B cells engineered to express pathogen-specific antibodies protect against infection

Reprogramming the antigen specificity of B cells using genome-editing technologies

(2019) James E Voss et al.   eLife

An Antibody Targeting the Fusion Machinery Neutralizes Dual-Tropic Infection and Defines a Site of Vulnerability on Epstein-Barr Virus

(2018) Joost Snijder et al.   IMMUNITY

Boosting half-life and effector functions of therapeutic antibodies by Fc-engineering: An interaction-function review

(2018) Marcela Helena Gambim Fonseca et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

The respiratory syncytial virus vaccine landscape: lessons from the graveyard and promising candidates

(2018) Natalie I Mazur et al.   LANCET INFECTIOUS DISEASES

Engineering Protein-Secreting Plasma Cells by Homology-Directed Repair in Primary Human B Cells

(2018) King L. Hung et al.   MOLECULAR THERAPY

Long-Term Persistence of Anti-HIV Broadly Neutralizing Antibody-Secreting Hematopoietic Cells in Humanized Mice

(2018) Anne-Sophie Kuhlmann et al.   MOLECULAR THERAPY

A high-fidelity Cas9 mutant delivered as a ribonucleoprotein complex enables efficient gene editing in human hematopoietic stem and progenitor cells

(2018) Christopher A. Vakulskas et al.   NATURE MEDICINE

Engineering of Primary Human B cells with CRISPR/Cas9 Targeted Nuclease

(2018) Matthew J. Johnson et al.   Scientific Reports

Global, regional, and national disease burden estimates of acute lower respiratory infections due to respiratory syncytial virus in young children in 2015: a systematic review and modelling study

(2017) Ting Shi et al.   LANCET

Therapeutic T cell engineering

(2017) Michel Sadelain et al.   NATURE

Massively parallel de novo protein design for targeted therapeutics

(2017) Aaron Chevalier et al.   NATURE

Next generation antibody drugs: pursuit of the 'high-hanging fruit'

(2017) Paul J. Carter et al.   NATURE REVIEWS DRUG DISCOVERY

Principles for computational design of binding antibodies

(2017) Dror Baran et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Molecular remission of infant B-ALL after infusion of universal TALEN gene-edited CAR T cells

(2017) Waseem Qasim et al.   Science Translational Medicine

The Individual and Population Genetics of Antibody Immunity

(2017) Corey T. Watson et al.   TRENDS IN IMMUNOLOGY

Nanoparticle delivery of Cas9 ribonucleoprotein and donor DNA in vivo induces homology-directed DNA repair

(2017) Kunwoo Lee et al.   Nature Biomedical Engineering

Structure and Function Analysis of an Antibody Recognizing All Influenza A Subtypes

(2016) Nicole L. Kallewaard et al.   CELL

Somatically Hypermutated Plasmodium-Specific IgM+ Memory B Cells Are Rapid, Plastic, Early Responders upon Malaria Rechallenge

(2016) Akshay T. Krishnamurty et al.   IMMUNITY

Efficient CRISPR-mediated mutagenesis in primary immune cells using CrispRGold and a C57BL/6 Cas9 transgenic mouse line

(2016) Van Trung Chu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Specifically modified Env immunogens activate B-cell precursors of broadly neutralizing HIV-1 antibodies in transgenic mice

(2016) Andrew T. McGuire et al.   Nature Communications

Rapid and highly efficient mammalian cell engineering via Cas9 protein transfection

(2015) Xiquan Liang et al.   JOURNAL OF BIOTECHNOLOGY

An Improved Single-Chain Fab Platform for Efficient Display and Recombinant Expression

(2015) James T. Koerber et al.   JOURNAL OF MOLECULAR BIOLOGY

A Lentiviral Vector Allowing Physiologically Regulated Membrane-anchored and Secreted Antibody Expression Depending on B-cell Maturation Status

(2015) Floriane Fusil et al.   MOLECULAR THERAPY

Hemagglutinin-stem nanoparticles generate heterosubtypic influenza protection

(2015) Hadi M Yassine et al.   NATURE MEDICINE

Management of Respiratory Viral Infections in Hematopoietic Cell Transplant Recipients and Patients With Hematologic Malignancies

(2014) Roy F. Chemaly et al.   CLINICAL INFECTIOUS DISEASES

The Agonists of TLR4 and 9 Are Sufficient to Activate Memory B Cells to Differentiate into Plasma Cells In Vitro but Not In Vivo

(2014) K. Richard et al.   JOURNAL OF IMMUNOLOGY

CD80 and PD-L2 define functionally distinct memory B cell subsets that are independent of antibody isotype

(2014) Griselda V Zuccarino-Catania et al.   NATURE IMMUNOLOGY

Adeno-associated virus delivery of broadly neutralizing antibodies

(2014) Bruce C. Schnepp et al.   Current Opinion in HIV and AIDS

Structure-Based Design of a Fusion Glycoprotein Vaccine for Respiratory Syncytial Virus

(2013) J. S. McLellan et al.   SCIENCE

Deletion and anergy of polyclonal B cells specific for ubiquitous membrane-bound self-antigen

(2012) Justin J. Taylor et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Universal Real-Time PCR for the Detection and Quantification of Adeno-Associated Virus Serotype 2-Derived Inverted Terminal Repeat Sequences

(2012) Christine Aurnhammer et al.   Human Gene Therapy Methods

Management of RSV infections in adult recipients of hematopoietic stem cell transplantation

(2010) J. N. Shah et al.   BLOOD

Structural Basis for Broad and Potent Neutralization of HIV-1 by Antibody VRC01

(2010) T. Zhou et al.   SCIENCE

Rational Design of Envelope Identifies Broadly Neutralizing Human Monoclonal Antibodies to HIV-1

(2010) X. Wu et al.   SCIENCE

Transcription elongation factor ELL2 directs immunoglobulin secretion in plasma cells by stimulating altered RNA processing

(2009) Kathleen Martincic et al.   NATURE IMMUNOLOGY

Engineering human hematopoietic stem/progenitor cells to produce a broadly neutralizing anti-HIV antibody after in vitro maturation to human B lymphocytes.

(2008) X. M. Luo et al.   BLOOD

Nonstructural Proteins 1 and 2 of Respiratory Syncytial Virus Suppress Maturation of Human Dendritic Cells

(2008) S. Munir et al.   JOURNAL OF VIROLOGY

Genetic delivery of an anti-RSV antibody to protect against pulmonary infection with RSV

(2008) Davor Skaricic et al.   VIROLOGY