Bioengineering strategies to accelerate stem cell therapeutics

Hearing Restoration: A Step Closer?

(2017) Jeff Lyon   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Regeneration of the entire human epidermis using transgenic stem cells

(2017) Tobias Hirsch et al.   NATURE

Guided self-organization and cortical plate formation in human brain organoids

(2017) Madeline A Lancaster et al.   NATURE BIOTECHNOLOGY

Synthetic hydrogels for human intestinal organoid generation and colonic wound repair

(2017) Ricardo Cruz-Acuña et al.   NATURE CELL BIOLOGY

Maintenance of neural progenitor cell stemness in 3D hydrogels requires matrix remodelling

(2017) Christopher M. Madl et al.   NATURE MATERIALS

Autologous Induced Stem-Cell–Derived Retinal Cells for Macular Degeneration

(2017) Michiko Mandai et al.   NEW ENGLAND JOURNAL OF MEDICINE

Injectable biomimetic liquid crystalline scaffolds enhance muscle stem cell transplantation

(2017) Eduard Sleep et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Instructing cells with programmable peptide DNA hybrids

(2017) Ronit Freeman et al.   Nature Communications

Clonal Expansion of Lgr5-Positive Cells from Mammalian Cochlea and High-Purity Generation of Sensory Hair Cells

(2017) Will J. McLean et al.   Cell Reports

HuCNS-SC Human NSCs Fail to Differentiate, Form Ectopic Clusters, and Provide No Cognitive Benefits in a Transgenic Model of Alzheimer's Disease

(2017) Samuel E. Marsh et al.   Stem Cell Reports

Preclinical Efficacy Failure of Human CNS-Derived Stem Cells for Use in the Pathway Study of Cervical Spinal Cord Injury

(2017) Aileen J. Anderson et al.   Stem Cell Reports

Marrow-inspired matrix cues rapidly affect early fate decisions of hematopoietic stem and progenitor cells

(2017) Ji Sun Choi et al.   Science Advances

Mature induced-pluripotent-stem-cell-derived human podocytes reconstitute kidney glomerular-capillary-wall function on a chip

(2017) Samira Musah et al.   Nature Biomedical Engineering

Versatile synthetic alternatives to Matrigel for vascular toxicity screening and stem cell expansion

(2017) Eric H. Nguyen et al.   Nature Biomedical Engineering

Injectable hydrogel promotes early survival of induced pluripotent stem cell-derived oligodendrocytes and attenuates longterm teratoma formation in a spinal cord injury model

(2016) T. Führmann et al.   BIOMATERIALS

Brain-Region-Specific Organoids Using Mini-bioreactors for Modeling ZIKV Exposure

(2016) Xuyu Qian et al.   CELL

Tissue Mechanics Orchestrate Wnt-Dependent Human Embryonic Stem Cell Differentiation

(2016) Laralynne Przybyla et al.   Cell Stem Cell

Cystic Fibrosis Patients Benefit from Mini Guts

(2016) Angela Saini   Cell Stem Cell

Designer matrices for intestinal stem cell and organoid culture

(2016) Nikolce Gjorevski et al.   NATURE

MicroRNA-21 preserves the fibrotic mechanical memory of mesenchymal stem cells

(2016) Chen Xi Li et al.   NATURE MATERIALS

N-cadherin adhesive interactions modulate matrix mechanosensing and fate commitment of mesenchymal stem cells

(2016) Brian D. Cosgrove et al.   NATURE MATERIALS

Defined three-dimensional microenvironments boost induction of pluripotency

(2016) Massimiliano Caiazzo et al.   NATURE MATERIALS

Self-organized amniogenesis by human pluripotent stem cells in a biomimetic implantation-like niche

(2016) Yue Shao et al.   NATURE MATERIALS

Instrumented cardiac microphysiological devices via multimaterial three-dimensional printing

(2016) Johan U. Lind et al.   NATURE MATERIALS

Human induced pluripotent stem cell–derived cardiomyocytes recapitulate the predilection of breast cancer patients to doxorubicin-induced cardiotoxicity

(2016) Paul W Burridge et al.   NATURE MEDICINE

Long-term glycemic control using polymer-encapsulated human stem cell–derived beta cells in immune-competent mice

(2016) Arturo J Vegas et al.   NATURE MEDICINE

Characterizing responses to CFTR-modulating drugs using rectal organoids derived from subjects with cystic fibrosis

(2016) Johanna F. Dekkers et al.   Science Translational Medicine

Engineering Immunomodulatory Biomaterials To Tune the Inflammatory Response

(2016) Ajaykumar Vishwakarma et al.   TRENDS IN BIOTECHNOLOGY

Substrate Stress-Relaxation Regulates Scaffold Remodeling and Bone Formation In Vivo

(2016) Max Darnell et al.   Advanced Healthcare Materials

Injectable Hydrogels with In Situ Double Network Formation Enhance Retention of Transplanted Stem Cells

(2015) Lei Cai et al.   ADVANCED FUNCTIONAL MATERIALS

Covalent Modification of Synthetic Hydrogels with Bioactive Proteins via Sortase-Mediated Ligation

(2015) Elena Cambria et al.   BIOMACROMOLECULES

Sequential delivery of immunomodulatory cytokines to facilitate the M1-to-M2 transition of macrophages and enhance vascularization of bone scaffolds

(2015) Kara L. Spiller et al.   BIOMATERIALS

Stem Cell Therapies in Clinical Trials: Progress and Challenges

(2015) Alan Trounson et al.   Cell Stem Cell

Injectable shear-thinning hydrogels used to deliver endothelial progenitor cells, enhance cell engraftment, and improve ischemic myocardium

(2015) Ann C. Gaffey et al.   JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY

Human embryonic stem cell-derived retinal pigment epithelium in patients with age-related macular degeneration and Stargardt's macular dystrophy: follow-up of two open-label phase 1/2 studies

(2015) Steven D Schwartz et al.   LANCET

Matrix elasticity of void-forming hydrogels controls transplanted-stem-cell-mediated bone formation

(2015) Nathaniel Huebsch et al.   NATURE MATERIALS

Stress-stiffening-mediated stem-cell commitment switch in soft responsive hydrogels

(2015) Rajat K. Das et al.   NATURE MATERIALS

A photoreversible protein-patterning approach for guiding stem cell fate in three-dimensional gels

(2015) Cole A. DeForest et al.   NATURE MATERIALS

Hydrogels with tunable stress relaxation regulate stem cell fate and activity

(2015) Ovijit Chaudhuri et al.   NATURE MATERIALS

Contractility of single cardiomyocytes differentiated from pluripotent stem cells depends on physiological shape and substrate stiffness

(2015) Alexandre J. S. Ribeiro et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Protein-engineered scaffolds for in vitro 3D culture of primary adult intestinal organoids

(2015) Rebecca L. DiMarco et al.   Biomaterials Science

Delivery of iPS-NPCs to the Stroke Cavity within a Hyaluronic Acid Matrix Promotes the Differentiation of Transplanted Cells

(2014) Jonathan Lam et al.   ADVANCED FUNCTIONAL MATERIALS

Sustained Delivery of VEGF Maintains Innervation and Promotes Reperfusion in Ischemic Skeletal Muscles Via NGF/GDNF Signaling

(2014) Dmitry Shvartsman et al.   MOLECULAR THERAPY

Light-triggered in vivo activation of adhesive peptides regulates cell adhesion, inflammation and vascularization of biomaterials

(2014) Ted T. Lee et al.   NATURE MATERIALS

Mechanical memory and dosing influence stem cell fate

(2014) Chun Yang et al.   NATURE MATERIALS

Rejuvenation of the muscle stem cell population restores strength to injured aged muscles

(2014) Benjamin D Cosgrove et al.   NATURE MEDICINE

Titrating T-Cell Epitopes within Self-Assembled Vaccines Optimizes CD4+ Helper T Cell and Antibody Outputs

(2014) Rebecca R. Pompano et al.   Advanced Healthcare Materials

Hydrogel Design of Experiments Methodology to Optimize Hydrogel for iPSC-NPC Culture

(2014) Jonathan Lam et al.   Advanced Healthcare Materials

Three-dimensional filamentous human diseased cardiac tissue model

(2013) Zhen Ma et al.   BIOMATERIALS

Toward the Development of a Global Induced Pluripotent Stem Cell Library

(2013) Marc Turner et al.   Cell Stem Cell

Degradation-mediated cellular traction directs stem cell fate in covalently crosslinked three-dimensional hydrogels

(2013) Sudhir Khetan et al.   NATURE MATERIALS

Biophysical regulation of epigenetic state and cell reprogramming

(2013) Timothy L. Downing et al.   NATURE MATERIALS

A fully defined and scalable 3D culture system for human pluripotent stem cell expansion and differentiation

(2013) Y. Lei et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Development of bioactive hydrogel capsules for the 3D expansion of pluripotent stem cells in bioreactors

(2013) Yoji Tabata et al.   Biomaterials Science

Nanotopography Influences Adhesion, Spreading, and Self-Renewal of Human Embryonic Stem Cells

(2012) Weiqiang Chen et al.   ACS Nano

Embryonic stem cell trials for macular degeneration: a preliminary report

(2012) Steven D Schwartz et al.   LANCET

Injectable Solid Peptide Hydrogel as a Cell Carrier: Effects of Shear Flow on Hydrogels and Cell Payload

(2012) Congqi Yan et al.   LANGMUIR

Microparticles bearing encephalitogenic peptides induce T-cell tolerance and ameliorate experimental autoimmune encephalomyelitis

(2012) Daniel R Getts et al.   NATURE BIOTECHNOLOGY

Rapid casting of patterned vascular networks for perfusable engineered three-dimensional tissues

(2012) Jordan S. Miller et al.   NATURE MATERIALS

Stiffening hydrogels to probe short- and long-term cellular responses to dynamic mechanics

(2012) Murat Guvendiren et al.   Nature Communications

Engineering the Regenerative Microenvironment with Biomaterials

(2012) Jeffrey J. Rice et al.   Advanced Healthcare Materials

The influence of substrate creep on mesenchymal stem cell behaviour and phenotype

(2011) Andrew. R. Cameron et al.   BIOMATERIALS

Nanoscale surfaces for the long-term maintenance of mesenchymal stem cell phenotype and multipotency

(2011) Rebecca J. McMurray et al.   NATURE MATERIALS

Artificial niche microarrays for probing single stem cell fate in high throughput

(2011) Samy Gobaa et al.   NATURE METHODS

Improving Viability of Stem Cells During Syringe Needle Flow Through the Design of Hydrogel Cell Carriers

(2011) Brian A. Aguado et al.   TISSUE ENGINEERING PART A

Synthetic polymer coatings for long-term growth of human embryonic stem cells

(2010) Luis G Villa-Diaz et al.   NATURE BIOTECHNOLOGY

Substrate elasticity provides mechanical signals for the expansion of hemopoietic stem and progenitor cells

(2010) Jeff Holst et al.   NATURE BIOTECHNOLOGY

Synthetic peptide-acrylate surfaces for long-term self-renewal and cardiomyocyte differentiation of human embryonic stem cells

(2010) Zara Melkoumian et al.   NATURE BIOTECHNOLOGY

Long-term self-renewal of human pluripotent stem cells on human recombinant laminin-511

(2010) Sergey Rodin et al.   NATURE BIOTECHNOLOGY

Harnessing traction-mediated manipulation of the cell/matrix interface to control stem-cell fate

(2010) Nathaniel Huebsch et al.   NATURE MATERIALS

A defined glycosaminoglycan-binding substratum for human pluripotent stem cells

(2010) Joseph R Klim et al.   NATURE METHODS

Soft Substrates Promote Homogeneous Self-Renewal of Embryonic Stem Cells via Downregulating Cell-Matrix Tractions

(2010) Farhan Chowdhury et al.   PLoS One

Substrate Elasticity Regulates Skeletal Muscle Stem Cell Self-Renewal in Culture

(2010) P. M. Gilbert et al.   SCIENCE

Engulfing tumors with synthetic extracellular matrices for cancer immunotherapy

(2009) Yuki Hori et al.   BIOMATERIALS

Scalable culture and cryopreservation of human embryonic stem cells on microcarriers

(2009) Ying Nie et al.   BIOTECHNOLOGY PROGRESS

Photodegradable Hydrogels for Dynamic Tuning of Physical and Chemical Properties

(2009) April M. Kloxin et al.   SCIENCE

Scalable Stirred-Suspension Bioreactor Culture of Human Pluripotent Stem Cells

(2009) Daniel E. Kehoe et al.   TISSUE ENGINEERING PART A

Vascularization Strategies for Tissue Engineering

(2009) Michael Lovett et al.   TISSUE ENGINEERING PART B-REVIEWS

Substrate Modulus Directs Neural Stem Cell Behavior

(2008) Krishanu Saha et al.   BIOPHYSICAL JOURNAL