Journal
JOURNAL OF CELLULAR PHYSIOLOGY
Volume 234, Issue 11, Pages 19352-19365Publisher
WILEY
DOI: 10.1002/jcp.28657
Keywords
ADCC; cell therapy; natural killer cells; tumor microenvironment
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Funding
- Stem Cell Research Centre, Tabriz University of Medical Sciences [TBZMED.REC.1394.1065, 94/5-3/8]
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Natural killer (NK) cells have significant capability in tumor immune-surveillance. The ability of lyse transformed cells immediately in an antigen-independent manner make them an attractive candidate for cancer cell therapy. Despite employment of NK cells in cancer immunotherapy, clinical trials are faced with serious limitations such as trouble with the penetration of NK cells in tumor sites, limited in vivo persistence, and tumor microenvironment interference. Taken together, the NK-cell cancer therapy is still infant scenario that has a long way to be translated in clinic. Current article first reviews characteristic features of NK lymphocytes. Then, it discusses about important disruptive barriers and motivator in the developmental stages of NK cells like as tumor microenvironment. Finally, some revolutionary approaches are highlighted utilizing of NK cells in cancer therapy.
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