Cellular backpacks for macrophage immunotherapy

The journey to CAR T cell therapy: the pediatric and young adult experience with relapsed or refractory B-ALL

(2019) George Hucks et al.   Blood Cancer Journal

Artificially Reprogrammed Macrophages as Tumor-Tropic Immunosuppression-Resistant Biologics to Realize Therapeutics Production and Immune Activation

(2019) Chu-Xin Li et al.   ADVANCED MATERIALS

CSF1R‐ and SHP2‐Inhibitor‐Loaded Nanoparticles Enhance Cytotoxic Activity and Phagocytosis in Tumor‐Associated Macrophages

(2019) Anujan Ramesh et al.   ADVANCED MATERIALS

CAR T-cell Therapy: A New Era in Cancer Immunotherapy

(2018) Miliotou N. Androulla et al.   CURRENT PHARMACEUTICAL BIOTECHNOLOGY

Interleukin-6 promotes pancreatic cancer cell migration by rapidly activating the small GTPase CDC42

(2018) Gina L. Razidlo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Repolarization of Tumor-Associated Macrophages in a Genetically Engineered Nonsmall Cell Lung Cancer Model by Intraperitoneal Administration of Hyaluronic Acid-Based Nanoparticles Encapsulating MicroRNA-125b

(2018) Neha N. Parayath et al.   NANO LETTERS

Scaffolds that mimic antigen-presenting cells enable ex vivo expansion of primary T cells

(2018) Alexander S Cheung et al.   NATURE BIOTECHNOLOGY

Enhancing T cell therapy through TCR-signaling-responsive nanoparticle drug delivery

(2018) Li Tang et al.   NATURE BIOTECHNOLOGY

Macrophage-mediated delivery of light activated nitric oxide prodrugs with spatial, temporal and concentration control

(2018) Michael A. Evans et al.   Chemical Science

A cancer vaccine-mediated postoperative immunotherapy for recurrent and metastatic tumors

(2018) Tingting Wang et al.   Nature Communications

Nitric Oxide Generated by Tumor-Associated Macrophages Is Responsible for Cancer Resistance to Cisplatin and Correlated With Syntaxin 4 and Acid Sphingomyelinase Inhibition

(2018) Cristiana Perrotta et al.   Frontiers in Immunology

M1 Macrophage-Derived Nanovesicles Potentiate the Anticancer Efficacy of Immune Checkpoint Inhibitors

(2018) Yeon Woong Choo et al.   ACS Nano

Functional muscle recovery with nanoparticle-directed M2 macrophage polarization in mice

(2018) Theresa M. Raimondo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Class IIa HDAC inhibition reduces breast tumours and metastases through anti-tumour macrophages

(2017) Jennifer L. Guerriero et al.   NATURE

Blockade of IDO-kynurenine-AhR metabolic circuitry abrogates IFN-γ-induced immunologic dormancy of tumor-repopulating cells

(2017) Yuying Liu et al.   Nature Communications

Precision Targeting of Tumor Macrophages with a CD206 Binding Peptide

(2017) Pablo Scodeller et al.   Scientific Reports

A Breakthrough: Macrophage-Directed Cancer Immunotherapy

(2016) C. D. Mills et al.   CANCER RESEARCH

Macrophage-based cell therapies: The long and winding road

(2016) Simon Lee et al.   JOURNAL OF CONTROLLED RELEASE

Iron oxide nanoparticles inhibit tumour growth by inducing pro-inflammatory macrophage polarization in tumour tissues

(2016) Saeid Zanganeh et al.   Nature Nanotechnology

The future of cancer treatment: immunomodulation, CARs and combination immunotherapy

(2016) Danny N. Khalil et al.   Nature Reviews Clinical Oncology

Monocyte Trafficking, Engraftment, and Delivery of Nanoparticles and an Exogenous Gene into the Acutely Inflamed Brain Tissue – Evaluations on Monocyte-Based Delivery System for the Central Nervous System

(2016) Hsin-I Tong et al.   PLoS One

Asymmetric Biodegradable Microdevices for Cell-Borne Drug Delivery

(2015) Junfei Xia et al.   ACS Applied Materials & Interfaces

Bioconjugated Manganese Dioxide Nanoparticles Enhance Chemotherapy Response by Priming Tumor-Associated Macrophages toward M1-like Phenotype and Attenuating Tumor Hypoxia

(2015) Manli Song et al.   ACS Nano

Monocyte-mediated delivery of polymeric backpacks to inflamed tissues: a generalized strategy to deliver drugs to treat inflammation

(2015) Aaron C. Anselmo et al.   JOURNAL OF CONTROLLED RELEASE

A dendritic cell vaccine increases the breadth and diversity of melanoma neoantigen-specific T cells

(2015) B. M. Carreno et al.   SCIENCE

Active targeting of chemotherapy to disseminated tumors using nanoparticle-carrying T cells

(2015) Bonnie Huang et al.   Science Translational Medicine

Macrophage activation in human diseases

(2015) Joachim L. Schultze et al.   SEMINARS IN IMMUNOLOGY

Opposite Effects of M1 and M2 Macrophage Subtypes on Lung Cancer Progression

(2015) Ang Yuan et al.   Scientific Reports

IFN-γ Primes Macrophage Activation by Increasing Phosphatase and Tensin Homolog via Downregulation of miR-3473b

(2014) Cong Wu et al.   JOURNAL OF IMMUNOLOGY

Angiogenesis and the Tumor Microenvironment: Vascular Endothelial Growth Factor and Beyond

(2014) Kriti Mittal et al.   SEMINARS IN ONCOLOGY

Macrophage Cytokines: Involvement in Immunity and Infectious Diseases

(2014) Guillermo Arango Duque et al.   Frontiers in Immunology

Macrophage biology in development, homeostasis and disease

(2013) Thomas A. Wynn et al.   NATURE

Inhibition of Tumor Growth and Alteration of Associated Macrophage Cell Type by an HO-1 Inhibitor in Breast Carcinoma-Bearing Mice

(2013) Rui Deng et al.   ONCOLOGY RESEARCH

High-Infiltration of Tumor-Associated Macrophages Predicts Unfavorable Clinical Outcome for Node-Negative Breast Cancer

(2013) Yue Zhang et al.   PLoS One

Cancer immunoediting by the innate immune system in the absence of adaptive immunity

(2012) Timothy O’Sullivan et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The Distribution of Macrophages with a M1 or M2 Phenotype in Relation to Prognosis and the Molecular Characteristics of Colorectal Cancer

(2012) Sofia Edin et al.   PLoS One

Cell-Based Drug Delivery Devices Using Phagocytosis-Resistant Backpacks

(2011) Nishit Doshi et al.   ADVANCED MATERIALS

Fabrication of Multilayered Microparticles by Integrating Layer-by-Layer Assembly and MicroContact Printing

(2011) Peipei Zhang et al.   Small

Frustrated phagocytosis on micro-patterned immune complexes to characterize lysosome movements in live macrophages

(2011) Arnaud Labrousse   Frontiers in Immunology

Bioactive Polyelectrolyte Multilayers: Hyaluronic Acid Mediated B Lymphocyte Adhesion

(2010) Fernando C. Vasconcellos et al.   BIOMACROMOLECULES

Macrophage Expression of Hypoxia-Inducible Factor-1  Suppresses T-Cell Function and Promotes Tumor Progression

(2010) A. L. Doedens et al.   CANCER RESEARCH

Clinical Use of Interferon-γ

(2009) Catriona H.T. Miller et al.   Annals of the New York Academy of Sciences