Biomineralized Bacterial Outer Membrane Vesicles Potentiate Safe and Efficient Tumor Microenvironment Reprogramming for Anticancer Therapy

Combining microenvironment normalization strategies to improve cancer immunotherapy

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Approaches to treat immune hot, altered and cold tumours with combination immunotherapies

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Nanoenabled Modulation of Acidic Tumor Microenvironment Reverses Anergy of Infiltrating T Cells and Potentiates Anti-PD-1 Therapy

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Mild photothermal therapy potentiates anti-PD-L1 treatment for immunologically cold tumors via an all-in-one and all-in-control strategy

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Addressing barriers to effective cancer immunotherapy with nanotechnology: achievements, challenges, and roadmap to the next generation of nanoimmunotherapeutics

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Nanoparticle-mediated Immunogenic Cell Death Enables and Potentiates Cancer Immunotherapy

(2018) Xiaopin Duan et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

T Cell Dysfunction in Cancer

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Nanoparticle anchoring targets immune agonists to tumors enabling anti-cancer immunity without systemic toxicity

(2018) Yuan Zhang et al.   Nature Communications

TLR7/8-agonist-loaded nanoparticles promote the polarization of tumour-associated macrophages to enhance cancer immunotherapy

(2018) Christopher B. Rodell et al.   Nature Biomedical Engineering

Nanoparticle-Conjugate TLR7/8 Agonist Localized Immunotherapy Provokes Safe Antitumoral Responses

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Tumor immunoevasion via acidosis-dependent induction of regulatory tumor-associated macrophages

(2018) Toszka Bohn et al.   NATURE IMMUNOLOGY

Tumors sweeten macrophages with acids

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In situ sprayed bioresponsive immunotherapeutic gel for post-surgical cancer treatment

(2018) Qian Chen et al.   Nature Nanotechnology

Efficient Near Infrared Light Triggered Nitric Oxide Release Nanocomposites for Sensitizing Mild Photothermal Therapy

(2018) Xiao Zhang et al.   Advanced Science

Antigen-capturing nanoparticles improve the abscopal effect and cancer immunotherapy

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Pathogen boosted adoptive cell transfer immunotherapy to treat solid tumors

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Bacterial outer membrane vesicles suppress tumor by interferon-γ-mediated antitumor response

(2017) Oh Youn Kim et al.   Nature Communications

Nano-enabled pancreas cancer immunotherapy using immunogenic cell death and reversing immunosuppression

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A Drug-Free Tumor Therapy Strategy: Cancer-Cell-Targeting Calcification

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Toll-like receptor 2 activation depends on lipopeptide shedding by bacterial surfactants

(2016) Dennis Hanzelmann et al.   Nature Communications

An immunostimulatory dual-functional nanocarrier that improves cancer immunochemotherapy

(2016) Yichao Chen et al.   Nature Communications

Mesothelin-Targeted CARs: Driving T Cells to Solid Tumors

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Bioengineered Bacterial Outer Membrane Vesicles as Cell-Specific Drug-Delivery Vehicles for Cancer Therapy

(2014) Vipul Gujrati et al.   ACS Nano

Multifactorial T-cell Hypofunction That Is Reversible Can Limit the Efficacy of Chimeric Antigen Receptor-Transduced Human T cells in Solid Tumors

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Macrophage Regulation of Tumor Responses to Anticancer Therapies

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Cancer Immunotherapy

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Managing uncertainty: A perspective on risk pertaining to product quality attributes as they bear on immunogenicity of therapeutic proteins

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Combination delivery of TGF-β inhibitor and IL-2 by nanoscale liposomal polymeric gels enhances tumour immunotherapy

(2012) Jason Park et al.   NATURE MATERIALS

Cancer immunotherapy comes of age

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Improved Survival with Ipilimumab in Patients with Metastatic Melanoma

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TGF-β and immune cells: an important regulatory axis in the tumor microenvironment and progression

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TLR2 Looks at Lipoproteins

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