Macrophage biology in development, homeostasis and disease

Macrophages as APC and the Dendritic Cell Myth

(2014) D. A. Hume   JOURNAL OF IMMUNOLOGY

Pleiotropic Actions of Insulin Resistance and Inflammation in Metabolic Homeostasis

(2013) J. I. Odegaard et al.   SCIENCE

Recruitment of monocytes/macrophages by tissue factor-mediated coagulation is essential for metastatic cell survival and premetastatic niche establishment in mice

(2012) A. M. Gil-Bernabe et al.   BLOOD

Adoptive transfer of IL-4Rα+ macrophages is sufficient to enhance eosinophilic inflammation in a mouse model of allergic lung inflammation

(2012) Andrew Q Ford et al.   BMC IMMUNOLOGY

Accessories to the Crime: Functions of Cells Recruited to the Tumor Microenvironment

(2012) Douglas Hanahan et al.   CANCER CELL

Mechanisms for Insulin Resistance: Common Threads and Missing Links

(2012) Varman T. Samuel et al.   CELL

Saturated Fatty Acid and TLR Signaling Link β Cell Dysfunction and Islet Inflammation

(2012) Kosei Eguchi et al.   Cell Metabolism

The CSF-1 receptor ligands IL-34 and CSF-1 exhibit distinct developmental brain expression patterns and regulate neural progenitor cell maintenance and maturation

(2012) Sayan Nandi et al.   DEVELOPMENTAL BIOLOGY

Reciprocal Regulation between Resting Microglial Dynamics and Neuronal Activity In Vivo

(2012) Ying Li et al.   DEVELOPMENTAL CELL

Transcript profiling of CD16-positive monocytes reveals a unique molecular fingerprint

(2012) Marion Frankenberger et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

A defect of CD16-positive monocytes can occur without disease

(2012) Marion Frankenberger et al.   IMMUNOBIOLOGY

Allergic airway disease is unaffected by the absence of IL-4Rα–dependent alternatively activated macrophages

(2012) Natalie E. Nieuwenhuizen et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Macrophage plasticity and polarization: in vivo veritas

(2012) Antonio Sica et al.   JOURNAL OF CLINICAL INVESTIGATION

Inflammation switches the differentiation program of Ly6Chimonocytes from antiinflammatory macrophages to inflammatory dendritic cells in the colon

(2012) Aymeric Rivollier et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Adult Langerhans cells derive predominantly from embryonic fetal liver monocytes with a minor contribution of yolk sac–derived macrophages

(2012) Guillaume Hoeffel et al.   JOURNAL OF EXPERIMENTAL MEDICINE

IL-34 is a tissue-restricted ligand of CSF1R required for the development of Langerhans cells and microglia

(2012) Yaming Wang et al.   NATURE IMMUNOLOGY

Deciphering the transcriptional network of the dendritic cell lineage

(2012) Jennifer C Miller et al.   NATURE IMMUNOLOGY

Re(de)fining the dendritic cell lineage

(2012) Ansuman T Satpathy et al.   NATURE IMMUNOLOGY

Gene-expression profiles and transcriptional regulatory pathways that underlie the identity and diversity of mouse tissue macrophages

(2012) Emmanuel L Gautier et al.   NATURE IMMUNOLOGY

Macrophage-derived Wnt opposes Notch signaling to specify hepatic progenitor cell fate in chronic liver disease

(2012) Luke Boulter et al.   NATURE MEDICINE

Melanoma exosomes educate bone marrow progenitor cells toward a pro-metastatic phenotype through MET

(2012) Héctor Peinado et al.   NATURE MEDICINE

Mechanisms of fibrosis: therapeutic translation for fibrotic disease

(2012) Thomas A Wynn et al.   NATURE MEDICINE

A Lineage of Myeloid Cells Independent of Myb and Hematopoietic Stem Cells

(2012) C. Schulz et al.   SCIENCE

Intestinal Inflammation Targets Cancer-Inducing Activity of the Microbiota

(2012) J. C. Arthur et al.   SCIENCE

Colony stimulating factors and myeloid cell biology in health and disease

(2012) John A. Hamilton et al.   TRENDS IN IMMUNOLOGY

Role of c-MYC in alternative activation of human macrophages and tumor-associated macrophage biology

(2011) O. M. Pello et al.   BLOOD

Macrophage presence is essential for the regeneration of ascending afferent fibres following a conditioning sciatic nerve lesion in adult rats

(2011) Ernesto A Aguilar Salegio et al.   BMC NEUROSCIENCE

Targeting the ANG2/TIE2 Axis Inhibits Tumor Growth and Metastasis by Impairing Angiogenesis and Disabling Rebounds of Proangiogenic Myeloid Cells

(2011) Roberta Mazzieri et al.   CANCER CELL

CCL18 from Tumor-Associated Macrophages Promotes Breast Cancer Metastasis via PITPNM3

(2011) Jingqi Chen et al.   CANCER CELL

Macrophage therapy for murine liver fibrosis recruits host effector cells improving fibrosis, regeneration, and function

(2011) James A. Thomas et al.   HEPATOLOGY

Krüppel-like factor 4 regulates macrophage polarization

(2011) Xudong Liao et al.   JOURNAL OF CLINICAL INVESTIGATION

An unrestrained proinflammatory M1 macrophage population induced by iron impairs wound healing in humans and mice

(2011) Anca Sindrilaru et al.   JOURNAL OF CLINICAL INVESTIGATION

Adipose tissue remodeling and obesity

(2011) Kai Sun et al.   JOURNAL OF CLINICAL INVESTIGATION

Neuroprotection and progenitor cell renewal in the injured adult murine retina requires healing monocyte-derived macrophages

(2011) Anat London et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The human syndrome of dendritic cell, monocyte, B and NK lymphoid deficiency

(2011) Venetia Bigley et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Bone marrow CD169+macrophages promote the retention of hematopoietic stem and progenitor cells in the mesenchymal stem cell niche

(2011) Andrew Chow et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Obstacles and opportunities for understanding macrophage polarization

(2011) P. J. Murray et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Interferon-γ links ultraviolet radiation to melanomagenesis in mice

(2011) M. Raza Zaidi et al.   NATURE

Regulation of angiogenesis by a non-canonical Wnt–Flt1 pathway in myeloid cells

(2011) James A. Stefater III et al.   NATURE

Alternatively activated macrophages produce catecholamines to sustain adaptive thermogenesis

(2011) Khoa D. Nguyen et al.   NATURE

CCL2 recruits inflammatory monocytes to facilitate breast-tumour metastasis

(2011) Bin-Zhi Qian et al.   NATURE

Progress and challenges in translating the biology of atherosclerosis

(2011) Peter Libby et al.   NATURE

VEGFR-3 controls tip to stalk conversion at vessel fusion sites by reinforcing Notch signalling

(2011) Tuomas Tammela et al.   NATURE CELL BIOLOGY

Mutations in the colony stimulating factor 1 receptor (CSF1R) gene cause hereditary diffuse leukoencephalopathy with spheroids

(2011) Rosa Rademakers et al.   NATURE GENETICS

IRF5 promotes inflammatory macrophage polarization and TH1-TH17 responses

(2011) Thomas Krausgruber et al.   NATURE IMMUNOLOGY

The immune system in atherosclerosis

(2011) Göran K Hansson et al.   NATURE IMMUNOLOGY

Setup and use of a two-laser multiphoton microscope for multichannel intravital fluorescence imaging

(2011) David Entenberg et al.   Nature Protocols

Advances in osteoclast biology: old findings and new insights from mouse models

(2011) James R. Edwards et al.   Nature Reviews Rheumatology

Absence of Colony Stimulation Factor-1 Receptor Results in Loss of Microglia, Disrupted Brain Development and Olfactory Deficits

(2011) Bryna Erblich et al.   PLoS One

Local Macrophage Proliferation, Rather than Recruitment from the Blood, Is a Signature of TH2 Inflammation

(2011) S. J. Jenkins et al.   SCIENCE

Synaptic Pruning by Microglia Is Necessary for Normal Brain Development

(2011) R. C. Paolicelli et al.   SCIENCE

Cancer-related inflammation: Common themes and therapeutic opportunities

(2011) Frances R. Balkwill et al.   SEMINARS IN CANCER BIOLOGY

Proteolytic networks in cancer

(2011) Steven D. Mason et al.   TRENDS IN CELL BIOLOGY

Macrophages, Inflammation, and Insulin Resistance

(2010) Jerrold M. Olefsky et al.   Annual Review of Physiology

Regulation of steady-state neutrophil homeostasis by macrophages

(2010) C. Gordy et al.   BLOOD

Tissue macrophages act as cellular chaperones for vascular anastomosis downstream of VEGF-mediated endothelial tip cell induction

(2010) A. Fantin et al.   BLOOD

Interactions between lymphocytes and myeloid cells regulate pro- versus anti-tumor immunity

(2010) David G. DeNardo et al.   CANCER AND METASTASIS REVIEWS

An Ets2-Driven Transcriptional Program in Tumor-Associated Macrophages Promotes Tumor Metastasis

(2010) T. Zabuawala et al.   CANCER RESEARCH

Nonresolving Inflammation

(2010) Carl Nathan et al.   CELL

Matrix Metalloproteinases: Regulators of the Tumor Microenvironment

(2010) Kai Kessenbrock et al.   CELL

Macrophage Diversity Enhances Tumor Progression and Metastasis

(2010) Bin-Zhi Qian et al.   CELL

Macrophages define dermal lymphatic vessel calibre during development by regulating lymphatic endothelial cell proliferation

(2010) E. J. Gordon et al.   DEVELOPMENT

Serum amyloid P attenuates M2 macrophage activation and protects against fungal spore–induced allergic airway disease

(2010) Ana Paula Moreira et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

More alternative activation of macrophages in lungs of asthmatic patients

(2010) Barbro N. Melgert et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

An Independent Subset of TLR Expressing CCR2-Dependent Macrophages Promotes Colonic Inflammation

(2010) A. M. Platt et al.   JOURNAL OF IMMUNOLOGY

Functional overlap but differential expression of CSF-1 and IL-34 in their CSF-1 receptor-mediated regulation of myeloid cells

(2010) Suwen Wei et al.   JOURNAL OF LEUKOCYTE BIOLOGY

MicroRNA-124 promotes microglia quiescence and suppresses EAE by deactivating macrophages via the C/EBP-α–PU.1 pathway

(2010) Eugene D Ponomarev et al.   NATURE MEDICINE

Inhibition of Mac-1 (CD11b/CD18) enhances tumor response to radiation by reducing myeloid cell recruitment

(2010) G.-O. Ahn et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Development of Monocytes, Macrophages, and Dendritic Cells

(2010) F. Geissmann et al.   SCIENCE

Fate Mapping Analysis Reveals That Adult Microglia Derive from Primitive Macrophages

(2010) F. Ginhoux et al.   SCIENCE

Macrophages: Master Regulators of Inflammation and Fibrosis

(2010) Thomas Wynn et al.   SEMINARS IN LIVER DISEASE

Leukocytes in Mammary Development and Cancer

(2010) L. M. Coussens et al.   Cold Spring Harbor Perspectives in Biology

A Novel Mouse Model of Inflammatory Bowel Disease Links Mammalian Target of Rapamycin-Dependent Hyperproliferation of Colonic Epithelium to Inflammation-Associated Tumorigenesis

(2009) Lin Deng et al.   AMERICAN JOURNAL OF PATHOLOGY

CD47 Is Upregulated on Circulating Hematopoietic Stem Cells and Leukemia Cells to Avoid Phagocytosis

(2009) Siddhartha Jaiswal et al.   CELL

Depletion of Liver Kupffer Cells Prevents the Development of Diet-Induced Hepatic Steatosis and Insulin Resistance

(2009) W. Huang et al.   DIABETES

Disordered macrophage cytokine secretion underlies impaired acute inflammation and bacterial clearance in Crohn's disease

(2009) Andrew M. Smith et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Identification of Two Distinct Macrophage Subsets with Divergent Effects Causing either Neurotoxicity or Regeneration in the Injured Mouse Spinal Cord

(2009) K. A. Kigerl et al.   JOURNAL OF NEUROSCIENCE

Interleukin 10 acts on regulatory T cells to maintain expression of the transcription factor Foxp3 and suppressive function in mice with colitis

(2009) Masako Murai et al.   NATURE IMMUNOLOGY

Macrophages regulate salt-dependent volume and blood pressure by a vascular endothelial growth factor-C–dependent buffering mechanism

(2009) Agnes Machnik et al.   NATURE MEDICINE

Infiltrating Blood-Derived Macrophages Are Vital Cells Playing an Anti-inflammatory Role in Recovery from Spinal Cord Injury in Mice

(2009) Ravid Shechter et al.   PLOS MEDICINE

HIF1α Induces the Recruitment of Bone Marrow-Derived Vascular Modulatory Cells to Regulate Tumor Angiogenesis and Invasion

(2008) Rose Du et al.   CANCER CELL

Adipocyte-Derived Th2 Cytokines and Myeloid PPARδ Regulate Macrophage Polarization and Insulin Sensitivity

(2008) Kihwa Kang et al.   Cell Metabolism

Alternative M2 Activation of Kupffer Cells by PPARδ Ameliorates Obesity-Induced Insulin Resistance

(2008) Justin I. Odegaard et al.   Cell Metabolism

“Re-educating” tumor-associated macrophages by targeting NF-κB

(2008) Thorsten Hagemann et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Deletion of vascular endothelial growth factor in myeloid cells accelerates tumorigenesis

(2008) Christian Stockmann et al.   NATURE