Enhancing T cell therapy through TCR-signaling-responsive nanoparticle drug delivery

Folate-targeted pH-responsive calcium zoledronate nanoscale metal-organic frameworks: Turning a bone antiresorptive agent into an anticancer therapeutic

(2016) Kin Man Au et al.   BIOMATERIALS

Membrane-attached Cytokines Expressed by mRNA Electroporation Act as Potent T-Cell Adjuvants

(2016) Hadas Weinstein-Marom et al.   JOURNAL OF IMMUNOTHERAPY

Polymer Nanoparticles Modified with Photo- and pH-Dual-Responsive Polypeptides for Enhanced and Targeted Cancer Therapy

(2016) Yang Yang et al.   MOLECULAR PHARMACEUTICS

Initiation of T cell signaling by CD45 segregation at 'close contacts'

(2016) Veronica T Chang et al.   NATURE IMMUNOLOGY

Tumor-Infiltrating Lymphocytes Genetically Engineered with an Inducible Gene Encoding Interleukin-12 for the Immunotherapy of Metastatic Melanoma

(2015) L. Zhang et al.   CLINICAL CANCER RESEARCH

Redistribution, Hyperproliferation, Activation of Natural Killer Cells and CD8 T Cells, and Cytokine Production During First-in-Human Clinical Trial of Recombinant Human Interleukin-15 in Patients With Cancer

(2015) Kevin C. Conlon et al.   JOURNAL OF CLINICAL ONCOLOGY

IL-15 Superagonist–Mediated Immunotoxicity: Role of NK Cells and IFN-γ

(2015) Yin Guo et al.   JOURNAL OF IMMUNOLOGY

Adoptive cell transfer as personalized immunotherapy for human cancer

(2015) S. A. Rosenberg et al.   SCIENCE

Remote control of therapeutic T cells through a small molecule-gated chimeric receptor

(2015) C.-Y. Wu et al.   SCIENCE

Active targeting of chemotherapy to disseminated tumors using nanoparticle-carrying T cells

(2015) Bonnie Huang et al.   Science Translational Medicine

Rational development and characterization of humanized anti–EGFR variant III chimeric antigen receptor T cells for glioblastoma

(2015) Laura A. Johnson et al.   Science Translational Medicine

Self-Immolative Linkers Literally Bridge Disulfide Chemistry and the Realm of Thiol-Free Drugs

(2015) Camilla Frich Riber et al.   Advanced Healthcare Materials

Comparison of the Superagonist Complex, ALT-803, to IL15 as Cancer Immunotherapeutics in Animal Models

(2015) P. R. Rhode et al.   Cancer Immunology Research

pH-Sensitive Nanoformulated Triptolide as a Targeted Therapeutic Strategy for Hepatocellular Carcinoma

(2014) Daishun Ling et al.   ACS Nano

Adoptive Immunotherapy for Cancer or Viruses

(2014) Marcela V. Maus et al.   Annual Review of Immunology

Going viral: chimeric antigen receptor T-cell therapy for hematological malignancies

(2014) Saar Gill et al.   IMMUNOLOGICAL REVIEWS

T-Cell Immunotherapy: Looking Forward

(2014) Jacqueline Corrigan-Curay et al.   MOLECULAR THERAPY

Chimeric Antigen Receptor T Cells for Sustained Remissions in Leukemia

(2014) Shannon L. Maude et al.   NEW ENGLAND JOURNAL OF MEDICINE

Oxidative Stress in Malignant Melanoma Enhances Tumor Necrosis Factor-α Secretion of Tumor-Associated Macrophages That Promote Cancer Cell Invasion

(2013) Xuzhu Lin et al.   ANTIOXIDANTS & REDOX SIGNALING

Injectable, porous, and cell-responsive gelatin cryogels

(2013) Sandeep T. Koshy et al.   BIOMATERIALS

In vivo targeting of adoptively transferred T-cells with antibody- and cytokine-conjugated liposomes

(2013) Yiran Zheng et al.   JOURNAL OF CONTROLLED RELEASE

Nanoclusters self-assembled from conformation-stabilized influenza M2e as broadly cross-protective influenza vaccines

(2013) Li Wang et al.   Nanomedicine-Nanotechnology Biology and Medicine

Cyclooxgenase-2 Inhibiting Perfluoropoly (Ethylene Glycol) Ether Theranostic Nanoemulsions—In Vitro Study

(2013) Sravan Kumar Patel et al.   PLoS One

Tumor-Specific Activation of an EGFR-Targeting Probody Enhances Therapeutic Index

(2013) L. R. Desnoyers et al.   Science Translational Medicine

PD-1- and CTLA-4-Based Inhibitory Chimeric Antigen Receptors (iCARs) Divert Off-Target Immunotherapy Responses

(2013) V. D. Fedorov et al.   Science Translational Medicine

Synapse-directed delivery of immunomodulators using T-cell-conjugated nanoparticles

(2012) Matthias T. Stephan et al.   BIOMATERIALS

Tumor-targeted T cells modified to secrete IL-12 eradicate systemic tumors without need for prior conditioning

(2012) H. J. Pegram et al.   BLOOD

Local Delivery of lnterleukin-12 Using T Cells Targeting VEGF Receptor-2 Eradicates Multiple Vascularized Tumors in Mice

(2012) D. Chinnasamy et al.   CLINICAL CANCER RESEARCH

Rendering Protein-Based Particles Transiently Insoluble for Therapeutic Applications

(2012) Jing Xu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Combinatorial antigen recognition with balanced signaling promotes selective tumor eradication by engineered T cells

(2012) Christopher C Kloss et al.   NATURE BIOTECHNOLOGY

PEG-urokinase nanogels with enhanced stability and controllable bioactivity

(2012) Hui Tan et al.   Soft Matter

IL-12 Release by Engineered T Cells Expressing Chimeric Antigen Receptors Can Effectively Muster an Antigen-Independent Macrophage Response on Tumor Cells That Have Shut Down Tumor Antigen Expression

(2011) M. Chmielewski et al.   CANCER RESEARCH

IL-15:IL-15 receptor alpha superagonist complex: High-level co-expression in recombinant mammalian cells, purification and characterization

(2011) Kai-ping Han et al.   CYTOKINE

Bioresponsive Mesoporous Silica Nanoparticles for Triggered Drug Release

(2011) Neetu Singh et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Case Report of a Serious Adverse Event Following the Administration of T Cells Transduced With a Chimeric Antigen Receptor Recognizing ERBB2

(2010) Richard A Morgan et al.   MOLECULAR THERAPY

Therapeutic cell engineering with surface-conjugated synthetic nanoparticles

(2010) Matthias T Stephan et al.   NATURE MEDICINE

Novel Human Interleukin-15 Agonists

(2009) X. Zhu et al.   JOURNAL OF IMMUNOLOGY

Protein adsorption and cell adhesion on nanoscale bioactive coatings formed from poly(ethylene glycol) and albumin microgels

(2008) Evan A. Scott et al.   BIOMATERIALS

Transforming Growth Factor-  Receptor Blockade Augments the Effectiveness of Adoptive T-Cell Therapy of Established Solid Cancers

(2008) A. Wallace et al.   CLINICAL CANCER RESEARCH