Cell‐Based Delivery Systems: Emerging Carriers for Immunotherapy

Cell-Membrane-Mimicking Nanodecoys against Infectious Diseases

(2020) Lang Rao et al.   ACS Nano

Camouflaging Nanoparticles with Brain Metastatic Tumor Cell Membranes: A New Strategy to Traverse Blood–Brain Barrier for Imaging and Therapy of Brain Tumors

(2020) Caixia Wang et al.   ADVANCED FUNCTIONAL MATERIALS

Fusion mechanism of 2019-nCoV and fusion inhibitors targeting HR1 domain in spike protein

(2020) Shuai Xia et al.   Cellular & Molecular Immunology

Combination of PI3K and MEK inhibitors yields durable remission in PDX models of PIK3CA-mutated metaplastic breast cancers

(2020) F. Coussy et al.   Journal of Hematology & Oncology

A pneumonia outbreak associated with a new coronavirus of probable bat origin

(2020) Peng Zhou et al.   NATURE

Vitamin lipid nanoparticles enable adoptive macrophage transfer for the treatment of multidrug-resistant bacterial sepsis

(2020) Xucheng Hou et al.   Nature Nanotechnology

‘Off-the-shelf’ allogeneic CAR T cells: development and challenges

(2020) S. Depil et al.   NATURE REVIEWS DRUG DISCOVERY

NK cells for cancer immunotherapy

(2020) Noriko Shimasaki et al.   NATURE REVIEWS DRUG DISCOVERY

The cell biology of mitochondrial membrane dynamics

(2020) Marta Giacomello et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Engineered probiotics for local tumor delivery of checkpoint blockade nanobodies

(2020) Candice R. Gurbatri et al.   Science Translational Medicine

Chemotaxis-driven delivery of nano-pathogenoids for complete eradication of tumors post-phototherapy

(2020) Min Li et al.   Nature Communications

Artificial Mini Dendritic Cells Boost T Cell–Based Immunotherapy for Ovarian Cancer

(2020) Shanshan Cheng et al.   Advanced Science

Harnessing the Formation of Natural Killer–Tumor Cell Immunological Synapses for Enhanced Therapeutic Effect in Solid Tumors

(2020) Sooseok Im et al.   ADVANCED MATERIALS

Engineered PD‐L1‐Expressing Platelets Reverse New‐Onset Type 1 Diabetes

(2020) Xudong Zhang et al.   ADVANCED MATERIALS

A Biomimetic Nanoparticle to “Lure and Kill” Phospholipase A2

(2020) Qiangzhe Zhang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

The Emerging Landscape of Immune Cell Therapies

(2020) Evan W. Weber et al.   CELL

SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor

(2020) Markus Hoffmann et al.   CELL

Human chimeric antigen receptor macrophages for cancer immunotherapy

(2020) Michael Klichinsky et al.   NATURE BIOTECHNOLOGY

Next-generation stem cells — ushering in a new era of cell-based therapies

(2020) Erin A. Kimbrel et al.   NATURE REVIEWS DRUG DISCOVERY

Translating IL-6 biology into effective treatments

(2020) Ernest H. Choy et al.   Nature Reviews Rheumatology

Effective treatment of severe COVID-19 patients with tocilizumab

(2020) Xiaoling Xu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cytokine release syndrome in severe COVID-19

(2020) John B. Moore et al.   SCIENCE

The human tumor microbiome is composed of tumor type–specific intracellular bacteria

(2020) Deborah Nejman et al.   SCIENCE

Pathogenic T-cells and inflammatory monocytes incite inflammatory storms in severe COVID-19 patients

(2020) Yonggang Zhou et al.   National Science Review

Cellular backpacks for macrophage immunotherapy

(2020) C. Wyatt Shields et al.   Science Advances

Targeting pulmonary tumor microenvironment with CXCR4-inhibiting nanocomplex to enhance anti–PD-L1 immunotherapy

(2020) Zhaoting Li et al.   Science Advances

Biomimetic anisotropic polymeric nanoparticles coated with red blood cell membranes for enhanced circulation and toxin removal

(2020) Elana Ben-Akiva et al.   Science Advances

Improving Cancer Immunotherapy by Cell Membrane‐Camouflaged Nanoparticles

(2020) Ziling Zeng et al.   ADVANCED FUNCTIONAL MATERIALS

Recent Advances of Cell Membrane‐Coated Nanomaterials for Biomedical Applications

(2020) Wen‐Long Liu et al.   ADVANCED FUNCTIONAL MATERIALS

On‐Demand Bacterial Reactivation by Restraining within a Triggerable Nanocoating

(2020) Pingping Feng et al.   ADVANCED MATERIALS

Engineered Cell‐Membrane‐Coated Nanoparticles Directly Present Tumor Antigens to Promote Anticancer Immunity

(2020) Yao Jiang et al.   ADVANCED MATERIALS

Phase I trial evaluating safety and efficacy of intratumorally administered inflammatory allogeneic dendritic cells (ilixadencel) in advanced gastrointestinal stromal tumors

(2020) Robin Fröbom et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Cellular Nanosponges Inhibit SARS-CoV-2 Infectivity

(2020) Qiangzhe Zhang et al.   NANO LETTERS

Targeted gene correction of human hematopoietic stem cells for the treatment of Wiskott - Aldrich Syndrome

(2020) Rajeev Rai et al.   Nature Communications

A Review on Nano-Based Drug Delivery System for Cancer Chemoimmunotherapy

(2020) Weiwei Mu et al.   Nano-Micro Letters

Human iPS Cells Loaded with MnO2-Based Nanoprobes for Photodynamic and Simultaneous Enhanced Immunotherapy Against Cancer

(2020) Yanlei Liu et al.   Nano-Micro Letters

An orally delivered microbial cocktail for the removal of nitrogenous metabolic waste in animal models of kidney failure

(2020) Di-Wei Zheng et al.   Nature Biomedical Engineering

Enzyme-powered Janus platelet cell robots for active and targeted drug delivery

(2020) Songsong Tang et al.   Science Robotics

Inducible MyD88/CD40 synergizes with IL-15 to enhance antitumor efficacy of CAR-NK cells

(2020) Xiaomei Wang et al.   Blood Advances

Engineering Stem Cell Derived Biomimetic Vesicles for Versatility and Effective Targeted Delivery

(2020) Honghui Wu et al.   ADVANCED FUNCTIONAL MATERIALS

Mesenchymal Stromal Cell‐Mediated Treatment of Local and Systemic Inflammation through the Triggering of an Anti‐Inflammatory Response

(2020) Jonathan O. Martinez et al.   ADVANCED FUNCTIONAL MATERIALS

Biomineralized Bacterial Outer Membrane Vesicles Potentiate Safe and Efficient Tumor Microenvironment Reprogramming for Anticancer Therapy

(2020) Shuang Qing et al.   ADVANCED MATERIALS

Engineering Macrophages for Cancer Immunotherapy and Drug Delivery

(2020) Yuqiong Xia et al.   ADVANCED MATERIALS

Promotion of cell membrane fusion by cell-cell attachment through cell surface modification with functional peptide-PEG-lipids

(2020) Akifumi Yoshihara et al.   BIOMATERIALS

Cytotoxic CD8+ T cells in cancer and cancer immunotherapy

(2020) Hans Raskov et al.   BRITISH JOURNAL OF CANCER

Single-Cell Analyses Identify Brain Mural Cells Expressing CD19 as Potential Off-Tumor Targets for CAR-T Immunotherapies

(2020) Kevin R. Parker et al.   CELL

Exploring the NK cell platform for cancer immunotherapy

(2020) Jacob A. Myers et al.   Nature Reviews Clinical Oncology

CRISPR–Cas9 wins Nobel

(2020) Paulina Strzyz   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Decoy nanoparticles protect against COVID-19 by concurrently adsorbing viruses and inflammatory cytokines

(2020) Lang Rao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A carotenoid-deficient mutant of the plant-associated microbe Pantoea sp. YR343 displays an altered membrane proteome

(2020) Sushmitha Vijaya Kumar et al.   Scientific Reports

A materials-science perspective on tackling COVID-19

(2020) Zhongmin Tang et al.   Nature Reviews Materials

GSH depletion liposome adjuvant for augmenting the photothermal immunotherapy of breast cancer

(2020) Zhanwei Zhou et al.   Science Advances

An implantable blood clot–based immune niche for enhanced cancer vaccination

(2020) Qin Fan et al.   Science Advances

Platelet-derived extracellular vesicles regulate cell cycle progression and cell migration in breast cancer cells

(2020) Mauro Vismara et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Thrombocytopathy and endotheliopathy: crucial contributors to COVID-19 thromboinflammation

(2020) Sean X. Gu et al.   Nature Reviews Cardiology

Current practice in patients with differentiated thyroid cancer

(2020) Martin Schlumberger et al.   Nature Reviews Endocrinology

Cytokine Storm

(2020) David C. Fajgenbaum et al.   NEW ENGLAND JOURNAL OF MEDICINE

Fluorine assembly nanocluster breaks the shackles of immunosuppression to turn the cold tumor hot

(2020) Zhaoting Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Combination of metabolic intervention and T cell therapy enhances solid tumor immunotherapy

(2020) Meixi Hao et al.   Science Translational Medicine

Vaccine elicitation of HIV broadly neutralizing antibodies from engineered B cells

(2020) Deli Huang et al.   Nature Communications

Cryo-shocked cancer cells for targeted drug delivery and vaccination

(2020) Tianyuan Ci et al.   Science Advances

DC-Based Vaccines for Cancer Immunotherapy

(2020) Chunmei Fu et al.   Vaccines

Insights from nanotechnology in COVID-19 treatment

(2020) Zhongmin Tang et al.   Nano Today

Cancer Stem Cell-Platelet Hybrid Membrane-Coated Magnetic Nanoparticles for Enhanced Photothermal Therapy of Head and Neck Squamous Cell Carcinoma

(2019) Lin-Lin Bu et al.   ADVANCED FUNCTIONAL MATERIALS

Efficacy and Safety of Avelumab for Patients With Recurrent or Refractory Ovarian Cancer

(2019) Mary L. Disis et al.   JAMA Oncology

Immune Cell-Derived Extracellular Vesicles – Functions and Therapeutic Applications

(2019) Rosanne E. Veerman et al.   TRENDS IN MOLECULAR MEDICINE

Driving CAR T cell translation forward

(2019) Liora Schultz et al.   Science Translational Medicine

Sustained B cell depletion by CD19-targeted CAR T cells is a highly effective treatment for murine lupus

(2019) Rita Kansal et al.   Science Translational Medicine

Highly efficient therapeutic gene editing of human hematopoietic stem cells

(2019) Yuxuan Wu et al.   NATURE MEDICINE

Microbial bile salt hydrolases mediate the efficacy of faecal microbiota transplant in the treatment of recurrent Clostridioides difficile infection

(2019) Benjamin H Mullish et al.   GUT

Extracellular vesicles as drug delivery systems methods of production and potential therapeutic applications

(2019) Magdalena Surman et al.   CURRENT PHARMACEUTICAL DESIGN

Innate lymphocytes—lineage, localization and timing of differentiation

(2019) Emily R. Kansler et al.   Cellular & Molecular Immunology

Expandable Immunotherapeutic Nanoplatforms Engineered from Cytomembranes of Hybrid Cells Derived from Cancer and Dendritic Cells

(2019) Wen‐Long Liu et al.   ADVANCED MATERIALS

Engineered Bacterial Bioreactor for Tumor Therapy via Fenton-Like Reaction with Localized H2 O2 Generation

(2019) Jin-Xuan Fan et al.   ADVANCED MATERIALS

Artificially Reprogrammed Macrophages as Tumor-Tropic Immunosuppression-Resistant Biologics to Realize Therapeutics Production and Immune Activation

(2019) Chu-Xin Li et al.   ADVANCED MATERIALS

Advanced Functional Biomaterials for Stem Cell Delivery in Regenerative Engineering and Medicine

(2019) Xinlong Wang et al.   ADVANCED FUNCTIONAL MATERIALS

Ultrasensitive detection of circulating exosomes with a 3D-nanopatterned microfluidic chip

(2019) Peng Zhang et al.   Nature Biomedical Engineering

Engineering Magnetosomes for Ferroptosis/Immunomodulation Synergism in Cancer

(2019) Fan Zhang et al.   ACS Nano

Ligand-Modified Cell Membrane Enables the Targeted Delivery of Drug Nanocrystals to Glioma

(2019) Zhilan Chai et al.   ACS Nano

Ferrimagnetic Nanochains‐Based Mesenchymal Stem Cell Engineering for Highly Efficient Post‐Stroke Recovery

(2019) Tianyuan Zhang et al.   ADVANCED FUNCTIONAL MATERIALS

A Macrophage–Magnesium Hybrid Biomotor: Fabrication and Characterization

(2019) Fangyu Zhang et al.   ADVANCED MATERIALS

Suppression of Exosomal PD-L1 Induces Systemic Anti-tumor Immunity and Memory

(2019) Mauro Poggio et al.   CELL

NK cells: An attractive candidate for cancer therapy

(2019) Behnaz Valipour et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Externalized histone H4 orchestrates chronic inflammation by inducing lytic cell death

(2019) Carlos Silvestre-Roig et al.   NATURE

Adverse effects of immune-checkpoint inhibitors: epidemiology, management and surveillance

(2019) Filipe Martins et al.   Nature Reviews Clinical Oncology

The softness of tumour-cell-derived microparticles regulates their drug-delivery efficiency

(2019) Qingle Liang et al.   Nature Biomedical Engineering

Sequentially Site-Specific Delivery of Thrombolytics and Neuroprotectant for Enhanced Treatment of Ischemic Stroke

(2019) Jianpei Xu et al.   ACS Nano

Materials for Immunotherapy

(2019) C. Wyatt Shields et al.   ADVANCED MATERIALS

Advances in Hydrogels in Organoids and Organs‐on‐a‐Chip

(2019) Haitao Liu et al.   ADVANCED MATERIALS

Cooperation between Constitutive and Inducible Chemokines Enables T Cell Engraftment and Immune Attack in Solid Tumors

(2019) Denarda Dangaj et al.   CANCER CELL

Biomimetic Hybrid Nanozymes with Self-Supplied H+ and Accelerated O2 Generation for Enhanced Starvation and Photodynamic Therapy against Hypoxic Tumors

(2019) Xue Yang et al.   NANO LETTERS

Advances in stem cell research and therapeutic development

(2019) Michele De Luca et al.   NATURE CELL BIOLOGY

Programmable bacteria induce durable tumor regression and systemic antitumor immunity

(2019) Sreyan Chowdhury et al.   NATURE MEDICINE

Macrophages at CNS interfaces: ontogeny and function in health and disease

(2019) Katrin Kierdorf et al.   NATURE REVIEWS NEUROSCIENCE

Cytomembrane nanovaccines show therapeutic effects by mimicking tumor cells and antigen presenting cells

(2019) Wen-Long Liu et al.   Nature Communications

Regulating intracellular fate of siRNA by endoplasmic reticulum membrane-decorated hybrid nanoplexes

(2019) Chong Qiu et al.   Nature Communications

T Cell Membrane Mimicking Nanoparticles with Bioorthogonal Targeting and Immune Recognition for Enhanced Photothermal Therapy

(2019) Yutong Han et al.   Advanced Science

Platelet Inflammatory Response to Stress

(2019) Fabrice Cognasse et al.   Frontiers in Immunology

Combinatorial targeting of cancer bone metastasis using mRNA engineered stem cells

(2019) Aude I. Segaliny et al.   EBioMedicine

B cells engineered to express pathogen-specific antibodies protect against infection

(2019) Howell F. Moffett et al.   Science Immunology

Biomaterials for Personalized Cell Therapy

(2019) Amanda L. Facklam et al.   ADVANCED MATERIALS

Nanomedicine‐Based Immunotherapy for the Treatment of Cancer Metastasis

(2019) Pengcheng Zhang et al.   ADVANCED MATERIALS

Increased Survival by Pulmonary Treatment of Established Lung Metastases with Dual STAT3/CXCR4 Inhibition by siRNA Nanoemulsions

(2019) Zhaoting Li et al.   MOLECULAR THERAPY

Author Correction: At the end of the beginning: immunotherapies as living drugs

(2019) Ellen G. Feigal et al.   NATURE IMMUNOLOGY

Clinical lessons learned from the first leg of the CAR T cell journey

(2019) Robbie G. Majzner et al.   NATURE MEDICINE

Mechanisms of haemolysis-induced kidney injury

(2019) Kristof Van Avondt et al.   Nature Reviews Nephrology

CRISPR-Edited Stem Cells in a Patient with HIV and Acute Lymphocytic Leukemia

(2019) Lei Xu et al.   NEW ENGLAND JOURNAL OF MEDICINE

Breast cancer

(2019) Nadia Harbeck et al.   Nature Reviews Disease Primers

Harnessing innate immunity in cancer therapy

(2019) Olivier Demaria et al.   NATURE

Developing neoantigen-targeted T cell–based treatments for solid tumors

(2019) Tori N. Yamamoto et al.   NATURE MEDICINE

CXCR1- or CXCR2-modified CAR T cells co-opt IL-8 for maximal antitumor efficacy in solid tumors

(2019) Linchun Jin et al.   Nature Communications

Responsive Exosome Nano-bioconjugates for Synergistic Cancer Therapy

(2019) Weidong Nie et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Imaging inflammation and its resolution in health and disease: current status, clinical needs, challenges, and opportunities

(2019) Christina H. Liu et al.   FASEB JOURNAL

In Vivo Monocyte/Macrophage-Hitchhiked Intratumoral Accumulation of Nanomedicines for Enhanced Tumor Therapy

(2019) Liyan Zheng et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Pseudoneutrophil Cytokine Sponges Disrupt Myeloid Expansion and Tumor Trafficking to Improve Cancer Immunotherapy

(2019) Shuya Li et al.   NANO LETTERS

Engineering strategies to overcome the current roadblocks in CAR T cell therapy

(2019) Sarwish Rafiq et al.   Nature Reviews Clinical Oncology

Engineered E. coli Nissle 1917 for the delivery of matrix-tethered therapeutic domains to the gut

(2019) Pichet Praveschotinunt et al.   Nature Communications

Nitinol thin films functionalized with CAR-T cells for the treatment of solid tumours

(2019) Michael E. Coon et al.   Nature Biomedical Engineering

Cell Membrane Coating Nanotechnology

(2018) Ronnie H. Fang et al.   ADVANCED MATERIALS

A Micro-Ark for Cells: Highly Open Porous Polyhydroxyalkanoate Microspheres as Injectable Scaffolds for Tissue Regeneration

(2018) Dai-Xu Wei et al.   ADVANCED MATERIALS

Consequences of dysregulated complement regulators on red blood cells

(2018) Astrid J.F. Thielen et al.   BLOOD REVIEWS

Cancer statistics, 2018

(2018) Rebecca L. Siegel et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Human iPSC-Derived Natural Killer Cells Engineered with Chimeric Antigen Receptors Enhance Anti-tumor Activity

(2018) Ye Li et al.   Cell Stem Cell

A guide to manufacturing CAR T cell therapies

(2018) Philipp Vormittag et al.   CURRENT OPINION IN BIOTECHNOLOGY

Mitochondria-based aircraft carrier enhances in vivo imaging of carbon quantum dots and delivery of anticancer drug

(2018) Wen-Qing Li et al.   Nanoscale

Enhancing T cell therapy through TCR-signaling-responsive nanoparticle drug delivery

(2018) Li Tang et al.   NATURE BIOTECHNOLOGY

Engineered modular biomaterial logic gates for environmentally triggered therapeutic delivery

(2018) Barry A. Badeau et al.   Nature Chemistry

Determinants of response and resistance to CD19 chimeric antigen receptor (CAR) T cell therapy of chronic lymphocytic leukemia

(2018) Joseph A. Fraietta et al.   NATURE MEDICINE

Extracellular vesicles in cancer — implications for future improvements in cancer care

(2018) Rong Xu et al.   Nature Reviews Clinical Oncology

Tisagenlecleucel in Children and Young Adults with B-Cell Lymphoblastic Leukemia

(2018) Shannon L. Maude et al.   NEW ENGLAND JOURNAL OF MEDICINE

Programming gene and engineered-cell therapies with synthetic biology

(2018) Tasuku Kitada et al.   SCIENCE

CAR T cell immunotherapy for human cancer

(2018) Carl H. June et al.   SCIENCE

Hematopoietic stem cell transplantation in its 60s: A platform for cellular therapies

(2018) Christian Chabannon et al.   Science Translational Medicine

CRISPR-enhanced engineering of therapy-sensitive cancer cells for self-targeting of primary and metastatic tumors

(2018) Clemens Reinshagen et al.   Science Translational Medicine

Red blood cell-hitchhiking boosts delivery of nanocarriers to chosen organs by orders of magnitude

(2018) Jacob S. Brenner et al.   Nature Communications

Granulocyte-colony stimulating factor controls neural and behavioral plasticity in response to cocaine

(2018) Erin S. Calipari et al.   Nature Communications

E. coli Nissle 1917-Derived Minicells for Targeted Delivery of Chemotherapeutic Drug to Hypoxic Regions for Cancer Therapy

(2018) Yunlei Zhang et al.   Theranostics

Living Bacteria in Thermoresponsive Gel for Treating Fungal Infections

(2018) Maayan Lufton et al.   ADVANCED FUNCTIONAL MATERIALS

Chemodynamic Therapy: Tumour Microenvironment-Mediated Fenton and Fenton-like Reaction

(2018) Zhongmin Tang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Bioengineering strategies to accelerate stem cell therapeutics

(2018) Christopher M. Madl et al.   NATURE

Biomaterial-assisted targeted modulation of immune cells in cancer treatment

(2018) Hua Wang et al.   NATURE MATERIALS

Neutrophil membrane-coated nanoparticles inhibit synovial inflammation and alleviate joint damage in inflammatory arthritis

(2018) Qiangzhe Zhang et al.   Nature Nanotechnology

Stem cell bioengineering: building from stem cell biology

(2018) Mukul Tewary et al.   NATURE REVIEWS GENETICS

Sandwich-Like Fibers/Sponge Composite Combining Chemotherapy and Hemostasis for Efficient Postoperative Prevention of Tumor Recurrence and Metastasis

(2018) Zhiyun Zhang et al.   ADVANCED MATERIALS

Nanoparticle‐Laden Macrophages for Tumor‐Tropic Drug Delivery

(2018) Weizhong Zhang et al.   ADVANCED MATERIALS

Emerging Cellular Therapies for Cancer

(2018) Sonia Guedan et al.   Annual Review of Immunology

ASBMT Consensus Grading for Cytokine Release Syndrome and Neurological Toxicity Associated with Immune Effector Cells

(2018) Daniel W Lee et al.   BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION

Conversion of hepatoma cells to hepatocyte-like cells by defined hepatocyte nuclear factors

(2018) Zhuo Cheng et al.   CELL RESEARCH

Disruption of a self-amplifying catecholamine loop reduces cytokine release syndrome

(2018) Verena Staedtke et al.   NATURE

Neoadjuvant immune checkpoint blockade in high-risk resectable melanoma

(2018) Rodabe N. Amaria et al.   NATURE MEDICINE

Mitochondria as a therapeutic target for common pathologies

(2018) Michael P. Murphy et al.   NATURE REVIEWS DRUG DISCOVERY

Trial watch: The clinical trial landscape for PD1/PDL1 immune checkpoint inhibitors

(2018) Jun Tang et al.   NATURE REVIEWS DRUG DISCOVERY

Wound Healing: A Cellular Perspective

(2018) Melanie Rodrigues et al.   PHYSIOLOGICAL REVIEWS

MR imaging tracking of inflammation-activatable engineered neutrophils for targeted therapy of surgically treated glioma

(2018) Meiying Wu et al.   Nature Communications

Conjugation of haematopoietic stem cells and platelets decorated with anti-PD-1 antibodies augments anti-leukaemia efficacy

(2018) Quanyin Hu et al.   Nature Biomedical Engineering

FDA Approval of Tisagenlecleucel

(2017) Peter B. Bach et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Inflammation-induced IgA+ cells dismantle anti-liver cancer immunity

(2017) Shabnam Shalapour et al.   NATURE

Neutrophil-mediated anticancer drug delivery for suppression of postoperative malignant glioma recurrence

(2017) Jingwei Xue et al.   Nature Nanotechnology

Delivery technologies for genome editing

(2017) Hao Yin et al.   NATURE REVIEWS DRUG DISCOVERY

CAR T therapies drive into new terrain

(2017) Katie Kingwell   NATURE REVIEWS DRUG DISCOVERY

Mitochondrial diseases: the contribution of organelle stress responses to pathology

(2017) Anu Suomalainen et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Phosphoproteins in extracellular vesicles as candidate markers for breast cancer

(2017) I-Hsuan Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Macrophage-like nanoparticles concurrently absorbing endotoxins and proinflammatory cytokines for sepsis management

(2017) Soracha Thamphiwatana et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Selected cytokine pathways in rheumatoid arthritis

(2017) Mélissa Noack et al.   Seminars in Immunopathology

Engineered probiotic Escherichia coli can eliminate and prevent Pseudomonas aeruginosa gut infection in animal models

(2017) In Young Hwang et al.   Nature Communications

Endothelial Activation and Blood–Brain Barrier Disruption in Neurotoxicity after Adoptive Immunotherapy with CD19 CAR-T Cells

(2017) Juliane Gust et al.   Cancer Discovery

Factors associated with time to diagnosis from symptom onset in patients with early rheumatoid arthritis

(2017) Soo-Kyoung Cho et al.   KOREAN JOURNAL OF INTERNAL MEDICINE

mSA2 affinity-enhanced biotin-binding CAR T cells for universal tumor targeting

(2017) Jason J. Lohmueller et al.   OncoImmunology

Type 1 diabetes mellitus

(2017) Anastasia Katsarou et al.   Nature Reviews Disease Primers

Current approaches to increase CAR T cell potency in solid tumors: targeting the tumor microenvironment

(2017) Irene Scarfò et al.   Journal for ImmunoTherapy of Cancer

In situ activation of platelets with checkpoint inhibitors for post-surgical cancer immunotherapy

(2017) Chao Wang et al.   Nature Biomedical Engineering

Extracellular vesicles for drug delivery

(2016) Pieter Vader et al.   ADVANCED DRUG DELIVERY REVIEWS

Red blood cells: Supercarriers for drugs, biologicals, and nanoparticles and inspiration for advanced delivery systems

(2016) Carlos H. Villa et al.   ADVANCED DRUG DELIVERY REVIEWS

Red Blood Cell-Facilitated Photodynamic Therapy for Cancer Treatment

(2016) Wei Tang et al.   ADVANCED FUNCTIONAL MATERIALS

Nanoparticles camouflaged in platelet membrane coating as an antibody decoy for the treatment of immune thrombocytopenia

(2016) Xiaoli Wei et al.   BIOMATERIALS

CRISPR-Cas9-mediated multiplex gene editing in CAR-T cells

(2016) Xiaojuan Liu et al.   CELL RESEARCH

Tumor-Produced Interleukin-8 Attracts Human Myeloid-Derived Suppressor Cells and Elicits Extrusion of Neutrophil Extracellular Traps (NETs)

(2016) C. Alfaro et al.   CLINICAL CANCER RESEARCH

TRAIL-coated leukocytes that prevent the bloodborne metastasis of prostate cancer

(2016) Elizabeth C. Wayne et al.   JOURNAL OF CONTROLLED RELEASE

Atezolizumab in patients with locally advanced and metastatic urothelial carcinoma who have progressed following treatment with platinum-based chemotherapy: a single-arm, multicentre, phase 2 trial

(2016) Jonathan E Rosenberg et al.   LANCET

Development of exosome-encapsulated paclitaxel to overcome MDR in cancer cells

(2016) Myung Soo Kim et al.   Nanomedicine-Nanotechnology Biology and Medicine

Targeting natural killer cells in cancer immunotherapy

(2016) Camille Guillerey et al.   NATURE IMMUNOLOGY

Driving CAR T-cells forward

(2016) Hollie J. Jackson et al.   Nature Reviews Clinical Oncology

The future of cancer treatment: immunomodulation, CARs and combination immunotherapy

(2016) Danny N. Khalil et al.   Nature Reviews Clinical Oncology

The global burden of SLE: prevalence, health disparities and socioeconomic impact

(2016) Erin E. Carter et al.   Nature Reviews Rheumatology

Hurdles of CAR-T cell-based cancer immunotherapy directed against solid tumors

(2016) Bing-Lan Zhang et al.   Science China-Life Sciences

Detoxification of Organophosphate Poisoning Using Nanoparticle Bioscavengers

(2015) Zhiqing Pang et al.   ACS Nano

A novel platform for cancer therapy using extracellular vesicles

(2015) Naoomi Tominaga et al.   ADVANCED DRUG DELIVERY REVIEWS

Anticancer Platelet-Mimicking Nanovehicles

(2015) Quanyin Hu et al.   ADVANCED MATERIALS

Immune Checkpoint Blockade in Cancer Therapy

(2015) Michael A. Postow et al.   JOURNAL OF CLINICAL ONCOLOGY

Macrophage mediated biomimetic delivery system for the treatment of lung metastasis of breast cancer

(2015) Jijun Fu et al.   JOURNAL OF CONTROLLED RELEASE

Cytosolic phospholipase A2: physiological function and role in disease

(2015) Christina C. Leslie   JOURNAL OF LIPID RESEARCH

ErbB2/HER2-Specific NK Cells for Targeted Therapy of Glioblastoma

(2015) Congcong Zhang et al.   JNCI-Journal of the National Cancer Institute

Nanoparticle uptake: The phagocyte problem

(2015) Heather Herd Gustafson et al.   Nano Today

Heparanase promotes tumor infiltration and antitumor activity of CAR-redirected T lymphocytes

(2015) Ignazio Caruana et al.   NATURE MEDICINE

Precision medicine for metastatic breast cancer—limitations and solutions

(2015) Monica Arnedos et al.   Nature Reviews Clinical Oncology

Pembrolizumab versus Ipilimumab in Advanced Melanoma

(2015) Caroline Robert et al.   NEW ENGLAND JOURNAL OF MEDICINE

Adoptive cell transfer as personalized immunotherapy for human cancer

(2015) S. A. Rosenberg et al.   SCIENCE

The future of immune checkpoint therapy

(2015) P. Sharma et al.   SCIENCE

Active targeting of chemotherapy to disseminated tumors using nanoparticle-carrying T cells

(2015) Bonnie Huang et al.   Science Translational Medicine

Macrophage Cell Membrane Camouflaged Mesoporous Silica Nanocapsules for In Vivo Cancer Therapy

(2015) Minjun Xuan et al.   Advanced Healthcare Materials

ErbB2/HER2-Specific NK Cells for Targeted Therapy of Glioblastoma

(2015) Congcong Zhang et al.   JNCI-Journal of the National Cancer Institute

Internalization of Rituximab and the Efficiency of B Cell Depletion in Rheumatoid Arthritis and Systemic Lupus Erythematosus

(2015) Venkat Reddy et al.   Arthritis & Rheumatology

Immunological Responses Triggered by Photothermal Therapy with Carbon Nanotubes in Combination with Anti-CTLA-4 Therapy to Inhibit Cancer Metastasis

(2014) Chao Wang et al.   ADVANCED MATERIALS

Targeted depletion of tumour-associated macrophages by an alendronate–glucomannan conjugate for cancer immunotherapy

(2014) Xiudan Zhan et al.   BIOMATERIALS

Role of the Microbiota in Immunity and Inflammation

(2014) Yasmine Belkaid et al.   CELL

Physical and mechanical regulation of macrophage phenotype and function

(2014) Frances Y. McWhorter et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Erythrocytes-based synthetic delivery systems: transition from conventional to novel engineering strategies

(2014) Manisha Bhateria et al.   Expert Opinion on Drug Delivery

Cancer Cell Membrane-Coated Nanoparticles for Anticancer Vaccination and Drug Delivery

(2014) Ronnie H. Fang et al.   NANO LETTERS

Mitochondrial form and function

(2014) Jonathan R. Friedman et al.   NATURE

The multifactorial role of neutrophils in rheumatoid arthritis

(2014) Helen L. Wright et al.   Nature Reviews Rheumatology

MSCs derived from iPSCs with a modified protocol are tumor-tropic but have much less potential to promote tumors than bone marrow MSCs

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Investigating the optimal size of anticancer nanomedicine

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Intra-articular hyaluronic acid injection versus oral non-steroidal anti-inflammatory drug for the treatment of knee osteoarthritis: a multi-center, randomized, open-label, non-inferiority trial

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Are natural killer cells superior CAR drivers?

(2014) Hans Klingemann   OncoImmunology

Delivering Nanoparticles to Lungs while Avoiding Liver and Spleen through Adsorption on Red Blood Cells

(2013) Aaron C. Anselmo et al.   ACS Nano

Nonviral Cell Labeling and Differentiation Agent for Induced Pluripotent Stem Cells Based on Mesoporous Silica Nanoparticles

(2013) Wei Chen et al.   ACS Nano

The Multifaceted Functions of Neutrophils

(2013) Tanya N. Mayadas et al.   Annual Review of Pathology-Mechanisms of Disease

Immune targeting of fibroblast activation protein triggers recognition of multipotent bone marrow stromal cells and cachexia

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Immunosuppression in sepsis: a novel understanding of the disorder and a new therapeutic approach

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A biomimetic nanosponge that absorbs pore-forming toxins

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The influence of ageing on the development and management of rheumatoid arthritis

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Transcytosis and brain uptake of transferrin-containing nanoparticles by tuning avidity to transferrin receptor

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Tumor Tropism of Intravenously Injected Human-Induced Pluripotent Stem Cell-Derived Neural Stem Cells and Their Gene Therapy Application in a Metastatic Breast Cancer Model

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Interaction of Mesoporous Silica Nanoparticles with Human Red Blood Cell Membranes: Size and Surface Effects

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Direct Signaling between Platelets and Cancer Cells Induces an Epithelial-Mesenchymal-Like Transition and Promotes Metastasis

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(2011) Mariana J. Kaplan   Nature Reviews Rheumatology

Mutator activity induced by microRNA-155 (miR-155) links inflammation and cancer

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(2010) Vladimir R Muzykantov   Expert Opinion on Drug Delivery

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(2010) Yan Ning et al.   INTERNATIONAL JOURNAL OF CANCER

Case Report of a Serious Adverse Event Following the Administration of T Cells Transduced With a Chimeric Antigen Receptor Recognizing ERBB2

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Therapeutic cell engineering with surface-conjugated synthetic nanoparticles

(2010) Matthias T Stephan et al.   NATURE MEDICINE

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Targeting mitochondria for cancer therapy

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Efficacy and safety of rituximab in moderately-to-severely active systemic lupus erythematosus: The randomized, double-blind, phase ii/iii systemic lupus erythematosus evaluation of rituximab trial

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(2009) George Q. Daley et al.   Cell Stem Cell

Activating systemic autoimmunity: B's, T's, and tolls

(2009) Mark J Shlomchik   CURRENT OPINION IN IMMUNOLOGY

DCVax®-Brain and DC vaccines in the treatment of GBM

(2009) Christopher J Wheeler et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Platelet functions beyond hemostasis, antiplatelet therapies in high-risk patient subgroups: the Fourth Annual Platelet Colloquium

(2009) Patricia A. French   JOURNAL OF THROMBOSIS AND THROMBOLYSIS

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In vitro Inhibition of Fungal Activity by Macrophage-Mediated Sequestration and Release of Encapsulated Amphotericin B Nanosupension in Red Blood Cells

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(2008) Eric Vivier et al.   NATURE IMMUNOLOGY