Programmable bacteria induce durable tumor regression and systemic antitumor immunity

The microbiome, cancer, and cancer therapy

(2019) Beth A. Helmink et al.   NATURE MEDICINE

SIRPα–CD47 Immune Checkpoint Blockade in Anticancer Therapy

(2018) André Veillette et al.   TRENDS IN IMMUNOLOGY

ALX148 blocks CD47 and enhances innate and adaptive antitumor immunity with a favorable safety profile

(2018) Steven E. Kauder et al.   PLoS One

Dual Targeting of Innate and Adaptive Checkpoints on Tumor Cells Limits Immune Evasion

(2018) Xiaojuan Liu et al.   Cell Reports

CD47 Blockade by Hu5F9-G4 and Rituximab in Non-Hodgkin’s Lymphoma

(2018) Ranjana Advani et al.   NEW ENGLAND JOURNAL OF MEDICINE

Engineering Microbial Living Therapeutics: The Synthetic Biology Toolbox

(2018) Danielle B. Pedrolli et al.   TRENDS IN BIOTECHNOLOGY

Localized CD47 blockade enhances immunotherapy for murine melanoma

(2017) Jessica R. Ingram et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Two-step enhanced cancer immunotherapy with engineeredSalmonella typhimuriumsecreting heterologous flagellin

(2017) Jin Hai Zheng et al.   Science Translational Medicine

Targeting CD47: the achievements and concerns of current studies on cancer immunotherapy

(2017) Yuting Huang et al.   Journal of Thoracic Disease

Synchronized cycles of bacterial lysis for in vivo delivery

(2016) M. Omar Din et al.   NATURE

Durable antitumor responses to CD47 blockade require adaptive immune stimulation

(2016) Jonathan T. Sockolosky et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

CD47 blockade triggers T cell–mediated destruction of immunogenic tumors

(2015) Xiaojuan Liu et al.   NATURE MEDICINE

Programmable probiotics for detection of cancer in urine

(2015) Tal Danino et al.   Science Translational Medicine

Measuring mRNA copy number in individual Escherichia coli cells using single-molecule fluorescent in situ hybridization

(2013) Samuel O Skinner et al.   Nature Protocols

Cell-Based Therapeutics: The Next Pillar of Medicine

(2013) M. A. Fischbach et al.   Science Translational Medicine

Alp7R Regulates Expression of the Actin-Like Protein Alp7A in Bacillus subtilis

(2012) A. I. Derman et al.   JOURNAL OF BACTERIOLOGY

The CD47-signal regulatory protein alpha (SIRPa) interaction is a therapeutic target for human solid tumors

(2012) S. B. Willingham et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cancer immunotherapy comes of age

(2011) Ira Mellman et al.   NATURE

Emerging biomedical applications of synthetic biology

(2011) Wilfried Weber et al.   NATURE REVIEWS GENETICS

Synthetic Biology Moving into the Clinic

(2011) W. C. Ruder et al.   SCIENCE

From DNA to Targeted Therapeutics: Bringing Synthetic Biology to the Clinic

(2011) Y. Y. Chen et al.   Science Translational Medicine

Inhibition of Tumor Growth and Metastasis by a Combination of Escherichia coli –mediated Cytolytic Therapy and Radiotherapy

(2010) Sheng-Nan Jiang et al.   MOLECULAR THERAPY

A synchronized quorum of genetic clocks

(2010) Tal Danino et al.   NATURE

CD47 Is Upregulated on Circulating Hematopoietic Stem Cells and Leukemia Cells to Avoid Phagocytosis

(2009) Siddhartha Jaiswal et al.   CELL

CD47 Is an Adverse Prognostic Factor and Therapeutic Antibody Target on Human Acute Myeloid Leukemia Stem Cells

(2009) Ravindra Majeti et al.   CELL

Synthetic Gene Networks That Count

(2009) A. E. Friedland et al.   SCIENCE