: Integrating Analytical and In Silico Techniques

(2018) Sarah R. Delaney et al.   CLINICAL PHARMACOKINETICS

Comparing Alternative Ranibizumab Dosages for Safety and Efficacy in Retinopathy of Prematurity

(2018) Andreas Stahl et al.   JAMA Pediatrics

Tissue Distribution of a Therapeutic Monoclonal Antibody Determined by Large Pore Microdialysis

(2017) Satyawan B. Jadhav et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Population PBPK modelling of trastuzumab: a framework for quantifying and predicting inter-individual variability

(2017) Paul R. V. Malik et al.   JOURNAL OF PHARMACOKINETICS AND PHARMACODYNAMICS

Interstitial IgG antibody pharmacokinetics assessed by combined in vivo - and physiologically-based pharmacokinetic modelling approaches

(2017) Miro J. Eigenmann et al.   JOURNAL OF PHYSIOLOGY-LONDON

Maximizing in vivo target clearance by design of pH-dependent target binding antibodies with altered affinity to FcRn

(2017) Danlin Yang et al.   mAbs

Pharmacokinetic Considerations for Antibody-Drug Conjugates against Cancer

(2017) Paul Malik et al.   PHARMACEUTICAL RESEARCH

SERUM VASCULAR ENDOTHELIAL GROWTH FACTOR AFTER BEVACIZUMAB OR RANIBIZUMAB TREATMENT FOR RETINOPATHY OF PREMATURITY

(2017) Wei-Chi Wu et al.   RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES

SYSTEMIC PHARMACOKINETICS AND PHARMACODYNAMICS OF INTRAVITREAL AFLIBERCEPT, BEVACIZUMAB, AND RANIBIZUMAB

(2017) Robert L. Avery et al.   RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES

Pharmacokinetics of Bevacizumab in Three Patients Under the Age of 3 Years with CNS Malignancies

(2017) Johannes Gojo et al.   Drugs in research & development

Pharmacokinetics of monoclonal antibodies and Fc-fusion proteins

(2017) Liming Liu   Protein & Cell

Assessment of Lower Doses of Intravitreous Bevacizumab for Retinopathy of Prematurity

(2017) David K. Wallace et al.   JAMA Ophthalmology

A Single Dose Monoclonal Antibody (mAb) Immunoprophylaxis Strategy to Prevent RSV Disease in All Infants: Results of the First in Infant Study with MEDI8897

(2017) Joseph B Domachowske et al.   Open Forum Infectious Diseases

Mechanism-Based Competitive Binding Model to Investigate the Effect of Neonatal Fc Receptor Binding Affinity on the Pharmacokinetic of Humanized Anti-VEGF Monoclonal IgG1 Antibody in Cynomolgus Monkey

(2016) Chee M. Ng et al.   AAPS Journal

Pharmacokinetic Considerations in Designing Pediatric Studies of Proteins, Antibodies, and Plasma-Derived Products

(2016) Iftekhar Mahmood   AMERICAN JOURNAL OF THERAPEUTICS

Physiologically based pharmacokinetic models of small molecules and therapeutic antibodies: a mini-review on fundamental concepts and applications

(2016) Gregory Z. Ferl et al.   BIOPHARMACEUTICS & DRUG DISPOSITION

Internalization of bevacizumab by retinal endothelial cells and its intracellular fate: Evidence for an involvement of the neonatal Fc receptor

(2016) Heidrun L. Deissler et al.   EXPERIMENTAL EYE RESEARCH

Physiologically-based pharmacokinetic modeling to predict the clinical pharmacokinetics of monoclonal antibodies

(2016) Patrick M. Glassman et al.   JOURNAL OF PHARMACOKINETICS AND PHARMACODYNAMICS

Eculizumab is a safe and effective treatment in pediatric patients with atypical hemolytic uremic syndrome

(2016) Larry A. Greenbaum et al.   KIDNEY INTERNATIONAL

A comprehensive review of the neonatal Fc receptor and its application in drug delivery

(2016) João Pedro Martins et al.   PHARMACOLOGY & THERAPEUTICS

Bevacizumab dosing strategy in paediatric cancer patients based on population pharmacokinetic analysis with external validation

(2015) Kelong Han et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

A possible influence of age on absorption and elimination of adalimumab in focal segmental glomerulosclerosis (FSGS)

(2015) David Ternant et al.   EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY

Pharmacokinetics of Bevacizumab and Its Effects on Serum VEGF and IGF-1 in Infants With Retinopathy of Prematurity

(2015) L. Kong et al.   INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE

Challenges and considerations for development of therapeutic proteins in pediatric patients

(2015) Yi Zhang et al.   JOURNAL OF CLINICAL PHARMACOLOGY

FcRn: The Architect Behind the Immune and Nonimmune Functions of IgG and Albumin

(2015) Michal Pyzik et al.   JOURNAL OF IMMUNOLOGY

Growth and Endothelial Function in the First 2 Years of Life

(2015) Robbert N.H. Touwslager et al.   JOURNAL OF PEDIATRICS

Efficacy of motavizumab for the prevention of respiratory syncytial virus disease in healthy Native American infants: a phase 3 randomised double-blind placebo-controlled trial

(2015) Katherine L O'Brien et al.   LANCET INFECTIOUS DISEASES

Internalization, Trafficking, Intracellular Processing and Actions of Antibody-Drug Conjugates

(2015) Shi Xu   PHARMACEUTICAL RESEARCH

PLASMA CONCENTRATIONS OF VASCULAR ENDOTHELIAL GROWTH FACTOR IN RETINOPATHY OF PREMATURITY AFTER INTRAVITREAL BEVACIZUMAB INJECTION

(2015) Yoo Rha Hong et al.   RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES

Pharmacokinetics of the chimeric anti-GD2 antibody, ch14.18, in children with high-risk neuroblastoma

(2014) Ami V. Desai et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

A Randomized Study of the Relative Pharmacokinetics, Pharmacodynamics, and Safety of Alirocumab, a Fully Human Monoclonal Antibody to PCSK9, After Single Subcutaneous Administration at Three Different Injection Sites in Healthy Subjects

(2014) Catherine Lunven et al.   Cardiovascular Therapeutics

Pharmacokinetics and Pharmacokinetic–Pharmacodynamic Relationships of Monoclonal Antibodies in Children

(2014) Helena Edlund et al.   CLINICAL PHARMACOKINETICS

Enhanced neonatal Fc receptor function improves protection against primate SHIV infection

(2014) Sung-Youl Ko et al.   NATURE

Dosing in neonates: special considerations in physiology and trial design

(2014) Lawrence C. Ku et al.   PEDIATRIC RESEARCH

Pharmacokinetics, Pharmacodynamics and Physiologically-Based Pharmacokinetic Modelling of Monoclonal Antibodies

(2013) Miroslav Dostalek et al.   CLINICAL PHARMACOKINETICS

Application of knockout mouse models to investigate the influence of FcγR on the pharmacokinetics and anti-platelet effects of MWReg30, a monoclonal anti-GPIIb antibody

(2013) Lubna Abuqayyas et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

The Antibody Drug Absorption Following Subcutaneous or Intramuscular Administration and Its Mathematical Description by Coupling Physiologically Based Absorption Process with the Conventional Compartment Pharmacokinetic Model

(2013) Liang Zhao et al.   JOURNAL OF CLINICAL PHARMACOLOGY

Distribution of rat neonatal Fc receptor in the principal organs of neonatal and pubertal rats

(2013) Zehua Tian et al.   JOURNAL OF RECEPTORS AND SIGNAL TRANSDUCTION

Implications of receptor-mediated endocytosis and intracellular trafficking dynamics in the development of antibody drug conjugates

(2013) Michael Ritchie et al.   mAbs

Effects of altered FcγR binding on antibody pharmacokinetics in cynomolgus monkeys

(2013) Maya K Leabman et al.   mAbs

The Lymphatic System Plays a Major Role in the Intravenous and Subcutaneous Pharmacokinetics of Trastuzumab in Rats

(2013) Annette M. Dahlberg et al.   MOLECULAR PHARMACEUTICS

Capillary Remodeling in Infants Born to Hypertensive Pregnancy: Pilot Study

(2012) Tarek F.T. Antonios et al.   AMERICAN JOURNAL OF HYPERTENSION

Population Pharmacokinetics of Palivizumab, a Humanized Anti-Respiratory Syncytial Virus Monoclonal Antibody, in Adults and Children

(2012) Gabriel J. Robbie et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Disposition and Interaction of Biotherapeutics in Pediatric Populations

(2012) Souzan Yanni   CURRENT DRUG METABOLISM

Influence of Growth During Infancy on Endothelium-Dependent Vasodilatation at the Age of 6 Months

(2012) Robbert N.H. Touwslager et al.   HYPERTENSION

Application of knockout mouse models to investigate the influence of FcγR on the tissue distribution and elimination of 8C2, a murine IgG1 monoclonal antibody

(2012) Lubna Abuqayyas et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Subcutaneous bioavailability of therapeutic antibodies as a function 
of FcRn binding affinity in mice

(2012) Rong Deng et al.   mAbs

Rational development and utilization of antibody-based therapeutic proteins in pediatrics

(2012) Zhenhua Xu et al.   PHARMACOLOGY & THERAPEUTICS

Serum Concentrations of Bevacizumab (Avastin) and Vascular Endothelial Growth Factor in Infants With Retinopathy of Prematurity

(2011) Tatsuhiko Sato et al.   AMERICAN JOURNAL OF OPHTHALMOLOGY

Nonclassical major histocompatibility complex I–like Fc neonatal receptor (FcRn) expression in neonatal human tissues

(2011) Corina Cianga et al.   HUMAN IMMUNOLOGY

Low Birth Weight Infants Do Not Have Capillary Rarefaction at Birth

(2011) Rohan D'Souza et al.   HYPERTENSION

Pharmacokinetics and pharmacodynamics of basiliximab in Japanese pediatric renal transplant patients

(2011) T. Nagai et al.   INTERNATIONAL JOURNAL OF CLINICAL PHARMACOLOGY AND THERAPEUTICS

Towards a platform PBPK model to characterize the plasma and tissue disposition of monoclonal antibodies in preclinical species and human

(2011) Dhaval K. Shah et al.   JOURNAL OF PHARMACOKINETICS AND PHARMACODYNAMICS

Normal ranges of heart rate and respiratory rate in children from birth to 18 years of age: a systematic review of observational studies

(2011) Susannah Fleming et al.   LANCET

A Randomized Controlled Trial of Motavizumab Versus Palivizumab for the Prophylaxis of Serious Respiratory Syncytial Virus Disease in Children With Hemodynamically Significant Congenital Heart Disease

(2011) Timothy F Feltes et al.   PEDIATRIC RESEARCH

A Randomized Study of a Monoclonal Antibody (Pagibaximab) to Prevent Staphylococcal Sepsis

(2011) L. E. Weisman et al.   PEDIATRICS

A phase 2, randomized, double-blind safety and pharmacokinetic assessment of respiratory syncytial virus (RSV) prophylaxis with motavizumab and palivizumab administered in the same season

(2010) Pilar Fernández et al.   BMC Pediatrics

Intracellular Activation of SGN-35, a Potent Anti-CD30 Antibody-Drug Conjugate

(2010) N. M. Okeley et al.   CLINICAL CANCER RESEARCH

Pediatric Dosing of Rituximab Revisited: Serum Concentrations in Opsoclonus-myoclonus Syndrome

(2010) Michael R. Pranzatelli et al.   JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY

Comparative pharmacokinetics of plasma- and albumin-free recombinant factor VIII in children and adults: the influence of blood sampling schedule on observed age-related differences and implications for dose tailoring

(2010) S. BJÖRKMAN et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Stability of IgG isotypes in serum

(2010) Ivan Correia   mAbs

Enhanced antibody half-life improves in vivo activity

(2010) Jonathan Zalevsky et al.   NATURE BIOTECHNOLOGY

Functional Capillary Density Decreases after the First Week of Life in Term Neonates

(2010) A.P.C. Top et al.   Neonatology

891 Population Pharmacokinetics Analysis of Motavizumab in Children at Risk for Respiratory Syncytial Virus Infection

(2010) L Zhao et al.   PEDIATRIC RESEARCH

1380 Predicted and Measured Pagibaximab Serum Levels in High-Risk Neonates

(2010) J F Kokai-Kun et al.   PEDIATRIC RESEARCH

Pediatric Dosing and Body Size in Biotherapeutics

(2010) Rong Shi et al.   Pharmaceutics

Safety and Pharmacokinetics of Urtoxazumab, a Humanized Monoclonal Antibody, against Shiga-Like Toxin 2 in Healthy Adults and in Pediatric Patients Infected with Shiga-Like Toxin-Producing Escherichia coli

(2009) E. L. Lopez et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Phase 1/2 Double-Blind, Placebo-Controlled, Dose Escalation, Safety, and Pharmacokinetic Study of Pagibaximab (BSYX-A110), an Antistaphylococcal Monoclonal Antibody for the Prevention of Staphylococcal Bloodstream Infections, in Very-Low-Birth-Weight Neonates

(2009) L. E. Weisman et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

The recycling and transcytotic pathways for IgG transport by FcRn are distinct and display an inherent polarity

(2009) Salit Tzaban et al.   JOURNAL OF CELL BIOLOGY

Phase I and Pharmacokinetic Study of Cetuximab and Irinotecan in Children With Refractory Solid Tumors: A Study of the Pediatric Oncology Experimental Therapeutic Investigators' Consortium

(2009) Tanya M. Trippett et al.   JOURNAL OF CLINICAL ONCOLOGY

Subcutaneous Bioavailability of Golimumab at 3 Different Injection Sites in Healthy Subjects

(2009) Zhenhua Xu et al.   JOURNAL OF CLINICAL PHARMACOLOGY

Safety, Tolerability, Pharmacokinetics, and Immunogenicity of Motavizumab, a Humanized, Enhanced-Potency Monoclonal Antibody for the Prevention of Respiratory Syncytial Virus Infection in At-Risk Children

(2009) Katia Abarca et al.   PEDIATRIC INFECTIOUS DISEASE JOURNAL

SAFETY AND ANTIVIRAL ACTIVITY OF MOTAVIZUMAB, A RESPIRATORY SYNCYTIAL VIRUS (RSV)–SPECIFIC HUMANIZED MONOCLONAL ANTIBODY, WHEN ADMINISTERED TO RSV-INFECTED CHILDREN

(2009) Rosanna Lagos et al.   PEDIATRIC INFECTIOUS DISEASE JOURNAL

Conditional deletion of the MHC class I-related receptor FcRn reveals the sites of IgG homeostasis in mice

(2009) Héctor Pérez Montoyo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mechanisms of neonatal increase in glomerular filtration rate

(2008) Anita J. Turner et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Vascular permeability, vascular hyperpermeability and angiogenesis

(2008) Janice A. Nagy et al.   ANGIOGENESIS

Monoclonal Antibody Pharmacokinetics and Pharmacodynamics

(2008) W Wang et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Whole body physiologically-based pharmacokinetic models: their use in clinical drug development

(2008) Andrea N Edginton et al.   Expert Opinion on Drug Metabolism & Toxicology

Phase I Trial and Pharmacokinetic Study of Bevacizumab in Pediatric Patients With Refractory Solid Tumors: A Children's Oncology Group Study

(2008) Julia L. Glade Bender et al.   JOURNAL OF CLINICAL ONCOLOGY

Phase I Study of ch14.18 With Granulocyte-Macrophage Colony-Stimulating Factor and Interleukin-2 in Children With Neuroblastoma After Autologous Bone Marrow Transplantation or Stem-Cell Rescue: A Report From the Children's Oncology Group

(2008) Andrew L. Gilman et al.   JOURNAL OF CLINICAL ONCOLOGY

Infliximab Treatment of Intravenous Immunoglobulin–Resistant Kawasaki Disease

(2008) Jane C. Burns et al.   JOURNAL OF PEDIATRICS

Plasma and albumin-free recombinant factorVIII: pharmacokinetics, efficacy and safety in previously treated pediatric patients

(2008) V. S. BLANCHETTE et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Safety and pharmacokinetics of daclizumab in pediatric renal transplant recipients

(2007) Mark D. Pescovitz et al.   PEDIATRIC TRANSPLANTATION